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Conserved domains on  [gi|17558934|ref|NP_504942|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
4-305 2.38e-91

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 274.81  E-value: 2.38e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934     4 EHPDTLITILHLITLLAIPIHVFGTYCILFKTPKSMESVKLIMLNFHVWCMVLDYGITVLTVPYLLFPVLGGFPLGILKD 83
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934    84 IGVPIEVQSYGILTLVAVVSAAAIDIIENRYYIVFA--QNTKWRRYRIILTIFNYSCSLAWTLPAFILLPDQNTAapgAL 161
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAA---KL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934   162 RILEKFGTVP-EYIRKAPIFVISFDLRTITLPCMIIAGFFVVEVVVFVVVMTRGMSKlKQTARFSKSTLKMQRNFLNAIY 240
Cdd:pfam10318 158 KVLKKLPCLPpEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFK-SVKSSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17558934   241 IQVSVYITSIQLPIFWFIVSILADVHFQAINNLGFVMFSFNGVVSTVIMIWIHRPYRDFCLKIVK 305
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
4-305 2.38e-91

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 274.81  E-value: 2.38e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934     4 EHPDTLITILHLITLLAIPIHVFGTYCILFKTPKSMESVKLIMLNFHVWCMVLDYGITVLTVPYLLFPVLGGFPLGILKD 83
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934    84 IGVPIEVQSYGILTLVAVVSAAAIDIIENRYYIVFA--QNTKWRRYRIILTIFNYSCSLAWTLPAFILLPDQNTAapgAL 161
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAA---KL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934   162 RILEKFGTVP-EYIRKAPIFVISFDLRTITLPCMIIAGFFVVEVVVFVVVMTRGMSKlKQTARFSKSTLKMQRNFLNAIY 240
Cdd:pfam10318 158 KVLKKLPCLPpEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFK-SVKSSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17558934   241 IQVSVYITSIQLPIFWFIVSILADVHFQAINNLGFVMFSFNGVVSTVIMIWIHRPYRDFCLKIVK 305
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
4-305 2.38e-91

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 274.81  E-value: 2.38e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934     4 EHPDTLITILHLITLLAIPIHVFGTYCILFKTPKSMESVKLIMLNFHVWCMVLDYGITVLTVPYLLFPVLGGFPLGILKD 83
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934    84 IGVPIEVQSYGILTLVAVVSAAAIDIIENRYYIVFA--QNTKWRRYRIILTIFNYSCSLAWTLPAFILLPDQNTAapgAL 161
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAA---KL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934   162 RILEKFGTVP-EYIRKAPIFVISFDLRTITLPCMIIAGFFVVEVVVFVVVMTRGMSKlKQTARFSKSTLKMQRNFLNAIY 240
Cdd:pfam10318 158 KVLKKLPCLPpEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFK-SVKSSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17558934   241 IQVSVYITSIQLPIFWFIVSILADVHFQAINNLGFVMFSFNGVVSTVIMIWIHRPYRDFCLKIVK 305
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
6-299 4.34e-14

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 71.81  E-value: 4.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934     6 PDTLITILHLITLLAIPIHVFGTYCILFKTPKsMESVKLIMLNFHVWCMVLDYGITVLTVPYLLFPVLGGFPLGILKDI- 84
Cdd:pfam10327   8 PFWLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVf 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934    85 GVPIEVQSYGILTLVAVVSAA----------AIDIIENRYYIVfaqntkwRRYRIILTIFNYSCSLAWTLPAFILLPDQN 154
Cdd:pfam10327  87 GISSHYLMTIFVFLLSFQLESlllcfvrkhqAIAKILSKHVIP-------KWLYIFLYILCHIFPFLTAFLFYQSGLSRE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934   155 TaapgALRILEKfgTVPEYI---RKAPIFVI-SFDLRTITLPCMIIAGFFVVEVVVFVVV--MTRGMSKLKQtaRFSKST 228
Cdd:pfam10327 160 E----QLEYVKE--NYPEYLsqfSSLPNFAIyDYNPWLIVFGILAIFGGSLSFLILVYLTvdMFRMLKRLRK--KISAQT 231
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17558934   229 LKMQRNFLNAIYIQVSVYITSIQLPIFWFIVSILADVHFQAINNLGFVMFSFNGVVSTVIMIWIHRPYRDF 299
Cdd:pfam10327 232 YQKHRAALRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKF 302
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
15-302 2.27e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 42.15  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934    15 LITLLAIPIHVFGTYCILFKTPKSMESVKLIMLN---FHVWCMVLDYGITVLTVPYLLfpVLGGFPLGILKDIGVPIEVQ 91
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNtaiTQIISCILAFFTQQRIIPNGV--SMALISYGPCKYFGPWFCYS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934    92 SYGILTLVAVVSAAAIDI-IENRYYIVFAQNTKWRRYRIILTIFnYSCSLAWTLpaFILLPDQNTAapgALRILEKFgTV 170
Cdd:pfam10317  85 GYSLLQHFLLHSGWSLLLtFYYRYYILKHVDPKRKKLILLIIIH-YIPSLSQLI--VIFLSPTDFL---PVEALTKE-LH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558934   171 PEYirKAPIFVISFDLRTITLPCMIIAGFFVVEVVVFVVVMT----RGMSKLK-QTARFSKSTLKMQRNFLNAIYIQVSV 245
Cdd:pfam10317 158 PNY--NLTDYTVTGFSDLQSFPALINTLIMTIPVFPIPIIILilrrKILKLLNsNSVNMSPTTKAQHRQLIKGLTIQALL 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17558934   246 YITSIQLPIFWFIVSILADVHFQAINNLGFVMFSFNGVVSTVIMIWIHRPYRDFCLK 302
Cdd:pfam10317 236 PLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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