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Conserved domains on  [gi|392919134|ref|NP_504533|]
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DUF4440 domain-containing protein [Caenorhabditis elegans]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 233)

nuclear transport factor 2 (NTF2) family protein, similar to Aspergillus flavus scytalone dehydratases, Pseudomonas putida benzene 1,2-dioxygenase subunit beta, and many other members with similar structural details but divergent functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTF2_like super family cl09109
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 14-130 6.84e-03

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


The actual alignment was detected with superfamily member pfam14534:

Pssm-ID: 471850 [Multi-domain]  Cd Length: 107  Bit Score: 34.29  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919134   14 DPTELKKILAPyfagfnqttevadaegSMRFMHPQGVIVQKDKDstfgKKALTDLFKRWYDFTgpyyfnRYDEKYSGGGD 93
Cdd:pfam14534  16 DPAALAALLAP----------------DFVLVGPSGPVLDKDEI----LEALASGGLDYSSIE------LEDEKVRVLGD 69

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 392919134   94 WIVVEAKMEL-VKVEGKEVILRGEVMHIWKKENDEWLM 130
Cdd:pfam14534  70 TAVVRGRVTVtGRGDGEPVTVRGRFTSVWKKEGGGWKI 107
 
Name Accession Description Interval E-value
DUF4440 pfam14534
Domain of unknown function (DUF4440);
14-130 6.84e-03

Domain of unknown function (DUF4440);


Pssm-ID: 434023 [Multi-domain]  Cd Length: 107  Bit Score: 34.29  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919134   14 DPTELKKILAPyfagfnqttevadaegSMRFMHPQGVIVQKDKDstfgKKALTDLFKRWYDFTgpyyfnRYDEKYSGGGD 93
Cdd:pfam14534  16 DPAALAALLAP----------------DFVLVGPSGPVLDKDEI----LEALASGGLDYSSIE------LEDEKVRVLGD 69

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 392919134   94 WIVVEAKMEL-VKVEGKEVILRGEVMHIWKKENDEWLM 130
Cdd:pfam14534  70 TAVVRGRVTVtGRGDGEPVTVRGRFTSVWKKEGGGWKI 107
 
Name Accession Description Interval E-value
DUF4440 pfam14534
Domain of unknown function (DUF4440);
14-130 6.84e-03

Domain of unknown function (DUF4440);


Pssm-ID: 434023 [Multi-domain]  Cd Length: 107  Bit Score: 34.29  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919134   14 DPTELKKILAPyfagfnqttevadaegSMRFMHPQGVIVQKDKDstfgKKALTDLFKRWYDFTgpyyfnRYDEKYSGGGD 93
Cdd:pfam14534  16 DPAALAALLAP----------------DFVLVGPSGPVLDKDEI----LEALASGGLDYSSIE------LEDEKVRVLGD 69

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 392919134   94 WIVVEAKMEL-VKVEGKEVILRGEVMHIWKKENDEWLM 130
Cdd:pfam14534  70 TAVVRGRVTVtGRGDGEPVTVRGRFTSVWKKEGGGWKI 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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