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Conserved domains on  [gi|71989231|ref|NP_504870|]
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Nuclear Hormone Receptor family [Caenorhabditis elegans]

Protein Classification

nuclear hormone receptor family protein( domain architecture ID 27854)

nuclear hormone receptor family protein is a ligand-regulated transcriptional modulator that may play a role in many developmental processes; similar to Rattus norvegicus nuclear receptor subfamily 0 group B member 2

CATH:  1.10.565.10
Gene Ontology:  GO:0004879
SCOP:  4001384

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NR_LBD super family cl11397
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription ...
31-74 6.45e-04

The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Ligand-binding domain (LBD) of nuclear receptor (NR): Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions in metazoans, from development, reproduction, to homeostasis and metabolism. The superfamily contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. The members of the family include receptors of steroids, thyroid hormone, retinoids, cholesterol by-products, lipids and heme. With few exceptions, NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).


The actual alignment was detected with superfamily member smart00430:

Pssm-ID: 472173  Cd Length: 163  Bit Score: 36.57  E-value: 6.45e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71989231     31 NLLMIIDYIKTFSYFNKLSTQDQLILTRHVLLKCKNLHTSNYTM 74
Cdd:smart00430   4 QLLLTVEWAKSFPGFRELSLEDQIVLLKSFWFELLLLELAYRSV 47
 
Name Accession Description Interval E-value
HOLI smart00430
Ligand binding domain of hormone receptors;
31-74 6.45e-04

Ligand binding domain of hormone receptors;


Pssm-ID: 214658  Cd Length: 163  Bit Score: 36.57  E-value: 6.45e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71989231     31 NLLMIIDYIKTFSYFNKLSTQDQLILTRHVLLKCKNLHTSNYTM 74
Cdd:smart00430   4 QLLLTVEWAKSFPGFRELSLEDQIVLLKSFWFELLLLELAYRSV 47
 
Name Accession Description Interval E-value
HOLI smart00430
Ligand binding domain of hormone receptors;
31-74 6.45e-04

Ligand binding domain of hormone receptors;


Pssm-ID: 214658  Cd Length: 163  Bit Score: 36.57  E-value: 6.45e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71989231     31 NLLMIIDYIKTFSYFNKLSTQDQLILTRHVLLKCKNLHTSNYTM 74
Cdd:smart00430   4 QLLLTVEWAKSFPGFRELSLEDQIVLLKSFWFELLLLELAYRSV 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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