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Conserved domains on  [gi|71981545|ref|NP_504105|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
29-315 8.17e-52

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 174.18  E-value: 8.17e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545    29 IIIKFSRPEYGSYKLLMMVMATLYAIYSAIEVIILPSYLVFEYNYLLYT--TQFVEYQLLSQILIVTFCSIFACMQVVLS 106
Cdd:pfam10326  22 LILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVdlKDLGLSKSVGQILLALYCGFYGVSISLLA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   107 TQFIYRYLSVASFHFLreRYFKGKRHVVWISLTSIFFTNWFLVAWFVYGNHGVYPKELEEEMFEKFDRNISQMAFTLVSY 186
Cdd:pfam10326 102 VQFIYRYLALCRPGKL--KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDIDEVAYVGPVY 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   187 AKQGENGKVLPNYLNIAMIVYLLACAMIPMNISLSCGIKTWLKIRSTINMA-QKSRHLQkqeRQLFFALLIQFTIPFIGN 265
Cdd:pfam10326 180 YPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGsEKTRKLQ---KQLFKALVIQTLIPTILM 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 71981545   266 TVPMLILFFCPALHISTEPYTNYICMPVPFYPIFDALATTFVIKDYYRGI 315
Cdd:pfam10326 257 YIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
29-315 8.17e-52

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 174.18  E-value: 8.17e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545    29 IIIKFSRPEYGSYKLLMMVMATLYAIYSAIEVIILPSYLVFEYNYLLYT--TQFVEYQLLSQILIVTFCSIFACMQVVLS 106
Cdd:pfam10326  22 LILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVdlKDLGLSKSVGQILLALYCGFYGVSISLLA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   107 TQFIYRYLSVASFHFLreRYFKGKRHVVWISLTSIFFTNWFLVAWFVYGNHGVYPKELEEEMFEKFDRNISQMAFTLVSY 186
Cdd:pfam10326 102 VQFIYRYLALCRPGKL--KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDIDEVAYVGPVY 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   187 AKQGENGKVLPNYLNIAMIVYLLACAMIPMNISLSCGIKTWLKIRSTINMA-QKSRHLQkqeRQLFFALLIQFTIPFIGN 265
Cdd:pfam10326 180 YPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGsEKTRKLQ---KQLFKALVIQTLIPTILM 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 71981545   266 TVPMLILFFCPALHISTEPYTNYICMPVPFYPIFDALATTFVIKDYYRGI 315
Cdd:pfam10326 257 YIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
204-306 1.24e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 40.28  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545 204 MIVYLLACAMIPMNISLSCGIKTWLKIRSTINMAQKSRHLQKQERQlffalliqftipfIGNTVPMLILFFCpalhISTE 283
Cdd:cd15081 179 MIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKE-------------VSRMVVVMIFAYC----FCWG 241
                        90       100
                ....*....|....*....|....*...
gi 71981545 284 PYTNYICMPV-----PFYPIFDALATTF 306
Cdd:cd15081 242 PYTFFACFAAanpgyAFHPLAAALPAYF 269
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
29-315 8.17e-52

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 174.18  E-value: 8.17e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545    29 IIIKFSRPEYGSYKLLMMVMATLYAIYSAIEVIILPSYLVFEYNYLLYT--TQFVEYQLLSQILIVTFCSIFACMQVVLS 106
Cdd:pfam10326  22 LILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVdlKDLGLSKSVGQILLALYCGFYGVSISLLA 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   107 TQFIYRYLSVASFHFLreRYFKGKRHVVWISLTSIFFTNWFLVAWFVYGNHGVYPKELEEEMFEKFDRNISQMAFTLVSY 186
Cdd:pfam10326 102 VQFIYRYLALCRPGKL--KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDIDEVAYVGPVY 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   187 AKQGENGKVLPNYLNIAMIVYLLACAMIPMNISLSCGIKTWLKIRSTINMA-QKSRHLQkqeRQLFFALLIQFTIPFIGN 265
Cdd:pfam10326 180 YPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGsEKTRKLQ---KQLFKALVIQTLIPTILM 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 71981545   266 TVPMLILFFCPALHISTEPYTNYICMPVPFYPIFDALATTFVIKDYYRGI 315
Cdd:pfam10326 257 YIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
29-315 7.40e-20

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 88.84  E-value: 7.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545    29 IIIKFSRPEYGSYKLLMMVMATLYAIYSAIEVIIlpSYLVFEYNYLLYTT----QFVEYQLLSQILIVTFCSIFACMQVV 104
Cdd:pfam10319  28 LIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLV--PLDIHSYRYCFVVFvsdgPFFEYSELGQHALSARCSFISASYAV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   105 LSTQFIYRYLSVASFHFLReRYFKGKRHVVWISLTSIFFTNWFLVAWF-VYGNHGVYpKELEEEMFEKFDRNISQMAFTL 183
Cdd:pfam10319 106 LLIHFIYRYLVLFNPQLTR-HYFRPWGILISILFFLFHGSVWTAICYFlLRANDEIR-DYIREDFRETYGVDSMDINMLG 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545   184 VSYaKQGENGKVLPNYLNIaMIVYLLACAMIPMNISLscGIKTWLKIRS-TINMAQKSRHLQkqeRQLFFALLIQFTIPF 262
Cdd:pfam10319 184 ALY-WEASDETVFRSWLGI-LLLTVISVYSIILYIVL--GYKIMRKLNKmSVTMSKKTKRLQ---KQLLKALIVQTIIPI 256
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 71981545   263 IGNTVPMLILFFCPALHISTEPYTNYICMP-VPFYPIFDALATTFVIKDYYRGI 315
Cdd:pfam10319 257 CISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
204-306 1.24e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 40.28  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981545 204 MIVYLLACAMIPMNISLSCGIKTWLKIRSTINMAQKSRHLQKQERQlffalliqftipfIGNTVPMLILFFCpalhISTE 283
Cdd:cd15081 179 MIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKE-------------VSRMVVVMIFAYC----FCWG 241
                        90       100
                ....*....|....*....|....*...
gi 71981545 284 PYTNYICMPV-----PFYPIFDALATTF 306
Cdd:cd15081 242 PYTFFACFAAanpgyAFHPLAAALPAYF 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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