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Conserved domains on  [gi|115534654|ref|NP_505875|]
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CUTiclin-Like [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 474-719 2.63e-12

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 67.80  E-value: 2.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   474 QCTFGFISVKVSPGNPDNHNLVGGEIYVRNGHSNCSKTIGTDGEAILKIRHNDttC-----ITKNGDIYETVVVVtqnve 548
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CgtrrqVNPDGIVYSNTLVV----- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   549 SVGNATVITIDDQL-FKVRCDYSNQKNAVAVAkTMNLRTTQFNKLDIYGKVNVkpmSMELRGKRE---IIKARTVKLGQS 624
Cdd:smart00241  74 SPFHPGFITRDDRAaYHFQCFYPENEKVSLNL-DVSTIPPTELSSVSEGPLTC---SYRLYKDDSfgsPYQSADYVLGDP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   625 LDLVFTVDNSTSARH-VFVKKCTAY---DQNGDEKIILIKNGCATQHAKEYVLR-DEIKETATGFVlpFRAFRFKQGEAV 699
Cdd:smart00241 150 VYHEWECDGADDPPLgLLVDNCYATpgpDPSSGPKYFIIDNGCPVDGYLDSTIPyNSNPLHRARFS--VKVFKFADRSLV 227

                          250       260
                   ....*....|....*....|....*
gi 115534654   700 KIECEVKYCEK-----CKKANCPSR 719
Cdd:smart00241 228 YFHCQIRLCDKddgssCDGPACSSR 252
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 105-177 1.45e-08

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 52.47  E-value: 1.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115534654 105 WDDRILVDKSQSVLKAETKLECLSLCAQEKRFPCLSAMFYRDSKDCLLNS--ASSSSAKLKMDTggfKVSYMELH 177
Cdd:cd01099    9 VLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDedRMSSGVKLLYDS---NVDYYENK 80
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 187-258 1.60e-04

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


:

Pssm-ID: 214680  Cd Length: 78  Bit Score: 40.64  E-value: 1.60e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115534654   187 NAFKMVAFDAIEIRGESRIFNGSDGLGKCMEKCK----DCDVVMYNEGFSECYSVWNDPSGQLLDFVNDEYQILTN 258
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLnsncSCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVDLYEK 77
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 474-719 2.63e-12

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 67.80  E-value: 2.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   474 QCTFGFISVKVSPGNPDNHNLVGGEIYVRNGHSNCSKTIGTDGEAILKIRHNDttC-----ITKNGDIYETVVVVtqnve 548
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CgtrrqVNPDGIVYSNTLVV----- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   549 SVGNATVITIDDQL-FKVRCDYSNQKNAVAVAkTMNLRTTQFNKLDIYGKVNVkpmSMELRGKRE---IIKARTVKLGQS 624
Cdd:smart00241  74 SPFHPGFITRDDRAaYHFQCFYPENEKVSLNL-DVSTIPPTELSSVSEGPLTC---SYRLYKDDSfgsPYQSADYVLGDP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   625 LDLVFTVDNSTSARH-VFVKKCTAY---DQNGDEKIILIKNGCATQHAKEYVLR-DEIKETATGFVlpFRAFRFKQGEAV 699
Cdd:smart00241 150 VYHEWECDGADDPPLgLLVDNCYATpgpDPSSGPKYFIIDNGCPVDGYLDSTIPyNSNPLHRARFS--VKVFKFADRSLV 227

                          250       260
                   ....*....|....*....|....*
gi 115534654   700 KIECEVKYCEK-----CKKANCPSR 719
Cdd:smart00241 228 YFHCQIRLCDKddgssCDGPACSSR 252
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 105-177 1.45e-08

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 52.47  E-value: 1.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115534654 105 WDDRILVDKSQSVLKAETKLECLSLCAQEKRFPCLSAMFYRDSKDCLLNS--ASSSSAKLKMDTggfKVSYMELH 177
Cdd:cd01099    9 VLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDedRMSSGVKLLYDS---NVDYYENK 80
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 105-153 8.45e-06

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 44.49  E-value: 8.45e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 115534654   105 WDDRILVDKSQSVLKAETKLECLSLCAQEkRFPCLSAMFYRDSKDCLLN 153
Cdd:smart00473   9 LPNTKLPGFSRIVISVASLEECASKCLNS-NCSCRSFTYNNGTKGCLLW 56
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 187-258 1.60e-04

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 40.64  E-value: 1.60e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115534654   187 NAFKMVAFDAIEIRGESRIFNGSDGLGKCMEKCK----DCDVVMYNEGFSECYSVWNDPSGQLLDFVNDEYQILTN 258
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLnsncSCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVDLYEK 77
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 106-176 3.25e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 37.15  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115534654  106 DDRILVDKSQSVLKAETKLECLSLCAQEKRfpCLSAMFYRDSKDCLLNSASSSSAKlKMDTGGFKVSYMEL 176
Cdd:pfam00024   7 PGSSLSGVDVSTVTVSSAEECAQRCTNEPR--CRSFTYNPKSKKCHLKSSSSGSLP-RLKRSDNKVDYYEK 74
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 474-719 2.63e-12

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 67.80  E-value: 2.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   474 QCTFGFISVKVSPGNPDNHNLVGGEIYVRNGHSNCSKTIGTDGEAILKIRHNDttC-----ITKNGDIYETVVVVtqnve 548
Cdd:smart00241   1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTDATSAFVSFEVPLNG--CgtrrqVNPDGIVYSNTLVV----- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   549 SVGNATVITIDDQL-FKVRCDYSNQKNAVAVAkTMNLRTTQFNKLDIYGKVNVkpmSMELRGKRE---IIKARTVKLGQS 624
Cdd:smart00241  74 SPFHPGFITRDDRAaYHFQCFYPENEKVSLNL-DVSTIPPTELSSVSEGPLTC---SYRLYKDDSfgsPYQSADYVLGDP 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534654   625 LDLVFTVDNSTSARH-VFVKKCTAY---DQNGDEKIILIKNGCATQHAKEYVLR-DEIKETATGFVlpFRAFRFKQGEAV 699
Cdd:smart00241 150 VYHEWECDGADDPPLgLLVDNCYATpgpDPSSGPKYFIIDNGCPVDGYLDSTIPyNSNPLHRARFS--VKVFKFADRSLV 227

                          250       260
                   ....*....|....*....|....*
gi 115534654   700 KIECEVKYCEK-----CKKANCPSR 719
Cdd:smart00241 228 YFHCQIRLCDKddgssCDGPACSSR 252
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 105-177 1.45e-08

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 52.47  E-value: 1.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115534654 105 WDDRILVDKSQSVLKAETKLECLSLCAQEKRFPCLSAMFYRDSKDCLLNS--ASSSSAKLKMDTggfKVSYMELH 177
Cdd:cd01099    9 VLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDedRMSSGVKLLYDS---NVDYYENK 80
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 105-153 8.45e-06

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 44.49  E-value: 8.45e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 115534654   105 WDDRILVDKSQSVLKAETKLECLSLCAQEkRFPCLSAMFYRDSKDCLLN 153
Cdd:smart00473   9 LPNTKLPGFSRIVISVASLEECASKCLNS-NCSCRSFTYNNGTKGCLLW 56
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 187-258 1.60e-04

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 40.64  E-value: 1.60e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115534654   187 NAFKMVAFDAIEIRGESRIFNGSDGLGKCMEKCK----DCDVVMYNEGFSECYSVWNDPSGQLLDFVNDEYQILTN 258
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLnsncSCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVDLYEK 77
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 106-176 3.25e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 37.15  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115534654  106 DDRILVDKSQSVLKAETKLECLSLCAQEKRfpCLSAMFYRDSKDCLLNSASSSSAKlKMDTGGFKVSYMEL 176
Cdd:pfam00024   7 PGSSLSGVDVSTVTVSSAEECAQRCTNEPR--CRSFTYNPKSKKCHLKSSSSGSLP-RLKRSDNKVDYYEK 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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