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Conserved domains on  [gi|17563546|ref|NP_505321|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-310 1.57e-97

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 290.90  E-value: 1.57e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546     5 TSRCELVGVGIASFSNSLLLYMLTFKATSSYGSYRRLMLSYTIVEIMYTFFNKICGMMAHSTETSFVVFNVYQG-YVSRS 83
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDlGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    84 LAPIFLLGFCAIYYTLITLLVVHFIYRYIVICDSAKLKYFDGGYLLCWVFGCAACGISMVTVKYFAFPQKERLTNELRDD 163
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546   164 FSQYYNLTMEEVVYNGPNYYNCDENGKCEISLVDWITMIIFCCGLMFSVIIMFCCGYFCCMKLEKNKLNASHHTVQLQKQ 243
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563546   244 LMIALIIQSLIPITLMYIPILILFVTPMIRIAAGPYVNIAIATVAIYPPVDQFAIIYVIKDFRTAVK 310
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-310 1.57e-97

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 290.90  E-value: 1.57e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546     5 TSRCELVGVGIASFSNSLLLYMLTFKATSSYGSYRRLMLSYTIVEIMYTFFNKICGMMAHSTETSFVVFNVYQG-YVSRS 83
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDlGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    84 LAPIFLLGFCAIYYTLITLLVVHFIYRYIVICDSAKLKYFDGGYLLCWVFGCAACGISMVTVKYFAFPQKERLTNELRDD 163
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546   164 FSQYYNLTMEEVVYNGPNYYNCDENGKCEISLVDWITMIIFCCGLMFSVIIMFCCGYFCCMKLEKNKLNASHHTVQLQKQ 243
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563546   244 LMIALIIQSLIPITLMYIPILILFVTPMIRIAAGPYVNIAIATVAIYPPVDQFAIIYVIKDFRTAVK 310
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-310 1.57e-97

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 290.90  E-value: 1.57e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546     5 TSRCELVGVGIASFSNSLLLYMLTFKATSSYGSYRRLMLSYTIVEIMYTFFNKICGMMAHSTETSFVVFNVYQG-YVSRS 83
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDlGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    84 LAPIFLLGFCAIYYTLITLLVVHFIYRYIVICDSAKLKYFDGGYLLCWVFGCAACGISMVTVKYFAFPQKERLTNELRDD 163
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546   164 FSQYYNLTMEEVVYNGPNYYNCDENGKCEISLVDWITMIIFCCGLMFSVIIMFCCGYFCCMKLEKNKLNASHHTVQLQKQ 243
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17563546   244 LMIALIIQSLIPITLMYIPILILFVTPMIRIAAGPYVNIAIATVAIYPPVDQFAIIYVIKDFRTAVK 310
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 14-309 7.15e-34

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 126.59  E-value: 7.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    14 GIASF-SNSLLLYMLTFKATSSYGSYRRLMLSYTIVEIMYTFFNKICGMMAHSTETSFVVFNVYQGYVSRS-LAPIFLLG 91
Cdd:pfam10319  15 GVLSFiVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSeLGQHALSA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    92 FCAIYYTLITLLVVHFIYRYIVICDSAKL-KYFDGGYLLCWVFGCAACGIS-MVTVKYFAFPQKERLtNELRDDFSQYYN 169
Cdd:pfam10319  95 RCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVwTAICYFLLRANDEIR-DYIREDFRETYG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546   170 -----LTMEEVVYNGPNYyncdengkcEISLVDWITMIIFCCGLMFSVIIMFCCGYFCCMKLEKNKLNASHHTVQLQKQL 244
Cdd:pfam10319 174 vdsmdINMLGALYWEASD---------ETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQL 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563546   245 MIALIIQSLIPITLMYIPILILFVTPMIRIAAGPYVN-IAIATVAIYPPVDQFAIIYVIKDFRTAV 309
Cdd:pfam10319 245 LKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNyLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 199-315 1.46e-09

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 58.32  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546   199 ITMIIFCCGLMFSVIIMFCCGYFCCMK---LEKNKLNASHHTVQLQKQLMIALIIQSLIPITLMYIPILILFVTPMIRIA 275
Cdd:pfam10318 183 STYFLICIVLLILILIIQILFFVFLTIyylFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYY 262

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 17563546   276 AGPYVNIAIATVAIYPPVDQFAIIYVIKDFRTAVKNFFKR 315
Cdd:pfam10318 263 NQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 15-310 2.49e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 57.56  E-value: 2.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    15 IASFSNSLLLYMLTFKATSSYGSYRRLMLSYTIVEIMYTFFNKICGMMAHSTETSFvvfnvyqGYVSRSLAPIFLLGFCA 94
Cdd:pfam10317  11 LGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSM-------ALISYGPCKYFGPWFCY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546    95 IYYTLITLLVVH--------FIYRYIVICDSAKLKYFDGGYLLCWVFGCAACGISMVTVKYFAFPQKERLTNELRDdfsq 166
Cdd:pfam10317  84 SGYSLLQHFLLHsgwsllltFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHPN---- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563546   167 yYNLTMEEVVYNgpnyyncdengkceISLVDW---ITMIIFCCGLMFSVIIMFCCGYFCCMKLEKNKLNASHHTVQLQKQ 243
Cdd:pfam10317 160 -YNLTDYTVTGF--------------SDLQSFpalINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQ 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17563546   244 LMIALIIQSLIPItLMYIPILILFVTPMIRIAAGPYVNIAIATVAIYPPV-DQFAIIYVIKDFRTAVK 310
Cdd:pfam10317 225 LIKGLTIQALLPL-FSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLlDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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