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Conserved domains on  [gi|922580712|ref|NP_503350|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 26-444 1.98e-32

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 127.35  E-value: 1.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  26 VAFFCLMSIFSNYTIMNFAFICMKNDMQGAVQGANGTLQSI-------YDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVK 98
Cdd:cd17318    3 LLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTlpveapeFDWSEKTQGIILSSFFYGYILTQIPGGYLAEK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  99 YGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVI 178
Cdd:cd17318   83 YGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 179 TTAVTGFLCtSSLGWRFSFYVHSIAGALCFVLWYFVysddplshssvtsrelaniqkgksaahfskrreIP--YLKMITN 256
Cdd:cd17318  163 AMPLSGFLC-ESLGWPSIFYIFGGLGLLWCLLWFFL---------------------------------VLpvWAIVVAH 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 257 SALACTWFnafmdlsmsiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISD------RITSINPKAkml 330
Cdd:cd17318  209 FGHNWGFY----------TLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADwlrsrgILSTTTVRK--- 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 331 IFNTISCGIVSILFGGLGFISkDQKWVAMFLLIAVNCLMSTNCAGFYQCGRHVSQQFADVVIAAIQFCKCLALFFVPAIV 410
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLG-SNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIV 354

                        410       420       430
                 ....*....|....*....|....*....|....
gi 922580712 411 AATVTDESDRGQWSHAFLVMSGLLLVANFSAYFF 444
Cdd:cd17318  355 GAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIF 388
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 26-444 1.98e-32

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 127.35  E-value: 1.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  26 VAFFCLMSIFSNYTIMNFAFICMKNDMQGAVQGANGTLQSI-------YDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVK 98
Cdd:cd17318    3 LLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTlpveapeFDWSEKTQGIILSSFFYGYILTQIPGGYLAEK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  99 YGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVI 178
Cdd:cd17318   83 YGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 179 TTAVTGFLCtSSLGWRFSFYVHSIAGALCFVLWYFVysddplshssvtsrelaniqkgksaahfskrreIP--YLKMITN 256
Cdd:cd17318  163 AMPLSGFLC-ESLGWPSIFYIFGGLGLLWCLLWFFL---------------------------------VLpvWAIVVAH 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 257 SALACTWFnafmdlsmsiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISD------RITSINPKAkml 330
Cdd:cd17318  209 FGHNWGFY----------TLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADwlrsrgILSTTTVRK--- 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 331 IFNTISCGIVSILFGGLGFISkDQKWVAMFLLIAVNCLMSTNCAGFYQCGRHVSQQFADVVIAAIQFCKCLALFFVPAIV 410
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLG-SNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIV 354

                        410       420       430
                 ....*....|....*....|....*....|....
gi 922580712 411 AATVTDESDRGQWSHAFLVMSGLLLVANFSAYFF 444
Cdd:cd17318  355 GAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIF 388
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 13-432 9.07e-25

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 106.37  E-value: 9.07e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   13 LPKLPYYRFIVMMVAFFCLMSIFSNYTIMNFAFICMKN-----------------DMQGAVQGANGTLQSIydytstgka 75
Cdd:TIGR00894  10 LPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNkenstdlaclsaeneldNIKNPNFKWSGALQGL--------- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   76 qLIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKW 155
Cdd:TIGR00894  81 -ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  156 APHDEVAFFVSVLTVFSPFATVITTAVTGFLCTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTSRELANIQK 235
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  236 GKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAF 315
Cdd:TIGR00894 240 SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  316 ISDRITSIN---PKAKMLIFNTISCGIVSILFGGLGFISKDQKWVAMFLLIAvNCLMSTNCAGFYQCGRHVSQQFAdVVI 392
Cdd:TIGR00894 320 LADFLKSSKtlsLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLA-NAVSSGPLAGVLINSLDLAPRFL-GFI 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 922580712  393 AAIQFCKCLALFFVPAIVAATVTDESDRGQWSHAFLVMSG 432
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAF 437
MFS_1 pfam07690
Major Facilitator Superfamily;
80-407 9.69e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.95  E-value: 9.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   80 AVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAgnSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHD 159
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  160 EVAFFVSVLTVFSPFATVITTAVTGFLCtSSLGWRFSFYVHSIAGALCFVLWYFVysDDPLSHSSVTSRELANIQKGKSA 239
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAILSLLAAVLLLLP--RPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  240 AHFSKRREIPYLkmitnsALACTWFNAFMdlsmsiMIITYSPIYfHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDR 319
Cdd:pfam07690 195 KALLRDPVLWLL------LALLLFGFAFF------GLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  320 ItsinPKAKMLIFNTISCGIVSILFGGLGFISkDQKWVAMFLLIAVNCLMSTNCAGFYQCGRHVSQQFADVVIAAIQFCK 399
Cdd:pfam07690 262 L----GRRRRLLLALLLLILAALGLLLLSLTL-SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336


                  ....*...
gi 922580712  400 CLALFFVP 407
Cdd:pfam07690 337 SLGGALGP 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
74-446 3.61e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 91.87  E-value: 3.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  74 KAQLIWAVAI---GTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGI 150
Cdd:COG2223   39 AAQLGLLFAIpvlVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 151 ICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPlshssvtsrel 230
Cdd:COG2223  117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL-IAAFGWRNAFLILGILLLVVAVLAWLFLRDPP----------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 231 aniqkgKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFK 310
Cdd:COG2223  185 ------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 311 FGAAFISDRItsinPKAKMLIFNTISCGIVSILFGGLGfiskDQKWVAMFLLIAVNCLMSTNCAGFYQ-CGRHVSQQFAD 389
Cdd:COG2223  259 PLGGWLSDRI----GGRRVLLIVFALMALGLLLLALAL----GSLWLFLVLFLLLGLALGGGNGAVFAlVPDIFPTKNAG 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 922580712 390 VVIAAIQFCKCLALFFVPaIVAATVTDESdrGQWSHAFLVMSGLLLVANFSAYFFFT 446
Cdd:COG2223  331 AVYGLVGAAGGLGGFLGP-LLFGALLDAT--GSYTAAFLVFAVLALVALVLTLLLYR 384
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 77-214 1.36e-03

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 40.85  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  77 LIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCtpFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWA 156
Cdd:PRK10091  43 MISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM--FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKII 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 922580712 157 PHDEVAFFVSVLTVFSPFATVITTAVTGFLCTsSLGWRFSFYVHSIAGALCFV-LWYFV 214
Cdd:PRK10091 121 KPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQ-EFSWRYTFLLIAVFNIAVLAsIYFWV 178
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 26-444 1.98e-32

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 127.35  E-value: 1.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  26 VAFFCLMSIFSNYTIMNFAFICMKNDMQGAVQGANGTLQSI-------YDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVK 98
Cdd:cd17318    3 LLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTlpveapeFDWSEKTQGIILSSFFYGYILTQIPGGYLAEK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  99 YGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVI 178
Cdd:cd17318   83 YGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 179 TTAVTGFLCtSSLGWRFSFYVHSIAGALCFVLWYFVysddplshssvtsrelaniqkgksaahfskrreIP--YLKMITN 256
Cdd:cd17318  163 AMPLSGFLC-ESLGWPSIFYIFGGLGLLWCLLWFFL---------------------------------VLpvWAIVVAH 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 257 SALACTWFnafmdlsmsiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISD------RITSINPKAkml 330
Cdd:cd17318  209 FGHNWGFY----------TLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADwlrsrgILSTTTVRK--- 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 331 IFNTISCGIVSILFGGLGFISkDQKWVAMFLLIAVNCLMSTNCAGFYQCGRHVSQQFADVVIAAIQFCKCLALFFVPAIV 410
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLG-SNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIV 354

                        410       420       430
                 ....*....|....*....|....*....|....
gi 922580712 411 AATVTDESDRGQWSHAFLVMSGLLLVANFSAYFF 444
Cdd:cd17318  355 GAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIF 388
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 13-432 9.07e-25

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 106.37  E-value: 9.07e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   13 LPKLPYYRFIVMMVAFFCLMSIFSNYTIMNFAFICMKN-----------------DMQGAVQGANGTLQSIydytstgka 75
Cdd:TIGR00894  10 LPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNkenstdlaclsaeneldNIKNPNFKWSGALQGL--------- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   76 qLIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKW 155
Cdd:TIGR00894  81 -ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  156 APHDEVAFFVSVLTVFSPFATVITTAVTGFLCTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTSRELANIQK 235
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  236 GKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAF 315
Cdd:TIGR00894 240 SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  316 ISDRITSIN---PKAKMLIFNTISCGIVSILFGGLGFISKDQKWVAMFLLIAvNCLMSTNCAGFYQCGRHVSQQFAdVVI 392
Cdd:TIGR00894 320 LADFLKSSKtlsLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLA-NAVSSGPLAGVLINSLDLAPRFL-GFI 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 922580712  393 AAIQFCKCLALFFVPAIVAATVTDESDRGQWSHAFLVMSG 432
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAF 437
MFS_1 pfam07690
Major Facilitator Superfamily;
80-407 9.69e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.95  E-value: 9.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   80 AVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAgnSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHD 159
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  160 EVAFFVSVLTVFSPFATVITTAVTGFLCtSSLGWRFSFYVHSIAGALCFVLWYFVysDDPLSHSSVTSRELANIQKGKSA 239
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAILSLLAAVLLLLP--RPPPESKRPKPAEEARLSLIVAW 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  240 AHFSKRREIPYLkmitnsALACTWFNAFMdlsmsiMIITYSPIYfHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDR 319
Cdd:pfam07690 195 KALLRDPVLWLL------LALLLFGFAFF------GLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  320 ItsinPKAKMLIFNTISCGIVSILFGGLGFISkDQKWVAMFLLIAVNCLMSTNCAGFYQCGRHVSQQFADVVIAAIQFCK 399
Cdd:pfam07690 262 L----GRRRRLLLALLLLILAALGLLLLSLTL-SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336


                  ....*...
gi 922580712  400 CLALFFVP 407
Cdd:pfam07690 337 SLGGALGP 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
74-446 3.61e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 91.87  E-value: 3.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  74 KAQLIWAVAI---GTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGI 150
Cdd:COG2223   39 AAQLGLLFAIpvlVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 151 ICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPlshssvtsrel 230
Cdd:COG2223  117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL-IAAFGWRNAFLILGILLLVVAVLAWLFLRDPP----------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 231 aniqkgKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFK 310
Cdd:COG2223  185 ------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 311 FGAAFISDRItsinPKAKMLIFNTISCGIVSILFGGLGfiskDQKWVAMFLLIAVNCLMSTNCAGFYQ-CGRHVSQQFAD 389
Cdd:COG2223  259 PLGGWLSDRI----GGRRVLLIVFALMALGLLLLALAL----GSLWLFLVLFLLLGLALGGGNGAVFAlVPDIFPTKNAG 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 922580712 390 VVIAAIQFCKCLALFFVPaIVAATVTDESdrGQWSHAFLVMSGLLLVANFSAYFFFT 446
Cdd:COG2223  331 AVYGLVGAAGGLGGFLGP-LLFGALLDAT--GSYTAAFLVFAVLALVALVLTLLLYR 384
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-444 2.11e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 89.54  E-value: 2.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  19 YRFIVMMVAFFCLMSIFSNYTIMNFAFicmkndmqgavqganGTLQSIYDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVK 98
Cdd:COG2271    7 YRWRILALLFLAYFLNYLDRSNLSVAA---------------PPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  99 YGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVI 178
Cdd:COG2271   72 FGRRRVLAIGLLLWGLATLLFGFA--TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 179 TTAVTGFLcTSSLGWRFSFYvhsIAGALCFVLwyfvysddplshssvtsrelaniqkgksaahfskrreipylkmitnsA 258
Cdd:COG2271  150 APPLLGWL-LAAFGWRAAFL---ILGLPGLLL-----------------------------------------------A 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 259 LACTWFNAFMDLSMSI---MIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRITSinpKAKMLIFNTI 335
Cdd:COG2271  179 LLRFWLLALAYFLVYFalyGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR---RRKLVLAIGL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 336 SCGIVSILFGGLGfiskDQKWVAMFLLIAVN-CLMSTNCAGFYQCGRHVSQQFADVVIAAIQFCKCLALFFVPAIVAATV 414
Cdd:COG2271  256 LLAALALLLLALL----PSPALAIALLFLAGfGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331

                        410       420       430
                 ....*....|....*....|....*....|
gi 922580712 415 tdesDRGQWSHAFLVMSGLLLVANFSAYFF 444
Cdd:COG2271  332 ----DATGYQAAFLLLAALALLAALLALLL 357
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 80-444 1.31e-18

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 87.39  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   80 AVAIGTIIGTVPYNWMYVKYGAKNVFlsAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHD 159
Cdd:TIGR00893  37 AFSWGYVVGQFPGGWLLDRFGARKTL--AVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPAS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  160 EVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPlSHSSVTSRELANI------ 233
Cdd:TIGR00893 115 ERATAVSIFNSAQGLGGIIGGPLVGWI-LIHFSWQWAFIIEGVLGIIWGVLWLKFIPDPP-QKAKWLTEEEKYIvvggll 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  234 --QKGKSAAHFSKRREIPYLKMITNSALACTWfnaFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIigitnfAQLPFKF 311
Cdd:TIGR00893 193 aeQQGKGPSTPKKYQIKELLKDRRVWGLALGQ---FLVNIGLGFFLTWFPTYLVQERGLSILEAGFM------ASLPGIV 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  312 GA------AFISDRITSINPKAKMLIFNTISCGIVSILFGGLGFISKDQKWVAMFLLIAVNCLMSTNCaGFYQCGRHVSQ 385
Cdd:TIGR00893 264 GFigmilgGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALVALGFFGLGAGAI-GWALISDNAPG 342

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 922580712  386 QFADVVIAAIQFCKCLALFFVPAIVAATVTDEsdrGQWSHAFLVMSGLLLVANFSAYFF 444
Cdd:TIGR00893 343 NIAGLTGGLINSLGNLGGIVGPIVIGAIAATT---GSFAGALMVVAALALIGALSYLLL 398
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-348 3.49e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.63  E-value: 3.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  14 PKLPYYRFIVMMVAFFCLMSIFSNYTIMNFAFICMKNDMQgavqgangtlqsiydyTSTGKAQLIWAV-AIGTIIGTVPY 92
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG----------------ASPAQAGLVVTAyLLGAALGAPLA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  93 NWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFS 172
Cdd:COG2814   66 GRLADRFGRRRVLLLGLLLFALGSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 173 PFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYsddPLSHSSVTSRELANIqkgksaahfskrreipyLK 252
Cdd:COG2814  144 GLGPALGPLLGGLL-ADLFGWRWVFLVNAVLALLALLLLLRLL---PESRPAARARLRGSL-----------------RE 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 253 MITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRItsinPKAKMLIF 332
Cdd:COG2814  203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF----GRRRLLLI 278

                        330
                 ....*....|....*.
gi 922580712 333 NTISCGIVSILFGGLG 348
Cdd:COG2814  279 GLLLLALGLLLLALAG 294
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 80-443 2.17e-15

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 77.23  E-value: 2.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  80 AVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHD 159
Cdd:cd17319   46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 160 EVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYsddplshssvtsrelaniqkgksa 239
Cdd:cd17319  124 ERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAVLWWFYL------------------------ 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 240 ahfskRREIPYlkMITNSALACTWFnafmdlsmsiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDR 319
Cdd:cd17319  179 -----RQVWGL--ALGYFGINYALY----------GLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 320 ITSINpkAKMLIFNTISCGIVSILFGGLGfiskDQKWVAMFLLIAVNCLMSTNCAGFYQ-CGRHVSQQFADVVIAAIQFC 398
Cdd:cd17319  242 LLRGA--RRLVIIIGLLLAAVGLLLAYLT----TSPVVAVILLSLAGFGIGAASPVFWSlPADLLPGEAAATAGGLINSG 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 922580712 399 KCLALFFVPAIVAATVTDEsdrGQWSHAFLVMSGLLLVANFSAYF 443
Cdd:cd17319  316 GNLGGFVAPLLIGYLVDAT---GSYTAAFLFLAAVALLAALLVLL 357
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 60-437 3.27e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.08  E-value: 3.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  60 NGTLQSIYDYTSTGKAQLIWAVA---IGTIIGTVPYNWMYVKYGAKNVFLSAGIisLVATSCTPFAAGNSYWLLLAIRLI 136
Cdd:cd06174   16 SPLLPALLQSFGLSASQLGLLFAlfsLGYALLQPLAGLLADRFGRRPVLLLGLL--LFALGALLFAFAPSFWLLLLGRFL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 137 QGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLCTS-SLGWRFSFYVHSIAGALCFVLWYFVY 215
Cdd:cd06174   94 LGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAALALLAAILLLLVV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 216 SDDPLSHSSvtsrelaniqkgKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQT 295
Cdd:cd06174  174 PDPPESARA------------KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 296 AFIIGITNFAQLPFKFGAAFISDRITSINPKAkmlifnTISCGIVSILFGGLGFISKDQKWVAMFLLIAVnCLMSTNCAG 375
Cdd:cd06174  242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL------LIGLLLMALGLALLLLAPSLLLLLLLLLLLGF-GLGGLLPLS 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922580712 376 FYQCGRHVSQQFADVVIAAIQFCKCLALFFVPAIVAATvtdESDRGQWSHAFLVMSGLLLVA 437
Cdd:cd06174  315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL---LAATFGLTGAFLVLAVLLLLA 373
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 67-216 3.04e-11

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 64.88  E-value: 3.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  67 YDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFA 146
Cdd:cd17380   29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 147 VIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYS 216
Cdd:cd17380  109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL-LEYYGWPSVFYFFGLLGLLWALVWLIYLP 177
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 71-214 9.34e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 62.52  E-value: 9.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  71 STGKAQLIWAVAIGTI---IGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAV 147
Cdd:COG0477   45 GASSAQLGWIVSAYLLgraIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPG 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 922580712 148 IGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFV 214
Cdd:COG0477  123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL-VAALGWRWIFLINAPLGLLALVLRLRL 188
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 67-214 1.38e-10

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 62.88  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  67 YDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVKYGAKnVFLSAGII-SLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADF 145
Cdd:cd17381   60 YDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGK-LLLGFGILgTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTF 138

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 922580712 146 AVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLCtSSLGWRFSFYVHSIAGALCFVLWYFV 214
Cdd:cd17381  139 PAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLIC-YYLDWTYVFYIFGAVGLLWFFLWIWL 206
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 80-370 3.83e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 61.08  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  80 AVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHD 159
Cdd:cd17316   44 AGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL--PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSK 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 160 EVAFFVSVLTVFSPFATVITTAVTGFL---CTSSLGWRFSFYVHSIAGALCFVLWYFVysddplshssvtsrelaniqkg 236
Cdd:cd17316  122 RRGFALGLLQSGWALGALLAALVASLLiplLSGDWGWRILFLIGALPALLALLLRRRT---------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 237 ksaahfskrreipylkmitnSALACTWFNAFMdlsMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFI 316
Cdd:cd17316  180 --------------------LLLILLWFFISF---GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLL 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 922580712 317 SDRItsinPKAKMLIFNTISCGIVSILFGGLGFISKDQKWVAMFLLIAVNCLMS 370
Cdd:cd17316  237 SDRI----GRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVW 286
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-345 1.78e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.13  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  77 LIWAV-AIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCtpFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKW 155
Cdd:cd17325   35 LIVAAyALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL--FAFATSYWQLLLARFLQGLASAAVWPAAMALIADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 156 APHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVysdDPLSHSSVTSRELANIQK 235
Cdd:cd17325  113 APPEERGRAMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAPFLVCAALALLALVLALLL---LPEPRPPPNKRAVSAARL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 236 GKSAAHFSKRREIpylkmitnsaLACTWFNAFMDLSMSiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAF 315
Cdd:cd17325  189 RSGLRLLLRDRRL----------LALFLAIFVLAFAFG-ALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257

                        250       260       270
                 ....*....|....*....|....*....|
gi 922580712 316 ISDRItsinPKAKMLIFNTISCGIVSILFG 345
Cdd:cd17325  258 LSDRI----GRKPLILIGLLLSAVALLLLP 283
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
52-444 1.88e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 56.02  E-value: 1.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  52 MQGAVQGANGTL----QSIYDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIisLVATSCTPFAAGNSY 127
Cdd:COG0738   19 LWGFATALWGPLipalKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL--LMALGLLLFALAPSY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 128 WLLLAIRLIQGIAYAADFAVIGIIcVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLCTSSLG--WRFSFYVHSIAGA 205
Cdd:COG0738   97 PLLLLALFLLGLGLGLLDVAANPY-VAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlsWHLPYLILAVLLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 206 LCFVLWYFVysddplshssvtsrelaNIQKGKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFH 285
Cdd:COG0738  176 LLALLFLRS-----------------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 286 TVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRITSinpkAKMLIFNTISCGIvsilfGGLGFISKDQKWVAMFLLIAV 365
Cdd:COG0738  239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP----VRLLRLSALLAAV-----GLLLALLAPGPWLALIGLALV 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 366 NCLMS-----TNCAGFYQCGRHVSQQFADVVIAAIqfckcLALFFVPAIVAATvtdeSDRGQWSHAFLVMSGLLLVANFS 440
Cdd:COG0738  310 GLGLSlmfptIFSLALDGLGKRTAAAVSAVLIMGI-----VGGAIGPPLIGFL----ADAFGLRAAFLVPLVCYLLILLL 380


                 ....
gi 922580712 441 AYFF 444
Cdd:COG0738  381 ALAL 384
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 63-364 3.18e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 55.46  E-value: 3.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   63 LQSIYDYTSTGKAQLIWAVAIGTIIGTVPYNWMYVKYGAKnVFLSAGIIsLVATSCTPFAAGNSYWLLLAIRLIQGIAYA 142
Cdd:TIGR00881  21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPR-VFLPIGLI-LCAIVNLFFGFSTSLWVMAALWALNGIFQG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  143 ADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLCTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSH 222
Cdd:TIGR00881  99 MGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSC 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  223 SSVTSRELANIQKGKSAA---HFSKRREIPYLKMITNSALactWFNAFMDL---SMSIMIITYSPIYFHTVLEFPIEQTA 296
Cdd:TIGR00881 179 GLPPAEEMPNEEPDGDAEkkeEELTKKQIFLQYVLLNKVL---WYISLGYVfvyVVRTGILDWSPLYLTQEKGFSKEKAS 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922580712  297 FIIGITNFAQLPFKFGAAFISDRITSiNPKAKMLIFNTisCGIVSILFGGLGFISKDQKWVAMFLLIA 364
Cdd:TIGR00881 256 WAFTLYELGGLVGTLLAGWLSDKLFN-GRRGPLAVFFM--ALIIVSLLVYWLNPAANPLMDLICLFAL 320
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 75-365 4.35e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.86  E-value: 4.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  75 AQLIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVK 154
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA--PSFALLLLARALAGLAHGGFWAIAAAYAAD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 155 WAPHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTSRELAniq 234
Cdd:cd17324  115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL-GQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSS--- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 235 kgksaahfskrreipYLKMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAqlpfKFGAA 314
Cdd:cd17324  191 ---------------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA----GVVGS 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 922580712 315 FISDRITSINPKAKMLIFNTIsCGIVSILFGGLGFIskdqkWVAMFLLIAV 365
Cdd:cd17324  252 PLAGRLADRGGRRALLIALLL-LAAALLLLTLLGPS-----PLLLLVGLVL 296
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 77-365 1.14e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 53.78  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  77 LIWAVAIGTIIGTVPYNWMYVKYGAKNV-FLSAGIISLVATSCtpfAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKW 155
Cdd:cd17475   36 LLSALNLGVAVSMLPAGWLLDRFGERRVlAVGLLLMGAAALLM---ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRW 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 156 APHDEVAFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVH---SIAGALCFVLWYfvysDDPLSHSSVTSRELAN 232
Cdd:cd17475  113 FPPRERGLAMGIRQTGVPLGGALAAALLPPL-ALHYGWRAAFVVAglvSILAAVLFWLFY----REPPAASAATESASTL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 233 IQKGKSaahfskrreipylkMITNSALACTWFNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFG 312
Cdd:cd17475  188 LRSLKE--------------VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 922580712 313 AAFISDRITSINPKAKMLifntISCGIVSILFGGLGFISKDQKWVAMFLLIAV 365
Cdd:cd17475  254 LGRVSDRVFGGRRRPVLV----ITAAIAAAALLVLSLLSPGTPLWLLVLLLIL 302
Sugar_tr pfam00083
Sugar (and other) transporter;
80-369 1.10e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 50.73  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   80 AVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFA-AGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPH 158
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  159 DEVAFFVSVLTVFSPFATVITTAVTGFL--CTSSLGWRFSFYVHSIAGALCFVLWYFVySDDPLSHSSVTSRELA----- 231
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLAYIFGLGLnkTSNSDGWRIPLGLQLVPALLLIIGLLFL-PESPRWLVEKGRLEEArevla 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  232 ----------NIQKGKSAAHFSKRREIPYLKMITNSALActWFNAFMDLSMSIM--------IITYSPIYFHTVLEFPIE 293
Cdd:pfam00083 213 klrgvpdvdrELDEIKDSLEAGQEAEKASWKELFSTKTR--RQRLLIGVMLQIFqqltginaIFYYSTTIFENLGLSDSF 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922580712  294 QTAFIIGITNFAqlpFKFGAAFISDRITsinpKAKMLIFNTISCGIVSILFGGLGFISKDQKWVAMFLLIAVNCLM 369
Cdd:pfam00083 291 LVTIIVGVVNFV---FTFIAIFLVDRFG----RRPLLLLGAAGMAICFVILGIVALLGVSKSDWAGIVAIVFIALF 359
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 98-368 8.37e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 8.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  98 KYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATV 177
Cdd:cd17473   61 RFGRKRLLIAGLLLYGIGGVAGLFL--DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGV 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 178 ITTAVTGFLctSSLGWRFSFYVHSIAGALCFVLWYFVysddplshssvtsRELANIQKGKSAAHFSKRREIPYLKMITNS 257
Cdd:cd17473  139 VFLLLGGAL--AEIGWRAPFLVYLLALPVLILVLLFL-------------PEPARKSKSAASPGAATAAALPWKRVLPIY 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 258 ALACTWFNAFMdlsmsiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQlpfkFGAAFISDRITSINPKAKMLIFNTISC 337
Cdd:cd17473  204 FLAFLAMLLFY------VIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRRLGKRRLLAIGFALM 273

                        250       260       270
                 ....*....|....*....|....*....|.
gi 922580712 338 GIvsilfgGLGFISKDQKWVAMFLLIAVNCL 368
Cdd:cd17473  274 AL------GFLLLALASGLWVVLLGAILAGL 298
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 102-219 1.26e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 47.27  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 102 KNVFLSAGIIsLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTA 181
Cdd:cd17312   67 IRRFMSAGLL-LSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPI 145

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 922580712 182 VTGFlCTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDP 219
Cdd:cd17312  146 LAAS-LASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 98-301 1.68e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.79  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  98 KYGAKNVFLSAGIIslVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATV 177
Cdd:cd17474   60 RFGRKKVLLPGLLL--FGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 178 ITTAVTGFLctSSLGWRFSFYVHSIAGALCFVLWYFvysddPLSHSSVTSRELANIQKGKSAAHFSKRReipylkMITNS 257
Cdd:cd17474  138 VGPLLGGLL--AAISWRYPFFLLAALIPVAFLAILF-----LLPEPKEKAKSSSATKLRDLKKALRGRG------LLTFL 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 922580712 258 ALACTWFNAFmdlsmsIMIITYSPIyfhtVLEFPIEQTAFIIGI 301
Cdd:cd17474  205 VSAFLYFFLY------FAFLTYLPF----LLELLYGISPIIIGL 238
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
75-186 1.87e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.82  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  75 AQLIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVK 154
Cdd:COG2211  267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAD 346

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 922580712 155 WAPHDEV-------AFFVSVLTVFSPFATVITTAVTGFL 186
Cdd:COG2211  347 VVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLL 385
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
94-362 2.10e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.79  E-value: 2.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  94 WMYVKYGAKNVFLSAGIISLVATSCTPFAAgnSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHdEVAFFVSVLTVFSP 173
Cdd:COG2807   75 RLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 174 FATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTSRElaniqkgkSAAHFSKRREipylkm 253
Cdd:COG2807  152 LGAALAAGLTVPL-AAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA--------SLRSLWRSPL------ 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 254 itnsALACTwfnAFMDLSMSI--MIITYSPIYFHTvLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRITSINPkakmli 331
Cdd:COG2807  217 ----AWLLT---LFFGLQSLLyyAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRP------ 282

                        250       260       270
                 ....*....|....*....|....*....|.
gi 922580712 332 FNTISCGIVSILFGGLGFISKDQKWVAMFLL 362
Cdd:COG2807  283 LLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 99-210 2.19e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.42  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  99 YGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHdEVAFFVSVLTVFSPFATVI 178
Cdd:cd17504   58 YGRKKVLLIVLAIYTAGSLLAAFA--PNLPVLIAGRALQGIGGAVFPLAFALVREEFPPE-RVPVAQGILSATFGIGAGI 134

                         90       100       110
                 ....*....|....*....|....*....|..
gi 922580712 179 TTAVTGFLcTSSLGWRFSFYVHSIAGALCFVL 210
Cdd:cd17504  135 GLPLGGWI-VQHLGWRWIFWTAAPVAVLLAAL 165
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 83-214 3.36e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 45.65  E-value: 3.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  83 IGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAgnSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVA 162
Cdd:cd17317   36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 922580712 163 FFVSVLTVFSPFATVITTAVtGFLCTSslgWRFSFYVHSIAGALCFVLWYFV 214
Cdd:cd17317  114 FVGILFGLFWALGYMLLALL-AYLIRD---WRWLQLAISLPGLLFLLLLWWL 161
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 81-379 1.51e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 44.24  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   81 VAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAgnSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDE 160
Cdd:TIGR00898 136 FFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP--NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  161 VAFFVSVLTVFSPFATVITTAVTGFLctssLGWRFSFYVHSIAGALCFVLWYFV-YSDDPLSHSSVTSRELANIQK---- 235
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFI----PDWRWLQLAVSLPTFLFFLLSWFVpESPRWLISQGRIEEALKILQRiaki 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  236 -GK----SAAHFSKRREIPYLKMITN-SALACTW-----FNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGItnf 304
Cdd:TIGR00898 290 nGKklpaEVLSLSLEKDLSSSKKQYSfLDLFRTPnlrktTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGL--- 366

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 922580712  305 AQLPFKFGAAFISDRITSINPKAKMLIFntiscGIVSILFggLGFISKDQKWvamfLLIAVNCLMSTNCAGFYQC 379
Cdd:TIGR00898 367 VELPAKLITLLLIDRLGRRYTMAASLLL-----AGVALLL--LLFVPVDLYF----LRTALAVLGKFGITSAFQM 430
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 110-361 1.75e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 43.69  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 110 IISLVAT--SCTPFAAGNSYWLLLAIRLI----------QGIAYAADFAvigiicvKWAPHDEVAFFVSVLTVFSPFATV 177
Cdd:cd17471   67 LLALLAGalGYLLFAFLRNYWVLLLVGVVllslgaaafpQLFALAREYA-------DRSSGRDATLFNSVLRAAFSLAWV 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 178 ITTAVtGFLCTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPlshssvtsRELANIQKGKSAAHFSKRREIPYLkmitns 257
Cdd:cd17471  140 IGPPL-AFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVK--------PPAQKATPASSLVKAPVNRRLLLL------ 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 258 ALACTWFNAFMDLSMSIMiitysPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRItsinPKAKMLIFntisc 337
Cdd:cd17471  205 FAAFTLLFAANSMYIIAM-----PLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRF----GKRRLLLA----- 270

                        250       260
                 ....*....|....*....|....
gi 922580712 338 GIVSILFGGLGFISKDQKWVAMFL 361
Cdd:cd17471  271 GFLAGVLFYLGLALATSLWQLIAL 294
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 98-210 2.03e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.32  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  98 KYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATV 177
Cdd:cd17321   57 RFGRKRVFLIGLALFGLASLLCALA--PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAA 134

                         90       100       110
                 ....*....|....*....|....*....|...
gi 922580712 178 ITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVL 210
Cdd:cd17321  135 LGPLLGGLL-LELFGWRWIFLINVPIGLVALLL 166
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 125-365 2.10e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.38  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 125 NSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFLCTSSLGWRFSFYVHSIAG 204
Cdd:cd17328   85 PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLG 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 205 ALCFVLWYFVYSDDPLSHSSVTSRELANIQKGKSAAHFSKRREIPYLKMITNSALACTWFNafmdLSMsimiitYSPIYF 284
Cdd:cd17328  165 VLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGA----LAF------WAPTFF 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 285 ---HTVLEFPIEQTAFIIG-ITNFAQLPFKFGAAFISDRITSINPKAKMLIfntisCGI---VSILFGGLGFISKDQKWV 357
Cdd:cd17328  235 lraFGVGDLSSADVGLIFGaITCIAGVLGVLLGGILADRLRRKTPRADPLV-----CAVgllAAAPFLFLALVLALSNLL 309


                 ....*...
gi 922580712 358 AMFLLIAV 365
Cdd:cd17328  310 LAWVLLFL 317
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 76-377 2.34e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.39  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  76 QLIWAVAI---GTIIGTVPYNWMYVKYGAkNVFLSAGIISLVATSCTPFAAGNsYWLLLAIRLIQGIAYAADFAVIGIIC 152
Cdd:cd17327   42 QYNWGNTVfyvGYIIFELPGNLLLQRFPP-SKWLSVFIVLWGLLTLLTAAVKN-FGGLIALRFFLGLFESGVFPGFILYL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 153 VKWAPHDE----VAFFVSVLTVFSPFATVITTAVTGFLCTSSL-GWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTS 227
Cdd:cd17327  120 GMWYKREEqakrIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTE 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 228 RE-------LANIQKGKSAAHFSKRREIPYLKMITNSALACTWFNAFMDLSmsiMIITYSPIyFHTVLEFPIEQTAF--- 297
Cdd:cd17327  200 EEkelaverLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNN---GISNFLPL-ILKSLGFYSLQTNLlsv 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 298 IIGITNFAQLPFkfgAAFISDRItsinpKAKMLIFnTISCGIVSILFGGLGFISKDQK------WVAMFLLIAVNCLM-- 369
Cdd:cd17327  276 PIGALGAVSLLI---AALLSDRF-----KKRGLFA-IFACVLALVGSIILLAAPNPPGayfaayILGGGSYAGFPILLsw 346


                 ....*....
gi 922580712 370 -STNCAGFY 377
Cdd:cd17327  347 iSSNCAGYT 355
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 99-213 2.42e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 43.33  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  99 YGAKNVFLSAGIISLVAtsCTPFAAGNSYWLLLAIRLIQGIAYAADFAVI-GIICVKWAPHdEVAFFVSVLTVFSPFATV 177
Cdd:cd17323   61 YGRRPVYLVSLFIFVIF--QIGCALAPNIAMLIILRFLQGFFGSSPLAIGaGTIADLFTPE-ERGKAMGVYSLGPLLGPA 137

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 922580712 178 ITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYF 213
Cdd:cd17323  138 LGPIIGGFI-TQSLGWRWIFWFLAIISGFCLILIFL 172
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 103-368 3.14e-04

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 43.00  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 103 NVFLSAG-IISLVATSCTPFA--AGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPF--ATV 177
Cdd:cd17345   68 KRFLAIGlILSAIINILIGFVpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVggGLV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 178 ITTAVTGFLCTSSLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTSRELAN----IQKGKSAAHFSKRREIpYLKM 253
Cdd:cd17345  148 GPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGdypeEADGEEEEQELSAWEI-FVKY 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 254 ITNSALActWFNAFMDLSMSIM---IITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRITsinpKAKML 330
Cdd:cd17345  227 VLKNKLL--WYIAIANVFVYLVrygILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLF----KGRRA 300

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 922580712 331 IFNTIScgIVSILFGGLGFISKDQKWVAMFLLIAVNCL 368
Cdd:cd17345  301 PTGIIF--MILVIVALIVYWLAPNVLVDLIALIALGFL 336
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 84-214 4.10e-04

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 42.71  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  84 GTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAF 163
Cdd:cd17382   61 GYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSR 140

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 922580712 164 FVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVLWYFV 214
Cdd:cd17382  141 LATTAFCGSYAGAVVGMPLSGIL-VQYVGWSSPFYVYGVFGIIWYMFWMLV 190
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 104-227 1.26e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 104 VFLSAGIISLVATSCTPFAAGNSYWLLLAiRLIQGIAyAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVT 183
Cdd:cd17490   63 LFIIIGLLFTVLASLIMILFPSPWGLLIA-RFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIG 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 922580712 184 GFLCTSsLGWRFSFYVHSIAGALCFVLWYFVYSDDPLSHSSVTS 227
Cdd:cd17490  141 GLIAEH-FGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTE 183
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 77-214 1.36e-03

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 40.85  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  77 LIWAVAIGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCtpFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWA 156
Cdd:PRK10091  43 MISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM--FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKII 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 922580712 157 PHDEVAFFVSVLTVFSPFATVITTAVTGFLCTsSLGWRFSFYVHSIAGALCFV-LWYFV 214
Cdd:PRK10091 121 KPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQ-EFSWRYTFLLIAVFNIAVLAsIYFWV 178
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 265-378 3.08e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.90  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 265 NAFMDLSMSiMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRitsINPKAKMLifntISCGIVSILF 344
Cdd:cd17329    8 SFLNRLGFF-MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR---FGRKPVML----AGLLLRALGF 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 922580712 345 GGLGFISkdqkwvaMFLLIAVNCLMSTNCAGFYQ 378
Cdd:cd17329   80 ALLGFAH-------SPWLFAIALVLTGFGGGLFE 106
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 106-254 3.18e-03

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 39.63  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 106 LSAGIIsLVATSCTPFAAGNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGF 185
Cdd:cd17343   71 FSSGLV-LSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATL 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 922580712 186 LCTsSLGWRFSFyvhSIAGALCF---VLWYFVYSDDPlSHSSVTSRELANIQ--KGKSAAHFSKRREI---PYLKMI 254
Cdd:cd17343  150 LAL-SYGWRSTL---SISGTVAVvmsVVCLLFIKNEP-SDVGLNNIEEEESKgkKKKSPRGESTLKELllsPFLWLL 221
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 73-203 3.75e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 39.56  E-value: 3.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  73 GKAQLIWAVAIGTIiGTVPY----NWMYVKYGAKNVFLSA----GIISLVatscTPFAAgnSYWLLLAIRLIQGIAYAAD 144
Cdd:PRK11551  48 DVAQMGWAFSAGIL-GLLPGallgGRLADRIGRKRILIVSvalfGLFSLA----TAQAW--DFPSLLVARLLTGVGLGGA 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 922580712 145 FAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITtAVTGFLCTSSLGWRFSFYVHSIA 203
Cdd:PRK11551 121 LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALA-SVIGVLAAGDAAWRHIFYVGGVG 178
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 83-375 5.46e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.10  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  83 IGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAyAADFAVIGIICVKWA-PHDEV 161
Cdd:cd17320   45 LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA--SSIEQLLIARFLQGLG-AAAGSVVARAIVRDLySGAEL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 162 AFFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGALCFVL-WYFVYSDDPLSHSSVTSRELANIqkgksaa 240
Cdd:cd17320  122 AKIFSLLMMILAIAPALAPLLGGLL-LLFFGWRAIFVFLALLGLLLLLLvLLFLPETLPEEKRKPLLSSLLRA------- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 241 hfskrreipYLKMITNSALactWFNAFMDLSMSIMI---ITYSPIYFHTVLEFPIEQTAFIIGITNFAQLpfkfGAAFIS 317
Cdd:cd17320  194 ---------YKRVLKNRRF---LGYALALGLSFAGLfayLAAAPFIYIEQLGLSPAQFGLLFALNAIALI----LGSLLN 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922580712 318 DRITSINPKAKMLIFNTIS---CGIVSILFGGLGFISKDQKWVAMFLLIAVNCLMSTNCAG 375
Cdd:cd17320  258 GRLVRRFGPRRLLRLGLLLllaAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATS 318
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
111-363 6.01e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 111 ISLVATSCTP-FAAGNSYWLLLAIRLIQGIAYAA-DFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVTGFL-- 186
Cdd:COG2211   93 LSFVLLFTAPdLSPTGKLIYALVTYLLLGLAYTLvNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLva 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 187 ---CTSSLGWRFSFYVHSIAGALCFVLWYFvysddplshsSVTSRELANIQKGKSAAHFSKrreipylkMITNSALACTW 263
Cdd:COG2211  173 afgGDAALGYRLTALIFAVLGLLAFLLTFF----------GTKERPVPEEEKVSLKESLKA--------LLKNRPFLLLL 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 264 FNAFMDLSMSIMIITYSPIYFHTVLEFPIEQTAFIIGITNFAQLPFKFGAAFISDRItsinPKAKMLIfntISCGIVSIL 343
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF----GKKKAFI---IGLLLAALG 307

                        250       260
                 ....*....|....*....|
gi 922580712 344 FGGLGFISKDQKWVAMFLLI 363
Cdd:COG2211  308 LLLLFFLGPGNLWLLLVLAA 327
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 24-210 6.51e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 38.71  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  24 MMVAFFclMSIFsNYTIMNFAFicmkNDMQGAVQGANGTLQSIydytSTGkaqliWAVAIGTIIGTVPynWMYVKYGAKN 103
Cdd:cd17503    1 LLLGAF--MAIL-DTTIVNVAL----PTIMGDLGASLDTVQWV----ITS-----YLLALAIMIPLSG--WLADRFGTRR 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712 104 VFLSAGIISLVATSCTPFAagNSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVAFFVSVLTVFSPFATVITTAVT 183
Cdd:cd17503   63 LFLTALALFTLGSLLCGLA--PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLG 140

                        170       180
                 ....*....|....*....|....*..
gi 922580712 184 GFLCTsSLGWRFSFYVHSIAGALCFVL 210
Cdd:cd17503  141 GWLTD-NLSWRWIFYINLPIGILALLL 166
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 74-367 6.65e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 38.82  E-value: 6.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   74 KAQLIWAVAI---GTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAaGNSYWLLLAIRLIQGIAyAADFAVIGI 150
Cdd:TIGR00886  36 TAQLGNLVAVpvlAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLA-VQSYSVLLLIRLFIGIA-GGSFASCMP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  151 ICVKWAPHDEVA-----------FFVSVLTVFSPFATVITTAVTGFLCTSSLGWRFSFYVHSIAgALCFVLWYFVYSDDP 219
Cdd:TIGR00886 114 WISFFFPKKIQGtalglaagwgnMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGIL-LLPALLIFFVGADTP 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  220 lshssvTSRELANIQKGKSAAHFSKRREIpylkMITNSALACTwFNAFmdLSMSIMIitysPIYFHTVLEFPIEQTAFII 299
Cdd:TIGR00886 193 ------PGKPATGKLSFKEALKVFGNRHT----WILALLYSVT-FGSF--LGVSSIF----AMLFKDQFGLSKVQAGAYA 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922580712  300 GITNFAQLPFKFGAAFISDRITSinPKAKMLIFNTISCGIVSILFGglgfiSKDQKWVAMFLLIAVNC 367
Cdd:TIGR00886 256 SLGGFLGSLARPAGGAISDRLGG--ARKLLMNFLGVAMGAFLVVLG-----LVSDGSLAAFIVLFVAL 316
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 83-332 9.21e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.11  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712   83 IGTIIGTVPYNWMYVKYGAKNVFLSAGIISLVATSCTPFAAgnSYWLLLAIRLIQGIAYAADFAVIGIICVKWAPHDEVA 162
Cdd:TIGR00895  63 IGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT--NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  163 FFVSVLTVFSPFATVITTAVTGFLcTSSLGWRFSFYVHSIAGA-LCFVLWYFV-------YSDDPLSHSSVTSRELANIQ 234
Cdd:TIGR00895 141 TAVGLMFCGYPIGAAVGGFLAGWL-IPVFGWRSLFYVGGIAPLlLLLLLMRFLpesidflVSKRPETVRRIVNAIAPQMQ 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580712  235 KGKSAAHFSKRREIPYLKMI--------TNSALACTWFNAFMDLSMSIMIITYSPiYFHTVLEFPIEQTAFIIGITNFAQ 306
Cdd:TIGR00895 220 AEAQSALPEQKSTQGTKRSVfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGG 298

                         250       260
                  ....*....|....*....|....*.
gi 922580712  307 LPFKFGAAFISDRitsINPKAKMLIF 332
Cdd:TIGR00895 299 VIGSIIFGWLADR---LGPRVTALLL 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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