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Conserved domains on  [gi|1254047669|ref|NP_505740|]
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Serpentine Receptor, class J [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-197 2.68e-93

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 275.66  E-value: 2.68e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669   1 MTLFCHNFLERYFLPHGIVVSVIYCLGLMSLWTFIAGFLSRKNrVERLSYIQESFKDYFGRDPLEINIIIVQYKEATEDF 80
Cdd:pfam10319 115 LVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRAN-DEIRDYIREDFRETYGVDSMDINMLGALYWEASDET 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669  81 IEASWIGIGLLSVVSIASLLFIVLIAYFTLAELTKRAGIMSESTKRQQNQLMKALIVQTITPTIACFSPCFFSWYLPVFG 160
Cdd:pfam10319 194 VFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFG 273

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1254047669 161 IDGGELLQLISAVEMSAFPFFDPLSTILVLPVLRRQI 197
Cdd:pfam10319 274 IDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-197 2.68e-93

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 275.66  E-value: 2.68e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669   1 MTLFCHNFLERYFLPHGIVVSVIYCLGLMSLWTFIAGFLSRKNrVERLSYIQESFKDYFGRDPLEINIIIVQYKEATEDF 80
Cdd:pfam10319 115 LVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRAN-DEIRDYIREDFRETYGVDSMDINMLGALYWEASDET 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669  81 IEASWIGIGLLSVVSIASLLFIVLIAYFTLAELTKRAGIMSESTKRQQNQLMKALIVQTITPTIACFSPCFFSWYLPVFG 160
Cdd:pfam10319 194 VFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFG 273

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1254047669 161 IDGGELLQLISAVEMSAFPFFDPLSTILVLPVLRRQI 197
Cdd:pfam10319 274 IDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-197 2.68e-93

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 275.66  E-value: 2.68e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669   1 MTLFCHNFLERYFLPHGIVVSVIYCLGLMSLWTFIAGFLSRKNrVERLSYIQESFKDYFGRDPLEINIIIVQYKEATEDF 80
Cdd:pfam10319 115 LVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRAN-DEIRDYIREDFRETYGVDSMDINMLGALYWEASDET 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669  81 IEASWIGIGLLSVVSIASLLFIVLIAYFTLAELTKRAGIMSESTKRQQNQLMKALIVQTITPTIACFSPCFFSWYLPVFG 160
Cdd:pfam10319 194 VFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFG 273

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1254047669 161 IDGGELLQLISAVEMSAFPFFDPLSTILVLPVLRRQI 197
Cdd:pfam10319 274 IDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-198 1.52e-20

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 87.51  E-value: 1.52e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669   5 CHNFLERYFLPHGIVVSVIYCLGLMSLWTFIAGFLSRKNRvERLSYIQESFKDYFGRDPLEINIIIVQYKEATEDFIEA- 83
Cdd:pfam10326 112 CRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDE-ETDEYLREELLENYNLDIDEVAYVGPVYYPTDENGSKVi 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669  84 ---SWIGIGLLSVVSIASLLFIVLIAYFTLAELTKRAGIMSESTKRQQNQLMKALIVQTITPTIACFSPCFFSWYLPVFG 160
Cdd:pfam10326 191 rwrSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFN 270

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1254047669 161 IDGGELLQLISAVeMSAFPFFDPLSTILVLPVLRRQIK 198
Cdd:pfam10326 271 IEIGFLSGIITAT-IALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 90-199 5.56e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 46.00  E-value: 5.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669  90 LLSVVSIASLLFIVLIAYF-----TLAELTKRAGIMSESTKRQQNQLMKALIVQTITPTIaCFSPCFFSWYLPVFGIDGG 164
Cdd:pfam10317 179 LINTLIMTIPVFPIPIIILilrrkILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLF-SYIPGVTLYLLSQLTGTEF 257

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1254047669 165 ELLQLISAVEMSAFPFFDPLSTILVLPVLRRQIKK 199
Cdd:pfam10317 258 LILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 77-160 7.26e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 42.53  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254047669  77 TEDFIEASWIGIGLLSVVSIASLLFIVLIAYFTLAELTKRagiMSESTKRQQNQLMKALIVQTITPTIACFSPCFFSWYL 156
Cdd:pfam10318 180 AIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSS---LSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFS 256


                  ....
gi 1254047669 157 PVFG 160
Cdd:pfam10318 257 IIFG 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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