EGF-like domain-containing protein [Caenorhabditis elegans]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
DUF5585 super family | cl39316 | Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
502-688 | 1.26e-05 | ||||
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. The actual alignment was detected with superfamily member pfam17823: Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.57 E-value: 1.26e-05
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EGF_2 | pfam07974 | EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
1505-1530 | 4.01e-04 | ||||
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. : Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 4.01e-04
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Name | Accession | Description | Interval | E-value | ||||
DUF5585 | pfam17823 | Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
502-688 | 1.26e-05 | ||||
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.57 E-value: 1.26e-05
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
503-563 | 1.67e-04 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 46.54 E-value: 1.67e-04
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
503-563 | 3.39e-04 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 45.38 E-value: 3.39e-04
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EGF_2 | pfam07974 | EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
1505-1530 | 4.01e-04 | ||||
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 4.01e-04
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MSCRAMM_ClfA | NF033609 | MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
500-649 | 4.27e-04 | ||||
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif. Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 45.29 E-value: 4.27e-04
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
502-563 | 1.44e-03 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 43.46 E-value: 1.44e-03
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
503-564 | 2.33e-03 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 42.69 E-value: 2.33e-03
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PHA03255 | PHA03255 | BDLF3; Provisional |
503-633 | 2.35e-03 | ||||
BDLF3; Provisional Pssm-ID: 165513 [Multi-domain] Cd Length: 234 Bit Score: 41.43 E-value: 2.35e-03
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SP4_N | cd22536 | N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ... |
500-564 | 4.55e-03 | ||||
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4. Pssm-ID: 411773 [Multi-domain] Cd Length: 623 Bit Score: 41.44 E-value: 4.55e-03
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Name | Accession | Description | Interval | E-value | ||||
DUF5585 | pfam17823 | Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
502-688 | 1.26e-05 | ||||
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.57 E-value: 1.26e-05
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Epiglycanin_TR | pfam05647 | Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ... |
503-563 | 3.04e-05 | ||||
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801). Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 43.46 E-value: 3.04e-05
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
503-563 | 1.67e-04 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 46.54 E-value: 1.67e-04
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Epiglycanin_TR | pfam05647 | Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ... |
502-561 | 2.61e-04 | ||||
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801). Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 40.77 E-value: 2.61e-04
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
503-563 | 3.39e-04 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 45.38 E-value: 3.39e-04
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Epiglycanin_TR | pfam05647 | Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ... |
507-563 | 3.72e-04 | ||||
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801). Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 40.38 E-value: 3.72e-04
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EGF_2 | pfam07974 | EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
1505-1530 | 4.01e-04 | ||||
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 4.01e-04
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MSCRAMM_ClfA | NF033609 | MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
500-649 | 4.27e-04 | ||||
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif. Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 45.29 E-value: 4.27e-04
|
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
502-563 | 1.44e-03 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 43.46 E-value: 1.44e-03
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ser_rich_anae_1 | NF033849 | serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ... |
503-564 | 2.33e-03 | ||||
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments. Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 42.69 E-value: 2.33e-03
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PHA03255 | PHA03255 | BDLF3; Provisional |
503-633 | 2.35e-03 | ||||
BDLF3; Provisional Pssm-ID: 165513 [Multi-domain] Cd Length: 234 Bit Score: 41.43 E-value: 2.35e-03
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FSA_C | pfam10479 | Fragile site-associated protein C-terminus; This is the conserved C-terminal half of the ... |
499-555 | 3.12e-03 | ||||
Fragile site-associated protein C-terminus; This is the conserved C-terminal half of the protein KIAA1109 which is the fragile site-associated protein FSA. Genome-wide-association studies showed this protein to linked to the susceptibility to coeliac disease. The protein may also be associated with polycystic kidney disease. Pssm-ID: 463105 Cd Length: 701 Bit Score: 42.09 E-value: 3.12e-03
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SP4_N | cd22536 | N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ... |
500-564 | 4.55e-03 | ||||
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4. Pssm-ID: 411773 [Multi-domain] Cd Length: 623 Bit Score: 41.44 E-value: 4.55e-03
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PRK10905 | PRK10905 | cell division protein DamX; Validated |
499-561 | 4.85e-03 | ||||
cell division protein DamX; Validated Pssm-ID: 236792 [Multi-domain] Cd Length: 328 Bit Score: 41.08 E-value: 4.85e-03
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SSP160 | pfam06933 | Special lobe-specific silk protein SSP160; This family consists of several special ... |
509-563 | 5.58e-03 | ||||
Special lobe-specific silk protein SSP160; This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomus (Midge) species. Pssm-ID: 115579 [Multi-domain] Cd Length: 758 Bit Score: 41.30 E-value: 5.58e-03
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Blast search parameters | ||||
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