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Conserved domains on  [gi|17558758|ref|NP_505536|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 13-312 5.65e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 294.75  E-value: 5.65e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    13 TQDVCGFISIFTNLFLIYLILKRSPDALGLYKWLMMYTSIFELTYSFVNLFAGCSVRTFGSAFIVFRKDQHFHL---ISQ 89
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLsksVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    90 FMAVNYCSFFGFSLAIIACHFIYRYGTVELEFHKKYISGSKHLLLYIGPISIGIIWGIVCSVYCGETPERSDYLRKNMMD 169
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   170 NYRLRIEDVGYISANYWPMGKNGTVRPDFDSFFGTFLMWIIVGASIGSVLYFGIGCYRWISHQLKIVetqSNTVKSLQKQ 249
Cdd:pfam10326 164 NYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558758   250 LFYALVVQSAIPSVLMYFPISMAFIFPMLNIELNLKYPFIGLTIAVYPAIDPLPSLLIIRSYR 312
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 13-312 5.65e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 294.75  E-value: 5.65e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    13 TQDVCGFISIFTNLFLIYLILKRSPDALGLYKWLMMYTSIFELTYSFVNLFAGCSVRTFGSAFIVFRKDQHFHL---ISQ 89
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLsksVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    90 FMAVNYCSFFGFSLAIIACHFIYRYGTVELEFHKKYISGSKHLLLYIGPISIGIIWGIVCSVYCGETPERSDYLRKNMMD 169
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   170 NYRLRIEDVGYISANYWPMGKNGTVRPDFDSFFGTFLMWIIVGASIGSVLYFGIGCYRWISHQLKIVetqSNTVKSLQKQ 249
Cdd:pfam10326 164 NYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558758   250 LFYALVVQSAIPSVLMYFPISMAFIFPMLNIELNLKYPFIGLTIAVYPAIDPLPSLLIIRSYR 312
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 13-312 5.65e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 294.75  E-value: 5.65e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    13 TQDVCGFISIFTNLFLIYLILKRSPDALGLYKWLMMYTSIFELTYSFVNLFAGCSVRTFGSAFIVFRKDQHFHL---ISQ 89
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLsksVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    90 FMAVNYCSFFGFSLAIIACHFIYRYGTVELEFHKKYISGSKHLLLYIGPISIGIIWGIVCSVYCGETPERSDYLRKNMMD 169
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   170 NYRLRIEDVGYISANYWPMGKNGTVRPDFDSFFGTFLMWIIVGASIGSVLYFGIGCYRWISHQLKIVetqSNTVKSLQKQ 249
Cdd:pfam10326 164 NYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558758   250 LFYALVVQSAIPSVLMYFPISMAFIFPMLNIELNLKYPFIGLTIAVYPAIDPLPSLLIIRSYR 312
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 18-312 4.72e-37

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 135.06  E-value: 4.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    18 GFISIFTNLFLIYLILKRSPDALGLYKWLMMYTSIFELTYSFVNLFAGCSVRTFGSAFIVFRKDQHFHLIS---QFMAVN 94
Cdd:pfam10319  15 GVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSelgQHALSA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    95 YCSFFGFSLAIIACHFIYRYGTV------ELEFHKKYISGSkhlLLYIgpISIGIIWGIVCSVYCGETPERSDYLRKNMM 168
Cdd:pfam10319  95 RCSFISASYAVLLIHFIYRYLVLfnpqltRHYFRPWGILIS---ILFF--LFHGSVWTAICYFLLRANDEIRDYIREDFR 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   169 DNYRLRIEDVGYISANYWPmGKNGTVrpdFDSFFGTFLMWIIVGASIgsVLYFGIGcyRWISHQL-KIVETQSNTVKSLQ 247
Cdd:pfam10319 170 ETYGVDSMDINMLGALYWE-ASDETV---FRSWLGILLLTVISVYSI--ILYIVLG--YKIMRKLnKMSVTMSKKTKRLQ 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17558758   248 KQLFYALVVQSAIPSVLMYFPISMAFIFPMLNIEL-NLKYPFIGLTIAVYPAIDPLPSLLIIRSYR 312
Cdd:pfam10319 242 KQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLgRWNNYLEVIALSAFPFIDPLAIILCLPVYR 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 16-315 1.16e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 64.49  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    16 VCGFISIFTNLFLIYLILKRSPDALGLYKWLMMYTSIFELTYSFVNLFAGCSVRTFGS--AFIVFRKDQHFHLISQFMAV 93
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVsmALISYGPCKYFGPWFCYSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    94 N-YCSFFGFSLAIIACHFIYRYGTVELEFHKKYISGSKHLLLYIGPISIGIIWGIVCSvycgeTPERSDYLRKNMMDNYR 172
Cdd:pfam10317  87 SlLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPT-----DFLPVEALTKELHPNYN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   173 LRIEDVGYISanywpmgkngtvrpDFDSFFGTFLMWIIVGASIGSvlYFGIGCYRW-ISHQLKIVETQ-SNTVKSLQKQL 250
Cdd:pfam10317 162 LTDYTVTGFS--------------DLQSFPALINTLIMTIPVFPI--PIIILILRRkILKLLNSNSVNmSPTTKAQHRQL 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17558758   251 FYALVVQSAIPsVLMYFPISMAFIFPMLNIE--LNLKYpFIGLTIAVYPAIDPLPSLLIIRSYREGC 315
Cdd:pfam10317 226 IKGLTIQALLP-LFSYIPGVTLYLLSQLTGTefLILEY-FIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 16-321 1.51e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 52.16  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    16 VCGFISIFTNLFLIYLILKRSPDALGLYKWLMMY----TSIFELTYS-------FVNLFAGCSVrTFGSAFIVFRKDQhF 84
Cdd:pfam10318  12 IITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNlhfwSALLDLSLSfltipyiFLPALAGYPL-GLLSYLGVPTPIQ-F 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758    85 HLISQFMAVNYCSFFGFslaiiachFIYRYGTveLEFHKKYISGSKHLLLYIgPISIGIIWGIVCSVYCgETPErSDYLR 164
Cdd:pfam10318  90 YIGVTSLALVGVSIILL--------FENRYSI--LFTNKKRITWKKTRVLYL-IFNYIIALLFLIPIYL-NIPD-QEAAK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   165 KNMMDNYrlriedvGYISANYWPmgKNGTVRPDFDSFFGTFLMWIIVGASIGSVLYFGIGCYRWISHQLKIveTQSNTVK 244
Cdd:pfam10318 157 LKVLKKL-------PCLPPEFFD--NPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS--SLSKKTR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558758   245 SLQKQLFYALVVQSAIPSVLMYFPISM---AFIFPMLNIELNlkyPFIGLTIAVYPAIDPLPSLLIIRSYREGCNDIFRK 321
Cdd:pfam10318 226 KLQKKFFIALIIQVSIPLIVILIPLIYilfSIIFGYYNQALN---NLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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