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Conserved domains on  [gi|392919110|ref|NP_504516|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 18324792)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 188-328 2.03e-31

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 115.75  E-value: 2.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919110  188 RIFLAIKGVLESIGILSAKSVLINWDDTYEIAELLQHVKPEVLEDLTIKCLGSER--ENLVGLEQWKKAKNLKLSKVPHF 265
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDqfEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392919110  266 SIIVKHLNHFKsmNFDFVGESFSRDDIIKFRDeVLLKSTNFEYFTSENVKFSARLLVKVFDLH 328
Cdd:pfam01827  82 SFPIEHLFHFE--EFDIKLDSFSVEDAIKIRD-ILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 39-87 2.19e-08

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


:

Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 49.82  E-value: 2.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392919110   39 PRALRICVLFQHLQGIEVFNAYKAMSKVFGDHFMEYRHFEYWYMGLANG 87
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSG 49
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 116-149 5.77e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.64  E-value: 5.77e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392919110 116 ILDKLNPIDLFAARAVCRDFKDIIDNQKSTLKKI 149
Cdd:cd22150   12 ILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKI 45
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 188-328 2.03e-31

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 115.75  E-value: 2.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919110  188 RIFLAIKGVLESIGILSAKSVLINWDDTYEIAELLQHVKPEVLEDLTIKCLGSER--ENLVGLEQWKKAKNLKLSKVPHF 265
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDqfEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392919110  266 SIIVKHLNHFKsmNFDFVGESFSRDDIIKFRDeVLLKSTNFEYFTSENVKFSARLLVKVFDLH 328
Cdd:pfam01827  82 SFPIEHLFHFE--EFDIKLDSFSVEDAIKIRD-ILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 39-87 2.19e-08

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 49.82  E-value: 2.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392919110   39 PRALRICVLFQHLQGIEVFNAYKAMSKVFGDHFMEYRHFEYWYMGLANG 87
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSG 49
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 116-149 5.77e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.64  E-value: 5.77e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392919110 116 ILDKLNPIDLFAARAVCRDFKDIIDNQKSTLKKI 149
Cdd:cd22150   12 ILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKI 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
108-148 5.64e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.51  E-value: 5.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392919110   108 LFTDVQAMILDKLNPIDLFAARAVCRDFKDIIDNQKSTLKK 148
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 105-147 1.46e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 1.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 392919110  105 FTGLFTDVQAMILDKLNPIDLFAARAVCRDFKDIIDNQKSTLK 147
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 188-328 2.03e-31

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 115.75  E-value: 2.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919110  188 RIFLAIKGVLESIGILSAKSVLINWDDTYEIAELLQHVKPEVLEDLTIKCLGSER--ENLVGLEQWKKAKNLKLSKVPHF 265
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDqfEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392919110  266 SIIVKHLNHFKsmNFDFVGESFSRDDIIKFRDeVLLKSTNFEYFTSENVKFSARLLVKVFDLH 328
Cdd:pfam01827  82 SFPIEHLFHFE--EFDIKLDSFSVEDAIKIRD-ILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 39-87 2.19e-08

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 49.82  E-value: 2.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392919110   39 PRALRICVLFQHLQGIEVFNAYKAMSKVFGDHFMEYRHFEYWYMGLANG 87
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSG 49
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 116-149 5.77e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.64  E-value: 5.77e-08
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392919110 116 ILDKLNPIDLFAARAVCRDFKDIIDNQKSTLKKI 149
Cdd:cd22150   12 ILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKI 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
108-148 5.64e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.51  E-value: 5.64e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392919110   108 LFTDVQAMILDKLNPIDLFAARAVCRDFKDIIDNQKSTLKK 148
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 105-147 1.46e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 1.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 392919110  105 FTGLFTDVQAMILDKLNPIDLFAARAVCRDFKDIIDNQKSTLK 147
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 111-144 4.90e-03

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 34.91  E-value: 4.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 392919110 111 DVQAMILDKLNPIDLFAARAVCRDFKDIIDNQKS 144
Cdd:cd22082    8 EVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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