Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 17563812 281 PQEYIWVKNGILKAPKGKsySIKAFQTSEYIIKTTTeGKLVWNYTTSGD 329
Cdd:cd20950  27 PSEYTWFKDGVVMPTNPK--STRAFSNSSYSLDPTT-GELVFDPLSASD 72

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563812 122 KVMPLSYVLHSYFMLQENFSRAMAHTERKtgktssVVCILDLKGLNLMDFMNPlsgpaQLARLVVQVWAEYFSEHLCKLL 201
Cdd:cd00170  35 KLLDLEELLRYLVYLLEKALRELEEQVEG------FVVIIDLKGFSLSNLSDL-----SLLKKLLKILQDHYPERLKKIY 103

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17563812 202 LINPPGIISVMWQVTKRLVDPNTVEKLAFL-SNVEDLKKYLEPEAIPVEYGGT 253
Cdd:cd00170 104 IVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKELGGT 156

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 17563812 281 PQEYIWVKNGILKAPKGKsySIKAFQTSEYIIKTTTeGKLVWNYTTSGD 329
Cdd:cd20950  27 PSEYTWFKDGVVMPTNPK--STRAFSNSSYSLDPTT-GELVFDPLSASD 72

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563812 122 KVMPLSYVLHSYFMLQENFSRAMAHTERKtgktssVVCILDLKGLNLMDFMNPlsgpaQLARLVVQVWAEYFSEHLCKLL 201
Cdd:cd00170  35 KLLDLEELLRYLVYLLEKALRELEEQVEG------FVVIIDLKGFSLSNLSDL-----SLLKKLLKILQDHYPERLKKIY 103

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17563812 202 LINPPGIISVMWQVTKRLVDPNTVEKLAFL-SNVEDLKKYLEPEAIPVEYGGT 253
Cdd:cd00170 104 IVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKELGGT 156

Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains; The members here are composed of the second Ig-like domain of Junctional adhesion molecule-1 (JAM1). JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The second Ig-like domain of JAM1 is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous but lacks a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 17563812 281 PQEYIWVKNGILKAPKGKsySIKAFQTSEYIIKTTTeGKLVWNYTTSGD 329
Cdd:cd20950  27 PSEYTWFKDGVVMPTNPK--STRAFSNSSYSLDPTT-GELVFDPLSASD 72