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Conserved domains on  [gi|17563338|ref|NP_504117|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
9-314 2.84e-57

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 187.37  E-value: 2.84e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338     9 EEPFGYTIVHYICTSISFPVYGLSIWILIFRTPSNFSDYRKYLVLHIFSGLLLEVYMGIIWKVTVVLPIPIMCSNSFTAE 88
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338    89 Y---APIIFLFLPACLIYTGISIISLFVYRMEAVVIHASEGSIARRCVMYLRYMFFIcvvfVCIFTILSYPDLKHQNEYK 165
Cdd:pfam10318  81 LgvpTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYII----ALLFLIPIYLNIPDQEAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   166 LKMEQRFGQFQPYMWC-DNCFFFNFDSTIFklFYVICAVTVVTGTTSATIAFGITIKCINSVRTRLSAKTKQMHRNFLIS 244
Cdd:pfam10318 157 LKVLKKLPCLPPEFFDnPPVFVLAIDSTYF--LICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIA 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   245 LLIAAAIHGGCILIPLLGFLWAISFVVSLsqcPYFPYILVLIIQEHGAVSTITMFLSNNLLRKALMRMLM 314
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYN---QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
9-314 2.84e-57

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 187.37  E-value: 2.84e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338     9 EEPFGYTIVHYICTSISFPVYGLSIWILIFRTPSNFSDYRKYLVLHIFSGLLLEVYMGIIWKVTVVLPIPIMCSNSFTAE 88
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338    89 Y---APIIFLFLPACLIYTGISIISLFVYRMEAVVIHASEGSIARRCVMYLRYMFFIcvvfVCIFTILSYPDLKHQNEYK 165
Cdd:pfam10318  81 LgvpTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYII----ALLFLIPIYLNIPDQEAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   166 LKMEQRFGQFQPYMWC-DNCFFFNFDSTIFklFYVICAVTVVTGTTSATIAFGITIKCINSVRTRLSAKTKQMHRNFLIS 244
Cdd:pfam10318 157 LKVLKKLPCLPPEFFDnPPVFVLAIDSTYF--LICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIA 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   245 LLIAAAIHGGCILIPLLGFLWAISFVVSLsqcPYFPYILVLIIQEHGAVSTITMFLSNNLLRKALMRMLM 314
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYN---QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
9-314 2.84e-57

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 187.37  E-value: 2.84e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338     9 EEPFGYTIVHYICTSISFPVYGLSIWILIFRTPSNFSDYRKYLVLHIFSGLLLEVYMGIIWKVTVVLPIPIMCSNSFTAE 88
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338    89 Y---APIIFLFLPACLIYTGISIISLFVYRMEAVVIHASEGSIARRCVMYLRYMFFIcvvfVCIFTILSYPDLKHQNEYK 165
Cdd:pfam10318  81 LgvpTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYII----ALLFLIPIYLNIPDQEAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   166 LKMEQRFGQFQPYMWC-DNCFFFNFDSTIFklFYVICAVTVVTGTTSATIAFGITIKCINSVRTRLSAKTKQMHRNFLIS 244
Cdd:pfam10318 157 LKVLKKLPCLPPEFFDnPPVFVLAIDSTYF--LICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIA 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   245 LLIAAAIHGGCILIPLLGFLWAISFVVSLsqcPYFPYILVLIIQEHGAVSTITMFLSNNLLRKALMRMLM 314
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYN---QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
5-302 1.10e-09

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 58.71  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338     5 SCSFEEPFGYTIVHYICTSISFPVYGLSIWILIFRTPSNFSdYRKYLVLHIFSGLLLEVYMGIIWKVTVVLPIPIMCSNS 84
Cdd:pfam10327   2 NIDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDN-FRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338    85 FTAEYAPI----IFLFLPACLIYTGISIISLFVYRMEAVVIHASEGSIARRCVMYLRYMFFICVVFVCIFTILSYPDLKH 160
Cdd:pfam10327  81 FLATVFGIsshyLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   161 QNEY-KLKMEQRFGQFQPYmwcDNcfFFNFDSTIFKLFYVICAVTVVTGTTSATIAFGI-TIKCINSVRTRLSAKTKQMH 238
Cdd:pfam10327 161 QLEYvKENYPEYLSQFSSL---PN--FAIYDYNPWLIVFGILAIFGGSLSFLILVYLTVdMFRMLKRLRKKISAQTYQKH 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563338   239 RNFLISLLIAAAIHGGCILIPLlgflwaISFVVSLSQCPYFPYI---LVLIIQEHGAVSTITMFLSN 302
Cdd:pfam10327 236 RAALRSLIAQFATSPVCILPPF------AFVVVVLFPIEYSQEIseiLLAIFSTHSSVNSIVLILTT 296
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
14-287 7.14e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 40.61  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338    14 YTIVHYICTSISFPVYGLSIWILIFRTPSNFSDYRKYL-------VLHIFSGLLLEVYMgiiwkVTVVLPIPIMCSNS-- 84
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLlntaitqIISCILAFFTQQRI-----IPNGVSMALISYGPck 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338    85 -FTAEYAPIIFLFLPACLIYTGISIISLFVYRMEavVIHASEGSIARRCVMYLRYMFFICVVFVCIFTILSYPDLKHQNE 163
Cdd:pfam10317  76 yFGPWFCYSGYSLLQHFLLHSGWSLLLTFYYRYY--ILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563338   164 YKLKMEQrfgQFQPYMWCDNCFFFNFDSTIFKLFYVICAVTVVtgttsaTIAFGI---TIKCINSVRTRLSAKTKQMHRN 240
Cdd:pfam10317 154 KELHPNY---NLTDYTVTGFSDLQSFPALINTLIMTIPVFPIP------IIILILrrkILKLLNSNSVNMSPTTKAQHRQ 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 17563338   241 FLISLLIAAAIHGGCILIPLLGFLWAISFVVSLSQCPYFPYILVLII 287
Cdd:pfam10317 225 LIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALP 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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