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Conserved domains on  [gi|17562516|ref|NP_504349|]
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Sugar transporter SWEET [Caenorhabditis elegans]

Protein Classification

PQ-loop repeat-containing protein( domain architecture ID 229534)

PQ-loop repeat-containing protein functions as a membrane-bound transporter; similar to Arabidopsis thaliana bidirectional sugar transporter SWEET2 that mediates both low-affinity uptake and efflux of sugar across the plasma membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtN3_slv super family cl46784
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 10-90 3.46e-07

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


The actual alignment was detected with superfamily member pfam03083:

Pssm-ID: 481124  Cd Length: 87  Bit Score: 46.81  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562516    10 LGIFSIGFTF------LPMFMVLdwHKRGTADGFSSVNFVLPMLVQSFWLRHGYMTNDQTNIIINSINLVFFAFYVSAFA 83
Cdd:pfam03083   3 LGILCVVFTVamflspLSILRKI--IKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 17562516    84 YYQPKRK 90
Cdd:pfam03083  81 VYPPKKA 87
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 10-90 3.46e-07

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 46.81  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562516    10 LGIFSIGFTF------LPMFMVLdwHKRGTADGFSSVNFVLPMLVQSFWLRHGYMTNDQTNIIINSINLVFFAFYVSAFA 83
Cdd:pfam03083   3 LGILCVVFTVamflspLSILRKI--IKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 17562516    84 YYQPKRK 90
Cdd:pfam03083  81 VYPPKKA 87
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 10-90 3.46e-07

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 46.81  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17562516    10 LGIFSIGFTF------LPMFMVLdwHKRGTADGFSSVNFVLPMLVQSFWLRHGYMTNDQTNIIINSINLVFFAFYVSAFA 83
Cdd:pfam03083   3 LGILCVVFTVamflspLSILRKI--IKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 17562516    84 YYQPKRK 90
Cdd:pfam03083  81 VYPPKKA 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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