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Conserved domains on  [gi|392901687|ref|NP_502676|]
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ADP,ATP carrier protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
UNC-93 super family cl47939
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
48-415 1.27e-77

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


The actual alignment was detected with superfamily member pfam05978:

Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 246.85  E-value: 1.27e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687   48 PDRISEYAGYYGQAIQYISFAFFSLFTATIQYYISSKSMLVLSSVLFTTCYIAYIHVNSYIFYSSQLLLGFAYAMYNSAE 127
Cdd:pfam05978   2 PGGISAYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  128 GTYLSEHSSRRTIDSNSALETGLGHTSLFFGGVTMLFVFhfvphTFDGHFLNFDEHVVQVIYFSLMTLTVVSVVLFTFLP 207
Cdd:pfam05978  82 GSYLSENSTRETIERNTSISWAMLQSSLIGGGIFLFIVF-----QSGGQGDEISDGQIKLLYSVFTAISIVGIVVFAFLP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  208 TKQFDSIaLNTQRVTPSMMAQFKRFGKSFSHLNTSLLIFTYVYMGCMVSFMYGIYPTSLSFTSETASDV-YIIALYLLSS 286
Cdd:pfam05978 157 SPDYENV-LSSKEKIQSFADQFKSTFRLLRTPKMLLLAVFFFYTGLEVSFWTSIYPTCISFTSKLGTNTtYLIAIYSIST 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  287 GLAAFLSAMFIRPMIKRLHKYKLIVPMAVHCTSMAIVLFLVYCSVPNQATQRPTSDlANLWITPSRYLSMIIGFLLGFAD 366
Cdd:pfam05978 236 GLGQIIGGIFFGPLGKRIRKFGRDPTILLGTLLHLVYFILIYLSFPNDAPLHPTDG-PGLLITPSLYLAFIISFLLGFSD 314
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 392901687  367 FTITMTRSVICQIAVPDFRAEIFSLTRIYQCVASCVILFISPYLTVTTW 415
Cdd:pfam05978 315 ACWNTQIYSILADAYPEDSSQAFAVFKFYQSIASCVAFFYSPYLTLYWH 363
 
Name Accession Description Interval E-value
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
48-415 1.27e-77

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 246.85  E-value: 1.27e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687   48 PDRISEYAGYYGQAIQYISFAFFSLFTATIQYYISSKSMLVLSSVLFTTCYIAYIHVNSYIFYSSQLLLGFAYAMYNSAE 127
Cdd:pfam05978   2 PGGISAYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  128 GTYLSEHSSRRTIDSNSALETGLGHTSLFFGGVTMLFVFhfvphTFDGHFLNFDEHVVQVIYFSLMTLTVVSVVLFTFLP 207
Cdd:pfam05978  82 GSYLSENSTRETIERNTSISWAMLQSSLIGGGIFLFIVF-----QSGGQGDEISDGQIKLLYSVFTAISIVGIVVFAFLP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  208 TKQFDSIaLNTQRVTPSMMAQFKRFGKSFSHLNTSLLIFTYVYMGCMVSFMYGIYPTSLSFTSETASDV-YIIALYLLSS 286
Cdd:pfam05978 157 SPDYENV-LSSKEKIQSFADQFKSTFRLLRTPKMLLLAVFFFYTGLEVSFWTSIYPTCISFTSKLGTNTtYLIAIYSIST 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  287 GLAAFLSAMFIRPMIKRLHKYKLIVPMAVHCTSMAIVLFLVYCSVPNQATQRPTSDlANLWITPSRYLSMIIGFLLGFAD 366
Cdd:pfam05978 236 GLGQIIGGIFFGPLGKRIRKFGRDPTILLGTLLHLVYFILIYLSFPNDAPLHPTDG-PGLLITPSLYLAFIISFLLGFSD 314
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 392901687  367 FTITMTRSVICQIAVPDFRAEIFSLTRIYQCVASCVILFISPYLTVTTW 415
Cdd:pfam05978 315 ACWNTQIYSILADAYPEDSSQAFAVFKFYQSIASCVAFFYSPYLTLYWH 363
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
15-411 1.04e-29

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340965  Cd Length: 387  Bit Score: 119.29  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  15 VFMMSIGTTFMFLGYDVQSMMAESVLHSVSTKNPDRISeyAGYYGQAIQYISFAFFSLFTATIQYYISSKSMLVLSSVLF 94
Cdd:cd17407    1 VIILGVAFMFIFTAFQTCGNIEQTVIKSLNQGNTTFHG--SGYTSLAIIYGVFAASNWIAPSVVAVIGPKWSMVVGGLTY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  95 TTCYIAYIHVNSYIFYSSQLLLGFAYAMYNSAEGTYLSEHSSRRTIDSNSALETGLGHTSLFFGGVTMLFVFHFVPHtfd 174
Cdd:cd17407   79 SLFIASFIQPMTWSLYTASVLLGIGAAVLWTGQGNFLTINSDSETIGRNSGIFWALLQCSLLFGNLYVYFAFQGKTT--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 175 ghflnFDEHVVQVIYFSLMTLTVVSVVLFTFLPTKQFDSialntqrvtPSMMaqfkrfgksfshlntsLLIFTYVYMGCM 254
Cdd:cd17407  156 -----ISDHDRRTVFIVLTVISLVGVVLLFLLRKPPSEP---------KEML----------------LLSVTFAYTGLE 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 255 VSFMYGIYPTSLSFTSETASD-VYIIALYLLSSGLAAFLSAMFIRPMIKRLHKY--KLIVPMAvhCTSMAIVLFLVYCSV 331
Cdd:cd17407  206 LTFFSGVYGTCIGNTNKFGEDaKSLIGLSGIFIGIGEILGGGLFGILGKKTNRFgrDPIVLLG--FVVHLIAFYLIFLNI 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 332 PNQATQRPTSDLANLwITPSRYLSMIIGFLLGFADFTI-TMTRSVICQIaVPDFRAEIFSLTRIYQCVASCVILFISPYL 410
Cdd:cd17407  284 PSDAPIAEGTNDSAY-IEPSAYVALFCSFLLGFGDSCFnTQIYSILGFM-YPEDSAPAFALFKFVQSIAAAIAFFYSNYL 361

                 .
gi 392901687 411 T 411
Cdd:cd17407  362 L 362
 
Name Accession Description Interval E-value
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
48-415 1.27e-77

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 246.85  E-value: 1.27e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687   48 PDRISEYAGYYGQAIQYISFAFFSLFTATIQYYISSKSMLVLSSVLFTTCYIAYIHVNSYIFYSSQLLLGFAYAMYNSAE 127
Cdd:pfam05978   2 PGGISAYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  128 GTYLSEHSSRRTIDSNSALETGLGHTSLFFGGVTMLFVFhfvphTFDGHFLNFDEHVVQVIYFSLMTLTVVSVVLFTFLP 207
Cdd:pfam05978  82 GSYLSENSTRETIERNTSISWAMLQSSLIGGGIFLFIVF-----QSGGQGDEISDGQIKLLYSVFTAISIVGIVVFAFLP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  208 TKQFDSIaLNTQRVTPSMMAQFKRFGKSFSHLNTSLLIFTYVYMGCMVSFMYGIYPTSLSFTSETASDV-YIIALYLLSS 286
Cdd:pfam05978 157 SPDYENV-LSSKEKIQSFADQFKSTFRLLRTPKMLLLAVFFFYTGLEVSFWTSIYPTCISFTSKLGTNTtYLIAIYSIST 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  287 GLAAFLSAMFIRPMIKRLHKYKLIVPMAVHCTSMAIVLFLVYCSVPNQATQRPTSDlANLWITPSRYLSMIIGFLLGFAD 366
Cdd:pfam05978 236 GLGQIIGGIFFGPLGKRIRKFGRDPTILLGTLLHLVYFILIYLSFPNDAPLHPTDG-PGLLITPSLYLAFIISFLLGFSD 314
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 392901687  367 FTITMTRSVICQIAVPDFRAEIFSLTRIYQCVASCVILFISPYLTVTTW 415
Cdd:pfam05978 315 ACWNTQIYSILADAYPEDSSQAFAVFKFYQSIASCVAFFYSPYLTLYWH 363
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
15-411 1.04e-29

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340965  Cd Length: 387  Bit Score: 119.29  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  15 VFMMSIGTTFMFLGYDVQSMMAESVLHSVSTKNPDRISeyAGYYGQAIQYISFAFFSLFTATIQYYISSKSMLVLSSVLF 94
Cdd:cd17407    1 VIILGVAFMFIFTAFQTCGNIEQTVIKSLNQGNTTFHG--SGYTSLAIIYGVFAASNWIAPSVVAVIGPKWSMVVGGLTY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  95 TTCYIAYIHVNSYIFYSSQLLLGFAYAMYNSAEGTYLSEHSSRRTIDSNSALETGLGHTSLFFGGVTMLFVFHFVPHtfd 174
Cdd:cd17407   79 SLFIASFIQPMTWSLYTASVLLGIGAAVLWTGQGNFLTINSDSETIGRNSGIFWALLQCSLLFGNLYVYFAFQGKTT--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 175 ghflnFDEHVVQVIYFSLMTLTVVSVVLFTFLPTKQFDSialntqrvtPSMMaqfkrfgksfshlntsLLIFTYVYMGCM 254
Cdd:cd17407  156 -----ISDHDRRTVFIVLTVISLVGVVLLFLLRKPPSEP---------KEML----------------LLSVTFAYTGLE 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 255 VSFMYGIYPTSLSFTSETASD-VYIIALYLLSSGLAAFLSAMFIRPMIKRLHKY--KLIVPMAvhCTSMAIVLFLVYCSV 331
Cdd:cd17407  206 LTFFSGVYGTCIGNTNKFGEDaKSLIGLSGIFIGIGEILGGGLFGILGKKTNRFgrDPIVLLG--FVVHLIAFYLIFLNI 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 332 PNQATQRPTSDLANLwITPSRYLSMIIGFLLGFADFTI-TMTRSVICQIaVPDFRAEIFSLTRIYQCVASCVILFISPYL 410
Cdd:cd17407  284 PSDAPIAEGTNDSAY-IEPSAYVALFCSFLLGFGDSCFnTQIYSILGFM-YPEDSAPAFALFKFVQSIAAAIAFFYSNYL 361

                 .
gi 392901687 411 T 411
Cdd:cd17407  362 L 362
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
19-410 2.97e-16

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 80.08  E-value: 2.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  19 SIGTTFMFLGYDVQSMMAESVlhsvstknpdrISEYAGYYGQAIQYISFAFFSLFTATIQYYISSKSMLVLSSVLFTTCY 98
Cdd:cd17338    5 SFGFLLIFLAYSALQNLQTSL-----------HENGLGSISLGILYSSFAVSSFIAPLLVKLLGEKITLVLGGLGYAIFI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687  99 IAYIHVNSYIFYSSQLLLGFAYAMYNSAEGTYLSEHSSRRTIDSNSALETGLGHTSLFFGGVTMLFVFHFVPhtfdghfl 178
Cdd:cd17338   74 ASNIFPIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSIFQLSQVFGNLISLALLNHSK-------- 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 179 nfDEHVVQVIYFSLMTLTVVSVVLFtFLPTKQFDSIALNTQRVTPSMMAQFKR-FGKSFSHLNTS---LLIFTYVYMGCM 254
Cdd:cd17338  146 --GSSGTTILFIVFMAIMLVGIILL-FFLRGPDNEVITEIESSSVGESMEKKNlFKLPFTLLKDKrflLLIPLLIYSGLE 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901687 255 VSFMYGIYPTSLSFTSETASDV-YIIALYLLSSGLAAFLSAMFIRpmiKRLHKYKLIVPMAVHCTSMAIVLFLVYCSVPn 333
Cdd:cd17338  223 QTFFSGVFTLIIGTPTTGIARVgYVMAVYGFGDALGSLVAGLLSD---WRFGRIVLAVIGAFVHIASLILLFLSGNVTP- 298
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392901687 334 qatqrptsdlanlWITPSRYLSMIIGFLLGFADFTITMTRSVICQIAVPDFRAEIFSLTRIYQCVASCVILFISPYL 410
Cdd:cd17338  299 -------------YGLGGSWLAYVSAILWGLGDAIFNTQIYALLGSLYENDSESAFAVYKLWQSIATAIAYFLSPYL 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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