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Conserved domains on  [gi|17558788|ref|NP_505457|]
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ATP-dependent 6-phosphofructokinase 2 [Caenorhabditis elegans]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 1003451)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

CATH:  3.40.50.460|3.40.50.450
EC:  2.7.1.11
Gene Ontology:  GO:0006007|GO:0006002|GO:0003872|GO:0000166|GO:0046872|GO:0070095

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
6PF1K_euk super family cl37119
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 11-750 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


The actual alignment was detected with superfamily member TIGR02478:

Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1189.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    11 HGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLING--NIELAKWAHVANVTHLGGSMIGTSRCDEFRTT 88
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGgdNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    89 DGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGRFGEELFAEGKITEEVANEGRELHLAGIVGSIDNDCIESDKS 168
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   169 IGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWPEQLCHQLGSVRKMGK 248
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   249 RQNVIILGEGVTNSKGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGKEEkegav 328
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPE----- 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   329 vtgqkTIAKVMCLRGHNIQRNELSRVIRQTETANEEIMQRHSDLACRLRGFGFLDKQTYLNFVSIPLSTTMPSRTKT--- 405
Cdd:TIGR02478 316 -----TPSPVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrl 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   406 -FAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQLP-SEMDLI 483
Cdd:TIGR02478 391 rIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPgDDLGTI 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   484 AEGLNSNNVDGLVIIGGFMAFESALILQQNRSEYTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAI 563
Cdd:TIGR02478 471 AYYFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSAS 550

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   564 GSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETNEKDLEKLAIETKERLDSGnLEKFLLIRSEGASDEIYSPDV 643
Cdd:TIGR02478 551 ASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG-RAGKLILRNEKASKVYTTDFI 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   644 KKIFDKVMKNKYGVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVN-------PVKMGDRD--CCVIGLRGSSLRYV 714
Cdd:TIGR02478 630 ARIISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEkikankhADKLSADDtsAVVIGIRGSNVLFT 709

                         730       740       750
                  ....*....|....*....|....*....|....*..
gi 17558788   715 PVQG-LGKKVCFEHGVPHNMWWLDLHPLVEAMTKKPQ 750
Cdd:TIGR02478 710 PVKQlLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 11-750 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1189.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    11 HGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLING--NIELAKWAHVANVTHLGGSMIGTSRCDEFRTT 88
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGgdNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    89 DGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGRFGEELFAEGKITEEVANEGRELHLAGIVGSIDNDCIESDKS 168
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   169 IGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWPEQLCHQLGSVRKMGK 248
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   249 RQNVIILGEGVTNSKGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGKEEkegav 328
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPE----- 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   329 vtgqkTIAKVMCLRGHNIQRNELSRVIRQTETANEEIMQRHSDLACRLRGFGFLDKQTYLNFVSIPLSTTMPSRTKT--- 405
Cdd:TIGR02478 316 -----TPSPVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrl 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   406 -FAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQLP-SEMDLI 483
Cdd:TIGR02478 391 rIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPgDDLGTI 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   484 AEGLNSNNVDGLVIIGGFMAFESALILQQNRSEYTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAI 563
Cdd:TIGR02478 471 AYYFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSAS 550

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   564 GSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETNEKDLEKLAIETKERLDSGnLEKFLLIRSEGASDEIYSPDV 643
Cdd:TIGR02478 551 ASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG-RAGKLILRNEKASKVYTTDFI 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   644 KKIFDKVMKNKYGVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVN-------PVKMGDRD--CCVIGLRGSSLRYV 714
Cdd:TIGR02478 630 ARIISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEkikankhADKLSADDtsAVVIGIRGSNVLFT 709

                         730       740       750
                  ....*....|....*....|....*....|....*..
gi 17558788   715 PVQG-LGKKVCFEHGVPHNMWWLDLHPLVEAMTKKPQ 750
Cdd:TIGR02478 710 PVKQlLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 8-747 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 653.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   8 GKDHGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLING--NIELAKWAHVANVTHLGGSMIGTSRCDEF 85
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  86 RTTDGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGRFGEELFAEGKITEEVANEGRELHLAGIVGSIDNDCIES 165
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 166 DKSIGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWPEQLCHQLGSVRK 245
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 246 MGKRQNVIILGEGVTNSKGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGKEEke 325
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPD-- 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 326 gavvtgqkTIAKVMCLRGHNIQRNELSRVIRQTETANEEIMQRHSDLACRLRGFGFLDKQTYLNFVSIPLSTTMPSRTK- 404
Cdd:cd00764 319 --------TPACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNl 390

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 405 TFAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQLPSE-MDLI 483
Cdd:cd00764 391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKdLETI 470

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 484 AEGLNSNNVDGLVIIGGFMAFESALILQQNRSEYTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAI 563
Cdd:cd00764 471 AYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSAS 550

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 564 GSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQ----VETNEKDLEKLAIETKERLDSGNLEKfLLIRSEGASD--- 636
Cdd:cd00764 551 GTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEepfnIRDLQENVEHLTEKMKTTIGRGLVLR-NEKCNENYTTvft 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 637 -EIYSPDVKKIFDkvmknkygVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVNPVKMG----------DRDCCVIG 705
Cdd:cd00764 630 yELYSEEGKGVFD--------CRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENyaagnefandPDFNCVNG 701

                       730       740       750       760
                ....*....|....*....|....*....|....*....|..
gi 17558788 706 LRGSSLRYVPVQGLgKKVCFEHGVPHNMWWLDLHPLVEAMTK 747
Cdd:cd00764 702 VKKYAVLFEPVEEL-KQTTFEHRIPKEQWWLSLRPLLKILAK 742
PFK pfam00365
Phosphofructokinase;
13-315 3.83e-122

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 366.66  E-value: 3.83e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevanegreLHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:pfam00365  82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIGFD 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEkwpEQLCHQLGSVRKmGKRQNV 252
Cdd:pfam00365 140 TALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDI---EELCEKIKELRK-GKRFSI 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558788   253 IILGEGVTNSKgqridvrQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQ 315
Cdd:pfam00365 216 IVVAEGASDGE-------FLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 13-358 1.84e-105

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 326.26  E-value: 1.84e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:COG0205   4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGRE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevanegreLHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:COG0205  84 KALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIGFD 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEkwpEQLCHQLGSVRKMGKRQNV 252
Cdd:COG0205 142 TAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDL---DKLLEKLKERRKRGKGYSI 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 253 IILGEGVTNSKGQRIDVR---------------QVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEV 317
Cdd:COG0205 219 IVVAEGAGDEDGEAVLEAdtdafghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELL 298

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 17558788 318 LKGKeekegavvTGqktiaKVMCLRGHNIQRNELSRVIRQT 358
Cdd:COG0205 299 LEGK--------TG-----VMVGIRRGEIVLVPLEEVANKE 326
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
13-321 1.64e-99

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 310.09  E-value: 1.64e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:PRK03202   4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEwgrfgeelfaegkiteevanegrELHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:PRK03202  84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEH-----------------------GIPVIGLPGTIDNDIAGTDYTIGFD 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwPEQLCHQLGSVRKMGKRQNV 252
Cdd:PRK03202 141 TALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGKKHAI 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788  253 IILGEGVTNSKGqridvrqVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGK 321
Cdd:PRK03202 218 IVVAEGVMPAEE-------LAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGK 279
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 11-750 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1189.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    11 HGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLING--NIELAKWAHVANVTHLGGSMIGTSRCDEFRTT 88
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGgdNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    89 DGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGRFGEELFAEGKITEEVANEGRELHLAGIVGSIDNDCIESDKS 168
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   169 IGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWPEQLCHQLGSVRKMGK 248
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   249 RQNVIILGEGVTNSKGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGKEEkegav 328
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPE----- 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   329 vtgqkTIAKVMCLRGHNIQRNELSRVIRQTETANEEIMQRHSDLACRLRGFGFLDKQTYLNFVSIPLSTTMPSRTKT--- 405
Cdd:TIGR02478 316 -----TPSPVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrl 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   406 -FAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQLP-SEMDLI 483
Cdd:TIGR02478 391 rIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPgDDLGTI 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   484 AEGLNSNNVDGLVIIGGFMAFESALILQQNRSEYTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAI 563
Cdd:TIGR02478 471 AYYFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSAS 550

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   564 GSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETNEKDLEKLAIETKERLDSGnLEKFLLIRSEGASDEIYSPDV 643
Cdd:TIGR02478 551 ASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG-RAGKLILRNEKASKVYTTDFI 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   644 KKIFDKVMKNKYGVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVN-------PVKMGDRD--CCVIGLRGSSLRYV 714
Cdd:TIGR02478 630 ARIISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEkikankhADKLSADDtsAVVIGIRGSNVLFT 709

                         730       740       750
                  ....*....|....*....|....*....|....*..
gi 17558788   715 PVQG-LGKKVCFEHGVPHNMWWLDLHPLVEAMTKKPQ 750
Cdd:TIGR02478 710 PVKQlLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 8-747 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 653.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   8 GKDHGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLING--NIELAKWAHVANVTHLGGSMIGTSRCDEF 85
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  86 RTTDGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGRFGEELFAEGKITEEVANEGRELHLAGIVGSIDNDCIES 165
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 166 DKSIGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWPEQLCHQLGSVRK 245
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 246 MGKRQNVIILGEGVTNSKGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGKEEke 325
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPD-- 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 326 gavvtgqkTIAKVMCLRGHNIQRNELSRVIRQTETANEEIMQRHSDLACRLRGFGFLDKQTYLNFVSIPLSTTMPSRTK- 404
Cdd:cd00764 319 --------TPACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNl 390

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 405 TFAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQLPSE-MDLI 483
Cdd:cd00764 391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKdLETI 470

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 484 AEGLNSNNVDGLVIIGGFMAFESALILQQNRSEYTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAI 563
Cdd:cd00764 471 AYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSAS 550

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 564 GSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQ----VETNEKDLEKLAIETKERLDSGNLEKfLLIRSEGASD--- 636
Cdd:cd00764 551 GTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEepfnIRDLQENVEHLTEKMKTTIGRGLVLR-NEKCNENYTTvft 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 637 -EIYSPDVKKIFDkvmknkygVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVNPVKMG----------DRDCCVIG 705
Cdd:cd00764 630 yELYSEEGKGVFD--------CRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENyaagnefandPDFNCVNG 701

                       730       740       750       760
                ....*....|....*....|....*....|....*....|..
gi 17558788 706 LRGSSLRYVPVQGLgKKVCFEHGVPHNMWWLDLHPLVEAMTK 747
Cdd:cd00764 702 VKKYAVLFEPVEEL-KQTTFEHRIPKEQWWLSLRPLLKILAK 742
PFK pfam00365
Phosphofructokinase;
13-315 3.83e-122

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 366.66  E-value: 3.83e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevanegreLHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:pfam00365  82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIGFD 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEkwpEQLCHQLGSVRKmGKRQNV 252
Cdd:pfam00365 140 TALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDI---EELCEKIKELRK-GKRFSI 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558788   253 IILGEGVTNSKgqridvrQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQ 315
Cdd:pfam00365 216 IVVAEGASDGE-------FLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-321 7.52e-111

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 340.04  E-value: 7.52e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:cd00363   3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevaNEGRELHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:cd00363  83 KAAENLKKHGIDALVVIGGDGSYTGADLLTEEWP-----------------SKYQGFNVIGLPGTIDNDIKGTDYTIGFD 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWPEQLCHQLGSVRKMGKRQNV 252
Cdd:cd00363 146 TALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGKRHGI 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788 253 IILGEGVTNSKGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGK 321
Cdd:cd00363 226 VIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGT 294
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 13-358 1.84e-105

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 326.26  E-value: 1.84e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:COG0205   4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGRE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevanegreLHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:COG0205  84 KALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIGFD 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEkwpEQLCHQLGSVRKMGKRQNV 252
Cdd:COG0205 142 TAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDL---DKLLEKLKERRKRGKGYSI 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 253 IILGEGVTNSKGQRIDVR---------------QVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEV 317
Cdd:COG0205 219 IVVAEGAGDEDGEAVLEAdtdafghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELL 298

                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 17558788 318 LKGKeekegavvTGqktiaKVMCLRGHNIQRNELSRVIRQT 358
Cdd:COG0205 299 LEGK--------TG-----VMVGIRRGEIVLVPLEEVANKE 326
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
13-321 1.64e-99

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 310.09  E-value: 1.64e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:PRK03202   4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEwgrfgeelfaegkiteevanegrELHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:PRK03202  84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEH-----------------------GIPVIGLPGTIDNDIAGTDYTIGFD 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwPEQLCHQLGSVRKMGKRQNV 252
Cdd:PRK03202 141 TALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGKKHAI 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788  253 IILGEGVTNSKGqridvrqVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGK 321
Cdd:PRK03202 218 IVVAEGVMPAEE-------LAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGK 279
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 13-321 2.76e-91

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 287.71  E-value: 2.76e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevanegreLHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:TIGR02482  82 KAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGG----------------------IPVIGLPGTIDNDIPGTDYTIGFD 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwPEQLCHQLGSVRKMGKRQNV 252
Cdd:TIGR02482 140 TALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYD---IDELIQRLKEQHEAGKKHSI 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788   253 IILGEGvtnskGQRIDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGK 321
Cdd:TIGR02482 217 IIVAEG-----NIVGSAKEVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGK 280
PFK pfam00365
Phosphofructokinase;
407-688 2.24e-89

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 281.54  E-value: 2.24e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   407 AVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQLPSE----MDL 482
Cdd:pfam00365   3 GILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteegREK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   483 IAEGLNSNNVDGLVIIGGFMAFESALILQQNRseytclSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNA 562
Cdd:pfam00365  83 IAENLKKLGIDALVVIGGDGSLTGANKLSEER------GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   563 IGSkNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETnekDLEKLAIETKERLDSGNleKFLLIRSEGASDeiySPD 642
Cdd:pfam00365 157 SSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF---DIEELCEKIKELRKGKR--FSIIVVAEGASD---GEF 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 17558788   643 VKKIFDKvmKNKYGVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFE 688
Cdd:pfam00365 228 LAKLIEE--GTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-321 4.70e-84

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 269.28  E-value: 4.70e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  13 VGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:cd00763   3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEGQA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  93 KAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEwgrfgeelfaegkiteevanegrELHLAGIVGSIDNDCIESDKSIGSD 172
Cdd:cd00763  83 KAIEQLKKHGIDALVVIGGDGSYMGAMRLTEH-----------------------GFPCVGLPGTIDNDIPGTDYTIGFD 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 173 TALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwPEQLCHQLGSVRKMGKRQNV 252
Cdd:cd00763 140 TALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGKKHAI 216

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788 253 IILGEGVTnskgqriDVRQVKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGYEAVQEVLKGK 321
Cdd:cd00763 217 VVVAEGVY-------DVDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGK 278
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 13-355 2.78e-63

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 214.47  E-value: 2.78e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    13 VGVLTSGGDSQGMNAAVRSVVRETI-RQGHRCYLIREGYNGLINGniELAKWAHVANVTHL---GGSMIGTSRCDEFRT- 87
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIaEYGWEVIGIRDGWRGLLEG--DTVPLLDLEDVRGIlprGGTILGSSRTNPFKYe 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    88 TDGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLkeewgrfgeelfaegkiteevANEGreLHLAGIVGSIDNDCIESDK 167
Cdd:TIGR02483  80 EDGDDKIVANLKELGLDALIAIGGDGTLGIARRL---------------------ADKG--LPVVGVPKTIDNDLEATDY 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   168 SIGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwPEQLCHQLGSVRKMG 247
Cdd:TIGR02483 137 TFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD---IDSVCEKVRERFARG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   248 KRQNVIILGEGVTNSKGQRIDVRQVK----------------EEIETRLQLEVRIATLGHLQRGGAPSFLDRLIGLRMGY 311
Cdd:TIGR02483 214 KRFAIVVVAEGAKPKGGEMVVQEGVKdafghvrlggignwlaEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGV 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 17558788   312 EAVQEVlkgKEEKEGAVVtgqktiakvmCLRGHNIQRNELSRVI 355
Cdd:TIGR02483 294 AAVDLV---HEGQFGHMV----------ALRGTDIVYVPIAEAV 324
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 404-715 3.13e-58

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 201.46  E-value: 3.13e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 404 KTFAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKR----QLPSE 479
Cdd:COG0205   2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRskpfKTEEG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 480 MDLIAEGLNSNNVDGLVIIGG---FMAfesALILqqnrSEYtcLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVD 556
Cdd:COG0205  82 REKALENLKKLGIDALVVIGGdgsLDG---AAKL----AEE--YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAID 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 557 NISQNAiGSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETnekDLEKLAIETKERLDSGNleKFLLIR-SEGAS 635
Cdd:COG0205 153 RLRDTA-ASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPF---DLDKLLEKLKERRKRGK--GYSIIVvAEGAG 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 636 DEIYSPDVKKIFDKVMKNKYG-----------------VRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVNpvkmGD 698
Cdd:COG0205 227 DEDGEAVLEADTDAFGHVRLGgigeylakeieertgieTRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE----GK 302

                       330
                ....*....|....*..
gi 17558788 699 RDCCViGLRGSSLRYVP 715
Cdd:COG0205 303 TGVMV-GIRRGEIVLVP 318
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
13-321 1.44e-50

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 181.04  E-value: 1.44e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   13 VGVLTSGGDSQGMNAAVRSVVRETIRQ-GHRCYLIREGYNGLINGNIELAKWaHVANVTHL---GGSMIGTS-RCDEFR- 86
Cdd:PRK14071   7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYIEL-DLDQVDDLlrmGGTILGTTnKGDPFAf 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   87 -TTDGRKK-AAAIMFDKriFH------LIVIGGDGSLMGAQKLKEEWGrfgeelfaegkiteevanegreLHLAGIVGSI 158
Cdd:PRK14071  86 pMPDGSLRdRSQEIIDG--YHslgldaLIGIGGDGSLAILRRLAQQGG----------------------INLVGIPKTI 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  159 DNDCIESDKSIGSDTALHRICEAIDGLVMTAQSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwPEQLCH 238
Cdd:PRK14071 142 DNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT---LENVCK 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  239 QLGSVRKMGKRQNVIILGEGVTNSKGQRIDVRQ-------------VKEEIETRLQLEVRIATLGHLQRGGAPSFLDRLI 305
Cdd:PRK14071 219 KIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLL 298

                        330
                 ....*....|....*.
gi 17558788  306 GLRMGYEAVQEVLKGK 321
Cdd:PRK14071 299 ASAFGVAAVDLIAQGK 314
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
415-715 5.11e-49

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 175.27  E-value: 5.11e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  415 CAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKR----QLPSEMDLIAEGLNSN 490
Cdd:PRK03202  13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARfpefKDEEGRAKAIENLKKL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  491 NVDGLVIIGG---FMAfesALILqqnrSEYtclSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAiGSKN 567
Cdd:PRK03202  93 GIDALVVIGGdgsYMG---AKRL----TEH---GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTA-SSHE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  568 KVMIIETMGSRSGFLATMTALSTGSQFALIRQVETnekDLEKLAIETKERLDSGnlEKFLLIR-SEGASDEiysPDVKKI 646
Cdd:PRK03202 162 RVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPF---DIEELCAKIKKGRERG--KKHAIIVvAEGVMPA---EELAKE 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788  647 FDKvmKNKYGVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVNpvkmGDRDCCViGLRGSSLRYVP 715
Cdd:PRK03202 234 IEE--RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE----GKGGRMV-GIQNNKIVHVP 295
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 404-745 4.32e-46

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 167.86  E-value: 4.32e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 404 KTFAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKR----QLPSE 479
Cdd:cd00363   1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARckefRTEEG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 480 MDLIAEGLNSNNVDGLVIIGGFMAFESALILQQNRSEyTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNIS 559
Cdd:cd00363  81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-KYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 560 QNAiGSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETNEKDLEKLAIETKERLDSGnlEKF-LLIRSEGASDEI 638
Cdd:cd00363 160 DTA-SSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERG--KRHgIVIVAEGAIDFI 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 639 YSPDVKKIFDKVMKNKYG--VRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIVNPVkmGDRDCCVIGLrgsslryvpv 716
Cdd:cd00363 237 PKPITEKLLAKLVEERLGfdTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGT--GGTPVGIQNL---------- 304

                       330       340
                ....*....|....*....|....*....
gi 17558788 717 qglgkkvcfehgvphNMWWLDLHPLVEAM 745
Cdd:cd00363 305 ---------------NENQVVRHPLTEAV 318
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 3-314 2.55e-41

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 161.91  E-value: 2.55e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   3 QKFKKGKDHGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLIREGYNGLINGNIELAKWAHVANVTHLGGSMIGTSRc 82
Cdd:cd00764 382 QPLPEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKR- 460

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  83 defRTTDGRKKAAAIMFDKRIFH-LIVIGGDGSLMGAQKLKEewgrfGEELFAEGKITEEVanegrelhlagIVGSIDND 161
Cdd:cd00764 461 ---TLPKKDLETIAYNFQKYGIDgLIIVGGFEAYKGLLQLRE-----AREQYEEFCIPMVL-----------IPATVSNN 521

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 162 CIESDKSIGSDTALHRICEAIDGLVMTAQS-HQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDekwpeqlCHQL 240
Cdd:cd00764 522 VPGTDFSLGSDTALNALMKYCDRIKQSASGtKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFN-------IRDL 594

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 241 gsvrkmgkRQNVIILGEGVTNSKGQRIDVRQVK---------------EEIETRlqLEVRIATLGHLQRGGAPSFLDRLI 305
Cdd:cd00764 595 --------QENVEHLTEKMKTTIGRGLVLRNEKcnenyttvftyelysEEGKGV--FDCRTNVLGHVQQGGAPSPFDRNF 664


                ....*....
gi 17558788 306 GLRMGYEAV 314
Cdd:cd00764 665 GTKFAVKAM 673
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 404-691 3.57e-35

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 136.00  E-value: 3.57e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 404 KTFAVVHIGSPCAGMNAATYSFTRMANHSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRqLPS----E 479
Cdd:cd00763   1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEfkdeE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 480 MDLIA-EGLNSNNVDGLVIIGGFMAFESALILqqnrseyTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNI 558
Cdd:cd00763  80 GQAKAiEQLKKHGIDALVVIGGDGSYMGAMRL-------TEHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRI 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 559 SQNAiGSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETNEKDLeklaIETKERLDSGNLEKFLLIRSEGASD-E 637
Cdd:cd00763 153 RDTS-SSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEV----ANRIKAGIERGKKHAIVVVAEGVYDvD 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 17558788 638 IYSPDVKKifdkvmKNKYGVRITNLGYSQLGGHPSCFDRQMGIRMGVRAFEGIV 691
Cdd:cd00763 228 ELAKEIEE------ATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLL 275
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 13-262 4.66e-26

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 112.06  E-value: 4.66e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   13 VGVLTSGGDSQGMNAAVRSVVRETIRQGH--RCYLIREGYNGLINGN-IELAKwAHVANVTHLGGSMIGTSRcdefrTTD 89
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDwIKLDP-KDVKTIHRLGGTILGSSR-----GGF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   90 GRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKlkeewgrfgeelfaegkITEEVANEGRELHLAGIVGSIDNDCIESDKSI 169
Cdd:PTZ00286 164 DPKVMVDTLIRHGINILFTLGGDGTHRGALA-----------------IYKELRRRKLNISVVGIPKTIDNDIPIIDESF 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  170 GSDTALHRICEAIDGLVMTAQSHQR-VFVVEVMGRHCGYLALTAAIAV-EADYVFYPEIPPDEKWPEQLCHQlgsvRKMG 247
Cdd:PTZ00286 227 GFQTAVEEAQNAIRAAYVEAKSAKNgVGIVKLMGRDSGFIALHASVASaDVNVCLIPEFDIPLEGVLEYIEQ----RLQK 302

                        250
                 ....*....|....*
gi 17558788  248 KRQNVIILGEGVTNS 262
Cdd:PTZ00286 303 KGHCVIVVAEGAGQS 317
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
13-258 6.99e-24

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 105.34  E-value: 6.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   13 VGVLTSGGDSQGMNAAVRSVVRE-TIRQG-HRCYLIREGYNGLIngnielAKWAH---------VANVTHLGGSMIGTSR 81
Cdd:PRK06830  83 AAIVTCGGLCPGLNDVIRAIVLElHHHYGvRRILGIRYGYQGLI------PRYGHdpveltpevVADIHEFGGTILGSSR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   82 cdefrttdGRKKAAAI---MFDKRIFHLIVIGGDGSLMGAQklkeewgrfgeelfaegKITEEVANEGRELHLAGIVGSI 158
Cdd:PRK06830 157 --------GPQDPEEIvdtLERMNINILFVIGGDGTLRGAS-----------------AIAEEIERRGLKISVIGIPKTI 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  159 DNDCIESDKSIGSDTALHRICEAIDGLVMTAQSHQR-VFVVEVMGRHCGYLALTAAIAV-EADYVFYPEIPPDEKWPEQL 236
Cdd:PRK06830 212 DNDINFIQKSFGFETAVEKATEAIRCAHVEANGAPNgIGLVKLMGRHSGFIAAYAALASkDVNFVLIPEVPFDLEGPNGL 291

                        250       260
                 ....*....|....*....|...
gi 17558788  237 CHQLGsvRKMGKRQN-VIILGEG 258
Cdd:PRK06830 292 LAALE--KRLAERGHaVIVVAEG 312
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
403-686 1.92e-23

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 102.84  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  403 TKTFAVVHIGSPCAGMNAATYSFTRMA-NHSGIQVIGIKHGWDGLKNKDVK--LLTWANVQGWAQFGGSMLGTKRQ---- 475
Cdd:PRK14071   4 KKRIGILTSGGDCAGLNAVIRAVVHRArGTYGWEVIGIRDATQGLMARPPQyiELDLDQVDDLLRMGGTILGTTNKgdpf 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  476 --------LPSEMDLIAEGLNSNNVDGLVIIGG--FMAFESALILQQNrseytclsIPIVVIPATISNNCPGTCMSLGVD 545
Cdd:PRK14071  84 afpmpdgsLRDRSQEIIDGYHSLGLDALIGIGGdgSLAILRRLAQQGG--------INLVGIPKTIDNDVGATEVSIGFD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  546 TALNEICRQVDNISQNAIgSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQVETnekDLEKLAIETKERLDSGNleK 625
Cdd:PRK14071 156 TAVNIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPY---TLENVCKKIRERQEEGK--N 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17558788  626 F-LLIRSEGASDEiySPDVKKIFDKVMKNKYG-----------------VRITNLGYSQLGGHPSCFDRQMGIRMGVRA 686
Cdd:PRK14071 230 FcLVVVSEAVRTE--EGEQVTKTQALGEDRYGgigqylaeqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAA 306
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 400-636 5.91e-23

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 102.81  E-value: 5.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  400 PSRTKTfAVVHIGSPCAGMNAATYSFTRMANHS-GI-QVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQlP 477
Cdd:PTZ00286  85 PKEVKA-GIVTCGGLCPGLNVVIRELVMNLINNyGVkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG-G 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  478 SEMDLIAEGLNSNNVDGLVIIGGFMAFESALILQQNRSEyTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDN 557
Cdd:PTZ00286 163 FDPKVMVDTLIRHGINILFTLGGDGTHRGALAIYKELRR-RKLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRA 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  558 ISQNAIGSKNKVMIIETMGSRSGFLATMTALSTGSqfALIRQVETNEKDLEKLAIETKERLDS-GNLekfLLIRSEGASD 636
Cdd:PTZ00286 242 AYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAD--VNVCLIPEFDIPLEGVLEYIEQRLQKkGHC---VIVVAEGAGQ 316
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
18-321 2.08e-16

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 82.22  E-value: 2.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   18 SGGDSQGMNAAVRSVVRETIRQG--HRCYLIREGYNGLINGN-IELAKW--AHVANVTHLGGSMIGTSRCDEFRTTDGRK 92
Cdd:PRK14072  11 SGGPTAVINASAAGVIEEARKHKkiGKVYGARNGIIGILDEDlIDLSKEsdEALAALAHTPSGALGSCRYKLKSLEEDRA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   93 KAAAIM--FDKR-IFHLIVIGGDGSlMGAQKlkeewgrfgeelfaegKITEEVANEGRELHLAGIVGSIDNDCIESDKSI 169
Cdd:PRK14072  91 EYERLLevFKAHdIGYFFYNGGNDS-MDTAL----------------KVSQLAKKMGYPIRCIGIPKTIDNDLPGTDHCP 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  170 GSDTALHRICEAI-----DGLVMTAQShqRVFVVEVMGRHCGYLALTAAIAVE-----ADYVFYPEIPPDEkwpEQLchq 239
Cdd:PRK14072 154 GFGSAAKYIATSVleaalDVAAMANTS--KVFILEVMGRHAGWLAAAAALAKQnpddaPHLIYLPERPFDE---EKF--- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  240 LGSVRKMGKRQN--VIILGEGVTNSKGQ-------RIDVR---Q-------VKEEIETRLQLEVRIATLGHLQR--GGAP 298
Cdd:PRK14072 226 LADVRAIVKRYGycVVVVSEGIRDADGKfiaeaglAEDAFghaQlggvapvLANLIKEKLGKKVHWAVLDYLQRaaRHIA 305

                        330       340
                 ....*....|....*....|...
gi 17558788  299 SFLDRLIGLRMGYEAVQEVLKGK 321
Cdd:PRK14072 306 SKTDVEEAYAVGKAAVEYALAGK 328
PLN02564 PLN02564
6-phosphofructokinase
 15-227 2.81e-16

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 82.49  E-value: 2.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   15 VLTSGGDSQGMNaavrSVVRETIRQGHRCYLIRE------GYNGLINGN-IELAkwAHVANVTH-LGGSMIGTSRCDEfr 86
Cdd:PLN02564  92 IVTCGGLCPGLN----TVIREIVCGLSYMYGVTRilgidgGYRGFYSRNtIPLT--PKVVNDIHkRGGTILGTSRGGH-- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   87 ttDGRKKAAAIMfDKRIFHLIVIGGDGSLMGAqklkeewgrfgeelfaeGKITEEVANEGRELHLAGIVGSIDNDCIESD 166
Cdd:PLN02564 164 --DTSKIVDSIQ-DRGINQVYIIGGDGTQKGA-----------------SVIYEEIRRRGLKVAVAGIPKTIDNDIPVID 223

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558788  167 KSIGSDTALHRICEAIDGLVMTAQS-HQRVFVVEVMGRHCGYLALTAAIAV-EADYVFYPEIP 227
Cdd:PLN02564 224 KSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESP 286
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
400-590 1.79e-14

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 76.45  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  400 PSRTKTfAVVHIGSPCAGMNAATYSFTRMANHS-GIQ-VIGIKHGWDGL---KNKDVKLLTWANVQGWAQFGGSMLGTKR 474
Cdd:PRK06830  78 PSKVKA-AIVTCGGLCPGLNDVIRAIVLELHHHyGVRrILGIRYGYQGLiprYGHDPVELTPEVVADIHEFGGTILGSSR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  475 --QLPSEMdliAEGLNSNNVDGLVIIGGFMAFESAL-----ILQQNrseytcLSIPIVVIPATISNNCPGTCMSLGVDTA 547
Cdd:PRK06830 157 gpQDPEEI---VDTLERMNINILFVIGGDGTLRGASaiaeeIERRG------LKISVIGIPKTIDNDINFIQKSFGFETA 227

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 17558788  548 LNEICRQVDNISQNAIGSKNKVMIIETMGSRSGFLATMTALST 590
Cdd:PRK06830 228 VEKATEAIRCAHVEANGAPNGIGLVKLMGRHSGFIAAYAALAS 270
PLN02884 PLN02884
6-phosphofructokinase
 14-227 4.18e-14

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 74.85  E-value: 4.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   14 GVLTSGGDSQGMNAAVRSVVRETIRQGHRCYL-IREGYNGLINGNI-ELAKWAHVANVTHL-GGSMIGTSRcdefrttdG 90
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVFTLEIYGVKNIVgIPFGYRGFFEKGLsEMPLSRKVVQNIHLsGGSLLGVSR--------G 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   91 RKKAAAI---MFDKRIFHLIVIGGDGSLMGAQKLKEE-WGRfgeelfaegkiteevaneGRELHLAGIVGSIDNDCIESD 166
Cdd:PLN02884 129 GAKTSDIvdsIEARGINMLFVLGGNGTHAGANAIHNEcRKR------------------KMKVSVVGVPKTIDNDILLMD 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558788  167 KSIGSDTALHRICEAIDGLVMTAQS-HQRVFVVEVMGRHCGYLALTAAIAV-EADYVFYPEIP 227
Cdd:PLN02884 191 KTFGFDTAVEEAQRAINSAYIEAHSaYHGIGLVKLMGRSSGFIAMHASLASgQVDICLIPEVP 253
PLN02884 PLN02884
6-phosphofructokinase
 407-591 2.87e-10

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 62.91  E-value: 2.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  407 AVVHIGSPCAGMNAATYSFTRMANHSGIQ-VIGIKHGWDGLKNKDVK--LLTWANVQGWAQFGGSMLGTKRQLPSEMDlI 483
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVFTLEIYGVKnIVGIPFGYRGFFEKGLSemPLSRKVVQNIHLSGGSLLGVSRGGAKTSD-I 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  484 AEGLNSNNVDGLVIIGGFMAFESALILQqNRSEYTCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAI 563
Cdd:PLN02884 136 VDSIEARGINMLFVLGGNGTHAGANAIH-NECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAH 214

                        170       180
                 ....*....|....*....|....*...
gi 17558788  564 GSKNKVMIIETMGSRSGFLATMTALSTG 591
Cdd:PLN02884 215 SAYHGIGLVKLMGRSSGFIAMHASLASG 242
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 3-259 3.13e-08

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 57.36  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788     3 QKFKKGKDHGVGVLTSGGDSQGMNAAVRSVVRETIRQGHRCYLI--REGYNGLINGNIELAKWAHVANVTHLGG-SMIGT 79
Cdd:PTZ00287  170 ESFKGGNVLKIGIILSGGPAPGGHNVISGIYDYAKRYNEQSQVIgfLGGIDGLYSKNYVTITDSLMNRFRNLGGfNMLWS 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788    80 SRcDEFRTTDGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEewgrfgeeLFAEGKITeevanegreLHLAGIVGSID 159
Cdd:PTZ00287  250 GR-GKVRNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISE--------YFAERQIP---------ISIIGIPKTID 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   160 NDcIESDK---SIGSDTALHRICEAIDGLVMTAQSHQRVF-VVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWP-- 233
Cdd:PTZ00287  312 GD-LKSEAieiSFGFDTATKTYSEVIGNLCTDVKTGHNVYhVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSlk 390

                         250       260
                  ....*....|....*....|....*....
gi 17558788   234 ---EQLCHQLGSVRKMGKRQNVIILGEGV 259
Cdd:PTZ00287  391 divSNIVNTILKRRSLNKNYGVILIPEGL 419
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 412-616 1.13e-07

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 55.81  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   412 GSPCAGMN---AATYSFTRMANHSGiQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGG-SMLGTKR-QLPSEMDLIA-E 485
Cdd:PTZ00287  186 GGPAPGGHnviSGIYDYAKRYNEQS-QVIGFLGGIDGLYSKNYVTITDSLMNRFRNLGGfNMLWSGRgKVRNKDDLIAiE 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   486 GLNSN-NVDGLVIIGGFMAFESALILQQNRSEYTcLSIPIVVIPATISNNCPGTCM--SLGVDTALNEICRQVDNISQNA 562
Cdd:PTZ00287  265 NIVAKlKLNGLVIIGGDGSNSNAALISEYFAERQ-IPISIIGIPKTIDGDLKSEAIeiSFGFDTATKTYSEVIGNLCTDV 343

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17558788   563 IGSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQvetnekDLEKLAIETKE 616
Cdd:PTZ00287  344 KTGHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGE------EVEKENLSLKD 391
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 13-217 2.02e-06

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 50.78  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   13 VGVLTSGGDSQGMNAAVRSVVR---------ETIrqghrCYliREGYNGLINGN---IELAKWAHVANVTHLGGSMIGTS 80
Cdd:PRK06555   6 VALLTAGGLAPCLSSAVGGLIEryteiapevEII-----AY--RSGYQGLLLGDsieITPAVRANAGLLHRYGGSPIGNS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   81 RCDEFRTTDGRK-----------KAAA--IMFDK-RIFHliVIGGDGSLMGAQKLkeewgrfgeelfaegkiTEEVANEG 146
Cdd:PRK06555  79 RVKLTNVADCVKrglvkegenplKVAAerLAADGvDILH--TIGGDDTNTTAADL-----------------AAYLAENG 139

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17558788  147 RELHLAGIVGSIDNDCIESDKSIGSDTALHRICEAIDGLVMTAQSHQRVFVV-EVMGRHCGYlaLTAAIAVE 217
Cdd:PRK06555 140 YDLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGW--LTAATARA 209
PLN02564 PLN02564
6-phosphofructokinase
 436-590 2.08e-06

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 50.90  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  436 VIGIKHGWDGLKNKDVKLLTWANVQGWAQFGGSMLGTKRQlPSEMDLIAEGLNSNNVDGLVIIGGFMAFESA-LILQQNR 514
Cdd:PLN02564 122 ILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSRG-GHDTSKIVDSIQDRGINQVYIIGGDGTQKGAsVIYEEIR 200

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17558788  515 SEytCLSIPIVVIPATISNNCPGTCMSLGVDTALNEICRQVDNISQNAIGSKNKVMIIETMGSRSGFLATMTALST 590
Cdd:PLN02564 201 RR--GLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLAS 274
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 385-597 1.11e-05

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 48.71  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 385 QTYLNFVSIPLSTTMPSRTKTFAVVHIGSPCAGMNAATYSFTRMAN-HSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWA 463
Cdd:cd00765  55 QPSVAFVPDQDAPSSAPKLKIGIVLSGGQAPGGHNVISGLFDYLKErAKGSTLYGFKGGPAGILKCDYIELNAEYIQPYR 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 464 QFGG-SMLG---TKRQLPSEMDLIAEGLNSNNVDGLVIIGGFMAFESALILQQNRSEyTCLSIPIVVIPATISNN--CPG 537
Cdd:cd00765 135 NTGGfDMICsgrTKIETEDQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAENFRS-KGLKTRVIGVPKTIDGDlkNKE 213

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788 538 TCMSLGVDTALNEICRQVDNISQNAIGSKNKVMIIETMGSRSGFLATMTALSTGSQFALI 597
Cdd:cd00765 214 IETSFGFDTATKIYSELIGNVMRDARSTGKYWHFVKLMGRSASHIALECALKTHPNICII 273
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 106-259 9.78e-05

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 46.12  E-value: 9.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   106 LIVIGGDGSLMGAQKLKEEWGRFGEELFAEGKITEevanegrelhlagIVGSIDNDCIESdkSIGSDTALHRICEAIdGL 185
Cdd:PTZ00468  200 LVVIGGDDSNTNAAVLAEYFKRNSSSTVVVGCPKT-------------IDGDLKNEVIET--SFGYDTAVKTYSEQI-GS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   186 VMTA--QSHQRVFVVEVMGRHCGYLALTAAIAVEADYVFYPEIPPDEKWP-----EQLCHQLGSVRKMGKRQNVIILGEG 258
Cdd:PTZ00468  264 IMDAikTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEENRSlmsivDEIVEMILKRDSLGKKHGIVLLPEG 343


                  .
gi 17558788   259 V 259
Cdd:PTZ00468  344 L 344
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
404-669 1.64e-04

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 44.85  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  404 KTFAVVHIGSPCAGMNAATYSFTRMA-NHSGI-QVIGIKHGWDGLKNK---DVKLLTWANVQGWAQFGGSMLGTKR-QL- 476
Cdd:PRK14072   4 GNALYAQSGGPTAVINASAAGVIEEArKHKKIgKVYGARNGIIGILDEdliDLSKESDEALAALAHTPSGALGSCRyKLk 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  477 -----PSEMDLIAEGLNSNNVDGLVIIGGfmafesalilqqNRSEYTCLSI---------PIVVI--PATISN------N 534
Cdd:PRK14072  84 sleedRAEYERLLEVFKAHDIGYFFYNGG------------NDSMDTALKVsqlakkmgyPIRCIgiPKTIDNdlpgtdH 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  535 CPG----------TCMSLGVDTAlneicrqvdnisqnAIGSKNKVMIIETMGSRSGFLATMTALstGSQFA-----LIRQ 599
Cdd:PRK14072 152 CPGfgsaakyiatSVLEAALDVA--------------AMANTSKVFILEVMGRHAGWLAAAAAL--AKQNPddaphLIYL 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  600 VETnEKDLEKLAIETKERLDSGNleKFLLIRSEGASDeiysPDVKKIFDkvmknkYGVRITNLGYSQLGG 669
Cdd:PRK14072 216 PER-PFDEEKFLADVRAIVKRYG--YCVVVVSEGIRD----ADGKFIAE------AGLAEDAFGHAQLGG 272
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-214 1.16e-03

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 42.17  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  13 VGVLTSGGDSQGMNAAVRSVVRETIR--QGHRCYLIREGYNGLINGN-IELAKwAHVANVTHLGG-SMIGTSRcDEFRTT 88
Cdd:cd00765  75 IGIVLSGGQAPGGHNVISGLFDYLKEraKGSTLYGFKGGPAGILKCDyIELNA-EYIQPYRNTGGfDMICSGR-TKIETE 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  89 DGRKKAAAIMFDKRIFHLIVIGGDGSLMGAQKLKEEWgrfgeelfaegkiteevANEGRELHLAGIVGSIDND--CIESD 166
Cdd:cd00765 153 DQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAENF-----------------RSKGLKTRVIGVPKTIDGDlkNKEIE 215

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 17558788 167 KSIGSDTALHRICEAIDGLVMTAQSHQRVF-VVEVMGRHCGYLALTAAI 214
Cdd:cd00765 216 TSFGFDTATKIYSELIGNVMRDARSTGKYWhFVKLMGRSASHIALECAL 264
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 400-612 1.56e-03

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 42.27  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   400 PSRtKTFAVVHIGSPCAGMN--AATYSFTRMANHSGiQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGG--------SM 469
Cdd:PTZ00468  101 PAR-RIGVVLSGGQASGGHNviAGLMSYIKLCNQSS-QLFGFLGGPEGVYSERYRELTEDDINGILNQGGfniicsgrHK 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788   470 LGTKRQLPSEMDlIAEGLNSNnvdGLVIIGGFMAFESALILqqnrSEY---TCLSIPIVVIPATISNNCPGTCM--SLGV 544
Cdd:PTZ00468  179 IETEEQMRASLE-ICEKLKLH---GLVVIGGDDSNTNAAVL----AEYfkrNSSSTVVVGCPKTIDGDLKNEVIetSFGY 250

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17558788   545 DTALNEICRQVDNISQNAIGSKNKVMIIETMGSRSGFLATMTALSTGSQFALIRQvETNEKDLEKLAI 612
Cdd:PTZ00468  251 DTAVKTYSEQIGSIMDAIKTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGE-EIKEENRSLMSI 317
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 431-607 2.08e-03

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 41.45  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  431 HSGIQVIGIKHGWDGLKNKDVKLLTWANVQGWAQFGG-SMLG---TKRQLPSEMDLIAEGLNSNNVDGLVIIGGFMAFES 506
Cdd:PRK07085 100 NPDSKLFGFIGGPLGLLNGKYIEITEEVIDEYRNTGGfDMIGsgrTKIETEEQKEACLETVKKLKLDGLVIIGGDDSNTN 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558788  507 ALILQQNRSEYTClSIPIVVIPATISNNCPGTCM--SLGVDTAlneiCR----QVDNISQNAIGSKNKVMIIETMGSRSG 580
Cdd:PRK07085 180 AAILAEYFAKHGC-KTQVIGVPKTIDGDLKNEFIetSFGFDTA----TKtyseMIGNISRDALSAKKYWHFIKLMGRSAS 254

                        170       180
                 ....*....|....*....|....*..
gi 17558788  581 FLATMTALSTGSQFALIRQvETNEKDL 607
Cdd:PRK07085 255 HIALECALQTHPNICLISE-EVAEKKM 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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