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Conserved domains on  [gi|17560270|ref|NP_504331|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-313 7.19e-107

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 314.78  E-value: 7.19e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270     8 QKRAQIFGVIFALLHNLLLIFLITEKSHKELGTYKNLIILVAISECFYAVLEVTVRPVIHSFGFTFALIVNVEDSFLEYG 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270    88 VLKVLLAMYCAFFGSFLVIFSVQFIYRYWAVSGNKHLKEFEGLRIFLWTLPSIFCGLIWWLVAYFPCAKRPSTDEYLRDS 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   168 VMKEFNLSIEENLYAAPYFYEVNTDGTTDIYYPSFISIILTTVLVNISVITVFYFGIKCYSSLREQGALVSQNTQKLQNQ 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17560270   248 LFYSLVIQTVIPLFLMHFPVAAMYCFTFLEIDVGSLSGIVTVTLAIFPAIDPLPTLIMVKSYRTAI 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-313 7.19e-107

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 314.78  E-value: 7.19e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270     8 QKRAQIFGVIFALLHNLLLIFLITEKSHKELGTYKNLIILVAISECFYAVLEVTVRPVIHSFGFTFALIVNVEDSFLEYG 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270    88 VLKVLLAMYCAFFGSFLVIFSVQFIYRYWAVSGNKHLKEFEGLRIFLWTLPSIFCGLIWWLVAYFPCAKRPSTDEYLRDS 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   168 VMKEFNLSIEENLYAAPYFYEVNTDGTTDIYYPSFISIILTTVLVNISVITVFYFGIKCYSSLREQGALVSQNTQKLQNQ 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17560270   248 LFYSLVIQTVIPLFLMHFPVAAMYCFTFLEIDVGSLSGIVTVTLAIFPAIDPLPTLIMVKSYRTAI 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-313 7.19e-107

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 314.78  E-value: 7.19e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270     8 QKRAQIFGVIFALLHNLLLIFLITEKSHKELGTYKNLIILVAISECFYAVLEVTVRPVIHSFGFTFALIVNVEDSFLEYG 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270    88 VLKVLLAMYCAFFGSFLVIFSVQFIYRYWAVSGNKHLKEFEGLRIFLWTLPSIFCGLIWWLVAYFPCAKRPSTDEYLRDS 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   168 VMKEFNLSIEENLYAAPYFYEVNTDGTTDIYYPSFISIILTTVLVNISVITVFYFGIKCYSSLREQGALVSQNTQKLQNQ 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17560270   248 LFYSLVIQTVIPLFLMHFPVAAMYCFTFLEIDVGSLSGIVTVTLAIFPAIDPLPTLIMVKSYRTAI 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 30-313 4.35e-31

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 119.27  E-value: 4.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270    30 ITEKSHKELGTYKNLIILVAISECFYAVLEVTVRPVIHSFGFTFALIVnVEDSFLEYGVL-KVLLAMYCAFFGSFLVIFS 108
Cdd:pfam10319  29 IFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFV-SDGPFFEYSELgQHALSARCSFISASYAVLL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   109 VQFIYRYWAVSGNKHLKE-FEGLRIFLWTLPSIFCGLIWWLVAYFPCAKRPSTDEYLRDSVMKEFNL-SIEENLYAAPYF 186
Cdd:pfam10319 108 IHFIYRYLVLFNPQLTRHyFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVdSMDINMLGALYW 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   187 yevntDGTTDIYYPSFISIILTTVLVNISVITVFYFGIKCYSSLREQGALVSQNTQKLQNQLFYSLVIQTVIPLFLMHFP 266
Cdd:pfam10319 188 -----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSP 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 17560270   267 -VAAMYCFTFLeIDVGS-LSGIVTVTLAIFPAIDPLPTLIMVKSYRTAI 313
Cdd:pfam10319 263 cVLAWYSPIFG-IDLGRwNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 33-313 3.82e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 59.87  E-value: 3.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270    33 KSHKELGTYKNLIILVAISECFYAVLEVTVRPVIHSFGFTFALIVNVEDSFLEYGVLKVLLAMYCAFFGSFLVIFSVQFI 112
Cdd:pfam10317  26 KSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLLQHFLLHSGWSLLLTFY 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   113 YRYWAVSGNKHLKEFEGLRIFLWTLPSIFCGLIWWLVAYFPCAKRPSTDEYLRDSVMKEFNLSieenlyaapyfyevntd 192
Cdd:pfam10317 106 YRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHPNYNLTDYTVT----------------- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   193 GTTDI-YYPSFISIILTTVLVNISVITVFYFGIKCYSSLREQGALVSQNTQKLQNQLFYSLVIQTVIPLFlMHFPVAAMY 271
Cdd:pfam10317 169 GFSDLqSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLF-SYIPGVTLY 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 17560270   272 CFTFLEIDVGSLSG-IVTVTLAIFPAIDPLPTLIMVKSYRTAI 313
Cdd:pfam10317 248 LLSQLTGTEFLILEyFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 95-313 2.18e-06

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 48.69  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270    95 MYCAFFGSFLVIFSV--QFIYRYWAVSGNKHLKEFEGLRIFLWTLPSIFCgliwwLVAYFPCAKRPSTDEYLRDSVMKEF 172
Cdd:pfam10318  89 FYIGVTSLALVGVSIilLFENRYSILFTNKKRITWKKTRVLYLIFNYIIA-----LLFLIPIYLNIPDQEAAKLKVLKKL 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560270   173 NLSIEENLYAAPYFYeVNTDGTtdiYYPSFISIILTTVLVNIsvitVFYFGIKCYSSLREQGALVSQNTQKLQNQLFYSL 252
Cdd:pfam10318 164 PCLPPEFFDNPPVFV-LAIDST---YFLICIVLLILILIIQI----LFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIAL 235

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17560270   253 VIQTVIPLFLMHFPVAAMYCFTFLEIDVGSLSGIVTVTLAIFPAIDPLPTLIMVKSYRTAI 313
Cdd:pfam10318 236 IIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFV 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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