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Conserved domains on  [gi|17560922|ref|NP_505410|]
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NOT2/NOT3/NOT5 C-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

NOT2/NOT3/NOT5 family protein( domain architecture ID 602)

NOT2/NOT3/NOT5 family protein similar to Homo sapiens CCR4-NOT transcription complex subunit 2 (CNOT2), which is a component of the CCR4-NOT complex that is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NOT2_3_5 super family cl02384
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
203-291 7.66e-13

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


The actual alignment was detected with superfamily member pfam04153:

Pssm-ID: 470561  Cd Length: 121  Bit Score: 65.31  E-value: 7.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560922   203 TFAGPFASEPLLPANMGLT----YNQVPNvyytartlqSSFDMLHNIPdKFGVHELFYIFYNLPKELWQLNAARELQYRG 278
Cdd:pfam04153   3 TFNSPWPLDAERPYEPDFRnpacYPQEPL---------PRLESPEKFS-KFDDETLFYIFYSMPGDYAQYLAAKELKKRS 72
                          90
                  ....*....|...
gi 17560922   279 WRYNMKEKLWVHK 291
Cdd:pfam04153  73 WRYHKKLRTWFTR 85
 
Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
203-291 7.66e-13

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 65.31  E-value: 7.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560922   203 TFAGPFASEPLLPANMGLT----YNQVPNvyytartlqSSFDMLHNIPdKFGVHELFYIFYNLPKELWQLNAARELQYRG 278
Cdd:pfam04153   3 TFNSPWPLDAERPYEPDFRnpacYPQEPL---------PRLESPEKFS-KFDDETLFYIFYSMPGDYAQYLAAKELKKRS 72
                          90
                  ....*....|...
gi 17560922   279 WRYNMKEKLWVHK 291
Cdd:pfam04153  73 WRYHKKLRTWFTR 85
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
168-294 5.38e-07

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 49.59  E-value: 5.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560922 168 KIKNENIEMMTIGFDLNELGVPMTTQDTNQKSVWETFAGPFA---SEPLLPANMgltynqVPNVYYTARTlQSSFDMLHN 244
Cdd:COG5601  10 QIEDEEQSIHDLGKDLLSEILSLVRPKKYQDRPSTTLYSPWAestKKPVQPMFM------LPNCYPNAPN-PPIFKVNIE 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17560922 245 IPDKFGVHE--LFYIFYNLPKELWQLNAARELQYRGWRYNMKEKLWVHKKLG 294
Cdd:COG5601  83 DMKMDNFHDetLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWLTFNPG 134
 
Name Accession Description Interval E-value
NOT2_3_5 pfam04153
NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that ...
203-291 7.66e-13

NOT2 / NOT3 / NOT5 family; NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.


Pssm-ID: 461199  Cd Length: 121  Bit Score: 65.31  E-value: 7.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560922   203 TFAGPFASEPLLPANMGLT----YNQVPNvyytartlqSSFDMLHNIPdKFGVHELFYIFYNLPKELWQLNAARELQYRG 278
Cdd:pfam04153   3 TFNSPWPLDAERPYEPDFRnpacYPQEPL---------PRLESPEKFS-KFDDETLFYIFYSMPGDYAQYLAAKELKKRS 72
                          90
                  ....*....|...
gi 17560922   279 WRYNMKEKLWVHK 291
Cdd:pfam04153  73 WRYHKKLRTWFTR 85
CDC36 COG5601
General negative regulator of transcription subunit [Transcription];
168-294 5.38e-07

General negative regulator of transcription subunit [Transcription];


Pssm-ID: 227888  Cd Length: 172  Bit Score: 49.59  E-value: 5.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560922 168 KIKNENIEMMTIGFDLNELGVPMTTQDTNQKSVWETFAGPFA---SEPLLPANMgltynqVPNVYYTARTlQSSFDMLHN 244
Cdd:COG5601  10 QIEDEEQSIHDLGKDLLSEILSLVRPKKYQDRPSTTLYSPWAestKKPVQPMFM------LPNCYPNAPN-PPIFKVNIE 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17560922 245 IPDKFGVHE--LFYIFYNLPKELWQLNAARELQYRGWRYNMKEKLWVHKKLG 294
Cdd:COG5601  83 DMKMDNFHDetLFYIFYSFPNDVLQEKAYDELLKRNWRFHKMLKCWLTFNPG 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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