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Conserved domains on  [gi|193208621|ref|NP_503535|]
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Globin domain-containing protein [Caenorhabditis elegans]

Protein Classification

globin family protein; hemoglobin alpha subunit family protein( domain architecture ID 10201291)

globin family protein is an all-helical protein that may bind porphyrins, phycobilins, and other non-heme cofactors, and may play various roles including as a sensor or transporter of oxygen| hemoglobin alpha subunit family protein is either one of alpha, zeta, mu, theta, or related hemoglobin (Hb) subunits. Hb is the oxygen transport protein of erythrocytes. It is an allosterically modulated heterotetramer. Hemoglobin A (HbA) is the most common Hb in adult humans, and is formed from two alpha-chains and two beta-chains (alpha2beta2). An equilibrium exists between deoxygenated/unliganded/T(tense state) Hb having low oxygen affinity, and oxygenated /liganded/R(relaxed state) Hb having a high oxygen affinity. Various endogenous heterotropic effectors bind Hb to modulate its oxygen affinity and cooperative behavior, e.g. hydrogen ions, chloride ions, carbon dioxide and 2,3-bisphosphoglycerate. Hb is also an allosterically regulated nitrite reductase; the plasma nitrite anion may be activated by hemoglobin in areas of hypoxia to bring about vasodilation.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CeGLB25-like cd14766
Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 ...
 41-183 3.34e-58

Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 genes encoding globins that are all transcribed. These are very diverse in gene and protein structure and are localized in a variety of cells. The C. elegans globin GLB-25 (locus tag T06A1.3), like the majority of them, was expressed in neuronal cells in the head and tail portions of the body and in the nerve cord.


:

Pssm-ID: 381279  Cd Length: 137  Bit Score: 179.05  E-value: 3.34e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208621  41 LKNWWKSVDRKRVEASTYMFSKYLNDFPQNKDLYLKLKNVNAQTvDMNCSDPGFEAIAAQYLKVFDDVITAVEekpgDVQ 120
Cdd:cd14766    1 LKKSWKGIARKIDETGKTMFLRMLTENPELKELFPKLKNLEDEE-DELRSSEILENHAARVMDTLDEAISNIE----NVD 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193208621 121 TACDRLQAVGKMHrQKVSGMDGTMFQNMEEPFIQMVSHILQDRFNEKAEMLYRKFFQFCLKYL 183
Cdd:cd14766   76 YVIDLLHKVGKMH-AKKPGFRPEMFWKIEEPFLEAVSETLGDRYTDNMENIYRKTIKFILQTL 137
 
Name Accession Description Interval E-value
CeGLB25-like cd14766
Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 ...
 41-183 3.34e-58

Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 genes encoding globins that are all transcribed. These are very diverse in gene and protein structure and are localized in a variety of cells. The C. elegans globin GLB-25 (locus tag T06A1.3), like the majority of them, was expressed in neuronal cells in the head and tail portions of the body and in the nerve cord.


Pssm-ID: 381279  Cd Length: 137  Bit Score: 179.05  E-value: 3.34e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208621  41 LKNWWKSVDRKRVEASTYMFSKYLNDFPQNKDLYLKLKNVNAQTvDMNCSDPGFEAIAAQYLKVFDDVITAVEekpgDVQ 120
Cdd:cd14766    1 LKKSWKGIARKIDETGKTMFLRMLTENPELKELFPKLKNLEDEE-DELRSSEILENHAARVMDTLDEAISNIE----NVD 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193208621 121 TACDRLQAVGKMHrQKVSGMDGTMFQNMEEPFIQMVSHILQDRFNEKAEMLYRKFFQFCLKYL 183
Cdd:cd14766   76 YVIDLLHKVGKMH-AKKPGFRPEMFWKIEEPFLEAVSETLGDRYTDNMENIYRKTIKFILQTL 137
 
Name Accession Description Interval E-value
CeGLB25-like cd14766
Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 ...
 41-183 3.34e-58

Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 genes encoding globins that are all transcribed. These are very diverse in gene and protein structure and are localized in a variety of cells. The C. elegans globin GLB-25 (locus tag T06A1.3), like the majority of them, was expressed in neuronal cells in the head and tail portions of the body and in the nerve cord.


Pssm-ID: 381279  Cd Length: 137  Bit Score: 179.05  E-value: 3.34e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208621  41 LKNWWKSVDRKRVEASTYMFSKYLNDFPQNKDLYLKLKNVNAQTvDMNCSDPGFEAIAAQYLKVFDDVITAVEekpgDVQ 120
Cdd:cd14766    1 LKKSWKGIARKIDETGKTMFLRMLTENPELKELFPKLKNLEDEE-DELRSSEILENHAARVMDTLDEAISNIE----NVD 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193208621 121 TACDRLQAVGKMHrQKVSGMDGTMFQNMEEPFIQMVSHILQDRFNEKAEMLYRKFFQFCLKYL 183
Cdd:cd14766   76 YVIDLLHKVGKMH-AKKPGFRPEMFWKIEEPFLEAVSETLGDRYTDNMENIYRKTIKFILQTL 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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