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Conserved domains on  [gi|17559328|ref|NP_504980|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-310 3.25e-91

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 274.33  E-value: 3.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328     8 SDRIAKCGVASVTIVNTFFIFLTVFHIRGISGTYKTMIIIMAVMGILLSILELLARPFVHNYNKGWIYFSLNSWMNVHEG 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    88 FLKLTMIFYSSFYIVMLSHISVQFLFRYLVLVSPKTAKKFTGKGILFSLCVSIFFGVIDGVALMIFGLSDEYSDEYMMVE 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   168 MLNKYELAIKDFPRFIIVIY--GADGS--LRYRNVMYLVSAGVDVAIQYLLIIFCGIKMHLVMNQGFKNVSVANKKIHKQ 243
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17559328   244 FLRALIVQTIVPTVLFVFPAVFVLLSPILDLEMSFQTGWIYALISMFPSIDSIGFMYFVSEYRKVIK 310
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-310 3.25e-91

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 274.33  E-value: 3.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328     8 SDRIAKCGVASVTIVNTFFIFLTVFHIRGISGTYKTMIIIMAVMGILLSILELLARPFVHNYNKGWIYFSLNSWMNVHEG 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    88 FLKLTMIFYSSFYIVMLSHISVQFLFRYLVLVSPKTAKKFTGKGILFSLCVSIFFGVIDGVALMIFGLSDEYSDEYMMVE 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   168 MLNKYELAIKDFPRFIIVIY--GADGS--LRYRNVMYLVSAGVDVAIQYLLIIFCGIKMHLVMNQGFKNVSVANKKIHKQ 243
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17559328   244 FLRALIVQTIVPTVLFVFPAVFVLLSPILDLEMSFQTGWIYALISMFPSIDSIGFMYFVSEYRKVIK 310
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-310 3.25e-91

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 274.33  E-value: 3.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328     8 SDRIAKCGVASVTIVNTFFIFLTVFHIRGISGTYKTMIIIMAVMGILLSILELLARPFVHNYNKGWIYFSLNSWMNVHEG 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    88 FLKLTMIFYSSFYIVMLSHISVQFLFRYLVLVSPKTAKKFTGKGILFSLCVSIFFGVIDGVALMIFGLSDEYSDEYMMVE 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   168 MLNKYELAIKDFPRFIIVIY--GADGS--LRYRNVMYLVSAGVDVAIQYLLIIFCGIKMHLVMNQGFKNVSVANKKIHKQ 243
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17559328   244 FLRALIVQTIVPTVLFVFPAVFVLLSPILDLEMSFQTGWIYALISMFPSIDSIGFMYFVSEYRKVIK 310
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 21-309 4.04e-25

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 102.71  E-value: 4.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    21 IVNTFFIFLTVFHIRGISGTYKTMIIIMAVMGILLSILELLARPFVHNYNKGWIYFSLNSWM----NVHEGFLKLTMIFY 96
Cdd:pfam10319  20 IVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFfeysELGQHALSARCSFI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    97 SSFYIVMLSHisvqFLFRYLVLVSPK-TAKKFTGKGILFSLCVSIFFGVIDGVALMIFGLSDEYSDEYMMVEMLNKYELA 175
Cdd:pfam10319 100 SASYAVLLIH----FIYRYLVLFNPQlTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   176 IKDFPRFIIVIYGADGSLRYRNVMYLVSAGVDVAIQYLLIIFCGIKMHLVMNQGFKNVSVANKKIHKQFLRALIVQTIVP 255
Cdd:pfam10319 176 SMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIP 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17559328   256 TVLFVFPAVFVLLSPI--LDLEMSFQTGWIYALiSMFPSIDSIGFMYFVSEYRKVI 309
Cdd:pfam10319 256 ICISFSPCVLAWYSPIfgIDLGRWNNYLEVIAL-SAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 21-311 8.11e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 61.80  E-value: 8.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    21 IVNTFFIFLTVFHIRGISGTYKTMIIIMAVMGILLSILELLARPFVHNYNKGWIYFSLNSWMNVHEGFLKLTMIFYSSFY 100
Cdd:pfam10317  14 ILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLLQHFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   101 IVMLSHISVQFLFRYLVLVSPKTAKKFTGKGILFSLCVSIFFGVIdgvalMIFGLSDEYSDEYMMVEMLNKYELAIKDFP 180
Cdd:pfam10317  94 LHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIV-----IFLSPTDFLPVEALTKELHPNYNLTDYTVT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   181 RFIIViygadGSLRYRNVMYLVSAGVdVAIqYLLIIFCGIKMHLVMNQGFKNVSVANKKIHKQFLRALIVQTIVPTVLFV 260
Cdd:pfam10317 169 GFSDL-----QSFPALINTLIMTIPV-FPI-PIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYI 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17559328   261 FPAVFVLLSPILDLEMSFQTGWIYALISMFPSIDSIGFMYFVSEYRKVIKK 311
Cdd:pfam10317 242 PGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 94-312 7.33e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 49.85  E-value: 7.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328    94 IFYSSFYIVMLSHISVQFLF--RYLVLVSPKtaKKFTGKGILFSLCVSIFFGVIDGVALMIFGLSDEysdEYMMVEMLNK 171
Cdd:pfam10318  88 QFYIGVTSLALVGVSIILLFenRYSILFTNK--KRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQ---EAAKLKVLKK 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559328   172 Y-ELAIKDFPRFIIVIYGADGSLryrNVMYLVSAGVDVAIQYLLIIFCgIKMHLVmNQGFKNVSVANKKIHKQFLRALIV 250
Cdd:pfam10318 163 LpCLPPEFFDNPPVFVLAIDSTY---FLICIVLLILILIIQILFFVFL-TIYYLF-KSVKSSLSKKTRKLQKKFFIALII 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559328   251 QTIVPTVLFVFPAVFVLLSPILDLEMSFQTGWIYALISMFPSIDSIGFMYFVSEYRKVIKKI 312
Cdd:pfam10318 238 QVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSL 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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