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Conserved domains on  [gi|72000577|ref|NP_505383|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-317 3.66e-108

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 318.25  E-value: 3.66e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    10 LKTAQFVGTCIANPLNIFLIYLILTKSSKKIGNYKYLMIYVSIYEILFSCSAIVTEPLLHSFTTRVIVIVDVHNSIFSRE 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    90 ICSILDCLMCAMYGVSMNVFALHFLYRYATLF-PKSKKLFDGARIIFWLTVPQIYGVVWLVTYYAVFRESPEYTEFIRKT 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCrPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   169 LMENLDINVDDVVYVGPYYYMEDKNGIHDMDWTAFWAMAIVWLLIMSSAVTVFICGYGCYKKITKglEVSSNSKQTKSIQ 248
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKK--LKSLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72000577   249 KQLFYALVVQSAIPFLLMYIPSTVVLFCTLIQLDVGSASLFISYSIAIYPVVDPLPTLFIVQNYRNAVK 317
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-317 3.66e-108

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 318.25  E-value: 3.66e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    10 LKTAQFVGTCIANPLNIFLIYLILTKSSKKIGNYKYLMIYVSIYEILFSCSAIVTEPLLHSFTTRVIVIVDVHNSIFSRE 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    90 ICSILDCLMCAMYGVSMNVFALHFLYRYATLF-PKSKKLFDGARIIFWLTVPQIYGVVWLVTYYAVFRESPEYTEFIRKT 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCrPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   169 LMENLDINVDDVVYVGPYYYMEDKNGIHDMDWTAFWAMAIVWLLIMSSAVTVFICGYGCYKKITKglEVSSNSKQTKSIQ 248
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKK--LKSLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72000577   249 KQLFYALVVQSAIPFLLMYIPSTVVLFCTLIQLDVGSASLFISYSIAIYPVVDPLPTLFIVQNYRNAVK 317
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-317 3.66e-108

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 318.25  E-value: 3.66e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    10 LKTAQFVGTCIANPLNIFLIYLILTKSSKKIGNYKYLMIYVSIYEILFSCSAIVTEPLLHSFTTRVIVIVDVHNSIFSRE 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    90 ICSILDCLMCAMYGVSMNVFALHFLYRYATLF-PKSKKLFDGARIIFWLTVPQIYGVVWLVTYYAVFRESPEYTEFIRKT 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCrPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   169 LMENLDINVDDVVYVGPYYYMEDKNGIHDMDWTAFWAMAIVWLLIMSSAVTVFICGYGCYKKITKglEVSSNSKQTKSIQ 248
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKK--LKSLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72000577   249 KQLFYALVVQSAIPFLLMYIPSTVVLFCTLIQLDVGSASLFISYSIAIYPVVDPLPTLFIVQNYRNAVK 317
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 24-316 1.36e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 115.42  E-value: 1.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    24 LNIFLIYLILTKSSKKIGNYKYLMIYVSIYEILFSCSAIVTEPLLHSFTTRVIVIVdVHNSIF-SREICSILDCLMCAMY 102
Cdd:pfam10319  21 VNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFV-SDGPFFeYSELGQHALSARCSFI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   103 GVSMNVFALHFLYRYATLFPKS--KKLFDGARIIFWLTVPQIYGVVWLVTYYAVFRESPEYTEFIRKTLMENLDINVDDV 180
Cdd:pfam10319 100 SASYAVLLIHFIYRYLVLFNPQltRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDSMDI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   181 VYVGPYYYmedkNGIHDMDWTAfWAMAIVWLLIMSSAVTVFIC-GYGCYKKITKglEVSSNSKQTKSIQKQLFYALVVQS 259
Cdd:pfam10319 180 NMLGALYW----EASDETVFRS-WLGILLLTVISVYSIILYIVlGYKIMRKLNK--MSVTMSKKTKRLQKQLLKALIVQT 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 72000577   260 AIPFLLMYIPSTVVLFCTLIQLDVGSASLFISYS-IAIYPVVDPLPTLFIVQNYRNAV 316
Cdd:pfam10319 253 IIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 23-318 8.12e-18

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 82.21  E-value: 8.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    23 PLNIFLIYLILTKSSKKIGNYKYLMIYVSIYEILFSCSAIVTEPLLHSFTTRVIVIVDVHNSIFSREICSILDCLMCAMY 102
Cdd:pfam10317  14 ILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLLQHFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   103 GVSMNVFALHFLYRYATL---FPKSKKLFdgaRIIFWLTVPQIYGVVWLVTyyavfreSPEYTEFIRKTLMENL-DINVD 178
Cdd:pfam10317  94 LHSGWSLLLTFYYRYYILkhvDPKRKKLI---LLIIIHYIPSLSQLIVIFL-------SPTDFLPVEALTKELHpNYNLT 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   179 DvvyvgpyyymEDKNGIHDMdwtAFWAMAIVWLLIMSSAVTVFICGYGCYKKITKGLEVSSN--SKQTKSIQKQLFYALV 256
Cdd:pfam10317 164 D----------YTVTGFSDL---QSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVnmSPTTKAQHRQLIKGLT 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72000577   257 VQSAIPfLLMYIPSTvvlFCTLIQLDVGSASLFISYSI----AIYPVVDPLPTLFIVQNYRNAVKK 318
Cdd:pfam10317 231 IQALLP-LFSYIPGV---TLYLLSQLTGTEFLILEYFIfvlpALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 9-322 9.07e-12

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 64.87  E-value: 9.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577     9 FLKTAQFVGTCIANPLNIFLIYLILTKSSKKIGNYKYLMIYV----SIYEILFSCSAI--VTEPLLHSFTTRVIVIVDVh 82
Cdd:pfam10318   5 FLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLhfwsALLDLSLSFLTIpyIFLPALAGYPLGLLSYLGV- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577    83 nsifSREICSILDCLMCAMYGVSMNVFalhFLYRYATLFPKSKKLFDGARIIFWLTvpqIYGVVWLVTYYAVFRESPEYT 162
Cdd:pfam10318  84 ----PTPIQFYIGVTSLALVGVSIILL---FENRYSILFTNKKRITWKKTRVLYLI---FNYIIALLFLIPIYLNIPDQE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   163 EFIRKTLMENLDINvDDVVYVGPYYYMEDkngihDMDWTAFWAMAIVWLLIMSSAVTVFICGYGCYKKITKGLevssnSK 242
Cdd:pfam10318 154 AAKLKVLKKLPCLP-PEFFDNPPVFVLAI-----DSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSL-----SK 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000577   243 QTKSIQKQLFYALVVQSAIPFLLMYIPSTVVLFCTLIQLDVGSASLFISYSIAIYPVVDPLPTLFIVQNYRNAVKKMITR 322
Cdd:pfam10318 223 KTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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