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Conserved domains on  [gi|17563582|ref|NP_505078|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-311 5.75e-92

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 277.03  E-value: 5.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582     7 HLVQYVGFFLAQFTNALLLCIIANKAKKLFGGYRYVMIVFVIYSLIYSWIEIAATPLMYGHRSM-IIIMVGSSLRYEDLA 85
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSfIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582    86 GTFIICLFCAAYSLMTALLATQFFYRYIVVCRPQFLHHIKGYKLCFIFLPGVVIFFLWYLNVHFGMKKTLEKAKFSQEVI 165
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582   166 LKNCEEDTFQIVFVALQYWEDDLNGKSHFRIIDFLSYLGFLLMIALCFLTIIFCALKIYFKLKEDIHSMSERTKELNRQL 245
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563582   246 MMTLTFQTIFPFFTMYSTVGAILTLPIFEIELGKLASVTGMLSGIYPAIEPVFAIFFVKEFRNFVL 311
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-311 5.75e-92

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 277.03  E-value: 5.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582     7 HLVQYVGFFLAQFTNALLLCIIANKAKKLFGGYRYVMIVFVIYSLIYSWIEIAATPLMYGHRSM-IIIMVGSSLRYEDLA 85
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSfIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582    86 GTFIICLFCAAYSLMTALLATQFFYRYIVVCRPQFLHHIKGYKLCFIFLPGVVIFFLWYLNVHFGMKKTLEKAKFSQEVI 165
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582   166 LKNCEEDTFQIVFVALQYWEDDLNGKSHFRIIDFLSYLGFLLMIALCFLTIIFCALKIYFKLKEDIHSMSERTKELNRQL 245
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563582   246 MMTLTFQTIFPFFTMYSTVGAILTLPIFEIELGKLASVTGMLSGIYPAIEPVFAIFFVKEFRNFVL 311
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-311 5.75e-92

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 277.03  E-value: 5.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582     7 HLVQYVGFFLAQFTNALLLCIIANKAKKLFGGYRYVMIVFVIYSLIYSWIEIAATPLMYGHRSM-IIIMVGSSLRYEDLA 85
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSfIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582    86 GTFIICLFCAAYSLMTALLATQFFYRYIVVCRPQFLHHIKGYKLCFIFLPGVVIFFLWYLNVHFGMKKTLEKAKFSQEVI 165
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582   166 LKNCEEDTFQIVFVALQYWEDDLNGKSHFRIIDFLSYLGFLLMIALCFLTIIFCALKIYFKLKEDIHSMSERTKELNRQL 245
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563582   246 MMTLTFQTIFPFFTMYSTVGAILTLPIFEIELGKLASVTGMLSGIYPAIEPVFAIFFVKEFRNFVL 311
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 3-308 1.57e-34

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 128.51  E-value: 1.57e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582     3 NFAVHLVQYVGFFLAQFTNALLLCIIANKAKKLFGGYRYVMIVFVIYSLIYSWIEIAATPLMYGHRSMIIIMVGSSLRYE 82
Cdd:pfam10319   4 NWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582    83 DLA-GTFIICLFCAAYSLMTALLATQFFYRYIVVCRPQFL-HHIKGYKLCFIFLPGVVIFFLWYLNVHFGMKKTLEKAKF 160
Cdd:pfam10319  84 YSElGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDY 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582   161 SQEVILKNCEEDTFQIVFVALQYWEddlnGKSHFRiidFLSYLGFLLMIALCFLTIIFC---ALKIYFKLKEDIHSMSER 237
Cdd:pfam10319 164 IREDFRETYGVDSMDINMLGALYWE----ASDETV---FRSWLGILLLTVISVYSIILYivlGYKIMRKLNKMSVTMSKK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17563582   238 TKELNRQLMMTLTFQTIFPFFTMYSTVGAILTLPIFEIELGKLASVTGMLS-GIYPAIEPVFAIFFVKEFRN 308
Cdd:pfam10319 237 TKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIAlSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 14-311 1.39e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 64.11  E-value: 1.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582    14 FFLAQFTNALLLCIIANKAKKLFGGYRYVMIVFVIYSLIYSWIEIAATP-LMYGHRSMIIIMVGSSLRYEDLAGTFIICL 92
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQrIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582    93 FCAAYSLMTALLATQFFYRYIVVCRPQFlHHIKGYKLCFIFLPGVVIFFLWYLNVhfgmkktlekakFSQEVILKNCEed 172
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHVDP-KRKKLILLIIIHYIPSLSQLIVIFLS------------PTDFLPVEALT-- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563582   173 tfQIVFVALQYWEDDLNGKShfRIIDFLSYLGFLLMIALCF---LTIIFCALKIYFKLKEDIHSMSERTKELNRQLMMTL 249
Cdd:pfam10317 154 --KELHPNYNLTDYTVTGFS--DLQSFPALINTLIMTIPVFpipIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGL 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17563582   250 TFQTIFPFFTMYSTVGAILTLPIFEIELGKLASVTGMLSGIYPAIEPVFAIFFVKEFRNFVL 311
Cdd:pfam10317 230 TIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 199-274 7.66e-03

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 37.52  E-value: 7.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563582   199 FLSYLGFLLMIALCFLTIIFCALKIYFKLKEDIHSMSERTKELNRQLMMTLTFQTIFPFFTMYSTVGAILTLPIFE 274
Cdd:pfam10318 185 YFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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