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Conserved domains on  [gi|17566554|ref|NP_506156|]
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putative cytochrome c 2.2 [Caenorhabditis elegans]

Protein Classification

c-type cytochrome( domain architecture ID 10007442)

c-type cytochrome is an electron carrier protein that contains one or more heme groups

CATH:  1.10.760.10
Gene Ontology:  GO:0020037|GO:0009055|GO:0046872
PubMed:  31252007|22723177|18568041|12594933|10647174|10395550
SCOP:  3000815

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyc7 COG3474
Cytochrome c2 [Energy production and conversion];
17-114 1.77e-44

Cytochrome c2 [Energy production and conversion];


:

Pssm-ID: 442697 [Multi-domain]  Cd Length: 101  Bit Score: 140.02  E-value: 1.77e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554  17 GDNEKGKKIFKQRCEQCHVVNS-LQTKTGPTLNGVIGRQSGQVAGFDYSAANKNKGVVWDRQTLFDYLADPKKYIPGTKM 95
Cdd:COG3474   1 GDAAAGEKLFNRKCAACHSVDGgAGNRVGPNLNGVVGRKAGSVEGFAYSDALKASGLVWDEETLDAWLADPKAFVPGTKM 80

                        90
                ....*....|....*....
gi 17566554  96 VFAGLKKADERADLIKFIE 114
Cdd:COG3474  81 PFAGLKDPEDRADLIAYLK 99
 
Name Accession Description Interval E-value
Cyc7 COG3474
Cytochrome c2 [Energy production and conversion];
17-114 1.77e-44

Cytochrome c2 [Energy production and conversion];


Pssm-ID: 442697 [Multi-domain]  Cd Length: 101  Bit Score: 140.02  E-value: 1.77e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554  17 GDNEKGKKIFKQRCEQCHVVNS-LQTKTGPTLNGVIGRQSGQVAGFDYSAANKNKGVVWDRQTLFDYLADPKKYIPGTKM 95
Cdd:COG3474   1 GDAAAGEKLFNRKCAACHSVDGgAGNRVGPNLNGVVGRKAGSVEGFAYSDALKASGLVWDEETLDAWLADPKAFVPGTKM 80

                        90
                ....*....|....*....
gi 17566554  96 VFAGLKKADERADLIKFIE 114
Cdd:COG3474  81 PFAGLKDPEDRADLIAYLK 99
PTZ00048 PTZ00048
cytochrome c; Provisional
 14-120 3.56e-43

cytochrome c; Provisional


Pssm-ID: 185414  Cd Length: 115  Bit Score: 137.30  E-value: 3.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554   14 IPEGDNEKGKKIFKQRCEQCHVVNSL-QTKTGPTLNGVIGRQSGQvAGFDYSAANKNKGVVWDRQTLFDYLADPKKYIPG 92
Cdd:PTZ00048  10 VPEGDAKKGAKLFKAKCAQCHTINKGgAVKQGPNLHGFYGRKSGS-ADFPYSDANKNSGIVWSDKHLFEYLVNPKLYIPG 88

                         90       100
                 ....*....|....*....|....*...
gi 17566554   93 TKMVFAGLKKADERADLIKFIeVEAAKK 120
Cdd:PTZ00048  89 TKMVFAGIKKEKERADLIAYL-KEASSK 115
Cytochrom_C pfam00034
Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and ...
 20-113 4.61e-09

Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.


Pssm-ID: 459641 [Multi-domain]  Cd Length: 89  Bit Score: 49.84  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554    20 EKGKKIFKQRCEQCHVVNS-LQTKTGPTLNGVIGRQSGQVAGFDYSAANKNKGVVWDRQtlfdyladpkKYIPGTKMVFA 98
Cdd:pfam00034   1 ARGKKLFAANCAACHGVNGeGAGAGGPDLAGLAARYPGDALGAIRENKHAIGGGGVDRA----------GGPPGTGMPAF 70

                          90
                  ....*....|....*
gi 17566554    99 GLKKADERADLIKFI 113
Cdd:pfam00034  71 DGLTDEEIADLVAYL 85
CxxCH_TIGR02603 TIGR02603
putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain ...
 17-50 2.25e-03

putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain limited to very few species but expanded into large paralogous families in some species that conain it. We find it in over 20 copies each in Pirellula sp. strain 1 (phylum Planctomycetes) and Verrucomicrobium spinosum DSM 4136 (phylum Verrucomicrobia), and no matches above trusted cutoff an any other species so far. This domain, about 140 amino acids long, contains an absolutely conserved motif CxxCH, the cytochrome c family heme-binding site signature (PS00190).


Pssm-ID: 274224  Cd Length: 133  Bit Score: 35.41  E-value: 2.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 17566554    17 GDNEKGKKIFKQRCEQCHVVNSLQTKTGPTLNGV 50
Cdd:TIGR02603   1 GDAARGKAVFAKVCYLCHRIGGQGVDFGPNLTTV 34
 
Name Accession Description Interval E-value
Cyc7 COG3474
Cytochrome c2 [Energy production and conversion];
17-114 1.77e-44

Cytochrome c2 [Energy production and conversion];


Pssm-ID: 442697 [Multi-domain]  Cd Length: 101  Bit Score: 140.02  E-value: 1.77e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554  17 GDNEKGKKIFKQRCEQCHVVNS-LQTKTGPTLNGVIGRQSGQVAGFDYSAANKNKGVVWDRQTLFDYLADPKKYIPGTKM 95
Cdd:COG3474   1 GDAAAGEKLFNRKCAACHSVDGgAGNRVGPNLNGVVGRKAGSVEGFAYSDALKASGLVWDEETLDAWLADPKAFVPGTKM 80

                        90
                ....*....|....*....
gi 17566554  96 VFAGLKKADERADLIKFIE 114
Cdd:COG3474  81 PFAGLKDPEDRADLIAYLK 99
PTZ00048 PTZ00048
cytochrome c; Provisional
 14-120 3.56e-43

cytochrome c; Provisional


Pssm-ID: 185414  Cd Length: 115  Bit Score: 137.30  E-value: 3.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554   14 IPEGDNEKGKKIFKQRCEQCHVVNSL-QTKTGPTLNGVIGRQSGQvAGFDYSAANKNKGVVWDRQTLFDYLADPKKYIPG 92
Cdd:PTZ00048  10 VPEGDAKKGAKLFKAKCAQCHTINKGgAVKQGPNLHGFYGRKSGS-ADFPYSDANKNSGIVWSDKHLFEYLVNPKLYIPG 88

                         90       100
                 ....*....|....*....|....*...
gi 17566554   93 TKMVFAGLKKADERADLIKFIeVEAAKK 120
Cdd:PTZ00048  89 TKMVFAGIKKEKERADLIAYL-KEASSK 115
PTZ00405 PTZ00405
cytochrome c; Provisional
 13-114 3.94e-37

cytochrome c; Provisional


Pssm-ID: 173596  Cd Length: 114  Bit Score: 122.07  E-value: 3.94e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554   13 AIPEGDNEKGKKIFKQRCEQCHV-VNSLQTKTGPTLNGVIGRQSGQVAGFDYSAANKNKGVVWDRQTLFDYLADPKKYIP 91
Cdd:PTZ00405   8 PLPPGDAERGEKLFKGRAAQCHTaTKGGSNGVGPNLFGIVNRKSGTVEGFAYSKANADSGVIWTPEVLDVYLENPKKFMP 87

                         90       100
                 ....*....|....*....|...
gi 17566554   92 GTKMVFAGLKKADERADLIKFIE 114
Cdd:PTZ00405  88 GTKMSFAGIKKPQERADVIAYLE 110
Cytochrom_C pfam00034
Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and ...
 20-113 4.61e-09

Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.


Pssm-ID: 459641 [Multi-domain]  Cd Length: 89  Bit Score: 49.84  E-value: 4.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566554    20 EKGKKIFKQRCEQCHVVNS-LQTKTGPTLNGVIGRQSGQVAGFDYSAANKNKGVVWDRQtlfdyladpkKYIPGTKMVFA 98
Cdd:pfam00034   1 ARGKKLFAANCAACHGVNGeGAGAGGPDLAGLAARYPGDALGAIRENKHAIGGGGVDRA----------GGPPGTGMPAF 70

                          90
                  ....*....|....*
gi 17566554    99 GLKKADERADLIKFI 113
Cdd:pfam00034  71 DGLTDEEIADLVAYL 85
CxxCH_TIGR02603 TIGR02603
putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain ...
 17-50 2.25e-03

putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain limited to very few species but expanded into large paralogous families in some species that conain it. We find it in over 20 copies each in Pirellula sp. strain 1 (phylum Planctomycetes) and Verrucomicrobium spinosum DSM 4136 (phylum Verrucomicrobia), and no matches above trusted cutoff an any other species so far. This domain, about 140 amino acids long, contains an absolutely conserved motif CxxCH, the cytochrome c family heme-binding site signature (PS00190).


Pssm-ID: 274224  Cd Length: 133  Bit Score: 35.41  E-value: 2.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 17566554    17 GDNEKGKKIFKQRCEQCHVVNSLQTKTGPTLNGV 50
Cdd:TIGR02603   1 GDAARGKAVFAKVCYLCHRIGGQGVDFGPNLTTV 34
TsdA COG3258
Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion ...
 16-83 6.71e-03

Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion transport and metabolism];


Pssm-ID: 442489 [Multi-domain]  Cd Length: 216  Bit Score: 34.83  E-value: 6.71e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17566554  16 EGDNEKGKKIFKQRCEQCHvvnslqtktGPTLNGViGRQSGQ-----VAGFDysaaNKNKGVVWDR-QTLFDYL 83
Cdd:COG3258 114 SADVERGKALYAERCASCH---------GADGEGQ-GRADGQygfppLWGGD----SYNDGAGMARlGTLADFI 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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