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Conserved domains on  [gi|17561044|ref|NP_505526|]
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Zinc finger protein ztf-7 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 307-394 2.06e-17

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 77.71  E-value: 2.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044   307 CIFCRYNARgNRSKIIHHLYMIHHLNLGSPDNLVFVTEYIEHLKEKLHR-NECIYCEKIFPDRNTLMDHMRKRNHREVNP 385
Cdd:pfam12756   1 CLFCGHTSS-TVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIGLgNECLYCGKQFKSLEALRQHMRDKGHCKIPY 79

                          90
                  ....*....|...
gi 17561044   386 KN----HYYDKFY 394
Cdd:pfam12756  80 ESeeewLEIAEFY 92
zf-C2H2_2 super family cl20464
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 449-521 1.13e-06

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


The actual alignment was detected with superfamily member pfam12756:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 47.28  E-value: 1.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561044   449 CLLCDASEDNAQSLLEHMKTTHEFDLlknvsDDKLNSYQRLRLINYIRKQ--NYHAdCWVCQKtEFENPLALQKH 521
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFI-----PEREYLVDLEGLLNYLREKigLGNE-CLYCGK-QFKSLEALRQH 68
dermokine super family cl42387
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 2-130 7.31e-05

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


The actual alignment was detected with superfamily member cd21118:

Pssm-ID: 455732 [Multi-domain]  Cd Length: 495  Bit Score: 45.76  E-value: 7.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044   2 STSGSGGGNTPDLSKENVASSPNANPKKNADTESSGGSKNNRQRRRSNTKGDGS--NSRNGSRTNSVSNSKNQSNRKDW- 78
Cdd:cd21118 208 SGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNsgGSNGGSSGNSGSGSGGSSSGGSNg 287

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17561044  79 --TDRKSFSQGGINVKSK-SPGDDHKRTRSSNSQSAKRNARDSTRTMSQASNGEG 130
Cdd:cd21118 288 wgGSSSSGGSGGSGGGNKpECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQA 342
 
Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 307-394 2.06e-17

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 77.71  E-value: 2.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044   307 CIFCRYNARgNRSKIIHHLYMIHHLNLGSPDNLVFVTEYIEHLKEKLHR-NECIYCEKIFPDRNTLMDHMRKRNHREVNP 385
Cdd:pfam12756   1 CLFCGHTSS-TVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIGLgNECLYCGKQFKSLEALRQHMRDKGHCKIPY 79

                          90
                  ....*....|...
gi 17561044   386 KN----HYYDKFY 394
Cdd:pfam12756  80 ESeeewLEIAEFY 92
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 449-521 1.13e-06

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 47.28  E-value: 1.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561044   449 CLLCDASEDNAQSLLEHMKTTHEFDLlknvsDDKLNSYQRLRLINYIRKQ--NYHAdCWVCQKtEFENPLALQKH 521
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFI-----PEREYLVDLEGLLNYLREKigLGNE-CLYCGK-QFKSLEALRQH 68
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 2-130 7.31e-05

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 45.76  E-value: 7.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044   2 STSGSGGGNTPDLSKENVASSPNANPKKNADTESSGGSKNNRQRRRSNTKGDGS--NSRNGSRTNSVSNSKNQSNRKDW- 78
Cdd:cd21118 208 SGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNsgGSNGGSSGNSGSGSGGSSSGGSNg 287

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17561044  79 --TDRKSFSQGGINVKSK-SPGDDHKRTRSSNSQSAKRNARDSTRTMSQASNGEG 130
Cdd:cd21118 288 wgGSSSSGGSGGSGGGNKpECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQA 342
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1-152 8.18e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.73  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044     1 MSTSGSGGGNTPDLSKENVASSPNANPKKNADTESSggsKNNRQRRRSNTKGDGSNSRNGSRTNSVSNSKNQSNR----- 75
Cdd:PTZ00108 1219 NSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSS---EDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKrpdge 1295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044    76 -----------KDWTDRKSFSQGGINVKSKSPGDDHKRTRSSNSQSAKRNARDSTRT---MSQASNGEGLDySDEYELDE 141
Cdd:PTZ00108 1296 snggskpssptKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLlrrPRKKKSDSSSE-DDDDSEVD 1374

                         170
                  ....*....|.
gi 17561044   142 PFSDSDDEDSR 152
Cdd:PTZ00108 1375 DSEDEDDEDDE 1385
 
Name Accession Description Interval E-value
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 307-394 2.06e-17

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 77.71  E-value: 2.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044   307 CIFCRYNARgNRSKIIHHLYMIHHLNLGSPDNLVFVTEYIEHLKEKLHR-NECIYCEKIFPDRNTLMDHMRKRNHREVNP 385
Cdd:pfam12756   1 CLFCGHTSS-TVEENLEHMFKSHGFFIPEREYLVDLEGLLNYLREKIGLgNECLYCGKQFKSLEALRQHMRDKGHCKIPY 79

                          90
                  ....*....|...
gi 17561044   386 KN----HYYDKFY 394
Cdd:pfam12756  80 ESeeewLEIAEFY 92
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 449-521 1.13e-06

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 47.28  E-value: 1.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17561044   449 CLLCDASEDNAQSLLEHMKTTHEFDLlknvsDDKLNSYQRLRLINYIRKQ--NYHAdCWVCQKtEFENPLALQKH 521
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFI-----PEREYLVDLEGLLNYLREKigLGNE-CLYCGK-QFKSLEALRQH 68
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 2-130 7.31e-05

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 45.76  E-value: 7.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044   2 STSGSGGGNTPDLSKENVASSPNANPKKNADTESSGGSKNNRQRRRSNTKGDGS--NSRNGSRTNSVSNSKNQSNRKDW- 78
Cdd:cd21118 208 SGSHESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNsgGSNGGSSGNSGSGSGGSSSGGSNg 287

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17561044  79 --TDRKSFSQGGINVKSK-SPGDDHKRTRSSNSQSAKRNARDSTRTMSQASNGEG 130
Cdd:cd21118 288 wgGSSSSGGSGGSGGGNKpECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQA 342
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1-152 8.18e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.73  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044     1 MSTSGSGGGNTPDLSKENVASSPNANPKKNADTESSggsKNNRQRRRSNTKGDGSNSRNGSRTNSVSNSKNQSNR----- 75
Cdd:PTZ00108 1219 NSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSS---EDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKrpdge 1295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561044    76 -----------KDWTDRKSFSQGGINVKSKSPGDDHKRTRSSNSQSAKRNARDSTRT---MSQASNGEGLDySDEYELDE 141
Cdd:PTZ00108 1296 snggskpssptKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLlrrPRKKKSDSSSE-DDDDSEVD 1374

                         170
                  ....*....|.
gi 17561044   142 PFSDSDDEDSR 152
Cdd:PTZ00108 1375 DSEDEDDEDDE 1385
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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