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Conserved domains on  [gi|133931216|ref|NP_503010|]
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Transmembrane protein 185B [Caenorhabditis elegans]

Protein Classification

TMEM185 family RING finger protein( domain architecture ID 10563171)

TMEM185 family protein with a RING finger domain similar to Arabidopsis thaliana transmembrane Fragile-X-F-associated protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 33-271 1.04e-61

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


:

Pssm-ID: 402059  Cd Length: 245  Bit Score: 199.99  E-value: 1.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216   33 LKLDGKVSFSYAFVFAPLWACNLLVFVGAIVGICSFCSKPPSRNEIVMRVDFSAMLITatehIFLCTFVSLVFIKLEFDY 112
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLESTY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  113 LfEPGYPLPWTIVFCPLFSLSILSIGIAIWSLRHDKPFEFEFFY-------------AINIVQLV----FIAFKLDKQVD 175
Cdd:pfam10269  77 V-GLSGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  176 ----WTWAVVFiplwvvlslaavGVLYALVLSVVLIRSRHFIPAH------RRQHVYSAILHTFFVIPALVCLVLLTGKL 245
Cdd:pfam10269 156 algwWDWFINF------------GVLYCFAFLVCTKWSNPVIASQsnisssSSTHIFYADWYSILKIPLIVFQVLLAAKL 223

                         250       260
                  ....*....|....*....|....*.
gi 133931216  246 DSMNwpdkGSVSELSYTLAMAPLQVS 271
Cdd:pfam10269 224 EGTP----AAVADIPIAVVFAPLFLL 245
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 33-271 1.04e-61

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 199.99  E-value: 1.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216   33 LKLDGKVSFSYAFVFAPLWACNLLVFVGAIVGICSFCSKPPSRNEIVMRVDFSAMLITatehIFLCTFVSLVFIKLEFDY 112
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLESTY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  113 LfEPGYPLPWTIVFCPLFSLSILSIGIAIWSLRHDKPFEFEFFY-------------AINIVQLV----FIAFKLDKQVD 175
Cdd:pfam10269  77 V-GLSGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  176 ----WTWAVVFiplwvvlslaavGVLYALVLSVVLIRSRHFIPAH------RRQHVYSAILHTFFVIPALVCLVLLTGKL 245
Cdd:pfam10269 156 algwWDWFINF------------GVLYCFAFLVCTKWSNPVIASQsnisssSSTHIFYADWYSILKIPLIVFQVLLAAKL 223

                         250       260
                  ....*....|....*....|....*.
gi 133931216  246 DSMNwpdkGSVSELSYTLAMAPLQVS 271
Cdd:pfam10269 224 EGTP----AAVADIPIAVVFAPLFLL 245
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 160-277 9.49e-04

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 39.21  E-value: 9.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216 160 IVQLVFIAFKLDKQVDWTWAVVFIPLWVVLSLAAVGVLyalvlsVVLIRSrhFIPAHRRQHVYSAILHTFFVIPALVCLV 239
Cdd:cd22816   25 LVFSVLLALKLEGHLSASWWTVFSPLFAADGLSAYFCV------IVFVRL--YQEGEKRLAVLRLFWSLTVLSLIFVFEM 96

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 133931216 240 LLTGKLDSMNwpdkgsvsELSYTLAMAPLQVSFFFMAI 277
Cdd:cd22816   97 LLCQKLEGQN--------ELWYSLVFSPLFILLQLLMI 126
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 33-271 1.04e-61

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 199.99  E-value: 1.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216   33 LKLDGKVSFSYAFVFAPLWACNLLVFVGAIVGICSFCSKPPSRNEIVMRVDFSAMLITatehIFLCTFVSLVFIKLEFDY 112
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFHAVVAT----PLLLAFELLLCIYLESTY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  113 LfEPGYPLPWTIVFCPLFSLSILSIGIAIWSLRHDKPFEFEFFY-------------AINIVQLV----FIAFKLDKQVD 175
Cdd:pfam10269  77 V-GLSGALDWTIVFLPLLALEVVILVDNIRMCRALRPGDEESFSdeaiwetlphfwvAISMVFFVaattFTLLKLDGDVE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  176 ----WTWAVVFiplwvvlslaavGVLYALVLSVVLIRSRHFIPAH------RRQHVYSAILHTFFVIPALVCLVLLTGKL 245
Cdd:pfam10269 156 algwWDWFINF------------GVLYCFAFLVCTKWSNPVIASQsnisssSSTHIFYADWYSILKIPLIVFQVLLAAKL 223

                         250       260
                  ....*....|....*....|....*.
gi 133931216  246 DSMNwpdkGSVSELSYTLAMAPLQVS 271
Cdd:pfam10269 224 EGTP----AAVADIPIAVVFAPLFLL 245
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 160-277 9.49e-04

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 39.21  E-value: 9.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216 160 IVQLVFIAFKLDKQVDWTWAVVFIPLWVVLSLAAVGVLyalvlsVVLIRSrhFIPAHRRQHVYSAILHTFFVIPALVCLV 239
Cdd:cd22816   25 LVFSVLLALKLEGHLSASWWTVFSPLFAADGLSAYFCV------IVFVRL--YQEGEKRLAVLRLFWSLTVLSLIFVFEM 96

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 133931216 240 LLTGKLDSMNwpdkgsvsELSYTLAMAPLQVSFFFMAI 277
Cdd:cd22816   97 LLCQKLEGQN--------ELWYSLVFSPLFILLQLLMI 126
PGAP4-like_fungal cd22189
uncharacterized fungal proteins similar to Post-GPI attachment to proteins factor 4; This ...
 196-245 2.65e-03

uncharacterized fungal proteins similar to Post-GPI attachment to proteins factor 4; This subfamily contains uncharacterized fungal proteins with similarity to animal post-GPI attachment to proteins factor 4 (PGAP4), also known as post-GPI attachment to proteins GalNAc transferase 4 or transmembrane protein 246 (TMEM246). PGAP4 has been shown to be a Golgi-resident GPI-GalNAc transferase. Many eukaryotic proteins are anchored to the cell surface through glycolipid glycosylphosphatidylinositol (GPI). GPIs have a conserved core but exhibit diverse N-acetylgalactosamine (GalNAc) modifications. PGAP4 knockout cells lose GPI-GalNAc structures. PGAP4 is most likely involved in the initial steps of GPI-GalNAc biosynthesis. In contrast to other Golgi glycotransferases, it contains three transmembrane domains. Proteins from this subfamily contain the putative catalytic site of PGAP4 and may have similar activities.


Pssm-ID: 409190  Cd Length: 375  Bit Score: 39.84  E-value: 2.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 133931216 196 VLYALVLSVVLIRSRHFIPAHRRQHVYSAILHTFFVIPALVCLVLLTGKL 245
Cdd:cd22189  248 LVVALVALALLLLRRRRRPARRSLTNPTIAVICLVCVPALILLFFAAGRV 297
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 24-135 8.20e-03

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 36.52  E-value: 8.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931216  24 LLIFTALFTLKLDGKVSFSYAFVFAPLWACNLL-VFVGAIVGICSFcsKPPSRNEIVMRVDFSAmlitatehiflcTFVS 102
Cdd:cd22816   24 LLVFSVLLALKLEGHLSASWWTVFSPLFAADGLsAYFCVIVFVRLY--QEGEKRLAVLRLFWSL------------TVLS 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 133931216 103 LVFIkleFDYLF----EPGYPLPWTIVFCPLFSLSIL 135
Cdd:cd22816   90 LIFV---FEMLLcqklEGQNELWYSLVFSPLFILLQL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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