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Conserved domains on  [gi|193208990|ref|NP_505690|]
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Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 82-652 6.86e-154

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 472.56  E-value: 6.86e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990    82 SQFPADIFSLQTRRRGGVIVHIGLLIYMFVALAVVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVF 161
Cdd:TIGR00927  440 AEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVF 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   162 VAQDNVGVGTIVGSATFNILCVLAFCTLFSRQVLHLTWWPLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVMFSMYIAYG 241
Cdd:TIGR00927  520 ISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYV 599

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   242 FFMKFNGFLELKTKQFLFR----KV--------GIGSEiaPETIVDAAAGCTPRSPHSLGAQGPRRSFPMIHGGQEVRKS 309
Cdd:TIGR00927  600 FTMKWNKQIELWVKEQLSRrpvaKVmalgdlskGDVAE--AEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKG 677

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   310 IAQ------------------------LVIGDEDDTSSSSSSSSSERSNKikpvSNGVPEIRQNGRTIMVKPANDPDAKF 365
Cdd:TIGR00927  678 ENEsegeipaerkgeqegegeieakeaDHKGETEAEEVEHEGETEAEGTE----DEGEIETGEEGEEVEDEGEGEAEGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   366 -------NNQNSIKTVITPIDFGDDHTIVINNNNNGKRKNGNNGTYLTPVEAINPSNGHLELAQTNGNPVPPIALD---- 434
Cdd:TIGR00927  754 evetegdRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKdetg 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   435 ----NLSIASSTA--------------------------------------------EKPLDLSWPEANHKKLIYLFLAP 466
Cdd:TIGR00927  834 eqelNAENQGEAKqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeenEEPLSLEWPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   467 ITFPLAYTLPDVRKPSLRKFFAITFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARK 546
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   547 GLGDMAVSSSIGSNLFDVCVGLPIPWLIHFAIGVFkseptQNISVTSNGLVCSLGLLFAMLIVLLTCVAISRWKMDKFFG 626
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGL-----QPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILG 1068

                          650       660
                   ....*....|....*....|....*.
gi 193208990   627 LLMIFSYCGFCMLCILLETGHLKCPL 652
Cdd:TIGR00927 1069 FTMFLLYFVFLIISVMLEDRIISCPV 1094
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 82-652 6.86e-154

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 472.56  E-value: 6.86e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990    82 SQFPADIFSLQTRRRGGVIVHIGLLIYMFVALAVVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVF 161
Cdd:TIGR00927  440 AEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVF 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   162 VAQDNVGVGTIVGSATFNILCVLAFCTLFSRQVLHLTWWPLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVMFSMYIAYG 241
Cdd:TIGR00927  520 ISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYV 599

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   242 FFMKFNGFLELKTKQFLFR----KV--------GIGSEiaPETIVDAAAGCTPRSPHSLGAQGPRRSFPMIHGGQEVRKS 309
Cdd:TIGR00927  600 FTMKWNKQIELWVKEQLSRrpvaKVmalgdlskGDVAE--AEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKG 677

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   310 IAQ------------------------LVIGDEDDTSSSSSSSSSERSNKikpvSNGVPEIRQNGRTIMVKPANDPDAKF 365
Cdd:TIGR00927  678 ENEsegeipaerkgeqegegeieakeaDHKGETEAEEVEHEGETEAEGTE----DEGEIETGEEGEEVEDEGEGEAEGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   366 -------NNQNSIKTVITPIDFGDDHTIVINNNNNGKRKNGNNGTYLTPVEAINPSNGHLELAQTNGNPVPPIALD---- 434
Cdd:TIGR00927  754 evetegdRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKdetg 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   435 ----NLSIASSTA--------------------------------------------EKPLDLSWPEANHKKLIYLFLAP 466
Cdd:TIGR00927  834 eqelNAENQGEAKqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeenEEPLSLEWPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   467 ITFPLAYTLPDVRKPSLRKFFAITFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARK 546
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   547 GLGDMAVSSSIGSNLFDVCVGLPIPWLIHFAIGVFkseptQNISVTSNGLVCSLGLLFAMLIVLLTCVAISRWKMDKFFG 626
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGL-----QPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILG 1068

                          650       660
                   ....*....|....*....|....*.
gi 193208990   627 LLMIFSYCGFCMLCILLETGHLKCPL 652
Cdd:TIGR00927 1069 FTMFLLYFVFLIISVMLEDRIISCPV 1094
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
475-636 4.04e-26

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 108.68  E-value: 4.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 475 LPDVRKPSLRKFFAITFIGAILWIAAySYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 554
Cdd:COG0530  142 LEEKPKMSLWKALLLLVLGLALLVVG-ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 555 SSIGSNLFDVCVGLPIPWLIHfaigvfkseptqNISVTSNGLVCSLGLLFAMLIVLLTcVAISRWKMDKFFGLLMIFSYC 634
Cdd:COG0530  221 NIIGSNIFNILLVLGIGALIT------------PIPVDPAVLSFDLPVMLAATLLLLG-LLRTGGRIGRWEGLLLLALYL 287


                 ..
gi 193208990 635 GF 636
Cdd:COG0530  288 AY 289
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 486-642 1.62e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 99.98  E-value: 1.62e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  486 FFAITFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVC 565
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  566 VGLPIPWLIhfaigvfkseptQNISVTSNGLVCSLGLLFAM----LIVLLTCVAISRWKMDKFFGLLMIFSYCGFCMLCI 641
Cdd:pfam01699  81 LVLGLSALI------------GPVKVDSLLLKLDLGVLLLValllLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQI 148


                  .
gi 193208990  642 L 642
Cdd:pfam01699 149 V 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 509-575 8.17e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 66.98  E-value: 8.17e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193208990 509 ANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVCVGLPIPWLIH 575
Cdd:PRK10734 197 ATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 82-652 6.86e-154

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 472.56  E-value: 6.86e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990    82 SQFPADIFSLQTRRRGGVIVHIGLLIYMFVALAVVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVF 161
Cdd:TIGR00927  440 AEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVF 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   162 VAQDNVGVGTIVGSATFNILCVLAFCTLFSRQVLHLTWWPLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVMFSMYIAYG 241
Cdd:TIGR00927  520 ISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYV 599

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   242 FFMKFNGFLELKTKQFLFR----KV--------GIGSEiaPETIVDAAAGCTPRSPHSLGAQGPRRSFPMIHGGQEVRKS 309
Cdd:TIGR00927  600 FTMKWNKQIELWVKEQLSRrpvaKVmalgdlskGDVAE--AEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKG 677

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   310 IAQ------------------------LVIGDEDDTSSSSSSSSSERSNKikpvSNGVPEIRQNGRTIMVKPANDPDAKF 365
Cdd:TIGR00927  678 ENEsegeipaerkgeqegegeieakeaDHKGETEAEEVEHEGETEAEGTE----DEGEIETGEEGEEVEDEGEGEAEGKH 753

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   366 -------NNQNSIKTVITPIDFGDDHTIVINNNNNGKRKNGNNGTYLTPVEAINPSNGHLELAQTNGNPVPPIALD---- 434
Cdd:TIGR00927  754 evetegdRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKdetg 833

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   435 ----NLSIASSTA--------------------------------------------EKPLDLSWPEANHKKLIYLFLAP 466
Cdd:TIGR00927  834 eqelNAENQGEAKqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeenEEPLSLEWPETRQKQAIYLFLLP 913

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   467 ITFPLAYTLPDVRKPSLRKFFAITFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARK 546
Cdd:TIGR00927  914 IVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARK 993

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   547 GLGDMAVSSSIGSNLFDVCVGLPIPWLIHFAIGVFkseptQNISVTSNGLVCSLGLLFAMLIVLLTCVAISRWKMDKFFG 626
Cdd:TIGR00927  994 GLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGL-----QPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILG 1068

                          650       660
                   ....*....|....*....|....*.
gi 193208990   627 LLMIFSYCGFCMLCILLETGHLKCPL 652
Cdd:TIGR00927 1069 FTMFLLYFVFLIISVMLEDRIISCPV 1094
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 486-631 2.71e-31

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 123.97  E-value: 2.71e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  486 FFAI-TFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDV 564
Cdd:TIGR00367 169 FFSLvLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNI 248

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193208990  565 CVGLPIPWLihfaigvFKSEPTQNISVTSNGLVCSLGLLFAMLIVlLTCVAISRWKMDKFFGLLMIF 631
Cdd:TIGR00367 249 LVGLGVPSL-------FMPIPVEPLAYNLDAPVMVIVTLLLMLFF-KTSMKLGRWEGILLLALYIAY 307
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 106-247 2.98e-29

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 118.20  E-value: 2.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  106 LIYMFVALAVVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVGSATFNILCVLA 185
Cdd:TIGR00367   6 YLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193208990  186 FCTLFSrQVLHLTWWpLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVmfsMYIAYGFFMKFN 247
Cdd:TIGR00367  86 LSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVV---LLILYIVYLLFL 142
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
475-636 4.04e-26

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 108.68  E-value: 4.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 475 LPDVRKPSLRKFFAITFIGAILWIAAySYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 554
Cdd:COG0530  142 LEEKPKMSLWKALLLLVLGLALLVVG-ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVG 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 555 SSIGSNLFDVCVGLPIPWLIHfaigvfkseptqNISVTSNGLVCSLGLLFAMLIVLLTcVAISRWKMDKFFGLLMIFSYC 634
Cdd:COG0530  221 NIIGSNIFNILLVLGIGALIT------------PIPVDPAVLSFDLPVMLAATLLLLG-LLRTGGRIGRWEGLLLLALYL 287


                 ..
gi 193208990 635 GF 636
Cdd:COG0530  288 AY 289
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 486-642 1.62e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 99.98  E-value: 1.62e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  486 FFAITFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVC 565
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  566 VGLPIPWLIhfaigvfkseptQNISVTSNGLVCSLGLLFAM----LIVLLTCVAISRWKMDKFFGLLMIFSYCGFCMLCI 641
Cdd:pfam01699  81 LVLGLSALI------------GPVKVDSLLLKLDLGVLLLValllLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQI 148


                  .
gi 193208990  642 L 642
Cdd:pfam01699 149 V 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 102-246 2.67e-21

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 90.74  E-value: 2.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  102 HIGLLIYMFVALAVVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVGSATFNIL 181
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193208990  182 CVLAFCTLFSRQVLHLTW----WPLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVMFSMYIAYGFFMKF 246
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
119-244 1.48e-15

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 77.48  E-value: 1.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 119 EFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVGSATFNILCVLAFCTLFSRqvLHLT 198
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 193208990 199 WWPLFRDMSFYTLSLFLLLIFFGDEVIEWQEALVMFSMYIAYGFFM 244
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
512-636 2.72e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 512 IGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVCVGLPIPWLIHfaigvfkseptqNISV 591
Cdd:COG0530   11 LARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR------------PLAV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 193208990 592 TSNGLVCSLG-LLFAMLIVLLTCV--AISRWkmdkfFGLLMIFSYCGF 636
Cdd:COG0530   79 DRRVLRRDLPfLLLASLLLLALLLdgTLSRI-----DGVILLLLYVLY 121
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 509-575 8.17e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 66.98  E-value: 8.17e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193208990 509 ANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVCVGLPIPWLIH 575
Cdd:PRK10734 197 ATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
106-240 1.34e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 62.84  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 106 LIYMFVALA--VVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVGSATFNILCV 183
Cdd:COG0530  154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 193208990 184 LAFCTLFSRqvLHLTWWPLFRDMSFYTLSL-FLLLIFFGDEVIEWQEALVMFSMYIAY 240
Cdd:COG0530  234 LGIGALITP--IPVDPAVLSFDLPVMLAATlLLLGLLRTGGRIGRWEGLLLLALYLAY 289
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 95-192 1.60e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 62.73  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   95 RRGGVIVHIGLLIYMFVALAVVCdEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVG 174
Cdd:TIGR00367 164 RRPQIFFSLVLLIIGLIGLVVGS-RLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIG 242

                          90
                  ....*....|....*...
gi 193208990  175 SATFNILCVLAFCTLFSR 192
Cdd:TIGR00367 243 SNIFNILVGLGVPSLFMP 260
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 99-197 1.80e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.43  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990   99 VIVHIGLLIYMFVALAVVCDEFfVPSLSVIT------------------EVLAISDDVAGATFMAAGGSAPEFFTSLFGV 160
Cdd:TIGR00845  75 ATVYFVAMVYMFLGVSIIADRF-MASIEVITsqekeitikkpngettvtTVRIWNETVSNLTLMALGSSAPEILLSVIEV 153

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 193208990  161 ----FVAQDnVGVGTIVGSATFNILCVLAFCTLF-----SRQVLHL 197
Cdd:TIGR00845 154 cghnFEAGD-LGPSTIVGSAAFNMFIIIAICVYVipdgeTRKIKHL 198
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 488-574 5.89e-09

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 58.10  E-value: 5.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  488 AITFIGAILWIAAYSY-LMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVCV 566
Cdd:TIGR00367   3 LIGYLILGLILLIYGAdLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILL 82


                  ....*...
gi 193208990  567 GLPIPWLI 574
Cdd:TIGR00367  83 ILGLSAIF 90
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 487-575 8.45e-09

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 57.73  E-value: 8.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 487 FAITFIGAILWIAAYSYLmVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSIGSNLFDVCV 566
Cdd:PRK10734   5 TALLIIGLLLLVYGADRL-VFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILL 83


                 ....*....
gi 193208990 567 GLPIPWLIH 575
Cdd:PRK10734  84 ILGLAALIR 92
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 473-636 5.61e-07

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 52.84  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 473 YTLPDvrKPSLRKFFAIT---FIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGlG 549
Cdd:PLN03151 470 YTEPD--RPPRRFLIPWVlggFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-G 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 550 D---MAVSSSIGSNLFDVCVGLPIPWLihfaIGVFKSEPTQNISVTSNGLVCSLGLLFAMLIVLLTCVAISRWKMDKFFG 626
Cdd:PLN03151 547 DgvqIAMSGCYAGPMFNTLVGLGMSML----LGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLG 622

                        170
                 ....*....|
gi 193208990 627 LLMIFSYCGF 636
Cdd:PLN03151 623 VGLIALYLIF 632
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 106-191 2.57e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 50.03  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 106 LIYMFVALAVVCDeffvpSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLFGVFVAQDNVGVGTIVGSATFNILCVLA 185
Cdd:PRK10734 183 LIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLG 257


                 ....*.
gi 193208990 186 FCTLFS 191
Cdd:PRK10734 258 LPALIS 263
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 490-634 9.77e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 45.55  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  490 TFIGAILWIAAYSYLMVWWANTIGETFGIPTEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSIGSNLFDVCVGL 568
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990  569 PIPWLI----HFAIG-VFKSEP-TQNISVTsngLVCSLGLLFAMLIV-------------------LLTCVAISRWKMDK 623
Cdd:TIGR00845 838 GVAWSIaaiyHAANGtQFKVSPgTLAFSVT---LFTIFAFICIGVLLyrrrpeiggelggprtaklLTSALFVLLWLLYI 914

                         170
                  ....*....|.
gi 193208990  624 FFGLLMifSYC 634
Cdd:TIGR00845 915 LFSSLE--AYC 923
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 106-259 5.87e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 39.75  E-value: 5.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193208990 106 LIYMFVALAVVCDEFFVPSLSVITEVLAISDDVAGATFMAAGGSAPEFFTSLfGVFVAQD--NVGVGTIVGSATFNILCV 183
Cdd:PLN03151 147 LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASI-AAFVGKDagEVGLNSVLGGAVFVTCVV 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193208990 184 LAFCTL-FSRQVLHLTWWPLFRDMSFY--TLSLFLLLIFFGdEVIEWQeALVMFSMYIAYGFFMKFNGFLELKTKQFLF 259
Cdd:PLN03151 226 VGIVSLcVADKEVQIDKRCFIRDLCFFlfTLVSLLVILMVG-KVTVGG-AIAFVSIYVVYAFLVAANEILRKHARRLKL 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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