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Conserved domains on  [gi|17544184|ref|NP_502852|]
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Putative T-box protein 40 [Caenorhabditis elegans]

Protein Classification

T-box-containing protein( domain architecture ID 10075811)

T-box-containing protein may act as a transcriptional regulator involved in developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 9-180 1.74e-49

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


:

Pssm-ID: 410312  Cd Length: 176  Bit Score: 164.69  E-value: 1.74e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   9 VQMAEEDRWLTQYPN-MEMIVNNKGpKPIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVrhATKKEQ 87
Cdd:cd00182   3 VSLRNEELWKKFHELgTEMIVTKSG-RRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGK--AEPPPE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  88 EIKYFLHPDGTKLGEELMKETIKFDTVRITNHKKfMDKDNVFFVETMHKYVPVLTVKNITNVESAN---HSMRMEVAQFF 164
Cdd:cd00182  80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKE-DKKEGHILLHSMHKYIPVLTIYEVDDNGLLSklvKEFRFPETEFI 158

                       170
                ....*....|....*.
gi 17544184 165 PVTVYNQESIGNWKSK 180
Cdd:cd00182 159 AVTAYQNDEITQLKID 174
 
Name Accession Description Interval E-value
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 9-180 1.74e-49

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 164.69  E-value: 1.74e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   9 VQMAEEDRWLTQYPN-MEMIVNNKGpKPIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVrhATKKEQ 87
Cdd:cd00182   3 VSLRNEELWKKFHELgTEMIVTKSG-RRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGK--AEPPPE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  88 EIKYFLHPDGTKLGEELMKETIKFDTVRITNHKKfMDKDNVFFVETMHKYVPVLTVKNITNVESAN---HSMRMEVAQFF 164
Cdd:cd00182  80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKE-DKKEGHILLHSMHKYIPVLTIYEVDDNGLLSklvKEFRFPETEFI 158

                       170
                ....*....|....*.
gi 17544184 165 PVTVYNQESIGNWKSK 180
Cdd:cd00182 159 AVTAYQNDEITQLKID 174
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 24-172 2.52e-33

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 122.28  E-value: 2.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184    24 MEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPskvrhATKKEQEI--KYFLHPDGTKLG 101
Cdd:pfam00907  17 TEMIITKSGRR-MFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVV-----AGKAEPHSppRVYIHPDSPATG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17544184   102 EELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVA-----QFFPVTVY-NQE 172
Cdd:pfam00907  91 SHWMKQPVSFDKLKLTNNK--EDKNGHIILNSMHKYQPRLHIVRVGGDEPSLPEENVKTFvfpetEFIAVTAYqNEE 165
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
9-174 8.79e-28

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 107.74  E-value: 8.79e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184      9 VQMAEEDRWLTQYP-NMEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVrhaTKKEQ 87
Cdd:smart00425   3 VSLEDKELWRKFHElGTEMIVTKSGRR-MFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGK---AEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184     88 EIKYFLHPDGTKLGEELMKETIKFDTVRITNHKkfMDKDN--VFFVETMHKYVPVLTVKNITNVE----SANHSMRMEVA 161
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQ--SDKNGhlQIILNSMHKYQPRLHIVEVDDISkeilSQFKTFVFPET 156

                          170
                   ....*....|...
gi 17544184    162 QFFPVTVYNQESI 174
Cdd:smart00425 157 QFIAVTAYQNQKI 169
 
Name Accession Description Interval E-value
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 9-180 1.74e-49

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 164.69  E-value: 1.74e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   9 VQMAEEDRWLTQYPN-MEMIVNNKGpKPIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVrhATKKEQ 87
Cdd:cd00182   3 VSLRNEELWKKFHELgTEMIVTKSG-RRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGK--AEPPPE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  88 EIKYFLHPDGTKLGEELMKETIKFDTVRITNHKKfMDKDNVFFVETMHKYVPVLTVKNITNVESAN---HSMRMEVAQFF 164
Cdd:cd00182  80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKE-DKKEGHILLHSMHKYIPVLTIYEVDDNGLLSklvKEFRFPETEFI 158

                       170
                ....*....|....*.
gi 17544184 165 PVTVYNQESIGNWKSK 180
Cdd:cd00182 159 AVTAYQNDEITQLKID 174
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 24-172 2.52e-33

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 122.28  E-value: 2.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184    24 MEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPskvrhATKKEQEI--KYFLHPDGTKLG 101
Cdd:pfam00907  17 TEMIITKSGRR-MFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVV-----AGKAEPHSppRVYIHPDSPATG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17544184   102 EELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVA-----QFFPVTVY-NQE 172
Cdd:pfam00907  91 SHWMKQPVSFDKLKLTNNK--EDKNGHIILNSMHKYQPRLHIVRVGGDEPSLPEENVKTFvfpetEFIAVTAYqNEE 165
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
9-174 8.79e-28

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 107.74  E-value: 8.79e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184      9 VQMAEEDRWLTQYP-NMEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVrhaTKKEQ 87
Cdd:smart00425   3 VSLEDKELWRKFHElGTEMIVTKSGRR-MFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGK---AEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184     88 EIKYFLHPDGTKLGEELMKETIKFDTVRITNHKkfMDKDN--VFFVETMHKYVPVLTVKNITNVE----SANHSMRMEVA 161
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQ--SDKNGhlQIILNSMHKYQPRLHIVEVDDISkeilSQFKTFVFPET 156

                          170
                   ....*....|...
gi 17544184    162 QFFPVTVYNQESI 174
Cdd:smart00425 157 QFIAVTAYQNQKI 169
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 8-181 8.08e-22

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 91.56  E-value: 8.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   8 NVQMAEEDRWLTQYPNM-EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSkvrhaTKKE 86
Cdd:cd20192   2 RVTLEDRELWKKFHSLTnEMIVTKSGRR-MFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYVNGEWVPG-----GKAE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  87 QEIK--YFLHPDGTKLGEELMKETIKFDTVRITNhkKFMDKDNVfFVETMHKYVPVLtvkNITNVESANH-----SMRME 159
Cdd:cd20192  76 PPPPssVYVHPDSPNFGAHWMKGPVSFSKVKLTN--KPNGEGQI-MLNSLHKYEPRV---HIVRVGSNNHerlvsTFSFP 149

                       170       180
                ....*....|....*....|..
gi 17544184 160 VAQFFPVTVYNQESIGNWKSKF 181
Cdd:cd20192 150 ETQFIAVTAYQNEEITALKIKY 171
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 25-139 3.29e-18

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 82.44  E-value: 3.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGpKPIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKW----------GPSKVRHATKKEQEIKYFLH 94
Cdd:cd20683  20 EMIITKSG-RCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFRNGRWnpidkdqrgdDAFSSGTADKSVLLPESYIH 98

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17544184  95 PDGTKLGEELMKETIKFDTVRITN----------------HKKFMDKDNVFFVETMHKYVP 139
Cdd:cd20683  99 PDGPQTGAFWMANGISFAKIKLSNrqpnssdrdgpkenitNSISALPDGHFFLTSFHKYQP 159
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 8-172 3.33e-18

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 81.67  E-value: 3.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   8 NVQMAEEDRWLtQYPNM--EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDN--IRYGFKNGKW---GPSKVR 80
Cdd:cd20682   2 QVELCSRELWL-QFHNLgnEMIITKAGRR-MFPALKVKLTGLDPDKLYIVWVDIVPVDSnrYRYVYHSSKWvvaGSGDVL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  81 HATKKeqeikyFLHPDGTKLGEELMKETIKFDTVRITNHKKFMDKDNVFFVeTMHKYVPVLTVKNITNVESANHSM--RM 158
Cdd:cd20682  80 PPANR------YIHPDSPASGKYWMSQIVSFDKLKLTNNKEPKQKGQISLH-SMHKYQPRIHIQPVEDDGRNVEKAinSS 152

                       170       180
                ....*....|....*....|..
gi 17544184 159 EVAQF-FP------VTVY-NQE 172
Cdd:cd20682 153 KALSFeFPetsfitVTAYqNQQ 174
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 6-182 6.55e-18

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 80.85  E-value: 6.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   6 QFNVQMAEEDRWlTQYPNM--EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPskvrhAT 83
Cdd:cd20202   1 ELKVSLEESELW-LRFKELtnEMIVTKNGRR-MFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVP-----GG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  84 KKEQEIK--YFLHPDGTKLGEELMKETIKFDTVRITNHkkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVA 161
Cdd:cd20202  74 KPEPQAPscVYIHPDSPNFGAHWMKAPVSFSKVKLTNK---LNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHSFPET 150

                       170       180
                ....*....|....*....|.
gi 17544184 162 QFFPVTVYNQESIGNWKSKFH 182
Cdd:cd20202 151 QFIAVTAYQNEEITALKIKYN 171
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 25-174 5.21e-17

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 78.14  E-value: 5.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGF-KNGKWGPSKVRHAtKKEQEIKYFLHPDGTKLGEE 103
Cdd:cd20681  20 EMIITKSGRR-MFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYsGNGGWVPAGGAEP-QPPLPRRIYIHPDSPATGDH 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17544184 104 LMKETIKFDTVRITNHkkFMDKDNVFFVETMHKYVPVLTV---KNITNVESA-NHSMRMEVAQFFPVTVYNQESI 174
Cdd:cd20681  98 WMSQPISFSKVKLTNN--TLDPQGNIVLTSMHKYQPRIHIvrcSDTLALPWApTASFTFPETEFIAVTAYQNERI 170
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 23-178 1.98e-15

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 73.66  E-value: 1.98e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  23 NMEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKvrHATKKEQEIKYFLHPDGTKLGE 102
Cdd:cd20194  19 QTEMIITKQGRR-MFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKFQSGKWVPCG--KAEGLPQGNRVYVHPDSPNTGA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 103 ELMKETIKFDTVRITNHKkfmDKDNVFFV-ETMHKYVPVLTVKNIT----NVESANHSMRMEVAQFFPVTVYNQESIGNW 177
Cdd:cd20194  96 HWMKQEISFSKLKLTNNK---GADQGMIVlNSMHKYQPRIHVIEVGgngpNEQRNLQTHSFPETQFIAVTAYQNTDITQL 172


                .
gi 17544184 178 K 178
Cdd:cd20194 173 K 173
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 25-178 3.90e-15

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 72.85  E-value: 3.90e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPskvrhATKKEQEI--KYFLHPDGTKLGE 102
Cdd:cd20189  20 EMIITKAGRR-MFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKFHDSEWVV-----AGKAEPAMpgRLYVHPDSPATGA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 103 ELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVP---VLTVKNITNVESANHSMRMEV---AQFFPVTVYNQESIGN 176
Cdd:cd20189  94 HWMRQLVSFQKLKLTNNH--LDQFGHIILNSMHKYQPrihIVQADDNNAFGSKNTAFSTHVfpeTAFIAVTAYQNHQITQ 171


                ..
gi 17544184 177 WK 178
Cdd:cd20189 172 LK 173
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 4-182 4.99e-15

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 72.75  E-value: 4.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   4 QAQFNVQMAEEDRWLT-QYPNMEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPskvrhA 82
Cdd:cd20201   3 EKQLQVSLEDAELWQRfKEVTNEMIVTKNGRR-MFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYVNGEWVP-----A 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  83 TKKEQEIK--YFLHPDGTKLGEELMKETIKFDTVRITNHkkfMDKDNVFFVETMHKYVPVLTVKNItnveSANHSMRMEV 160
Cdd:cd20201  77 GKPEPHSHscVYIHPDSPNFGAHWMKAPISFSKVKLTNK---LNGGGQIMLNSLHKYEPQIHIVRV----GGPHRMVTNC 149

                       170       180
                ....*....|....*....|....*.
gi 17544184 161 A----QFFPVTVYNQESIGNWKSKFH 182
Cdd:cd20201 150 SfpetQFIAVTAYQNEEITALKIKYN 175
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 25-178 9.73e-15

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 71.84  E-value: 9.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKvrhatKKEQEI--KYFLHPDGTKLGE 102
Cdd:cd20190  20 EMIITKSGRR-MFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKWNKRRWEPSG-----KAEPHLpdRVYIHPDSPAPGA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 103 ELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESAN----HSMRMEVAQFFPVTVYNQESIGNWK 178
Cdd:cd20190  94 HWMRQPISFHKLKLTNNT--LDPHGHLILHSMHKYQPRIHLVQSADLCSQHwggmASFRFPETTFIAVTAYQNPQITKLK 171
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 25-178 3.01e-14

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 70.26  E-value: 3.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYgfkngKWGPSKVRHATKKEQEI--KYFLHPDGTKLGE 102
Cdd:cd20197  20 EMIITKSGRR-MFPQCKIRVSGLLPYAKYVMLVDFVPVDNFRY-----KWNKDQWEVAGKAEPQPpcRTYVHPDSPAPGS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 103 ELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEV----AQFFPVTVYNQESIGNWK 178
Cdd:cd20197  94 HWMKQPISFQKLKLTNNT--LDQHGHIILHSMHRYQPRFHIVQADDLFNVRWSLFQVFsfpeTVFTAVTAYQNEKITKLK 171
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 25-169 4.92e-14

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 69.77  E-value: 4.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKwgpSKVRHATKKEQEIK--YFLHPDGTKLGE 102
Cdd:cd20193  20 EMIITKSGRR-MFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHR---SSWLVAGKADPPLParLYVHPDSPFTGE 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17544184 103 ELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVP----VLTVKNITNVESANHsmrMEVAQF-FPVTVY 169
Cdd:cd20193  96 QLLKQMVSFEKVKLTNNE--LDKHGHIILNSMHKYQPrvhiVKKKDHTASLVNLKS---EEFRTFiFPETVF 162
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 25-178 9.19e-14

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 69.38  E-value: 9.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKvrHATKKEQEIKYFLHPDGTKLGEEL 104
Cdd:cd20204  21 EMIITKQGRR-MFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCG--KADTNVQGNRVYMHPDSPNTGAHW 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 105 MKETIKFDTVRITNHKKFMDKDNVFFV-ETMHKYVPVLTVKNITN--VESANHSMRMEV-----AQFFPVTVYNQESIGN 176
Cdd:cd20204  98 MRQEISFGKLKLTNNKGASNNNGQMVVlQSLHKYQPRLHVVEVNEdgTEDTSQPGRVQTftfpeTQFIAVTAYQNTDITQ 177


                ..
gi 17544184 177 WK 178
Cdd:cd20204 178 LK 179
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 25-186 4.01e-13

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 67.07  E-value: 4.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWGPSKVRHAtkkEQEIKYFLHPDGTKLGEEL 104
Cdd:cd20195  20 EMILTKQGRR-MFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEP---HVLGRVFIHPESPATGRHW 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 105 MKETIKFDTVRITNHkkFMDKDNVFFVETMHKYVP---VLTVKNITNVESAN----HSMRMEVAQFFPVTVYNQESIGNW 177
Cdd:cd20195  96 MDQPVSFYKLKLTNN--TLDQEGHIILHSMHRYLPrlhVVPADKEVDVIQLNgpdvHTFTFPQTEFFAVTAYQNKQITQL 173


                ....*....
gi 17544184 178 KSKFHKNAT 186
Cdd:cd20195 174 KIDYNPFAK 182
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 25-178 6.22e-13

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 67.01  E-value: 6.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWgpSKVRHATKKEQEIKYFLHPDGTKLGEEL 104
Cdd:cd20205  21 EMIITKQGRR-MFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKW--VTCGKADNNMQGNKVYVHPESPNTGAHW 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 105 MKETIKFDTVRITNHKKFMDKDNVFFV-ETMHKYVPVLTVKNIT-------NVESANHSMRMEVAQFFPVTVYNQESIGN 176
Cdd:cd20205  98 MRQEISFGKLKLTNNKGANNNNTQMIVlQSLHKYQPRLHIVEVSedgvedlNDSSKTQTFTFPENQFIAVTAYQNTDITQ 177


                ..
gi 17544184 177 WK 178
Cdd:cd20205 178 LK 179
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 25-178 2.65e-12

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 64.98  E-value: 2.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184  25 EMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDNIRYGFKNGKWgpskvRHATKKEQEI---KYFLHPDGTKLG 101
Cdd:cd20203  21 EMIITKQGRR-MFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWRYQGGKW-----VQCGKAEGNMpgnRLYVHPDSPNTG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184 102 EELMKETIKFDTVRITNHKKFMDKDNVFFV-ETMHKYVPVLTVKNITNVE-------SANHSMRMEVAQFFPVTVYNQES 173
Cdd:cd20203  95 AHWMRQEVSFGKLKLTNNKGASNNVTQMIVlQSLHKYQPRLHIVEVKEGEteeayssSKTHTFTFPETQFIAVTAYQNAE 174


                ....*
gi 17544184 174 IGNWK 178
Cdd:cd20203 175 ITQLK 179
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 1-143 1.20e-10

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 60.51  E-value: 1.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544184   1 MIQQAQFNVQMAEEDRWLTQYP-NMEMIVNNKGPKpIFPELNFNITGLEEKSRYVVLLSIQKFDN--IRYGFKNGKWgps 77
Cdd:cd20198   1 TSSMEEIQVELQCADLWKRFHDiGTEMIITKAGRR-MFPAMRVKITGLDPHQQYYIAMDIVPVDNkrYRYVYHSSKW--- 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17544184  78 KVRHATKKEQEIKYFLHPDGTKLGEELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTV 143
Cdd:cd20198  77 MVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNE--LDDQGHIILHSMHKYQPRVHV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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