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Conserved domains on  [gi|17559224|ref|NP_506269|]
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Sodium/potassium-transporting ATPase subunit alpha [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
40-993 0e+00

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 1956.01  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVV 119
Cdd:cd02608   1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEEEPSNDNLYLGIVLAAVVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:cd02608  81 VTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 SEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVF 279
Cdd:cd02608 161 SEPQTRSPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEHFIHIITGVAVF 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 280 LGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 359
Cdd:cd02608 241 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 360 TQNRMTVAHMWYDETIHECDTTETQTSQE-KRTGASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTE 438
Cdd:cd02608 321 TQNRMTVAHMWFDNQIHEADTTEDQSGASfDKSSATWLALSRIAGLCNRAEFKAGQENVPILKRDVNGDASESALLKCIE 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 439 LTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGD----HYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTA 514
Cdd:cd02608 401 LSCGSVMEMRERNPKVAEIPFNSTNKYQLSIHENEDpgdpRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNA 480
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 515 YLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHP 594
Cdd:cd02608 481 YLELGGLGERVLGFCHLYLPDDKFPEGFKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 560
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 595 ITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhseIVFARTSPQQKLMI 674
Cdd:cd02608 561 ITAKAIAKGVGI------------------------------------------------------IVFARTSPQQKLII 586
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 675 VEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLT 754
Cdd:cd02608 587 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 666
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 755 SNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQ 834
Cdd:cd02608 667 SNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQ 746
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 835 ASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLIISKTRR 914
Cdd:cd02608 747 ALAGFFTYFVIMAENGFLPSDLLGLRVQWDDKYVNDLEDSYGQEWTYEQRKILEYTCHTAFFVSIVVVQWADLIICKTRR 826
                       890       900       910       920       930       940       950
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17559224 915 NSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIRRYPGGWVERE 993
Cdd:cd02608 827 NSVFQQGMKNKILNFGLFFETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPFSLLIFVYDEVRKLIIRRNPGGWVEKE 905
HAD pfam12710
haloacid dehalogenase-like hydrolase;
574-657 6.83e-04

haloacid dehalogenase-like hydrolase;


:

Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 41.75  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   574 DAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG---IISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHGSDLREMSEDQ 650
Cdd:pfam12710  91 ELLAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRRLRAWLAARGLGLD 170

                  ....*..
gi 17559224   651 LAEIIKY 657
Cdd:pfam12710 171 LADSVAY 177
 
Name Accession Description Interval E-value
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
40-993 0e+00

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 1956.01  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVV 119
Cdd:cd02608   1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEEEPSNDNLYLGIVLAAVVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:cd02608  81 VTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 SEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVF 279
Cdd:cd02608 161 SEPQTRSPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEHFIHIITGVAVF 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 280 LGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 359
Cdd:cd02608 241 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 360 TQNRMTVAHMWYDETIHECDTTETQTSQE-KRTGASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTE 438
Cdd:cd02608 321 TQNRMTVAHMWFDNQIHEADTTEDQSGASfDKSSATWLALSRIAGLCNRAEFKAGQENVPILKRDVNGDASESALLKCIE 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 439 LTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGD----HYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTA 514
Cdd:cd02608 401 LSCGSVMEMRERNPKVAEIPFNSTNKYQLSIHENEDpgdpRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNA 480
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 515 YLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHP 594
Cdd:cd02608 481 YLELGGLGERVLGFCHLYLPDDKFPEGFKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 560
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 595 ITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhseIVFARTSPQQKLMI 674
Cdd:cd02608 561 ITAKAIAKGVGI------------------------------------------------------IVFARTSPQQKLII 586
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 675 VEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLT 754
Cdd:cd02608 587 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 666
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 755 SNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQ 834
Cdd:cd02608 667 SNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQ 746
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 835 ASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLIISKTRR 914
Cdd:cd02608 747 ALAGFFTYFVIMAENGFLPSDLLGLRVQWDDKYVNDLEDSYGQEWTYEQRKILEYTCHTAFFVSIVVVQWADLIICKTRR 826
                       890       900       910       920       930       940       950
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17559224 915 NSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIRRYPGGWVERE 993
Cdd:cd02608 827 NSVFQQGMKNKILNFGLFFETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPFSLLIFVYDEVRKLIIRRNPGGWVEKE 905
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
6-996 0e+00

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 1859.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224     6 KKQELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVG 85
Cdd:TIGR01106   2 KKRDLDELKKEVEMDDHKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    86 AILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVV 165
Cdd:TIGR01106  82 AILCFLAYGIQASTEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   166 GDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGESEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVM 245
Cdd:TIGR01106 162 GDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVM 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   246 GRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLT 325
Cdd:TIGR01106 242 GRIASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLT 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   326 AKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTSQE-KRTGASFEALVRIASL 404
Cdd:TIGR01106 322 AKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGVSfDKSSATWLALSRIAGL 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   405 CNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGD----HYLLVM 480
Cdd:TIGR01106 402 CNRAVFKAGQENVPILKRAVAGDASESALLKCIELCLGSVMEMRERNPKVVEIPFNSTNKYQLSIHENEDprdpRHLLVM 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   481 KGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVG 560
Cdd:TIGR01106 482 KGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNFPTDNLCFVG 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   561 LMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHG 640
Cdd:TIGR01106 562 LISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHG 641
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   641 SDLREMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAD 720
Cdd:TIGR01106 642 SDLKDMTSEQLDEILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAD 721
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   721 MILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEA 800
Cdd:TIGR01106 722 MILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKA 801
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   801 ESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWT 880
Cdd:TIGR01106 802 ESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPLHLVGLRVQWDDRWINDLEDSYGQEWT 881
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   881 YANRKILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSW 960
Cdd:TIGR01106 882 YEQRKYVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTW 961
                         970       980       990
                  ....*....|....*....|....*....|....*.
gi 17559224   961 WFCALPFSILIFVYDEIRRFLIRRYPGGWVERETYY 996
Cdd:TIGR01106 962 WFCAFPYSLLIFVYDEIRKLIIRRNPGGWVEKETYY 997
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
22-985 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 898.70  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  22 HIVPIEELVARLGTNlETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAysvdyftme 101
Cdd:COG0474   9 HALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL--------- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 102 ypskDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADL 181
Cdd:COG0474  79 ----GDWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 182 RVVSAFGFKVDNSSLTGESEPQSRSPDCTNEN--PLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGM 259
Cdd:COG0474 155 RLLEAKDLQVDESALTGESVPVEKSADPLPEDapLGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEK 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 260 TPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNL 339
Cdd:COG0474 235 TPLQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRL 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 340 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETqtsqekrtgASFEALVRIASLCNRAEFkagQQDTPI 419
Cdd:COG0474 315 PAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFD---------PALEELLRAAALCSDAQL---EEETGL 382
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 420 lrrdctGDASEIALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIH-DNGDHYLLVMKGAPERILDVCSTIFLNG 498
Cdd:COG0474 383 ------GDPTEGALLVAAAKAGLDVEELRKEYPRVDEIPFDSERKRMSTVHeDPDGKRLLIVKGAPEVVLALCTRVLTGG 456
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 499 KESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADkfPKGFKFDVEevnfplKNLRFVGLMSMIDPPRAAVPDAVAK 578
Cdd:COG0474 457 GVVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELPAD--PELDSEDDE------SDLTFLGLVGMIDPPRPEAKEAIAE 528
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 579 CRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTEtvediairrgipveevnpreakaaVIHGSDLREMSEDQLAEIIKYH 658
Cdd:COG0474 529 CRRAGIRVKMITGDHPATARAIARQLGLGDDGDR------------------------VLTGAELDAMSDEELAEAVEDV 584
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 659 SeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEG 738
Cdd:COG0474 585 D--VFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 739 RLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPirdklv 818
Cdd:COG0474 663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWP------ 736
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 819 NERLIS----LAYGQIGMIQASAGFFTYFWIMAdngfmpwdlyqlraqwdsraynnvldsYGQEWTYAnrkileytcQTA 894
Cdd:COG0474 737 DEPILSrfllLRILLLGLLIAIFTLLTFALALA---------------------------RGASLALA---------RTM 780
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 895 YFVSIVVVQWADLIISKTRRNSLVQQGM-SNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFV 973
Cdd:COG0474 781 AFTTLVLSQLFNVFNCRSERRSFFKSGLfPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLL 860
                       970
                ....*....|..
gi 17559224 974 YDEIRRFLIRRY 985
Cdd:COG0474 861 LVELVKLLRRRF 872
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
25-756 6.67e-99

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 332.03  E-value: 6.67e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   25 PIEELVARLGTNLEtGLTRQKAQEVLAKNGPNALSPPETTPEWIKF--C-KNLFGgfaMLLWVGAIlcyiaysVDYFTme 101
Cdd:PRK10517  53 PEEELWKTFDTHPE-GLNEAEVESAREQHGENELPAQKPLPWWVHLwvCyRNPFN---ILLTILGA-------ISYAT-- 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  102 ypskDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHR------DGQKQQVKTEELVVGDIVEVKGGD 175
Cdd:PRK10517 120 ----EDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVPGDIIKLAAGD 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  176 RVPADLRVVSAFGFKVDNSSLTGESEP---QSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLA 252
Cdd:PRK10517 196 MIPADLRILQARDLFVAQASLTGESLPvekFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRV 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  253 SGLDtgmtpiaREIEHFIHLITGVAVFLgISFF-----IIAFILGY---HWLTAVVFLIGIIVANVPEGLIATVTVCLTL 324
Cdd:PRK10517 276 SEQD-------SEPNAFQQGISRVSWLL-IRFMlvmapVVLLINGYtkgDWWEAALFALSVAVGLTPEMLPMIVTSTLAR 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  325 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHmwydetiHecdtTETQtsqekrtGASFEALVRIASL 404
Cdd:PRK10517 348 GAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN-------H----TDIS-------GKTSERVLHSAWL 409
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  405 cnRAEFKAGQQDtpILrrdctgdasEIALLKFTELTQGnvIAVREKNKKIAEIPFNST-NKYQVSIHDNGDHYLLVMKGA 483
Cdd:PRK10517 410 --NSHYQTGLKN--LL---------DTAVLEGVDEESA--RSLASRWQKIDEIPFDFErRRMSVVVAENTEHHQLICKGA 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  484 PERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFkfdVEEvnfplKNLRFVGLMS 563
Cdd:PRK10517 475 LEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQR---ADE-----SDLILEGYIA 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  564 MIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGtetvediairrgipveevnpreakaaVIHGSDL 643
Cdd:PRK10517 547 FLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE--------------------------VLIGSDI 600
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  644 REMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMIL 723
Cdd:PRK10517 601 ETLSDDELANLAERTT--LFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIIL 677
                        730       740       750
                 ....*....|....*....|....*....|...
gi 17559224  724 LDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSN 756
Cdd:PRK10517 678 LEKSLMVLEEGVIEGRRTFANMLKYIKMTASSN 710
E1-E2_ATPase pfam00122
E1-E2 ATPase;
141-332 2.01e-45

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 161.59  E-value: 2.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   141 NMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSPdctnenpletRNI 220
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEKKK----------GDM 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   221 AFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVV 300
Cdd:pfam00122  70 VYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALL 149
                         170       180       190
                  ....*....|....*....|....*....|..
gi 17559224   301 FLIGIIVANVPEGLIATVTVCLTLTAKRMASK 332
Cdd:pfam00122 150 RALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
18-92 1.79e-21

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 89.18  E-value: 1.79e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17559224     18 KMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIA 92
Cdd:smart00831   1 ELDWHALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
HAD pfam12710
haloacid dehalogenase-like hydrolase;
574-657 6.83e-04

haloacid dehalogenase-like hydrolase;


Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 41.75  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   574 DAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG---IISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHGSDLREMSEDQ 650
Cdd:pfam12710  91 ELLAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRRLRAWLAARGLGLD 170

                  ....*..
gi 17559224   651 LAEIIKY 657
Cdd:pfam12710 171 LADSVAY 177
 
Name Accession Description Interval E-value
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
40-993 0e+00

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 1956.01  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVV 119
Cdd:cd02608   1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEEEPSNDNLYLGIVLAAVVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:cd02608  81 VTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 SEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVF 279
Cdd:cd02608 161 SEPQTRSPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEHFIHIITGVAVF 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 280 LGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTL 359
Cdd:cd02608 241 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 360 TQNRMTVAHMWYDETIHECDTTETQTSQE-KRTGASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTE 438
Cdd:cd02608 321 TQNRMTVAHMWFDNQIHEADTTEDQSGASfDKSSATWLALSRIAGLCNRAEFKAGQENVPILKRDVNGDASESALLKCIE 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 439 LTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGD----HYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTA 514
Cdd:cd02608 401 LSCGSVMEMRERNPKVAEIPFNSTNKYQLSIHENEDpgdpRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNA 480
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 515 YLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHP 594
Cdd:cd02608 481 YLELGGLGERVLGFCHLYLPDDKFPEGFKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 560
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 595 ITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhseIVFARTSPQQKLMI 674
Cdd:cd02608 561 ITAKAIAKGVGI------------------------------------------------------IVFARTSPQQKLII 586
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 675 VEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLT 754
Cdd:cd02608 587 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 666
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 755 SNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQ 834
Cdd:cd02608 667 SNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQ 746
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 835 ASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLIISKTRR 914
Cdd:cd02608 747 ALAGFFTYFVIMAENGFLPSDLLGLRVQWDDKYVNDLEDSYGQEWTYEQRKILEYTCHTAFFVSIVVVQWADLIICKTRR 826
                       890       900       910       920       930       940       950
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17559224 915 NSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIRRYPGGWVERE 993
Cdd:cd02608 827 NSVFQQGMKNKILNFGLFFETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPFSLLIFVYDEVRKLIIRRNPGGWVEKE 905
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
6-996 0e+00

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 1859.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224     6 KKQELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVG 85
Cdd:TIGR01106   2 KKRDLDELKKEVEMDDHKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    86 AILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVV 165
Cdd:TIGR01106  82 AILCFLAYGIQASTEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   166 GDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGESEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVM 245
Cdd:TIGR01106 162 GDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVM 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   246 GRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLT 325
Cdd:TIGR01106 242 GRIASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLT 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   326 AKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTSQE-KRTGASFEALVRIASL 404
Cdd:TIGR01106 322 AKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGVSfDKSSATWLALSRIAGL 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   405 CNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGD----HYLLVM 480
Cdd:TIGR01106 402 CNRAVFKAGQENVPILKRAVAGDASESALLKCIELCLGSVMEMRERNPKVVEIPFNSTNKYQLSIHENEDprdpRHLLVM 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   481 KGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVG 560
Cdd:TIGR01106 482 KGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNFPTDNLCFVG 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   561 LMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHG 640
Cdd:TIGR01106 562 LISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHG 641
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   641 SDLREMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAD 720
Cdd:TIGR01106 642 SDLKDMTSEQLDEILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAD 721
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   721 MILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEA 800
Cdd:TIGR01106 722 MILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKA 801
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   801 ESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWT 880
Cdd:TIGR01106 802 ESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPLHLVGLRVQWDDRWINDLEDSYGQEWT 881
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   881 YANRKILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSW 960
Cdd:TIGR01106 882 YEQRKYVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTW 961
                         970       980       990
                  ....*....|....*....|....*....|....*.
gi 17559224   961 WFCALPFSILIFVYDEIRRFLIRRYPGGWVERETYY 996
Cdd:TIGR01106 962 WFCAFPYSLLIFVYDEIRKLIIRRNPGGWVEKETYY 997
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
22-985 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 898.70  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  22 HIVPIEELVARLGTNlETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAysvdyftme 101
Cdd:COG0474   9 HALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL--------- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 102 ypskDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADL 181
Cdd:COG0474  79 ----GDWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 182 RVVSAFGFKVDNSSLTGESEPQSRSPDCTNEN--PLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGM 259
Cdd:COG0474 155 RLLEAKDLQVDESALTGESVPVEKSADPLPEDapLGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEK 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 260 TPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNL 339
Cdd:COG0474 235 TPLQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRL 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 340 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETqtsqekrtgASFEALVRIASLCNRAEFkagQQDTPI 419
Cdd:COG0474 315 PAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFD---------PALEELLRAAALCSDAQL---EEETGL 382
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 420 lrrdctGDASEIALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIH-DNGDHYLLVMKGAPERILDVCSTIFLNG 498
Cdd:COG0474 383 ------GDPTEGALLVAAAKAGLDVEELRKEYPRVDEIPFDSERKRMSTVHeDPDGKRLLIVKGAPEVVLALCTRVLTGG 456
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 499 KESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADkfPKGFKFDVEevnfplKNLRFVGLMSMIDPPRAAVPDAVAK 578
Cdd:COG0474 457 GVVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELPAD--PELDSEDDE------SDLTFLGLVGMIDPPRPEAKEAIAE 528
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 579 CRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTEtvediairrgipveevnpreakaaVIHGSDLREMSEDQLAEIIKYH 658
Cdd:COG0474 529 CRRAGIRVKMITGDHPATARAIARQLGLGDDGDR------------------------VLTGAELDAMSDEELAEAVEDV 584
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 659 SeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEG 738
Cdd:COG0474 585 D--VFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEG 662
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 739 RLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPirdklv 818
Cdd:COG0474 663 RRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWP------ 736
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 819 NERLIS----LAYGQIGMIQASAGFFTYFWIMAdngfmpwdlyqlraqwdsraynnvldsYGQEWTYAnrkileytcQTA 894
Cdd:COG0474 737 DEPILSrfllLRILLLGLLIAIFTLLTFALALA---------------------------RGASLALA---------RTM 780
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 895 YFVSIVVVQWADLIISKTRRNSLVQQGM-SNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFV 973
Cdd:COG0474 781 AFTTLVLSQLFNVFNCRSERRSFFKSGLfPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLL 860
                       970
                ....*....|..
gi 17559224 974 YDEIRRFLIRRY 985
Cdd:COG0474 861 LVELVKLLRRRF 872
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
40-810 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 650.06  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFcknlFGGFA-----MLLWVGAILCYIAYSVDyftmeypskdnlylGIVL 114
Cdd:cd02089   1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKF----LEQFKdfmviVLLAAAVISGVLGEYVD--------------AIVI 62
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 115 MTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNS 194
Cdd:cd02089  63 IAIVILNAVLGFVQEYKAEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEES 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 195 SLTGESEPQSRSPD--CTNENPL-ETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIH 271
Cdd:cd02089 143 SLTGESEPVEKDADtlLEEDVPLgDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGK 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 272 LITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTI 351
Cdd:cd02089 223 RLAIAALIICALVFALGLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVI 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 352 CSDKTGTLTQNRMTVAHMWYdetihecdttetqtsqekrtgasfealvriaslcnraefkagqqdtpilrrdcTGDASEI 431
Cdd:cd02089 303 CSDKTGTLTQNKMTVEKIYT-----------------------------------------------------IGDPTET 329
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 432 ALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGDHYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDF 511
Cdd:cd02089 330 ALIRAARKAGLDKEELEKKYPRIAEIPFDSERKLMTTVHKDAGKYIVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKI 409
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 512 NTAYLELGGMGERVLGFCDFVLPADKFPKgfKFDVEevnfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTG 591
Cdd:cd02089 410 LAVNEEFSEEALRVLAVAYKPLDEDPTES--SEDLE------NDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITG 481
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 592 DHPITAKAIAKSVGIISDGTEtvediairrgipveevnpreakaaVIHGSDLREMSEDQLAEIIKYHSeiVFARTSPQQK 671
Cdd:cd02089 482 DHKLTARAIAKELGILEDGDK------------------------ALTGEELDKMSDEELEKKVEQIS--VYARVSPEHK 535
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 672 LMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAY 751
Cdd:cd02089 536 LRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRY 615
                       730       740       750       760       770
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17559224 752 TLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPR 810
Cdd:cd02089 616 LLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKPR 674
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
40-977 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 638.15  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNlfggFA-----MLLWVGAILCYIAYSVDyftmeypskdnlylGIVL 114
Cdd:cd02080   1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQ----FNnpliyILLAAAVVTAFLGHWVD--------------AIVI 62
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 115 MTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNS 194
Cdd:cd02080  63 FGVVLINAIIGYIQEGKAEKALAAIKNMLSPEATVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQIDES 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 195 SLTGESEPQSRSPDCTNEN-PL-ETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHL 272
Cdd:cd02080 143 ALTGESVPVEKQEGPLEEDtPLgDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKA 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 273 ITGVAVFLGISFFIIAFILG-YHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTI 351
Cdd:cd02080 223 LLIVILVLAALTFVFGLLRGdYSLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVI 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 352 CSDKTGTLTQNRMTVahmwydetihecdttetqtsqekrtgasfealVRIASLCNRAEFKAGQQDTPIlrrdcTGDASEI 431
Cdd:cd02080 303 CSDKTGTLTRNEMTV--------------------------------QAIVTLCNDAQLHQEDGHWKI-----TGDPTEG 345
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 432 ALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDN-GDHYLLVmKGAPERILDVCSTIFLNGKESELtDKLRED 510
Cdd:cd02080 346 ALLVLAAKAGLDPDRLASSYPRVDKIPFDSAYRYMATLHRDdGQRVIYV-KGAPERLLDMCDQELLDGGVSPL-DRAYWE 423
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 511 FNTAylELGGMGERVLGFcdfvlpADKFPKGFKFDVEEVNFPlKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVT 590
Cdd:cd02080 424 AEAE--DLAKQGLRVLAF------AYREVDSEVEEIDHADLE-GGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMIT 494
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 591 GDHPITAKAIAKSVGIISDGTetvediairrgipveevnpreakaaVIHGSDLREMSEDQLAEIIKYHSeiVFARTSPQQ 670
Cdd:cd02080 495 GDHAETARAIGAQLGLGDGKK-------------------------VLTGAELDALDDEELAEAVDEVD--VFARTSPEH 547
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 671 KLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIA 750
Cdd:cd02080 548 KLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFIL 627
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 751 YTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPirdklvNERLIS-LAYGQ 829
Cdd:cd02080 628 FTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDP------SEPLLSrELIWR 701
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 830 I---GMIQASAGFFTYFWiMADNGfmpwdlyqlraqwdsraynnvldsYGQEwtyanrkileyTCQTAYFVSIVVVQWAD 906
Cdd:cd02080 702 IllvSLLMLGGAFGLFLW-ALDRG------------------------YSLE-----------TARTMAVNTIVVAQIFY 745
                       890       900       910       920       930       940       950
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559224 907 LIISKTRRNSLVQQGM-SNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEI 977
Cdd:cd02080 746 LFNCRSLHRSILKLGVfSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVVEL 817
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
22-983 1.86e-159

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 495.27  E-value: 1.86e-159
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  22 HIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAIlcyIAYSVDYFTME 101
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAI---ISFVLALFEEG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 102 YPSKDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDG-QKQQVKTEELVVGDIVEVKGGDRVPAD 180
Cdd:cd02083  78 EEGVTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNGkGVQRIRARELVPGDIVEVAVGDKVPAD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 181 LRVVSAFG--FKVDNSSLTGESEPQSRS----PDCTNENPlETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASG 254
Cdd:cd02083 158 IRIIEIKSttLRVDQSILTGESVSVIKHtdvvPDPRAVNQ-DKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAE 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 255 LDTGMTPIAREIEHF-------IHLITgVAVFL-GISFF-----IIAFILG--YHWLTAVvfliGIIVANVPEGLIATVT 319
Cdd:cd02083 237 TEEEKTPLQQKLDEFgeqlskvISVIC-VAVWAiNIGHFndpahGGSWIKGaiYYFKIAV----ALAVAAIPEGLPAVIT 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 320 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-YDETIHECDTTE------------TQTS 386
Cdd:cd02083 312 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFiLDKVEDDSSLNEfevtgstyapegEVFK 391
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 387 QEKRTGAS-FEALV---RIASLCNRAEFKAgQQDTPILRRdcTGDASEIALLKFTE-------LTQGNVIAVR------- 448
Cdd:cd02083 392 NGKKVKAGqYDGLVelaTICALCNDSSLDY-NESKGVYEK--VGEATETALTVLVEkmnvfntDKSGLSKRERanacndv 468
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 449 --EKNKKIAEIPFNSTNK----YQVSIHDNGDHYLLVmKGAPERILDVCSTIFLN-GKESELTDKLREDFNTAYLELGGM 521
Cdd:cd02083 469 ieQLWKKEFTLEFSRDRKsmsvYCSPTKASGGNKLFV-KGAPEGVLERCTHVRVGgGKVVPLTAAIKILILKKVWGYGTD 547
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 522 GERVLGFCdfvlPADKFPKGFKFDVEEVNFPLK---NLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAK 598
Cdd:cd02083 548 TLRCLALA----TKDTPPKPEDMDLEDSTKFYKyetDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAE 623
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 599 AIAKSVGIISDgTETVEDIAIRrGIPVEEVNPREAKAAVIHGSdlremsedqlaeiikyhseiVFARTSPQQKLMIVEGF 678
Cdd:cd02083 624 AICRRIGIFGE-DEDTTGKSYT-GREFDDLSPEEQREACRRAR--------------------LFSRVEPSHKSKIVELL 681
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 679 QKQGQIVAVTGDGVNDSPALKKADIGVAMGIaGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIP 758
Cdd:cd02083 682 QSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIG 760
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 759 E-ISPFLTYILfGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPiRDKLVNERLIsLAYGQIGMI--QA 835
Cdd:cd02083 761 EvVSIFLTAAL-GLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKP-DEPLISGWLF-FRYLAIGTYvgLA 837
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 836 SAGFFTYFWIMADNG-FMPWdlYQLRaQWDSRAynnvldSYGQEWTYANRKILEYTCQTAYFVSI-VVVQWADLIISKTR 913
Cdd:cd02083 838 TVGAFAWWFMYYEEGpQVSF--YQLT-HFMQCS------SWEPNFEGVDCEIFEDPHPMTMALSVlVVIEMFNALNSLSE 908
                       970       980       990      1000      1010      1020      1030
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17559224 914 RNSLVQqgMSNWTlNFGLVFETALA----WFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIR 983
Cdd:cd02083 909 NQSLLV--MPPWS-NPWLVGAIALSmalhFVILYVPPLATIFQITPLSFAEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
25-823 1.29e-153

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 477.02  E-value: 1.29e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    25 PIEELVARLGTNLETGLTrqKAQEVLAKN---GPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAilcyiaySVDYFTME 101
Cdd:TIGR01522   8 SVEETCSKLQTDLQNGLN--SSQEASHRRafhGWNEFDVEEDESLWKKFLSQFVKNPLILLLIAS-------AVISVFMG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   102 ypSKDNLyLGIVLMTVVVITGVFqyYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADL 181
Cdd:TIGR01522  79 --NIDDA-VSITLAILIVVTVGF--VQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   182 RVVSAFGFKVDNSSLTGESEPQSRSPDCTNENPL----ETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDT 257
Cdd:TIGR01522 154 RIVEAVDLSIDESNLTGETTPVSKVTAPIPAATNgdlaERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   258 GMTPIAREIEHFIHLITGVAvFLGISFF-IIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLV 336
Cdd:TIGR01522 234 PKTPLQKSMDLLGKQLSLVS-FGVIGVIcLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIV 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   337 KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTSQEK----------RTGASFEALVRIASLCN 406
Cdd:TIGR01522 313 RKLPSVETLGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEvivdgdvlhgFYTVAVSRILEAGNLCN 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   407 RAEFKagqQDTPILrrdcTGDASEIALLKFTEltQGNVIAVREKNKKIAEIPFNSTNKYQVS--IHDNGDHYLLVMKGAP 484
Cdd:TIGR01522 393 NAKFR---NEADTL----LGNPTDVALIELLM--KFGLDDLRETYIRVAEVPFSSERKWMAVkcVHRQDRSEMCFMKGAY 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   485 ERILDVCSTiFL--NGKESELTDKLREDFNTAYLELGGMGERVLGFcdfvlpadkfpkgfkfdveeVNFPLKN-LRFVGL 561
Cdd:TIGR01522 464 EQVLKYCTY-YQkkDGKTLTLTQQQRDVIQEEAAEMASAGLRVIAF--------------------ASGPEKGqLTFLGL 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   562 MSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEdiairrgipveevnpreakaavihGS 641
Cdd:TIGR01522 523 VGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAVSIARRLGMPSKTSQSVS------------------------GE 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   642 DLREMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADM 721
Cdd:TIGR01522 579 KLDAMDDQQLSQIVPKVA--VFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIGVAMGQTGTDVAKEAADM 656
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   722 ILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAE 801
Cdd:TIGR01522 657 ILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWINILMDGPPAQSLGVEPVD 736
                         810       820
                  ....*....|....*....|..
gi 17559224   802 SDIMKRQPRdPIRDKLVNERLI 823
Cdd:TIGR01522 737 KDVMRKPPR-PRNDKILTKDLI 757
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
50-855 1.31e-152

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 471.88  E-value: 1.31e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  50 LAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAilcyiaySVDYFTMEYPSKdnlyLGIVLMTVVVITGVFqyYQE 129
Cdd:cd02085   2 RKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSA-------VVSVVMKQYDDA----VSITVAILIVVTVAF--VQE 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 130 SKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGESEPQSRS--P 207
Cdd:cd02085  69 YRSEKSLEALNKLVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTteV 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 208 DCTNEN-PLETR-NIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAvFLGISF- 284
Cdd:cd02085 149 IPKASNgDLTTRsNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYS-FIIIGVi 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 285 FIIAFILGYHWLTavVFLIGI--IVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQN 362
Cdd:cd02085 228 MLIGWLQGKNLLE--MFTIGVslAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKN 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 363 RMTVAHMWydetihecdttetqtsqekrTGAsfealvriasLCNRAEFkagQQDTPIlrrdctGDASEIALLKFTELTQg 442
Cdd:cd02085 306 EMTVTKIV--------------------TGC----------VCNNAVI---RNNTLM------GQPTEGALIALAMKMG- 345
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 443 nVIAVREKNKKIAEIPFNSTNKY---QVSIHDNGDHY-LLVMKGAPERILDVCSTIFL-NGKESELTDKLREDFNTAYLE 517
Cdd:cd02085 346 -LSDIRETYIRKQEIPFSSEQKWmavKCIPKYNSDNEeIYFMKGALEQVLDYCTTYNSsDGSALPLTQQQRSEINEEEKE 424
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 518 LGGMGERVLGFCdfVLPAdkfpkgfkfdveevnfpLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITA 597
Cdd:cd02085 425 MGSKGLRVLALA--SGPE-----------------LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETA 485
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 598 KAIAKSVGIISDGTETVEdiairrgipveevnpreakaavihGSDLREMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEG 677
Cdd:cd02085 486 IAIGSSLGLYSPSLQALS------------------------GEEVDQMSDSQLASVVRKVT--VFYRASPRHKLKIVKA 539
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 678 FQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNI 757
Cdd:cd02085 540 LQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSI 619
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 758 PEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPR---DPIRDKLVNERLISLAYgqigmIQ 834
Cdd:cd02085 620 AALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRnvkDPILTRSLILNVLLSAA-----II 694
                       810       820
                ....*....|....*....|.
gi 17559224 835 ASAGFFTYFWIMADNGFMPWD 855
Cdd:cd02085 695 VSGTLWVFWKEMSDDNVTPRD 715
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
113-983 3.09e-150

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 469.26  E-value: 3.09e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   113 VLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVD 192
Cdd:TIGR01116  41 VILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVD 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   193 NSSLTGESEP---QSRS-PDCTNENPlETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEH 268
Cdd:TIGR01116 121 QSILTGESVSvnkHTESvPDERAVNQ-DKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDE 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   269 FIHLITGVAVFLGISFFII------AFILGYHWLTAVVFLIGIIVA----NVPEGLIATVTVCLTLTAKRMASKNCLVKN 338
Cdd:TIGR01116 200 FGELLSKVIGLICILVWVInighfnDPALGGGWIQGAIYYFKIAVAlavaAIPEGLPAVITTCLALGTRKMAKKNAIVRK 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   339 LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWY----DETIHECDTTETQTSQEKR--------TGASFEALVR---IAS 403
Cdd:TIGR01116 280 LPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAldpsSSSLNEFCVTGTTYAPEGGvikddgpvAGGQDAGLEElatIAA 359
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   404 LCNRAEFKAGQQDTPILRrdcTGDASEIALLKFTE------LTQGNVIAVREKN----------KKIAEIPFNSTNK-YQ 466
Cdd:TIGR01116 360 LCNDSSLDFNERKGVYEK---VGEATEAALKVLVEkmglpaTKNGVSSKRRPALgcnsvwndkfKKLATLEFSRDRKsMS 436
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   467 VSIHDNGDHYLLVmKGAPERILDVCSTIFL-NGKESELTDKLREDFNTAYLELGGM-GERVLGFCdFVLPADKFPKGFKF 544
Cdd:TIGR01116 437 VLCKPSTGNKLFV-KGAPEGVLERCTHILNgDGRAVPLTDKMKNTILSVIKEMGTTkALRCLALA-FKDIPDPREEDLLS 514
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   545 DVEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTEtVEDIAIRrGIP 624
Cdd:TIGR01116 515 DPANFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDED-VTFKSFT-GRE 592
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   625 VEEVNPREAKAAVIHGsdlremsedqlaeiikyhseIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIG 704
Cdd:TIGR01116 593 FDEMGPAKQRAACRSA--------------------VLFSRVEPSHKSELVELLQEQGEIVAMTGDGVNDAPALKKADIG 652
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   705 VAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCID 784
Cdd:TIGR01116 653 IAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVN 731
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   785 LGTDMVPAISLAYEEAESDIMKRQPRDPiRDKLVNERLIsLAYGQIGMiqasagfftYFWIMADNGFMPWDLYQLRAQWD 864
Cdd:TIGR01116 732 LVTDGLPATALGFNPPDKDIMWKPPRRP-DEPLITGWLF-FRYLVVGV---------YVGLATVGGFVWWYLLTHFTGCD 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   865 SRAYNNVLDSYGQEWTYANRKileYTCQTAYFVSIVVVQWADLIISKTRRNSLVQqgMSNWT---LNFGLVFETALAWFM 941
Cdd:TIGR01116 801 EDSFTTCPDFEDPDCYVFEGK---QPARTISLSVLVVIEMFNALNALSEDQSLLR--MPPWVnkwLIGAICLSMALHFLI 875
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|..
gi 17559224   942 CYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIR 983
Cdd:TIGR01116 876 LYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
40-828 4.13e-147

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 461.15  E-value: 4.13e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLwvgailcYIAYSVDYFTMEYPSkdnlylGIVLMTVVV 119
Cdd:cd02086   1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVL-------IIAMALSFAVKDWIE------GGVIAAVIA 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:cd02086  68 LNVIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGE 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 SEPQSRSPDCT----NENPLETR-NIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGM--------------- 259
Cdd:cd02086 148 SLPVIKDAELVfgkeEDVSVGDRlNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKALRGKGGLIsrdrvkswlygtliv 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 260 --------------TPIAREIEHFIHLITGVAVFLGISFFIIAfilGYHWLTAV-VFLIGIIVANVPEGLIATVTVCLTL 324
Cdd:cd02086 228 twdavgrflgtnvgTPLQRKLSKLAYLLFFIAVILAIIVFAVN---KFDVDNEViIYAIALAISMIPESLVAVLTITMAV 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 325 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYdetihecdttetqtsqekrtgasfealvrIASL 404
Cdd:cd02086 305 GAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWI-----------------------------PAAL 355
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 405 CNRAE-FKAGQQDTPILRrdctGDASEIALLKF-TELTQGNVIAV---REKNKKIAEIPFNSTNKYQVSIHDN---GDHY 476
Cdd:cd02086 356 CNIATvFKDEETDCWKAH----GDPTEIALQVFaTKFDMGKNALTkggSAQFQHVAEFPFDSTVKRMSVVYYNnqaGDYY 431
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 477 LLvMKGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGfkfdvEEVNFPLK-- 554
Cdd:cd02086 432 AY-MKGAVERVLECCSSMYGKDGIIPLDDEFRKTIIKNVESLASQGLRVLAFASRSFTKAQFNDD-----QLKNITLSra 505
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 555 ----NLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIIsDGTETVEDIAIrrgipveevnp 630
Cdd:cd02086 506 daesDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGIL-PPNSYHYSQEI----------- 573
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 631 reAKAAVIHGSDLREMSE---DQLAEIikyhsEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAM 707
Cdd:cd02086 574 --MDSMVMTASQFDGLSDeevDALPVL-----PLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAM 646
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 708 GIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILF----GIPL-PLGTVTILC 782
Cdd:cd02086 647 GLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFkdedGLSVfPLSPVEILW 726
                       810       820       830       840
                ....*....|....*....|....*....|....*....|....*..
gi 17559224 783 IDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLIS-LAYG 828
Cdd:cd02086 727 INMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDtFVYG 773
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
117-824 3.97e-144

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 447.03  E-value: 3.97e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 117 VVVITGVFQYYQESK----SSKIMDSfknmvpTFAlVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVD 192
Cdd:cd02081  75 VVLVTAGNDYQKEKQfrklNSKKEDQ------KVT-VIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKID 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 193 NSSLTGESEPQSRSPDCTNENPLetrniaFFS-TNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIH 271
Cdd:cd02081 148 ESSLTGESDPIKKTPDNQIPDPF------LLSgTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAV 221
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 272 LITGVAVFLGISFFIIAFI--------------LGYHWLTAVVFLI---GIIVANVPEGLIATVTVCLTLTAKRMASKNC 334
Cdd:cd02081 222 QIGKVGLIVAALTFIVLIIrfiidgfvndgksfSAEDLQEFVNFFIiavTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNN 301
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 335 LVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWydetihecdttetqtsqekrtgasfealvriaslcnraefkagq 414
Cdd:cd02081 302 LVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGY-------------------------------------------- 337
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 415 qdtpilrrdcTGDASEIALLKFTELTQGN--VIAVREKNKKIAEIPFNSTNKYQVSIHDNGDH-YLLVMKGAPERILDVC 491
Cdd:cd02081 338 ----------IGNKTECALLGFVLELGGDyrYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGgYRLYVKGASEIVLKKC 407
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 492 STIF-LNGKESELTDKLREDFNTAYLELGGMGERVLGFC--DFVlPADKFPKGFKFDVEEVnfPLKNLRFVGLMSMIDPP 568
Cdd:cd02081 408 SYILnSDGEVVFLTSEKKEEIKRVIEPMASDSLRTIGLAyrDFS-PDEEPTAERDWDDEED--IESDLTFIGIVGIKDPL 484
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 569 RAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTEtvediairrgipveevnpreakAAVIHGSDLREMSE 648
Cdd:cd02081 485 RPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGED----------------------GLVLEGKEFRELID 542
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 649 DQLAEIIKYHSEI------VFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMI 722
Cdd:cd02081 543 EEVGEVCQEKFDKiwpklrVLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDII 622
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 723 LLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIpeISPFLTYI--LFGIPLPLGTVTILCIDLGTDMVPAISLAYEEA 800
Cdd:cd02081 623 LLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNV--VAVILAFIgaVVTKDSPLTAVQMLWVNLIMDTLAALALATEPP 700
                       730       740
                ....*....|....*....|....
gi 17559224 801 ESDIMKRQPRDPirdklvNERLIS 824
Cdd:cd02081 701 TEDLLKRKPYGR------DKPLIS 718
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
113-781 4.33e-143

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 438.29  E-value: 4.33e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   113 VLMTVVVITGVFQYYQESKSSKIMDSFKNMV--PTFALVHRDGQkQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFk 190
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLvnTATVLVLRNGW-KEISSKDLVPGDVVLVKSGDTVPADGVLLSGSAF- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   191 VDNSSLTGESEPQSRSPDCTNENPletrniaFFSTNAVEGTAKGIVIYTGDNTVMGRIAHL---ASGLDTGMTPIAREIE 267
Cdd:TIGR01494  79 VDESSLTGESLPVLKTALPDGDAV-------FAGTINFGGTLIVKVTATGILTTVGKIAVVvytGFSTKTPLQSKADKFE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   268 HFIhlITGVAVFLGISFFI---IAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVET 344
Cdd:TIGR01494 152 NFI--FILFLLLLALAVFLllpIGGWDGNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEE 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   345 LGSTSTICSDKTGTLTQNRMTVAHMWYDETIHEcdttetqtsqekrtgASFEALVRIASLcnraefkagqqdtpilrRDC 424
Cdd:TIGR01494 230 LGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEE---------------ASLALALLAASL-----------------EYL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   425 TGDASEIALLKFTElTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDNGDH-YLLVMKGAPERILDVCSTIflngkesel 503
Cdd:TIGR01494 278 SGHPLERAIVKSAE-GVIKSDEINVEYKILDVFPFSSVLKRMGVIVEGANGsDLLFVKGAPEFVLERCNNE--------- 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   504 tdklrEDFNTAYLELGGMGERVLGFCDFVLPAdkfpkgfkfdveevnfplkNLRFVGLMSMIDPPRAAVPDAVAKCRSAG 583
Cdd:TIGR01494 348 -----NDYDEKVDEYARQGLRVLAFASKKLPD-------------------DLEFLGLLTFEDPLRPDAKETIEALRKAG 403
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   584 IKVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhseIVF 663
Cdd:TIGR01494 404 IKVVMLTGDNVLTAKAIAKELGI------------------------------------------------------DVF 429
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   664 ARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAgsDVSKQAADMILLDDNFASIVVGVEEGRLIFD 743
Cdd:TIGR01494 430 ARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFS 507
                         650       660       670
                  ....*....|....*....|....*....|....*...
gi 17559224   744 NLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTIL 781
Cdd:TIGR01494 508 NIKKNIFWAIAYNLILIPLALLLIVIILLPPLLAALAL 545
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
40-829 2.19e-135

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 421.85  E-value: 2.19e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILcyiaysvdYFTMEYPSKdnlylGIVLMTVVV 119
Cdd:cd07538   1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALI--------YFVLGDPRE-----GLILLIFVV 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:cd07538  68 VIIAIEVVQEWRTERALEALKNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGE 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 SEPQSRSPDCTNENPLE--TRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVA 277
Cdd:cd07538 148 SVPVWKRIDGKAMSAPGgwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCALAA 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 278 VFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTG 357
Cdd:cd07538 228 LVFCALIVAVYGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTG 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 358 TLTQNRMTVAHMWYdetihecdttetqtsqekrtgasfeaLVRiaslcnraefkagqqdtpilrrdctgdaseiallkft 437
Cdd:cd07538 308 TLTKNQMEVVELTS--------------------------LVR------------------------------------- 324
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 438 eltqgnviavreknkkiaEIPFNSTNKYQVSIHDNGDHYLLVMKGAPERILDVCStifLNGKESeltDKLREdfntAYLE 517
Cdd:cd07538 325 ------------------EYPLRPELRMMGQVWKRPEGAFAAAKGSPEAIIRLCR---LNPDEK---AAIED----AVSE 376
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 518 LGGMGERVLGFCDFVLPADKFPKgfkfDVEEVNFplknlRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITA 597
Cdd:cd07538 377 MAGEGLRVLAVAACRIDESFLPD----DLEDAVF-----IFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATA 447
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 598 KAIAKSVGIisdgtetvediairrgipveevnprEAKAAVIHGSDLREMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEG 677
Cdd:cd07538 448 KAIAKQIGL-------------------------DNTDNVITGQELDAMSDEELAEKVRDVN--IFARVVPEQKLRIVQA 500
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 678 FQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNI 757
Cdd:cd07538 501 FKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHV 580
                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559224 758 PEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPiRDKLVNERLISLAYGQ 829
Cdd:cd07538 581 PIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPP-DEPLFGPRLVIKAILQ 651
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
112-798 3.71e-126

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 397.17  E-value: 3.71e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 112 IVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRD--GQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGF 189
Cdd:cd07539  61 VLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRApaGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADDL 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 190 KVDNSSLTGESEPQSRSPDCTNENPL-ETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGlDTGMTPIAREIEH 268
Cdd:cd07539 141 EVDESALTGESLPVDKQVAPTPGAPLaDRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAP-VETATGVQAQLRE 219
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 269 FIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGST 348
Cdd:cd07539 220 LTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRV 299
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 349 STICSDKTGTLTQNRMtvahmwydetihecdttetqtsqekrtgasfeALVRIAslcnraefkagqqdTPIlrrdctgda 428
Cdd:cd07539 300 DTICFDKTGTLTENRL--------------------------------RVVQVR--------------PPL--------- 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 429 seiallkfteltqgnviavreknkkiAEIPFNSTNKYQVSIHD-NGDHYLLVMKGAPERILDVCSTIFLNGKESELTDKL 507
Cdd:cd07539 325 --------------------------AELPFESSRGYAAAIGRtGGGIPLLAVKGAPEVVLPRCDRRMTGGQVVPLTEAD 378
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 508 REDFNTAYLELGGMGERVLGFCDFVLpaDKFPKGFKFDVEEvnfplkNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVV 587
Cdd:cd07539 379 RQAIEEVNELLAGQGLRVLAVAYRTL--DAGTTHAVEAVVD------DLELLGLLGLADTARPGAAALIAALHDAGIDVV 450
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 588 MVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnprEAKAAVIHGSDLREMSEDQLAEIIKyhSEIVFARTS 667
Cdd:cd07539 451 MITGDHPITARAIAKELGL-------------------------PRDAEVVTGAELDALDEEALTGLVA--DIDVFARVS 503
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 668 PQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKK 747
Cdd:cd07539 504 PEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRD 583
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|.
gi 17559224 748 SIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYE 798
Cdd:cd07539 584 AVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
40-756 3.87e-126

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 401.24  E-value: 3.87e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYftmeyPSKDNLYLGIVLMTVVV 119
Cdd:cd02077   1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLA-----PGEFDLVGALIILLMVL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDG-QKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTG 198
Cdd:cd02077  76 ISGLLDFIQEIRSLKAAEKLKKMVKNTATVIRDGsKYMEIPIDELVPGDIVYLSAGDMIPADVRIIQSKDLFVSQSSLTG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 199 ESEP---QSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGlDTGMTPIAREIEHFIHLItg 275
Cdd:cd02077 156 ESEPvekHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSITE-KRPETSFDKGINKVSKLL-- 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 276 vAVFLGISFFIIAFILGY---HWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTIC 352
Cdd:cd02077 233 -IRFMLVMVPVVFLINGLtkgDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILC 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 353 SDKTGTLTQNRMTVAHmWYDetihecdtTETQTSQEkrtgasfeaLVRIASLcnRAEFKAGQQDtPIlrrdctgdasEIA 432
Cdd:cd02077 312 TDKTGTLTQDKIVLER-HLD--------VNGKESER---------VLRLAYL--NSYFQTGLKN-LL----------DKA 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 433 LLKFTELTQGNVIAvrEKNKKIAEIPFN-STNKYQVSIHDNGDHYLLVMKGAPERILDVCSTIFLNGKESELTDKLREDF 511
Cdd:cd02077 361 IIDHAEEANANGLI--QDYTKIDEIPFDfERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKI 438
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 512 NTAYLELGGMGERVLGFCDFVLPADKfpkgFKFDVEEVnfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTG 591
Cdd:cd02077 439 LAQVEELNREGLRVLAIAYKKLPAPE----GEYSVKDE----KELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTG 510
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 592 DHPITAKAIAKSVGIISDGtetvediairrgipveevnpreakaaVIHGSDLREMSEDQLAEIIKyhSEIVFARTSPQQK 671
Cdd:cd02077 511 DNEIVTKAICKQVGLDINR--------------------------VLTGSEIEALSDEELAKIVE--ETNIFAKLSPLQK 562
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 672 LMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAY 751
Cdd:cd02077 563 ARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKM 641

                ....*
gi 17559224 752 TLTSN 756
Cdd:cd02077 642 TASSN 646
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
33-985 2.59e-123

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 401.70  E-value: 2.59e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224     33 LGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYsvDYFTmeypskdnlylGI 112
Cdd:TIGR01523   19 IGTSIPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMH--DWIE-----------GG 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    113 VLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVD 192
Cdd:TIGR01523   86 VISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTD 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    193 NSSLTGESEPQSRSPDCT----NENPLETR-NIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAH-------LAS------- 253
Cdd:TIGR01523  166 EALLTGESLPVIKDAHATfgkeEDTPIGDRiNLAFSSSAVTKGRAKGICIATALNSEIGAIAAglqgdggLFQrpekddp 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    254 ----------------------GLDTGmTPIAREIEHFIHLITGVAVFLGIsffIIAFILGYHWLTAV-VFLIGIIVANV 310
Cdd:TIGR01523  246 nkrrklnkwilkvtkkvtgaflGLNVG-TPLHRKLSKLAVILFCIAIIFAI---IVMAAHKFDVDKEVaIYAICLAISII 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    311 PEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-------------------- 370
Cdd:TIGR01523  322 PESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWiprfgtisidnsddafnpne 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    371 ---------------------------YDETIHECDTTETQTSQEkrtgasFEALVRIASLCNRAE-FKAGQQDTPILRr 422
Cdd:TIGR01523  402 gnvsgiprfspyeyshneaadqdilkeFKDELKEIDLPEDIDMDL------FIKLLETAALANIATvFKDDATDCWKAH- 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    423 dctGDASEIALLKF-------------------------TELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHDN--GDH 475
Cdd:TIGR01523  475 ---GDPTEIAIHVFakkfdlphnaltgeedllksnendqSSLSQHNEKPGSAQFEFIAEFPFDSEIKRMASIYEDnhGET 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    476 YLLVMKGAPERILDVCSTifLNGKE----SELTDKLREDFNTAYLELGGMGERVLGFCDFVL-PADKFPKGFKFDVEEVN 550
Cdd:TIGR01523  552 YNIYAKGAFERIIECCSS--SNGKDgvkiSPLEDCDRELIIANMESLAAEGLRVLAFASKSFdKADNNDDQLKNETLNRA 629
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    551 FPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGII-----SDGTETVEDIairrgipv 625
Cdd:TIGR01523  630 TAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfiHDRDEIMDSM-------- 701
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    626 eevnpreakaaVIHGSDLREMSEDQLAEIIKYhsEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGV 705
Cdd:TIGR01523  702 -----------VMTGSQFDALSDEEVDDLKAL--CLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGI 768
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    706 AMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEIspflTYILFGIP---------LPLG 776
Cdd:TIGR01523  769 AMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEA----ILLIIGLAfrdengksvFPLS 844
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    777 TVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDpirdklvnerlislayGQIGMIQAS--AGFFTYFWIMADNGFMPW 854
Cdd:TIGR01523  845 PVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHD----------------NEVGIFQKEliIDMFAYGFFLGGSCLASF 908
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    855 --DLYqlraqwdsrAYNNVLDSYGQEWTYANRKILEYTCQTAYFvsiVVVQWADLIIS---KTRRNSLVQQGMSNWT-LN 928
Cdd:TIGR01523  909 tgILY---------GFGSGNLGHDCDAHYHAGCNDVFKARSAAF---ATMTFCALILAvevKDFDNSFFNLHGIPDGdSN 976
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559224    929 FGLVFETA-----LAWFMC----------YCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIRRY 985
Cdd:TIGR01523  977 FKEFFHSIvenkfLAWAIAfaavsafptiYIPVINDDVFKHKPIGAEWGLAAAATIAFFFGAEIWKCGKRRL 1048
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
350-795 4.40e-114

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 354.07  E-value: 4.40e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 350 TICSDKTGTLTQNRMTVAHMWydetihecdttetqtsqekrtgasfealvriaslcnraefkagqqdtpilrrdctgdas 429
Cdd:cd01431   1 VICSDKTGTLTKNGMTVTKLF----------------------------------------------------------- 21
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 430 eiallkfteltqgnviavreknkkIAEIPFNSTNKYQVSIHDNGDHYLLVMKGAPERILDVCSTiflngkesELTDKLRE 509
Cdd:cd01431  22 ------------------------IEEIPFNSTRKRMSVVVRLPGRYRAIVKGAPETILSRCSH--------ALTEEDRN 69
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 510 DFNTAYLELGGMGERVLGFCDFVLPADkfpkgfkfdvEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMV 589
Cdd:cd01431  70 KIEKAQEESAREGLRVLALAYREFDPE----------TSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMI 139
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 590 TGDHPITAKAIAKSVGIISDGTETVEdiairrgipveevnpreakaavihGSDLREMSEDQLAEIIkyHSEIVFARTSPQ 669
Cdd:cd01431 140 TGDNPLTAIAIAREIGIDTKASGVIL------------------------GEEADEMSEEELLDLI--AKVAVFARVTPE 193
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 670 QKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSI 749
Cdd:cd01431 194 QKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNI 273
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 17559224 750 AYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISL 795
Cdd:cd01431 274 TYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDLIPALAL 319
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
9-810 4.38e-111

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 366.41  E-value: 4.38e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224     9 ELHD-LKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVL--AKNGPNALSPPETTPEWiKFCKNLFGGFAMLLWVG 85
Cdd:TIGR01517  27 DLTDiFKKAMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERreKVYGKNELPEKPPKSFL-QIVWAALSDQTLILLSV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    86 A-----ILCYIAYSVDYFTMEYPSK--DNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTfalVHRDGQKQQV 158
Cdd:TIGR01517 106 AavvslVLGLYVPSVGEDKADTETGwiEGVAILVSVILVVLVTAVNDYKKELQFRQLNREKSAQKIA---VIRGGQEQQI 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   159 KTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGESEPQSRSPDctnenpleTRNIAFFSTNAVEGTAKGIVIY 238
Cdd:TIGR01517 183 SIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPV--------QDPFLLSGTVVNEGSGRMLVTA 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   239 TGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFIL---------------GYHWLTAV-VFL 302
Cdd:TIGR01517 255 VGVNSFGGKLMMELRQAGEEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRyvfriirgdgrfedtEEDAQTFLdHFI 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   303 IG--IIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDT 380
Cdd:TIGR01517 335 IAvtIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRD 414
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   381 tetQTSQEKRTGASFEALVRIASLCNRAE-FKAGQQDTPILrrdctGDASEIALLKFTEL---TQGNVIAVREKNKKIAE 456
Cdd:TIGR01517 415 ---EIVLRNLPAAVRNILVEGISLNSSSEeVVDRGGKRAFI-----GSKTECALLDFGLLlllQSRDVQEVRAEEKVVKI 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   457 IPFNSTNKYQ--VSIHDNGDhYLLVMKGAPERILDVCSTIF-LNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVL 533
Cdd:TIGR01517 487 YPFNSERKFMsvVVKHSGGK-YREFRKGASEIVLKPCRKRLdSNGEATPISEDDKDRCADVIEPLASDALRTICLAYRDF 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   534 PADKFPKGfkfdveevNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTET 613
Cdd:TIGR01517 566 APEEFPRK--------DYPNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGGLA 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   614 VEdiairrgipveevnpreakaavihGSDLREMSEDQLAEIIKyhSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVN 693
Cdd:TIGR01517 638 ME------------------------GKEFRSLVYEEMDPILP--KLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTN 691
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   694 DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPE-ISPFLTYILFGIP 772
Cdd:TIGR01517 692 DAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAvILTFVGSCISSSH 771
                         810       820       830
                  ....*....|....*....|....*....|....*....
gi 17559224   773 L-PLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPR 810
Cdd:TIGR01517 772 TsPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPI 810
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
40-962 2.51e-110

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 359.62  E-value: 2.51e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALsPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYS-VDyftmeypskdnlylGIVLMTVV 118
Cdd:cd02076   1 GLTSEEAAKRLKEYGPNEL-PEKKENPILKFLSFFWGPIPWMLEAAAILAAALGDwVD--------------FAIILLLL 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 119 VITGVFQYYQESKSSKIMDSFKN-MVPTfALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLT 197
Cdd:cd02076  66 LINAGIGFIEERQAGNAVAALKKsLAPK-ARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALT 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 198 GESEPQSRSPDctnenpletrNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHL-ASGLDTG-MTPIAREIEHFIHLITG 275
Cdd:cd02076 145 GESLPVTKHPG----------DEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALvASAEEQGhLQKVLNKIGNFLILLAL 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 276 VAVFLgisFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDK 355
Cdd:cd02076 215 ILVLI---IVIVALYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDK 291
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 356 TGTLTQNRMtvahmwydeTIHECDTTetqtsqekrTGASFEALVRIASLCNRAEfKAGQQDTPILR--RDCTGDASEIAL 433
Cdd:cd02076 292 TGTLTLNKL---------SLDEPYSL---------EGDGKDELLLLAALASDTE-NPDAIDTAILNalDDYKPDLAGYKQ 352
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 434 LKFTeltqgnviavreknkkiaeiPFNSTNKYQVS-IHDNGDHYLLVMKGAPERILDVCstiflngkesELTDKLREDFN 512
Cdd:cd02076 353 LKFT--------------------PFDPVDKRTEAtVEDPDGERFKVTKGAPQVILELV----------GNDEAIRQAVE 402
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 513 TAYLELGGMGERVLGfcdfVLpadkfpkgfkfdveeVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGD 592
Cdd:cd02076 403 EKIDELASRGYRSLG----VA---------------RKEDGGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMITGD 463
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 593 HPITAKAIAKSVGIisdGTETVEdiairrgipvEEVNPREAKAAVIHGSDLREMSEDqlAEiikyhseiVFARTSPQQKL 672
Cdd:cd02076 464 QLAIAKETARQLGM---GTNILS----------AERLKLGGGGGGMPGSELIEFIED--AD--------GFAEVFPEHKY 520
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 673 MIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYT 752
Cdd:cd02076 521 RIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYR 599
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 753 LTSNIpEISPFLT--YILFGiPLPLGTVTILCIDLGTDMvPAISLAYEeaesdimkrqpRDPIRDKLVNERL-----ISL 825
Cdd:cd02076 600 IAETL-RILVFFTlgILILN-FYPLPLIMIVLIAILNDG-ATLTIAYD-----------NVPPSPRPVRWNMpellgIAT 665
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 826 AYGQIGMIqasaGFFTYFWIMADNGFMPWdlyqlraqwdsraynnVLDSYGQEwtyanrkileytcQTAYFVSIVVVqwA 905
Cdd:cd02076 666 VLGVVLTI----SSFLLLWLLDDQGWFED----------------IVLSAGEL-------------QTILYLQLSIS--G 710
                       890       900       910       920       930       940
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17559224 906 DLIISKTRRNSLVQQGMSNWTLNFGLVFETALA-------WFMCYCPGLDNGLRMYGLRFSWWF 962
Cdd:cd02076 711 HLTIFVTRTRGPFWRPRPSPLLFIAVVLTQILAtllavygWFMFAGIGWGWALLVWIYALVWFV 774
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
25-756 6.67e-99

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 332.03  E-value: 6.67e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   25 PIEELVARLGTNLEtGLTRQKAQEVLAKNGPNALSPPETTPEWIKF--C-KNLFGgfaMLLWVGAIlcyiaysVDYFTme 101
Cdd:PRK10517  53 PEEELWKTFDTHPE-GLNEAEVESAREQHGENELPAQKPLPWWVHLwvCyRNPFN---ILLTILGA-------ISYAT-- 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  102 ypskDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHR------DGQKQQVKTEELVVGDIVEVKGGD 175
Cdd:PRK10517 120 ----EDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVPGDIIKLAAGD 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  176 RVPADLRVVSAFGFKVDNSSLTGESEP---QSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLA 252
Cdd:PRK10517 196 MIPADLRILQARDLFVAQASLTGESLPvekFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRV 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  253 SGLDtgmtpiaREIEHFIHLITGVAVFLgISFF-----IIAFILGY---HWLTAVVFLIGIIVANVPEGLIATVTVCLTL 324
Cdd:PRK10517 276 SEQD-------SEPNAFQQGISRVSWLL-IRFMlvmapVVLLINGYtkgDWWEAALFALSVAVGLTPEMLPMIVTSTLAR 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  325 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHmwydetiHecdtTETQtsqekrtGASFEALVRIASL 404
Cdd:PRK10517 348 GAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN-------H----TDIS-------GKTSERVLHSAWL 409
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  405 cnRAEFKAGQQDtpILrrdctgdasEIALLKFTELTQGnvIAVREKNKKIAEIPFNST-NKYQVSIHDNGDHYLLVMKGA 483
Cdd:PRK10517 410 --NSHYQTGLKN--LL---------DTAVLEGVDEESA--RSLASRWQKIDEIPFDFErRRMSVVVAENTEHHQLICKGA 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  484 PERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFkfdVEEvnfplKNLRFVGLMS 563
Cdd:PRK10517 475 LEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQR---ADE-----SDLILEGYIA 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  564 MIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGtetvediairrgipveevnpreakaaVIHGSDL 643
Cdd:PRK10517 547 FLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE--------------------------VLIGSDI 600
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  644 REMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMIL 723
Cdd:PRK10517 601 ETLSDDELANLAERTT--LFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIIL 677
                        730       740       750
                 ....*....|....*....|....*....|...
gi 17559224  724 LDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSN 756
Cdd:PRK10517 678 LEKSLMVLEEGVIEGRRTFANMLKYIKMTASSN 710
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
40-855 5.73e-97

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 323.12  E-value: 5.73e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    40 GLTRQKAQEVLAKNGPNALsPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYFtmeypskdnlyLGIVLMtvVV 119
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNEL-PEKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVDF-----------VIILGL--LL 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   120 ITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:TIGR01647  67 LNATIGFIEENKAGNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGE 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   200 SEPQSRspdctnenplETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTG---MTPIAREIEHFihLITGV 276
Cdd:TIGR01647 147 SLPVTK----------KTGDIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGsghLQKILSKIGLF--LIVLI 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   277 AVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKT 356
Cdd:TIGR01647 215 GVLVLIELVVLFFGRGESFREGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKT 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   357 GTLTQNRMTVAhmwyDETIHECdttetqtsqekrtGASFEALVRIASLCNRAEfKAGQQDTPILRRDCtgDASEIallkf 436
Cdd:TIGR01647 295 GTLTLNKLSID----EILPFFN-------------GFDKDDVLLYAALASREE-DQDAIDTAVLGSAK--DLKEA----- 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   437 teltqgnviavREKNKKIAEIPFNSTNKY-QVSIHDNGD-HYLLVMKGAPERILDVCstiflngkesELTDKLREDFNTA 514
Cdd:TIGR01647 350 -----------RDGYKVLEFVPFDPVDKRtEATVEDPETgKRFKVTKGAPQVILDLC----------DNKKEIEEKVEEK 408
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   515 YLELGGMGERVLGfcdfVLPADKFpkgfkfdveevnfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHP 594
Cdd:TIGR01647 409 VDELASRGYRALG----VARTDEE---------------GRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHL 469
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   595 ITAKAIAKSVGIisdGTetveDIairrgIPVEEVNpreakaavihGSDLREMSEDQLAEIIkyhsEIV--FARTSPQQKL 672
Cdd:TIGR01647 470 AIAKETARRLGL---GT----NI-----YTADVLL----------KGDNRDDLPSGLGEMV----EDAdgFAEVFPEHKY 523
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   673 MIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAmgIAG-SDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAY 751
Cdd:TIGR01647 524 EIVEILQKRGHLVGMTGDGVNDAPALKKADVGIA--VAGaTDAARSAADIVLTEPGLSVIVDAILESRKIFQRMKSYVIY 601
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   752 TLTSNIP-EISPFLTYILFGIPLPlgTVTILCIDLGTDmVPAISLAYEEAESdimkrqPRDPIRDKLVNERLISLAYGQI 830
Cdd:TIGR01647 602 RIAETIRiVFFFGLLILILNFYFP--PIMVVIIAILND-GTIMTIAYDNVKP------SKLPQRWNLREVFTMSTVLGIY 672
                         810       820       830
                  ....*....|....*....|....*....|
gi 17559224   831 GMIqASAGFF-----TYFWIMADNGFMPWD 855
Cdd:TIGR01647 673 LVI-STFLLLaialdTTFFIDKFGLQLLHG 701
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
25-756 2.03e-84

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 291.93  E-value: 2.03e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   25 PIEELVARLGTNLEtGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFamlLWVGAILCYIAYSVDYFTMEYPS 104
Cdd:PRK15122  31 SLEETLANLNTHRQ-GLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPF---IYVLMVLAAISFFTDYWLPLRRG 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  105 KDNLYLG-IVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHR------DGQKQQVKTEELVVGDIVEVKGGDRV 177
Cdd:PRK15122 107 EETDLTGvIIILTMVLLSGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  178 PADLRVVSAFGFKVDNSSLTGESEP------------QSRSPDCTNE-NPLETRNIAFFSTNAVEGTAKGIVIYTGDNTV 244
Cdd:PRK15122 187 PADVRLIESRDLFISQAVLTGEALPvekydtlgavagKSADALADDEgSLLDLPNICFMGTNVVSGTATAVVVATGSRTY 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  245 MGRIAHLASG------LDTGMTPIAReiehfiHLITGVAVFLGISFFIIAFILGyHWLTAVVFLIGIIVANVPEGLIATV 318
Cdd:PRK15122 267 FGSLAKSIVGtraqtaFDRGVNSVSW------LLIRFMLVMVPVVLLINGFTKG-DWLEALLFALAVAVGLTPEMLPMIV 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  319 TVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMwYDETIHECDTtetqtsqekrtgasfeaL 398
Cdd:PRK15122 340 SSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHH-LDVSGRKDER-----------------V 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  399 VRIASLCNRAEfkAGQQDTpilrrdctgdaSEIALLKFTELTQGnvIAVREKNKKIAEIPFN-STNKYQVSIHDNGDHYL 477
Cdd:PRK15122 402 LQLAWLNSFHQ--SGMKNL-----------MDQAVVAFAEGNPE--IVKPAGYRKVDELPFDfVRRRLSVVVEDAQGQHL 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  478 LVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLgfcdfVLPADKFPKGfkfdveEVNFPL---- 553
Cdd:PRK15122 467 LICKGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAYNADGFRVL-----LVATREIPGG------ESRAQYstad 535
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  554 -KNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevNPRE 632
Cdd:PRK15122 536 eRDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTAKICREVGL----------------------EPGE 593
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  633 akaaVIHGSDLREMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGS 712
Cdd:PRK15122 594 ----PLLGTEIEAMDDAALAREVEERT--VFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGISVD-SGA 666
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....
gi 17559224  713 DVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSN 756
Cdd:PRK15122 667 DIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYLNMTASSN 710
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
40-799 1.33e-83

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 284.17  E-value: 1.33e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  40 GLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVdyftmeypsKDNLYLGIVLMTVVV 119
Cdd:cd02609   1 GLTTKEVEERQAEGKVNDQVEPVSRSVWQIVRENVFTLFNLINFVIAVLLILVGSY---------SNLAFLGVIIVNTVI 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 120 itGVFQyyqESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGE 199
Cdd:cd02609  72 --GIVQ---EIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGE 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 SEPQSRSPDCTnenpletrniaFFS-TNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAV 278
Cdd:cd02609 147 SDLIPKKAGDK-----------LLSgSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILKFTSFIII 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 279 FLGISFFIIA-FILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTG 357
Cdd:cd02609 216 PLGLLLFVEAlFRRGGGWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTG 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 358 TLTQNRMTVaHMWYDETIHECDTTETqtsqekrtgasfealvRIASLCNRAEfkagqqdtpilrrdcTGDASEIALLKFT 437
Cdd:cd02609 296 TITEGKMKV-ERVEPLDEANEAEAAA----------------ALAAFVAASE---------------DNNATMQAIRAAF 343
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 438 ElTQGNVIAVreknkkiAEIPFNSTNKYQ-VSIHDNGDHYLlvmkGAPERILdvcstiflngkeseltDKLREDFNTAYL 516
Cdd:cd02609 344 F-GNNRFEVT-------SIIPFSSARKWSaVEFRDGGTWVL----GAPEVLL----------------GDLPSEVLSRVN 395
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 517 ELGGMGERVLgfcdfVLPADKfpkgfkfdvEEVNFPLKNLRF--VGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHP 594
Cdd:cd02609 396 ELAAQGYRVL-----LLARSA---------GALTHEQLPVGLepLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNP 461
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 595 ITAKAIAKSVGIisDGTEtvEDIAIRRGIPVEEVnpreakaavihgsdlremseDQLAEiiKYHseiVFARTSPQQKLMI 674
Cdd:cd02609 462 VTVSAIAKRAGL--EGAE--SYIDASTLTTDEEL--------------------AEAVE--NYT---VFGRVTPEQKRQL 512
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 675 VEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLT 754
Cdd:cd02609 513 VQALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNNIERVASLFLV 591
                       730       740       750       760
                ....*....|....*....|....*....|....*....|....*
gi 17559224 755 SNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEE 799
Cdd:cd02609 592 KTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEP 636
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
110-776 1.55e-61

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 219.81  E-value: 1.55e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   110 LGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHR-DGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFG 188
Cdd:TIGR01525  20 EGALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQgDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGES 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   189 FkVDNSSLTGESEPQSRSPDctnenpletrNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEH 268
Cdd:TIGR01525 100 E-VDESALTGESMPVEKKEG----------DEVFAGTINGDGSLTIRVTKLGEDSTLAQIVELVEEAQSSKAPIQRLADR 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   269 FIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGST 348
Cdd:TIGR01525 169 IASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   349 STICSDKTGTLTQNRMTVahmwydetihecdttetqTSQEKRTGASFEALVRIASlcnraefKAGQQDT-PILRrdctgd 427
Cdd:TIGR01525 249 KTVVFDKTGTLTTGKPTV------------------VDIEPLDDASEEELLALAA-------ALEQSSShPLAR------ 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   428 aseiALLKFTEltqgnVIAVREKNKKIAEIPfnstnKYQVSIHDNGDHYLLVmkgaperildvcstiflnGKESELTDK- 506
Cdd:TIGR01525 298 ----AIVRYAK-----ERGLELPPEDVEEVP-----GKGVEATVDGGREVRI------------------GNPRFLGNRe 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   507 LREDFNTAYLELGGMGERVLGFCDFVlpadkfpkgfkfdveevnfpLKNLRFVGLMSMIDPPRAAVPDAVAK-CRSAGIK 585
Cdd:TIGR01525 346 LAIEPISASPDLLNEGESQGKTVVFV--------------------AVDGELLGVIALRDQLRPEAKEAIAAlKRAGGIK 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   586 VVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhSEIVFAR 665
Cdd:TIGR01525 406 LVMLTGDNRSAAEAVAAELGI----------------------------------------------------DDEVHAE 433
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   666 TSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNL 745
Cdd:TIGR01525 434 LLPEDKLAIVKKLQEEGGPVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRII 512
                         650       660       670
                  ....*....|....*....|....*....|.
gi 17559224   746 KKSIAYTltsnipeispfLTYILFGIPLPLG 776
Cdd:TIGR01525 513 KQNLAWA-----------LGYNLVAIPLAAG 532
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
113-732 2.06e-61

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 223.10  E-value: 2.06e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 113 VLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVD 192
Cdd:COG2217 181 MIIFLLLLGRYLEARAKGRARAAIRALLSLQPKTARVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VD 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 193 NSSLTGESEPQSRSPD------CTNEN-PLEtrniaffstnaVEGTAkgiviyTGDNTVMGRIAHL---ASGLDtgmTPI 262
Cdd:COG2217 260 ESMLTGESLPVEKTPGdevfagTINLDgSLR-----------VRVTK------VGSDTTLARIIRLveeAQSSK---API 319
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 263 AREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGL-IATVTVCLTLTAkRMASKNCLVKNLEA 341
Cdd:COG2217 320 QRLADRIARYFVPAVLAIAALTFLVWLLFGGDFSTALYRAVAVLVIACPCALgLATPTAIMVGTG-RAARRGILIKGGEA 398
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 342 VETLGSTSTICSDKTGTLTQNRMTVAHMwydETIHECDTTEtqtsqEKRTGASFE---------ALVRiaslcnraefKA 412
Cdd:COG2217 399 LERLAKVDTVVFDKTGTLTEGKPEVTDV---VPLDGLDEDE-----LLALAAALEqgsehplarAIVA----------AA 460
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 413 GQQDTPILRRDctgdaseiallKFTELT-QGnviaVReknkkiAEIpfnstnkyqvsihdNGDHYLLvmkGAPERILDvc 491
Cdd:COG2217 461 KERGLELPEVE-----------DFEAIPgKG----VE------ATV--------------DGKRVLV---GSPRLLEE-- 500
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 492 STIFLNGKESELTDKLREDFNTA-YLELGGmgervlgfcdfvlpadkfpkgfkfdveevnfplknlRFVGLMSMIDPPRA 570
Cdd:COG2217 501 EGIDLPEALEERAEELEAEGKTVvYVAVDG------------------------------------RLLGLIALADTLRP 544
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 571 AVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremseDQ 650
Cdd:COG2217 545 EAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI------------------------------------------DE 582
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 651 laeiikyhseiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFAS 730
Cdd:COG2217 583 -----------VRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRG 650

                ..
gi 17559224 731 IV 732
Cdd:COG2217 651 VP 652
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
115-757 6.47e-61

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 219.39  E-value: 6.47e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 115 MTVVVITGVFQ---YYQE---SKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFG 188
Cdd:cd02079  89 EEAAMLLFLFLlgrYLEErarSRARSALKALLSLAPETATVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGES 168
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 189 FkVDNSSLTGESEPQSRSPDCT------NEN-PLEtrniaffstnaVEGTAkgiviyTGDNTVMGRIAHLASGLDTGMTP 261
Cdd:cd02079 169 S-VDESSLTGESLPVEKGAGDTvfagtiNLNgPLT-----------IEVTK------TGEDTTLAKIIRLVEEAQSSKPP 230
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 262 IAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEA 341
Cdd:cd02079 231 LQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLALYRALAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDV 310
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 342 VETLGSTSTICSDKTGTLTQNRMTVAhmwydetihECDTTETQTSQekrtgasfEALVRIASLCNRAEFkagqqdtPILR 421
Cdd:cd02079 311 LETLAKVDTVAFDKTGTLTEGKPEVT---------EIEPLEGFSED--------ELLALAAALEQHSEH-------PLAR 366
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 422 rdctgdaseiALLKFTEltqgNVIAVREKNKKIAEIPfnstnKYQVSIHDNGDHYLLvmkGAPERILDvcstiflNGKES 501
Cdd:cd02079 367 ----------AIVEAAE----EKGLPPLEVEDVEEIP-----GKGISGEVDGREVLI---GSLSFAEE-------EGLVE 417
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 502 ELTDKLREDFNTA-YLELGGmgervlgfcdfvlpadkfpkgfkfdveevnfplknlRFVGLMSMIDPPRAAVPDAVAKCR 580
Cdd:cd02079 418 AADALSDAGKTSAvYVGRDG------------------------------------KLVGLFALEDQLRPEAKEVIAELK 461
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 581 SAGIKVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhsE 660
Cdd:cd02079 462 SGGIKVVMLTGDNEAAAQAVAKELGI-----------------------------------------------------D 488
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 661 IVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRL 740
Cdd:cd02079 489 EVHAGLLPEDKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARR 567
                       650
                ....*....|....*..
gi 17559224 741 IFDNLKKSIAYTLTSNI 757
Cdd:cd02079 568 TRRIIKQNLAWALGYNA 584
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
111-783 2.49e-56

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 204.48  E-value: 2.49e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   111 GIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfK 190
Cdd:TIGR01512  21 GALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVLSGTS-S 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   191 VDNSSLTGESEPQSRSPDctNENPLETRNiaffstnaVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFI 270
Cdd:TIGR01512 100 VDESALTGESVPVEKAPG--DEVFAGAIN--------LDGVLTIEVTKLPADSTIAKIVNLVEEAQSRKAPTQRFIDRFA 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   271 HLITGVAVFLGISFFIIAFILGYHWLTAVVFL-IGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTS 349
Cdd:TIGR01512 170 RYYTPAVLAIALAAALVPPLLGAGPFLEWIYRaLVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIK 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   350 TICSDKTGTLTQNRMTVahmwydetihecdttetqTSQEKRTGASFEALVRIASlcnraefKAGQQDT-PILRrdctgda 428
Cdd:TIGR01512 250 TVAFDKTGTLTTGKPKV------------------TDVHPADGHSESEVLRLAA-------AAEQGSThPLAR------- 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   429 seiallkfteltqgnviAVREKNKKiAEIPFNSTnkyqvsihdngDHYLLVMKGAperildvcsTIFLNGKESELTDK-- 506
Cdd:TIGR01512 298 -----------------AIVDYARA-RELAPPVE-----------DVEEVPGEGV---------RAVVDGGEVRIGNPrs 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   507 -LREDFNTAYLELGGMGervlgfcDFVLPAdkfpkgfkfdveevnfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGI- 584
Cdd:TIGR01512 340 lSEAVGASIAVPESAGK-------TIVLVA------------------RDGTLLGYIALSDELRPDAAEAIAELKALGIk 394
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   585 KVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhsEIVFA 664
Cdd:TIGR01512 395 RLVMLTGDRRAVAEAVARELGI-----------------------------------------------------DEVHA 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   665 RTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDN 744
Cdd:TIGR01512 422 ELLPEDKLEIVKELREKAGPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRI 501
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 17559224   745 LKKSIAYTLTSnipeISPFLTYILFG-IPLPLGT-----VTILCI 783
Cdd:TIGR01512 502 IKQNVVIALGI----ILVLILLALFGvLPLWLAVlghegSTVLVI 542
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
130-774 9.23e-51

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 190.38  E-value: 9.23e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 130 SKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVV---SAfgfkVDNSSLTGESEPQSRS 206
Cdd:cd02094 124 GKTSEAIKKLLGLQPKTARVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVegeSS----VDESMLTGESLPVEKK 199
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 207 PDctnenpletrniaffsTNAVEGT--AKGIVIY----TGDNTVMGRIAHLASGLDTGMTPIAReiehFIHLITG--VAV 278
Cdd:cd02094 200 PG----------------DKVIGGTinGNGSLLVratrVGADTTLAQIIRLVEEAQGSKAPIQR----LADRVSGvfVPV 259
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 279 FLGISF--FIIAFILGY--HWLTAVVFLIGIIVANVPEGL-IATVTVCLTLTAKrmASKN-CLVKNLEAVETLGSTSTIC 352
Cdd:cd02094 260 VIAIAIltFLVWLLLGPepALTFALVAAVAVLVIACPCALgLATPTAIMVGTGR--AAELgILIKGGEALERAHKVDTVV 337
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 353 SDKTGTLTQNRMTVAHMWYDEtihecdttetqtsqekrtGASFEALVRI-ASLCNRAEFkagqqdtPILRrdctgdasei 431
Cdd:cd02094 338 FDKTGTLTEGKPEVTDVVPLP------------------GDDEDELLRLaASLEQGSEH-------PLAK---------- 382
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 432 ALLKFTELTQGNVIAVREknkkiaeipFNSTNKYQVSIHDNGDHYLLvmkGAPERILDvcSTIFLNGKESELtDKLREDF 511
Cdd:cd02094 383 AIVAAAKEKGLELPEVED---------FEAIPGKGVRGTVDGRRVLV---GNRRLMEE--NGIDLSALEAEA-LALEEEG 447
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 512 NTA-YLELGGmgervlgfcdfvlpadkfpkgfkfdveevnfplknlRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVT 590
Cdd:cd02094 448 KTVvLVAVDG------------------------------------ELAGLIAVADPLKPDAAEAIEALKKMGIKVVMLT 491
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 591 GDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhsEIVFARTSPQQ 670
Cdd:cd02094 492 GDNRRTARAIAKELGI-----------------------------------------------------DEVIAEVLPED 518
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 671 KLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIA 750
Cdd:cd02094 519 KAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIKQNLF 597
                       650       660
                ....*....|....*....|....*..
gi 17559224 751 YTLTSN---IPeISPFLTYILFGIPLP 774
Cdd:cd02094 598 WAFIYNvigIP-LAAGVLYPFGGILLS 623
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
111-783 2.55e-47

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 179.37  E-value: 2.55e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 111 GIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALV-HRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGf 189
Cdd:cd07551  78 GALLIFIFSLSHALEDYAMGRSKRAITALMQLAPETARRiQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS- 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 190 KVDNSSLTGESEPQSRSPDCTnenpletrniAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHF 269
Cdd:cd07551 157 SIDEASITGESIPVEKTPGDE----------VFAGTINGSGALTVRVTKLSSDTVFAKIVQLVEEAQSEKSPTQSFIERF 226
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 270 --IHLITGVAVFLGIsFFIIAFILGYHWLTAvvFLIGII--VANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETL 345
Cdd:cd07551 227 erIYVKGVLLAVLLL-LLLPPFLLGWTWADS--FYRAMVflVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENL 303
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 346 GSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTSQEKrtgASFEALVRiaSLCNRAEFKAGQQDTPILRRDCT 425
Cdd:cd07551 304 GSVKAIAFDKTGTLTEGKPRVTDVIPAEGVDEEELLQVAAAAES---QSEHPLAQ--AIVRYAEERGIPRLPAIEVEAVT 378
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 426 GdaseiallkfteltQGNVIAVREKNKKIAEIPFnstnkyqvsIHDNGDhyllvmkgaperildvcstiflNGKESELTD 505
Cdd:cd07551 379 G--------------KGVTATVDGQTYRIGKPGF---------FGEVGI----------------------PSEAAALAA 413
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 506 KLREDFNTaylelggmgervlgfcdfvlpadkfpkgfkfdveeVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIK 585
Cdd:cd07551 414 ELESEGKT-----------------------------------VVYVARDDQVVGLIALMDTPRPEAKEAIAALRLGGIK 458
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 586 VVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevnpreakaavihgsdlremseDQlaeiikyhseiVFAR 665
Cdd:cd07551 459 TIMLTGDNERTAEAVAKELGI------------------------------------------DE-----------VVAN 485
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 666 TSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIV----VGVEEGRLI 741
Cdd:cd07551 486 LLPEDKVAIIRELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPyairLSRKMRRII 564
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|
gi 17559224 742 FDNLKKS---IAYTLTSNipeispfltyILFGIPLPLGTV-----TILCI 783
Cdd:cd07551 565 KQNLIFAlavIALLIVAN----------LFGLLNLPLGVVghegsTLLVI 604
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
130-793 5.97e-46

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 174.39  E-value: 5.97e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   130 SKSSKIMDSFKNMVPTFA-LVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSPD 208
Cdd:TIGR01511  76 GRASDALSKLAKLQPSTAtLLTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGESE-VDESLVTGESLPVPKKVG 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   209 ctnenpleTRNIA--FFSTNAVEGTAKGiviyTGDNTVMGRIAHLasgLDTGMTPIAReIEHFIHLITGVAVFLGISFFI 286
Cdd:TIGR01511 155 --------DPVIAgtVNGTGSLVVRATA----TGEDTTLAQIVRL---VRQAQQSKAP-IQRLADKVAGYFVPVVIAIAL 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   287 IAFILgyhWLTAVVFLIGIIVANVPEGL-IATVTVCLTLTAkRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMT 365
Cdd:TIGR01511 219 ITFVI---WLFALEFAVTVLIIACPCALgLATPTVIAVATG-LAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPT 294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   366 VAHMwydETIHECDTTetqtsqekrtgasfEALVRIASLCNRAEFkagqqdtPIlrrdCTGDASEIALLKFTELTQGNVI 445
Cdd:TIGR01511 295 VTDV---HVFGDRDRT--------------ELLALAAALEAGSEH-------PL----AKAIVSYAKEKGITLVTVSDFK 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   446 AVREKNkkiaeipfnstnkyqVSIHDNGDHYLLvmkGAPErildvcstiFLNGKESELTDKlREDFNTAYLelggmgerv 525
Cdd:TIGR01511 347 AIPGIG---------------VEGTVEGTKIQL---GNEK---------LLGENAIKIDGK-AGQGSTVVL--------- 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   526 lgfcdfvlpadkfpkgfkfdvEEVNFPLknlrfVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG 605
Cdd:TIGR01511 390 ---------------------VAVNGEL-----AGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELG 443
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   606 IisdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhseIVFARTSPQQKLMIVEGFQKQGQIV 685
Cdd:TIGR01511 444 I------------------------------------------------------DVRAEVLPDDKAALIKKLQEKGPVV 469
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   686 AVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIpeispflt 765
Cdd:TIGR01511 470 AMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQNLLWAFGYNV-------- 540
                         650       660
                  ....*....|....*....|....*...
gi 17559224   766 yilFGIPLPLGTVtilcIDLGTDMVPAI 793
Cdd:TIGR01511 541 ---IAIPIAAGVL----YPIGILLSPAV 561
E1-E2_ATPase pfam00122
E1-E2 ATPase;
141-332 2.01e-45

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 161.59  E-value: 2.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   141 NMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSPdctnenpletRNI 220
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEKKK----------GDM 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   221 AFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVV 300
Cdd:pfam00122  70 VYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALL 149
                         170       180       190
                  ....*....|....*....|....*....|..
gi 17559224   301 FLIGIIVANVPEGLIATVTVCLTLTAKRMASK 332
Cdd:pfam00122 150 RALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
3-718 8.98e-45

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 176.02  E-value: 8.98e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224      3 KKDKKQELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALS-PPETTPE--WIKFCK--NLFGG 77
Cdd:TIGR01657  102 KQRFSYHEKELKIFSPLPYLFKEKSFGVYSTCAGHSNGLTTGDIAQRKAKYGKNEIEiPVPSFLEllKEEVLHpfYVFQV 181
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224     78 FAMLLWvgaiLC--YIAYSvdyftmeypskdnlyLGIVLMTVVVI-TGVFQyyqeskSSKIMDSFKNMV--PTFALVHRD 152
Cdd:TIGR01657  182 FSVILW----LLdeYYYYS---------------LCIVFMSSTSIsLSVYQ------IRKQMQRLRDMVhkPQSVIVIRN 236
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    153 GQKQQVKTEELVVGDIVEVKG--GDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSP---DCTNENPL-----ETRNIAF 222
Cdd:TIGR01657  237 GKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSGSCI-VNESMLTGESVPVLKFPipdNGDDDEDLflyetSKKHVLF 315
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    223 FSTNAV-------EGTAKGIVIYTGDNTVMGRIahLASGLDTGMTPIAREIEHFIHLITgVAVFLGISFFIIAFIL---G 292
Cdd:TIGR01657  316 GGTKILqirpypgDTGCLAIVVRTGFSTSKGQL--VRSILYPKPRVFKFYKDSFKFILF-LAVLALIGFIYTIIELikdG 392
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    293 YHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMT---VAHM 369
Cdd:TIGR01657  393 RPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDlrgVQGL 472
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    370 WYDETI--HECDTTETQTSQEKRTGASFEALVRIaslcnraefkagqQDTPIlrrdctGDASEIALLKFTELTqgnVIAV 447
Cdd:TIGR01657  473 SGNQEFlkIVTEDSSLKPSITHKALATCHSLTKL-------------EGKLV------GDPLDKKMFEATGWT---LEED 530
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    448 REKN----KKIAEIPFNSTNKYQV-------------SI---HDNGDHYLLVMKGAPERILDVCSTiflngkeseltDKL 507
Cdd:TIGR01657  531 DESAeptsILAVVRTDDPPQELSIirrfqfssalqrmSVivsTNDERSPDAFVKGAPETIQSLCSP-----------ETV 599
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    508 REDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVV 587
Cdd:TIGR01657  600 PSDYQEVLKSYTREGYRVLALAYKELPKLTLQKAQDLSRDAVE---SNLTFLGFIVFENPLKPDTKEVIKELKRASIRTV 676
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    588 MVTGDHPITAKAIAKSVGIIS-----------------------------DGTETVEDIAIRRGIPVEEVNPREAKAAVI 638
Cdd:TIGR01657  677 MITGDNPLTAVHVARECGIVNpsntlilaeaeppesgkpnqikfevidsiPFASTQVEIPYPLGQDSVEDLLASRYHLAM 756
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    639 HGSDLR---EMSEDQLAEIIKYHSeiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAM-----GIA 710
Cdd:TIGR01657  757 SGKAFAvlqAHSPELLLRLLSHTT--VFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLseaeaSVA 834

                   ....*...
gi 17559224    711 GSDVSKQA 718
Cdd:TIGR01657  835 APFTSKLA 842
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
138-753 1.10e-43

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 168.37  E-value: 1.10e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 138 SFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPQSRSPDCTnenplet 217
Cdd:cd07545  89 SLMDIAPKTALVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGES-SVNQAAITGESLPVEKGVGDE------- 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 218 rniAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIA-FILGYHWL 296
Cdd:cd07545 161 ---VFAGTLNGEGALEVRVTKPAEDSTIARIIHLVEEAQAERAPTQAFVDRFARYYTPVVMAIAALVAIVPpLFFGGAWF 237
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 297 TAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAhmwyDETIH 376
Cdd:cd07545 238 TWIYRGLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVT----DVVVL 313
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 377 ECdTTETqtsqekrtgasfEALVRIASLCNRAE-------FKAGQQdtpilrRDCTGDASEiallKFTELTQGNVIAVRe 449
Cdd:cd07545 314 GG-QTEK------------ELLAIAAALEYRSEhplasaiVKKAEQ------RGLTLSAVE----EFTALTGRGVRGVV- 369
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 450 knkkiaeipfnstnkyqvsihdNGDHYLLvmkGAPeRILDVCSTIFLNGKESELtDKLREDFNTAYLElgGMGERVLgfc 529
Cdd:cd07545 370 ----------------------NGTTYYI---GSP-RLFEELNLSESPALEAKL-DALQNQGKTVMIL--GDGERIL--- 417
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 530 dfvlpadkfpkgfkfdveevnfplknlrfvGLMSMIDPPRAAVPDAVAKCRSAGI-KVVMVTGDHPITAKAIAKSVGIis 608
Cdd:cd07545 418 ------------------------------GVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQVGV-- 465
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 609 dgtetvediairrgipveevnpreakaavihgSDLRemsedqlAEIIkyhseivfartsPQQKLMIVEGFQKQGQIVAVT 688
Cdd:cd07545 466 --------------------------------SDIR-------AELL------------PQDKLDAIEALQAEGGRVAMV 494
                       570       580       590       600       610       620
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17559224 689 GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTL 753
Cdd:cd07545 495 GDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFAL 559
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
74-855 1.41e-43

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 170.51  E-value: 1.41e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  74 LFGGFAMLLWvgailcyiaYSVDYftMEYPSkdnlylGIVLMTVVVItgVFQYYQESKSSKIMdsfKNMV--PTFALVHR 151
Cdd:cd07542  36 VFQLFSVILW---------SSDDY--YYYAA------CIVIISVISI--FLSLYETRKQSKRL---REMVhfTCPVRVIR 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 152 DGQKQQVKTEELVVGDIVEVKG-GDRVPADLRVVSAfGFKVDNSSLTGESEPQSRSP--DCTNENPLETRNIAFFST--- 225
Cdd:cd07542  94 DGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSG-SCIVNESMLTGESVPVTKTPlpDESNDSLWSIYSIEDHSKhtl 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 226 ----------NAVEGTAKGIVIYTGDNTVMGRiahLASGLdtgMTPIAREIEHFIHL---ITGVAVFLGISFFIIAFIL- 291
Cdd:cd07542 173 fcgtkviqtrAYEGKPVLAVVVRTGFNTTKGQ---LVRSI---LYPKPVDFKFYRDSmkfILFLAIIALIGFIYTLIILi 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 292 --GYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahm 369
Cdd:cd07542 247 lnGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDL--- 323
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 370 wydetiHECDTTETQTSQEKRTGASFEALVriASLCNRAEFKAGQQDTPILRRDCT--GDASEIALLKFTeltqGNVIAV 447
Cdd:cd07542 324 ------WGVRPVSGNNFGDLEVFSLDLDLD--SSLPNGPLLRAMATCHSLTLIDGElvGDPLDLKMFEFT----GWSLEI 391
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 448 reknkkIAEIPFNST-NKYQVSIHDNGDHYLLV-MKGAPERILDVCSTiflngkeseltDKLREDFNTAYLELGGMGERV 525
Cdd:cd07542 392 ------LRQFPFSSAlQRMSVIVKTPGDDSMMAfTKGAPEMIASLCKP-----------ETVPSNFQEVLNEYTKQGFRV 454
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 526 LGFCDFVLPAdKFPKGFKFDVEEVNfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG 605
Cdd:cd07542 455 IALAYKALES-KTWLLQKLSREEVE---SDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECG 530
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 606 IISDGtetvediaiRRGIPVEEVNPREAKAAVIHGSDLREMSedqlaeiikyhseiVFARTSPQQKLMIVEGFQKQGQIV 685
Cdd:cd07542 531 MISPS---------KKVILIEAVKPEDDDSASLTWTLLLKGT--------------VFARMSPDQKSELVEELQKLDYTV 587
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 686 AVTGDGVNDSPALKKADIGVAM-----GIAGSDVSKQAadmillddNFASIVVGVEEGR--LI--FDNLKKSIAYTLTSn 756
Cdd:cd07542 588 GMCGDGANDCGALKAADVGISLseaeaSVAAPFTSKVP--------DISCVPTVIKEGRaaLVtsFSCFKYMALYSLIQ- 658
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 757 ipeispFLT-YILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQprdPIRDKLVNERLISLaYGQIgMIQA 835
Cdd:cd07542 659 ------FISvLILYSINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKR---PPASLVSPPVLVSL-LGQI-VLIL 727
                       810       820
                ....*....|....*....|
gi 17559224 836 SAGFFTYFWIMADNGFMPWD 855
Cdd:cd07542 728 LFQVIGFLIVRQQPWYIPPE 747
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
142-753 3.36e-41

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 161.03  E-value: 3.36e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 142 MVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPQSRSPDctneNPLETRNIA 221
Cdd:cd07546  96 LVPETALREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAG----DKVFAGSIN 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 222 FFSTNAVEGTAKgiviyTGDNTVmGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFII-AFILGYHWLTAV- 299
Cdd:cd07546 171 VDGVLRIRVTSA-----PGDNAI-DRILHLIEEAEERRAPIERFIDRFSRWYTPAIMAVALLVIVVpPLLFGADWQTWIy 244
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 300 ----VFLIGI---IVANVPegliATVTVCLTLTAKRMAskncLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwyd 372
Cdd:cd07546 245 rglaLLLIGCpcaLVISTP----AAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVV------ 310
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 373 etihecdtTETQTSQEKRTGasfEALVRIASLCNRAEFKAGQQdtpILRRdctGDASEIALLKFTELT-------QGNVi 445
Cdd:cd07546 311 --------TDVVPLTGISEA---ELLALAAAVEMGSSHPLAQA---IVAR---AQAAGLTIPPAEEARalvgrgiEGQV- 372
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 446 avreknkkiaeipfnstnkyqvsihdNGDHYLLvmkGAPERIldvcstiflngkESELTDKLREDFNTayLELGGmgerv 525
Cdd:cd07546 373 --------------------------DGERVLI---GAPKFA------------ADRGTLEVQGRIAA--LEQAG----- 404
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 526 lgfcdfvlpadkfpkgfkfdvEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG 605
Cdd:cd07546 405 ---------------------KTVVVVLANGRVLGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELG 463
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 606 IisdgtetvediairrgipveevnprEAKAAVIhgsdlremsedqlaeiikyhseivfartsPQQKLMIVEGFQKQGQiV 685
Cdd:cd07546 464 L-------------------------DFRAGLL-----------------------------PEDKVKAVRELAQHGP-V 488
                       570       580       590       600       610       620
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17559224 686 AVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTL 753
Cdd:cd07546 489 AMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIAL 555
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
149-787 5.59e-39

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 153.97  E-value: 5.59e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 149 VHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSPDCTnenpletrniAFFSTNAV 228
Cdd:cd07550 104 VERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEKREGDL----------VFASTVVE 172
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 229 EGTakgIVIY---TGDNTVMGRIAHL---ASGLDTGMTPIAREIEHFIHLITgvavfLGISFFIIAFILGYHWLTAVV-- 300
Cdd:cd07550 173 EGQ---LVIRaerVGRETRAARIAELieqSPSLKARIQNYAERLADRLVPPT-----LGLAGLVYALTGDISRAAAVLlv 244
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 301 -FLIGIivanvpeGLIATVTVcltLTAKRMASKN-CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMwydetihec 378
Cdd:cd07550 245 dFSCGI-------RLSTPVAV---LSALNHAARHgILVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI--------- 305
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 379 DTTETQTSQEkrtgasfeALVRIASlcnraefKAGQQDT-PILRrdctgdaseiALLKFTElTQGnvIAVREKNKKiaei 457
Cdd:cd07550 306 ITFDGRLSEE--------DLLYLAA-------SAEEHFPhPVAR----------AIVREAE-ERG--IEHPEHEEV---- 353
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 458 pfnstnKYQVSihdngdHYLLVMKGApERILdVCSTIFLNGKESELTDKLREdfntaylelgGMGERVLGFCDFVLPAdk 537
Cdd:cd07550 354 ------EYIVG------HGIASTVDG-KRIR-VGSRHFMEEEEIILIPEVDE----------LIEDLHAEGKSLLYVA-- 407
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 538 fpkgfkfdveevnfplKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIK-VVMVTGDHPITAKAIAKSVGIisdgtetved 616
Cdd:cd07550 408 ----------------IDGRLIGVIGLSDPLRPEAAEVIARLRALGGKrIIMLTGDHEQRARALAEQLGI---------- 461
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 617 iairrgipveevnpreakaavihgsdlremseDQlaeiikYHSEIvfartSPQQKLMIVEGFQKQGQIVAVTGDGVNDSP 696
Cdd:cd07550 462 --------------------------------DR------YHAEA-----LPEDKAEIVEKLQAEGRTVAFVGDGINDSP 498
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 697 ALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIpeispflTYILFGIPLPLG 776
Cdd:cd07550 499 ALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNT-------AVLAGGVFGLLS 570
                       650
                ....*....|.
gi 17559224 777 TVTILCIDLGT 787
Cdd:cd07550 571 PILAAVLHNGT 581
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
80-732 9.71e-39

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 154.00  E-value: 9.71e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  80 MLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITgVFQYYQESKS----SKIMDSFKNMVPTFALVHRDGQK 155
Cdd:cd07552  63 MTLIALGITVAYVYSVYAFLGNYFGEHGMDFFWELATLIVIM-LLGHWIEMKAvmgaGDALKKLAELLPKTAHLVTDGSI 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 156 QQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSPDctnenpleTRNIAFfSTNAvEGTAKGI 235
Cdd:cd07552 142 EDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGESKPVEKKPG--------DEVIGG-SVNG-NGTLEVK 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 236 VIYTGDNTVMGRIAHL---ASGLDTGMTPIAREiehfihlitgVAVFLgisfFIIAFILGyhwltAVVFLIGIIVANVPE 312
Cdd:cd07552 211 VTKTGEDSYLSQVMELvaqAQASKSRAENLADK----------VAGWL----FYIALGVG-----IIAFIIWLILGDLAF 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 313 GLIATVTV----C----------LTLTAKRMASKN-CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMwydetihe 377
Cdd:cd07552 272 ALERAVTVlviaCphalglaiplVVARSTSIAAKNgLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDV-------- 343
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 378 cdTTETQTSQEkrtgasfEALVRIASLCNRAEFkagqqdtPIlrrdctgdaseiallkftelTQGNVIAVREKNKKIAEI 457
Cdd:cd07552 344 --ITFDEYDED-------EILSLAAALEAGSEH-------PL--------------------AQAIVSAAKEKGIRPVEV 387
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 458 P-FNSTNKYQVSIHDNGDHYLLVMKGAPERILdvcstiflNGKESELTDKLREDFNTaylelggmgervlgfcdfvlpad 536
Cdd:cd07552 388 EnFENIPGVGVEGTVNGKRYQVVSPKYLKELG--------LKYDEELVKRLAQQGNT----------------------- 436
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 537 kfpkgfkfdveeVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgTEtved 616
Cdd:cd07552 437 ------------VSFLIQDGEVIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGI----DE---- 496
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 617 iairrgipveevnpreakaavihgsdlremsedqlaeiikyhseiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSP 696
Cdd:cd07552 497 ---------------------------------------------YFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAP 531
                       650       660       670
                ....*....|....*....|....*....|....*.
gi 17559224 697 ALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIV 732
Cdd:cd07552 532 ALAQADVGIAIG-AGTDVAIESADVVLVKSDPRDIV 566
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
112-736 9.86e-38

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 150.55  E-value: 9.86e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 112 IVLMtvvvITG--VFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGf 189
Cdd:cd07544  79 ILLM----LTGgeALEDYAQRRASRELTALLDRAPRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTA- 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 190 KVDNSSLTGESEPQSRSPD------CTN-ENPLETRNiaffSTNAVEGTAKGIViytgdntvmgRIAHLAsgldtgmtpi 262
Cdd:cd07544 154 TLDESSLTGESKPVSKRPGdrvmsgAVNgDSALTMVA----TKLAADSQYAGIV----------RLVKEA---------- 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 263 AREIEHFIHLITGVAVFlgisFFIIAFIL-GYHWLT---AVVFLIGIIVANvPEGLIATVTVCLTLTAKRMASKNCLVKN 338
Cdd:cd07544 210 QANPAPFVRLADRYAVP----FTLLALAIaGVAWAVsgdPVRFAAVLVVAT-PCPLILAAPVAIVSGMSRSSRRGILVKD 284
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 339 LEAVETLGSTSTICSDKTGTLTQNRMTVahmwydetihecdttetqTSQEKRTGASFEALVRIASlcnraefKAGQQDTP 418
Cdd:cd07544 285 GGVLEKLARAKTVAFDKTGTLTYGQPKV------------------VDVVPAPGVDADEVLRLAA-------SVEQYSSH 339
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 419 ILRRDCT--GDASEIALLKFTELTQ-------GNViavreknkkiaeipfnstNKYQVSIhdngdhyllvmkgaperild 489
Cdd:cd07544 340 VLARAIVaaARERELQLSAVTELTEvpgagvtGTV------------------DGHEVKV-------------------- 381
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 490 vcstiflnGKESELTDKLREDFNTAYLELGGMGErvlgfcdFVLPADKFpkgfkfdveevnfplknlrfVGLMSMIDPPR 569
Cdd:cd07544 382 --------GKLKFVLARGAWAPDIRNRPLGGTAV-------YVSVDGKY--------------------AGAITLRDEVR 426
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 570 AAVPDAVAKCRSAGI-KVVMVTGDHPITAKAIAKSVGIisdgTEtvediairrgipveevnpreakaavihgsdlremse 648
Cdd:cd07544 427 PEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEVGI----DE------------------------------------ 466
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 649 dqlaeiikyhseiVFARTSPQQKLMIVEGFQKQGqIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNF 728
Cdd:cd07544 467 -------------VRAELLPEDKLAAVKEAPKAG-PTIMVGDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDL 532

                ....*...
gi 17559224 729 ASIVVGVE 736
Cdd:cd07544 533 DRVVDAVA 540
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
772-981 1.13e-33

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 127.74  E-value: 1.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   772 PLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPiRDKLVNERLISLAYGQiGMIQASAGFFTYFWIMADNGF 851
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKP-KEPLFSRKMLRRILLQ-GLLIAILTLLVFFLGLLGFGI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   852 mpwdlyqlraqwdsraynnvldsygqewtyanrkILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGM-SNWTLNFG 930
Cdd:pfam00689  79 ----------------------------------SESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLfSNKLLLLA 124
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17559224   931 LVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFL 981
Cdd:pfam00689 125 ILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
134-707 4.09e-33

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 137.90  E-value: 4.09e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 134 KIMDSFKNM--VPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDR---VPADLRVVSAFGFkVDNSSLTGESEPQSRSP- 207
Cdd:cd07543  73 KNLSEFRTMgnKPYTIQVYRDGKWVPISSDELLPGDLVSIGRSAEdnlVPCDLLLLRGSCI-VNEAMLTGESVPLMKEPi 151
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 208 -DCTNENPLET-----RNIAFFSTNAVEGTAK-------------GIVIYTGDNTVMGRIahlasgLDTGMTPIAR---- 264
Cdd:cd07543 152 eDRDPEDVLDDdgddkLHVLFGGTKVVQHTPPgkgglkppdggclAYVLRTGFETSQGKL------LRTILFSTERvtan 225
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 265 EIEHFIhlitgVAVFLGIsFFIIAfiLGYHW--------------LTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMa 330
Cdd:cd07543 226 NLETFI-----FILFLLV-FAIAA--AAYVWiegtkdgrsryklfLECTLILTSVVPPELPMELSLAVNTSLIALAKLY- 296
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 331 sknclVKNLEA--VETLGSTSTICSDKTGTLTQNRMTVAHMwydetIHECDTTETQTSQEKRTGASFEALVRIASLcnrA 408
Cdd:cd07543 297 -----IFCTEPfrIPFAGKVDICCFDKTGTLTSDDLVVEGV-----AGLNDGKEVIPVSSIEPVETILVLASCHSL---V 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 409 EFKAGqqdtpilrrDCTGDASEIALLKFTE--LTQGN-VIAVREKNKKIAEI---PFNSTNKYQVSI------HDNGDHY 476
Cdd:cd07543 364 KLDDG---------KLVGDPLEKATLEAVDwtLTKDEkVFPRSKKTKGLKIIqrfHFSSALKRMSVVasykdpGSTDLKY 434
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 477 LLVMKGAPERIldvcstiflngkeSELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNfplKNL 556
Cdd:cd07543 435 IVAVKGAPETL-------------KSMLSDVPADYDEVYKEYTRQGSRVLALGYKELGHLTKQQARDYKREDVE---SDL 498
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 557 RFVGLMSMIDPPRaavPDAVAKCRS---AGIKVVMVTGDHPITAKAIAKSVGIISDgtETVEDIAIRRGIPVEEVNPREA 633
Cdd:cd07543 499 TFAGFIVFSCPLK---PDSKETIKElnnSSHRVVMITGDNPLTACHVAKELGIVDK--PVLILILSEEGKSNEWKLIPHV 573
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17559224 634 KaavihgsdlremsedqlaeiikyhseiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAM 707
Cdd:cd07543 574 K---------------------------VFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
110-715 9.50e-33

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 136.57  E-value: 9.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 110 LGIVLMTVVVITGVFqYYQESKSSKIMDSFKNmvPTFALVHRDGQK-QQVKTEELVVGDIVEVKG-GDRVPADLRVVSAf 187
Cdd:cd02082  54 ITVVFMTTINSLSCI-YIRGVMQKELKDACLN--NTSVIVQRHGYQeITIASNMIVPGDIVLIKRrEVTLPCDCVLLEG- 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 188 GFKVDNSSLTGESEPQSR------SPDCTNENPLETRNIAFFSTNAVEGTA-------KGIVIYTGDNTVMGRIahLASG 254
Cdd:cd02082 130 SCIVTEAMLTGESVPIGKcqiptdSHDDVLFKYESSKSHTLFQGTQVMQIIppeddilKAIVVRTGFGTSKGQL--IRAI 207
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 255 LDTGMTPIAREIEHFIHLITgVAVFLGISFfIIAFILGYHWLTAVVFLI----GIIVANVPEGLIATVTVCLTLTAKRMA 330
Cdd:cd02082 208 LYPKPFNKKFQQQAVKFTLL-LATLALIGF-LYTLIRLLDIELPPLFIAfeflDILTYSVPPGLPMLIAITNFVGLKRLK 285
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 331 SKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQT----SQEKRTGASFEALVRIASLCn 406
Cdd:cd02082 286 KNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQNQTFDPIQCQDpnniSIEHKLFAICHSLTKINGKL- 364
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 407 raefkagqqdtpilrrdcTGDASEIALLKFTELTQGNVIAVREKNKKIA--------EIPFNST-------NKYQVSIHD 471
Cdd:cd02082 365 ------------------LGDPLDVKMAEASTWDLDYDHEAKQHYSKSGtkrfyiiqVFQFHSAlqrmsvvAKEVDMITK 426
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 472 NGDHYLLvMKGAPERILDVCSTIflngkeseltdklREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEVNf 551
Cdd:cd02082 427 DFKHYAF-IKGAPEKIQSLFSHV-------------PSDEKAQLSTLINEGYRVLALGYKELPQSEIDAFLDLSREAQE- 491
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 552 plKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRgiPVEEVNPR 631
Cdd:cd02082 492 --ANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIINRKNPTIIIHLLIP--EIQKDNST 567
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 632 EAKAaVIHGSdlremsedqlaeiikyhseiVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAG 711
Cdd:cd02082 568 QWIL-IIHTN--------------------VFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISLAEAD 626

                ....
gi 17559224 712 SDVS 715
Cdd:cd02082 627 ASFA 630
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
83-739 4.30e-31

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 130.84  E-value: 4.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  83 WVGAILC-YIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNM-VPTFA-LVHRDGQKQQVK 159
Cdd:cd02078  31 EIGSIITtVLTFFPLLFSGGGPAGFNLAVSLWLWFTVLFANFAEAIAEGRGKAQADSLRKTkTETQAkRLRNDGKIEKVP 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 160 TEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPQSRSP--DctnenpletrniafFStnAVEGTAK---- 233
Cdd:cd02078 111 ATDLKKGDIVLVEAGDIIPADGEVIEGVA-SVDESAITGESAPVIRESggD--------------RS--SVTGGTKvlsd 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 234 GIVIYTGDN---TVMGRIAHLASGLDTGMTPiaREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVAnv 310
Cdd:cd02078 174 RIKVRITANpgeTFLDRMIALVEGASRQKTP--NEIALTILLVGLTLIFLIVVATLPPFAEYSGAPVSVTVLVALLVC-- 249
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 311 pegLIATvTVCLTLTA------KRMASKNCLVKNLEAVETLGSTSTICSDKTGTLT-QNRMTVAHMWYDetihecdttet 383
Cdd:cd02078 250 ---LIPT-TIGGLLSAigiagmDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITlGNRQATEFIPVG----------- 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 384 qtsqekrtGASFEALVRIASLCNRAEfkagqqDTPILRrdctgdaseiallKFTELTQGNVIAVREKNKKIAE-IPFNST 462
Cdd:cd02078 315 --------GVDEKELADAAQLASLAD------ETPEGR-------------SIVILAKQLGGTERDLDLSGAEfIPFSAE 367
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 463 NKYQVSIHDNGDHyllVMKGAPERILdvcstiflngkeseltdklredfntAYL-ELGGmgervlgfcdfvlpadKFPKG 541
Cdd:cd02078 368 TRMSGVDLPDGTE---IRKGAVDAIR-------------------------KYVrSLGG----------------SIPEE 403
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 542 FKFDVEEVN----FPL---KNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgtetv 614
Cdd:cd02078 404 LEAIVEEISkqggTPLvvaEDDRVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV-------- 475
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 615 ediairrgipveevnpreakaavihgsdlremsEDQLAEiikyhseivfarTSPQQKLMIVEGFQKQGQIVAVTGDGVND 694
Cdd:cd02078 476 ---------------------------------DDFLAE------------AKPEDKLELIRKEQAKGKLVAMTGDGTND 510
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....*
gi 17559224 695 SPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGR 739
Cdd:cd02078 511 APALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKLIEVVEIGK 554
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
403-494 3.89e-30

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 114.24  E-value: 3.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   403 SLCNRAEFKagqQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIH--DNGDHYLLVM 480
Cdd:pfam13246   1 ALCNSAAFD---ENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVAEIPFNSDRKRMSTVHklPDDGKYRLFV 77
                          90
                  ....*....|....
gi 17559224   481 KGAPERILDVCSTI 494
Cdd:pfam13246  78 KGAPEIILDRCTTI 91
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
107-719 1.01e-29

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 127.29  E-value: 1.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 107 NLYLGIV-LMTVVVITGVFQYYQESKSSKiMDSFKNMVPTfaLVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVS 185
Cdd:cd02073  47 GPYTTLLpLLFVLGVTAIKEGYEDIRRHK-SDNEVNNRPV--QVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLS 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 186 -------AFgfkVDNSSLTGESEPQSRSPDCTNENPLETRNIAFFST-----------NAVEGTAK-------------- 233
Cdd:cd02073 124 ssepdglCY---VETANLDGETNLKIRQALPETALLLSEEDLARFSGeieceqpnndlYTFNGTLElnggrelplspdnl 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 234 --------------GIVIYTGDNT-VMgriahlasgLDTGMTPIAR-EIEHFIHLITGVAVFLGISFFIIAFILGYHWLT 297
Cdd:cd02073 201 llrgctlrntewvyGVVVYTGHETkLM---------LNSGGTPLKRsSIEKKMNRFIIAIFCILIVMCLISAIGKGIWLS 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 298 AVV---------------------FLIGIIVAN--VPEGLIATVTVCLTLTAKRMAS----------KNCLVKNLEAVET 344
Cdd:cd02073 272 KHGrdlwyllpkeerspalefffdFLTFIILYNnlIPISLYVTIEVVKFLQSFFINWdldmydeetdTPAEARTSNLNEE 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 345 LGSTSTICSDKTGTLTQNRMTvahmwydetIHECDTTETQTsqekrtgASFEALvriaSLCNRAEFKAGQQDTPILRRDC 424
Cdd:cd02073 352 LGQVEYIFSDKTGTLTENIME---------FKKCSINGVDY-------GFFLAL----ALCHTVVPEKDDHPGQLVYQAS 411
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 425 TGDasEIALLK--------FTELTQGNVIAVREKNKKIAEI----PFNSTNKYQ-VSIHDNGDHYLLVMKGAPERILDVC 491
Cdd:cd02073 412 SPD--EAALVEaardlgfvFLSRTPDTVTINALGEEEEYEIlhilEFNSDRKRMsVIVRDPDGRILLYCKGADSVIFERL 489
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 492 STifLNGKESELTDKLREDFNTAylelggmGERVLGFCDFVLPADKFpKGFKFDVEEVNFPL---------------KNL 556
Cdd:cd02073 490 SP--SSLELVEKTQEHLEDFASE-------GLRTLCLAYREISEEEY-EEWNEKYDEASTALqnreelldevaeeieKDL 559
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 557 RFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVediairrgipveevnpreakAA 636
Cdd:cd02073 560 ILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDMENL--------------------AL 619
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 637 VIHGSDL----REMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQ-IVAVTGDGVNDSPALKKADIGVamGIAG 711
Cdd:cd02073 620 VIDGKTLtyalDPELERLFLELALKCKAVICCRVSPLQKALVVKLVKKSKKaVTLAIGDGANDVSMIQEAHVGV--GISG 697

                ....*...
gi 17559224 712 SDvSKQAA 719
Cdd:cd02073 698 QE-GMQAA 704
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
142-723 1.02e-29

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 126.65  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  142 MVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPQSRSPDctnenpletRNIA 221
Cdd:PRK11033 240 LVPETATRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSPFA-SFDESALTGESIPVERATG---------EKVP 309
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  222 FFSTnAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFII-AFILGYHWLTAV- 299
Cdd:PRK11033 310 AGAT-SVDRLVTLEVLSEPGASAIDRILHLIEEAEERRAPIERFIDRFSRIYTPAIMLVALLVILVpPLLFAAPWQEWIy 388
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  300 ----VFLIGIIVANVpeglIAT---VTVCLTLTAKRMAskncLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwyd 372
Cdd:PRK11033 389 rgltLLLIGCPCALV----ISTpaaITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTEGKPQV------ 454
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  373 etihecdttetqTSQEKRTGASFEALVRIAslcnrAEFKAGQQDtPILRrdctgdaseiALLKFTElTQGNVIAVREKNK 452
Cdd:PRK11033 455 ------------TDIHPATGISESELLALA-----AAVEQGSTH-PLAQ----------AIVREAQ-VRGLAIPEAESQR 505
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  453 KIAeipfNSTNKYQVsihdNGDHYLLVmkgAPERIldvcstiflngkeseltDKLREDFNTAYLELGGMGERVLgfcdfV 532
Cdd:PRK11033 506 ALA----GSGIEGQV----NGERVLIC---APGKL-----------------PPLADAFAGQINELESAGKTVV-----L 552
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  533 LpadkfpkgfkfdveevnfpLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgte 612
Cdd:PRK11033 553 V-------------------LRNDDVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI------ 607
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  613 tvediairrgipveevnprEAKAAVIhgsdlremsedqlaeiikyhseivfartsPQQKLMIVEGFQKQgQIVAVTGDGV 692
Cdd:PRK11033 608 -------------------DFRAGLL-----------------------------PEDKVKAVTELNQH-APLAMVGDGI 638
                        570       580       590
                 ....*....|....*....|....*....|.
gi 17559224  693 NDSPALKKADIGVAMGiAGSDVSKQAADMIL 723
Cdd:PRK11033 639 NDAPAMKAASIGIAMG-SGTDVALETADAAL 668
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
143-753 1.90e-28

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 122.08  E-value: 1.90e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 143 VPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPQSRSPDctneNPLETRNIAF 222
Cdd:cd02092 125 ARGAQRLQADGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTS-ELDRSLLTGESAPVTVAPG----DLVQAGAMNL 199
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 223 FSTNAVEGTAkgiviyTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFL 302
Cdd:cd02092 200 SGPLRLRATA------AGDDTLLAEIARLMEAAEQGRSRYVRLADRAARLYAPVVHLLALLTFVGWVAAGGDWRHALLIA 273
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 303 IGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTV--AHMWydetihecdt 380
Cdd:cd02092 274 VAVLIITCPCALGLAVPAVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLvgAHAI---------- 343
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 381 TETQTSQEKRTG-ASFEALVRiaslcnraefkAGQQDTPIlRRDCTGDASEIAllkftelTQGnVIAVREknkkiaeipf 459
Cdd:cd02092 344 SADLLALAAALAqASRHPLSR-----------ALAAAAGA-RPVELDDAREVP-------GRG-VEGRID---------- 393
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 460 nstnkyqvsihdnGDHYLLvmkGAPerilDVCSTIFLNGKESELTdkLREDFNTAYLelggmgervlgfcdfvlpadkfp 539
Cdd:cd02092 394 -------------GARVRL---GRP----AWLGASAGVSTASELA--LSKGGEEAAR----------------------- 428
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 540 kgFKFDveevnfplknlrfvglmsmiDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgtetvediai 619
Cdd:cd02092 429 --FPFE--------------------DRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGI------------- 473
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 620 rrgipveevnpreakaavihgsdlremsEDQLAEIikyhseivfartSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALK 699
Cdd:cd02092 474 ----------------------------EDWRAGL------------TPAEKVARIEELKAQGRRVLMVGDGLNDAPALA 513
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17559224 700 KADIGVAMGIAgSDVSKQAADMILLDDNFASIVVGVE----EGRLIFDNLKKSIAYTL 753
Cdd:cd02092 514 AAHVSMAPASA-VDASRSAADIVFLGDSLAPVPEAIEiarrARRLIRQNFALAIGYNV 570
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
123-739 1.79e-26

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 115.80  E-value: 1.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 123 VFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEP 202
Cdd:cd07548  87 LFQDLAVERSRKSIKALLDIRPDYANLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGESF-LDTSALTGESVP 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 203 QSRSPDctnenplETRNIAFFSTNAVEgTAKgiVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGI 282
Cdd:cd07548 166 VEVKEG-------SSVLAGFINLNGVL-EIK--VTKPFKDSAVAKILELVENASARKAPTEKFITKFARYYTPIVVFLAL 235
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 283 SFFIIAFILGYH-----WL-TAVVFLIgI-----IVANVPEGLIATVTVcltltakrmASKN-CLVKNLEAVETLGSTST 350
Cdd:cd07548 236 LLAVIPPLFSPDgsfsdWIyRALVFLV-IscpcaLVISIPLGYFGGIGA---------ASRKgILIKGSNYLEALSQVKT 305
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 351 ICSDKTGTLTQNRMTVAhmwydetihECDTTEtqtsqekrtGASFEALVRIASLCNraefkagqqdtpilrrdctgdase 430
Cdd:cd07548 306 VVFDKTGTLTKGVFKVT---------EIVPAP---------GFSKEELLKLAALAE------------------------ 343
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 431 iallkfteltqgnviavreknkkiaeipFNSTNKYQVSIHDNGDHYLlvmkgaperildvcstiflngKESELTDklred 510
Cdd:cd07548 344 ----------------------------SNSNHPIARSIQKAYGKMI---------------------DPSEIED----- 369
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 511 fntaYLELGGMGERVLGFCDFVLPA-DKFPKGFKFDVEEVNFP------LKNLRFVGLMSMIDPPRAAVPDAVAKCRSAG 583
Cdd:cd07548 370 ----YEEIAGHGIRAVVDGKEILVGnEKLMEKFNIEHDEDEIEgtivhvALDGKYVGYIVISDEIKEDAKEAIKGLKELG 445
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 584 IK-VVMVTGDHPITAKAIAKSVGIISdgtetvediairrgipveevnpreakaavihgsdlremsedqlaeiikyhseiV 662
Cdd:cd07548 446 IKnLVMLTGDRKSVAEKVAKKLGIDE-----------------------------------------------------V 472
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17559224 663 FARTSPQQKLMIVEGF--QKQGQIVAVtGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGR 739
Cdd:cd07548 473 YAELLPEDKVEKVEELkaESKGKVAFV-GDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAEAIKIAR 550
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
107-719 6.31e-24

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 109.01  E-value: 6.31e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    107 NLYLGIV-LMTVVVITGVFQYYQESKSSKIMDSFKNMvpTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVS 185
Cdd:TIGR01652   49 YRGTSIVpLAFVLIVTAIKEAIEDIRRRRRDKEVNNR--LTEVLEGHGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLS 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    186 A-------FgfkVDNSSLTGESEPQSR-SPDCTN-------------------------------------ENPLETRNI 220
Cdd:TIGR01652  127 SsepdgvcY---VETANLDGETNLKLRqALEETQkmldeddiknfsgeieceqpnaslysfqgnmtingdrQYPLSPDNI 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    221 AFFSTN-AVEGTAKGIVIYTGDNTvmgRIAHLASGLDTGMTPIAREIEHFIhlITGVAVFLGISFFIIAFILGYH----- 294
Cdd:TIGR01652  204 LLRGCTlRNTDWVIGVVVYTGHDT---KLMRNATQAPSKRSRLEKELNFLI--IILFCLLFVLCLISSVGAGIWNdahgk 278
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    295 ---------------WLTAVVFLIGIIVAN--VPEGLIATVTVCLTLTAKRMAS-------KN---CLVKNLEAVETLGS 347
Cdd:TIGR01652  279 dlwyirldvsernaaANGFFSFLTFLILFSslIPISLYVSLELVKSVQAYFINSdlqmyheKTdtpASVRTSNLNEELGQ 358
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    348 TSTICSDKTGTLTQNRMT--VAHM-------WYDET---IHEC---DTTETQTSQEKRTGASF--EALVRI-------AS 403
Cdd:TIGR01652  359 VEYIFSDKTGTLTQNIMEfkKCSIagvsygdGFTEIkdgIRERlgsYVENENSMLVESKGFTFvdPRLVDLlktnkpnAK 438
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    404 LCNRAeFKA----------GQQDTPILRRDCTGDASEIALLK--------FTELTQGNV---IAVR--EKNKKIAEI-PF 459
Cdd:TIGR01652  439 RINEF-FLAlalchtvvpeFNDDGPEEITYQAASPDEAALVKaardvgfvFFERTPKSIsllIEMHgeTKEYEILNVlEF 517
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    460 NSTNKYQ-VSIHDNGDHYLLVMKGAPERILDVCSTiFLNGKESELTDKLrEDFNTAYLELGGMGERVLGFCDFvlpaDKF 538
Cdd:TIGR01652  518 NSDRKRMsVIVRNPDGRIKLLCKGADTVIFKRLSS-GGNQVNEETKEHL-ENYASEGLRTLCIAYRELSEEEY----EEW 591
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    539 PKgfKFD------------VEEV-NFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG 605
Cdd:TIGR01652  592 NE--EYNeastaltdreekLDVVaESIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCR 669
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224    606 IISDG-------TETVEDI-----AIRRGIP-----VEEVNPREAKAAVIHGSD----LREMSEDQLAEIIKYHSEIVFA 664
Cdd:TIGR01652  670 LLSRNmeqivitSDSLDATrsveaAIKFGLEgtseeFNNLGDSGNVALVIDGKSlgyaLDEELEKEFLQLALKCKAVICC 749
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17559224    665 RTSPQQKLMIVEGFQKQ-GQIVAVTGDGVNDSPALKKADIGVamGIAGSDvSKQAA 719
Cdd:TIGR01652  750 RVSPSQKADVVRLVKKStGKTTLAIGDGANDVSMIQEADVGV--GISGKE-GMQAV 802
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
149-719 1.30e-21

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 101.14  E-value: 1.30e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 149 VHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVS----AFGFKVDNSSLTGESEPQSR-SPDCTNENP--------- 214
Cdd:cd07536  87 SKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRtsepQGSCYVETAQLDGETDLKLRvAVSCTQQLPalgdlmkis 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 215 -------------------------------LETRNIAFFSTNAVE-GTAKGIVIYTGDNTvmgriahlASGLDTGMTPI 262
Cdd:cd07536 167 ayvecqkpqmdihsfegnftledsdppihesLSIENTLLRASTLRNtGWVIGVVVYTGKET--------KLVMNTSNAKN 238
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 263 ARE-IEHFIHLITGVAVFLGISFFIIAFILGYHW-------------------LTAVVFLIGIIVAN--VPEGLIATVTV 320
Cdd:cd07536 239 KVGlLDLELNRLTKALFLALVVLSLVMVTLQGFWgpwygeknwyikkmdttsdNFGRNLLRFLLLFSyiIPISLRVNLDM 318
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 321 CLTLTAKRM----------ASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMwydetiheCDTTETQTSQEKR 390
Cdd:cd07536 319 VKAVYAWFImwdenmyyigNDTGTVARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRC--------HIGGVSYGGQVLS 390
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 391 tgasFEALvriaslcNRAEFKAGQQDTPILRRDCTgdASEIALLKfteltqgnviavreKNKKIAEIPFNSTNKYQVSIH 470
Cdd:cd07536 391 ----FCIL-------QLLEFTSDRKRMSVIVRDES--TGEITLYM--------------KGADVAISPIVSKDSYMEQYN 443
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 471 DNGDHYllvmkgAPERILDVCSTiflngkESELTDKLREDFNTAYLElggmgervlgfcdfvlpADKFPKGFKFDVEEVN 550
Cdd:cd07536 444 DWLEEE------CGEGLRTLCVA------KKALTENEYQEWESRYTE-----------------ASLSLHDRSLRVAEVV 494
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 551 FPL-KNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIIS---------DGTETVEDIAIR 620
Cdd:cd07536 495 ESLeRELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSrtqdihllrQDTSRGERAAIT 574
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 621 RGIPVEEVNPREAK--AAVIHGSDLR---EMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQ-GQIVAVTGDGVND 694
Cdd:cd07536 575 QHAHLELNAFRRKHdvALVIDGDSLEvalKYYRHEFVELACQCPAVICCRVSPTQKARIVTLLKQHtGRRTLAIGDGGND 654
                       650       660
                ....*....|....*....|....*
gi 17559224 695 SPALKKADIGVamGIAGSDvSKQAA 719
Cdd:cd07536 655 VSMIQAADCGV--GISGKE-GKQAS 676
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
149-739 1.78e-21

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 100.16  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  149 VHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPqsrspdCTNENPLETRNIAFFSTNAV 228
Cdd:PRK14010 109 IKQDGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLA-TVDESAITGESAP------VIKESGGDFDNVIGGTSVAS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  229 EGTAKGIVIYTGdNTVMGRIAHLASGLDTGMTPiaREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVA 308
Cdd:PRK14010 182 DWLEVEITSEPG-HSFLDKMIGLVEGATRKKTP--NEIALFTLLMTLTIIFLVVILTMYPLAKFLNFNLSIAMLIALAVC 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  309 NVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQ-NRMTvahmwyDETIHECDTtetqtsq 387
Cdd:PRK14010 259 LIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYgNRMA------DAFIPVKSS------- 325
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  388 ekrtgaSFEALVRIASLCNRaefkagQQDTPilrrdctgDASEIALLKftelTQGNVIAVREKNKKiaeIPFNSTNKYQV 467
Cdd:PRK14010 326 ------SFERLVKAAYESSI------ADDTP--------EGRSIVKLA----YKQHIDLPQEVGEY---IPFTAETRMSG 378
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  468 SIHDNGDHYllvmKGAPERILDvcstiflngKESELTDKLREDFNTAYLELGGMGervlgfcdfvlpadkfpkGFKFDVE 547
Cdd:PRK14010 379 VKFTTREVY----KGAPNSMVK---------RVKEAGGHIPVDLDALVKGVSKKG------------------GTPLVVL 427
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  548 EVNFPLknlrfvGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipvee 627
Cdd:PRK14010 428 EDNEIL------GVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGV--------------------- 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  628 vnpreakaavihgsdlremsedqlaeiikyhsEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAM 707
Cdd:PRK14010 481 --------------------------------DRFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAM 528
                        570       580       590
                 ....*....|....*....|....*....|..
gi 17559224  708 GiAGSDVSKQAADMILLDDNFASIVVGVEEGR 739
Cdd:PRK14010 529 N-SGTMSAKEAANLIDLDSNPTKLMEVVLIGK 559
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
18-92 1.79e-21

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 89.18  E-value: 1.79e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17559224     18 KMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIA 92
Cdd:smart00831   1 ELDWHALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
copA PRK10671
copper-exporting P-type ATPase CopA;
131-776 3.94e-21

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 99.43  E-value: 3.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  131 KSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFkVDNSSLTGESEPQSRSP-DC 209
Cdd:PRK10671 309 RSSKALEKLLDLTPPTARVVTDEGEKSVPLADVQPGMLLRLTTGDRVPVDGEITQGEAW-LDEAMLTGEPIPQQKGEgDS 387
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  210 TNENPLETRNIAFFSTNAVegtakgiviytGDNTVMGRIAHLASGLDTGMTPI---AREIEH-FIHLITGVAVFLGISFF 285
Cdd:PRK10671 388 VHAGTVVQDGSVLFRASAV-----------GSHTTLSRIIRMVRQAQSSKPEIgqlADKISAvFVPVVVVIALVSAAIWY 456
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  286 II--AFILGYhwlTAVVFLIGIIVA-------NVPEGLIATVtvcltltaKRMASKNCLVKNLEAVETLGSTSTICSDKT 356
Cdd:PRK10671 457 FFgpAPQIVY---TLVIATTVLIIAcpcalglATPMSIISGV--------GRAAEFGVLVRDADALQRASTLDTLVFDKT 525
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  357 GTLTQNRMTVAhmwydeTIHecdtTETQTSQEkrtgasfEALVRIASLCNRAEF--------KAGQQDTP------ILR- 421
Cdd:PRK10671 526 GTLTEGKPQVV------AVK----TFNGVDEA-------QALRLAAALEQGSSHplaraildKAGDMTLPqvngfrTLRg 588
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  422 RDCTGDASEIALLKFTE-LTQGNVIAVREKNKKIAEipfnstnkyQVSihdngdhyllvmKGAPERILDVcstiflNGKe 500
Cdd:PRK10671 589 LGVSGEAEGHALLLGNQaLLNEQQVDTKALEAEITA---------QAS------------QGATPVLLAV------DGK- 640
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  501 seltdklredfntaylelggmgervlgfcdfvlpadkfpkgfkfdveevnfplknlrFVGLMSMIDPPRAAVPDAVAKCR 580
Cdd:PRK10671 641 ---------------------------------------------------------AAALLAIRDPLRSDSVAALQRLH 663
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  581 SAGIKVVMVTGDHPITAKAIAKSVGIisdgtetveDIAIRRGIPveevnprEAKAAVIhgsdlremsedqlaeiikyhse 660
Cdd:PRK10671 664 KAGYRLVMLTGDNPTTANAIAKEAGI---------DEVIAGVLP-------DGKAEAI---------------------- 705
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224  661 ivfartspqQKLmivegfQKQGQIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVVGVEEGRL 740
Cdd:PRK10671 706 ---------KRL------QSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGVADALAISRA 769
                        650       660       670
                 ....*....|....*....|....*....|....*.
gi 17559224  741 IFDNLKKSIaytltsnipeISPFLtYILFGIPLPLG 776
Cdd:PRK10671 770 TLRNMKQNL----------LGAFI-YNSLGIPIAAG 794
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
153-783 6.07e-21

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 98.35  E-value: 6.07e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 153 GQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGfKVDNSSLTGESEPQSrspdctnenpLETRNIAFFSTNAVEGTA 232
Cdd:cd07553 136 GSRIKTRADQIKSGDVYLVASGQRVPVDGKLLSEQA-SIDMSWLTGESLPRI----------VERGDKVPAGTSLENQAF 204
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 233 KGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHwLTAVVFLIGIIVAnVPE 312
Cdd:cd07553 205 EIRVEHSLAESWSGSILQKVEAQEARKTPRDLLADKIIHYFTVIALLIAVAGFGVWLAIDLS-IALKVFTSVLIVA-CPC 282
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 313 GLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwydetihecdtTETQTsqekrTG 392
Cdd:cd07553 283 ALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSF--------------VMVNP-----EG 343
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 393 ASFEALVRIASLCNRAEFkagqqdtPILRrdctgdaseiALLKFTEltqgNVIAVREKNKKIAEIPFNStnkyqVSIHDN 472
Cdd:cd07553 344 IDRLALRAISAIEAHSRH-------PISR----------AIREHLM----AKGLIKAGASELVEIVGKG-----VSGNSS 397
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 473 GDHYLLVmkgapeRILDVCstiflngkeseltdklredfntaylelgGMGERvlgfcdfvlpadkfPKGFKFDVeevnfp 552
Cdd:cd07553 398 GSLWKLG------SAPDAC----------------------------GIQES--------------GVVIARDG------ 423
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 553 lknlRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgtetvediairrgipveevNPRE 632
Cdd:cd07553 424 ----RQLLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLGL----------------------DPRQ 477
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 633 akaavihgsdlremsedqlaeiikyhseiVFARTSPQQKLMIVEGFQKQGqiVAVTGDGVNDSPALKKADIGVAmgIAGS 712
Cdd:cd07553 478 -----------------------------LFGNLSPEEKLAWIESHSPEN--TLMVGDGANDALALASAFVGIA--VAGE 524
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17559224 713 -DVSKQAADMILLDDNFASI--VVGVEEGR--LIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCI 783
Cdd:cd07553 525 vGVSLEAADIYYAGNGIGGIrdLLTLSKQTikAIKGLFAFSLLYNLVAIGLALSGWISPLVAAILMPLSSITILGI 600
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
150-719 1.02e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 94.78  E-value: 1.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 150 HRDGQKQQVKTEELVVGDIVEVKGGDRVPAD---------------------------LRVVSAFGFKVDNSSLTGE--- 199
Cdd:cd07541  86 TVRGETVEIPSSDIKVGDLIIVEKNQRIPADmvllrtseksgscfirtdqldgetdwkLRIAVPCTQKLPEEGILNSisa 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 200 ---SEPQS---------RSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTvmgRIAHLASGLDTGMTPIAREIe 267
Cdd:cd07541 166 vyaEAPQKdihsfygtfTINDDPTSESLSVENTLWANTVVASGTVIGVVVYTGKET---RSVMNTSQPKNKVGLLDLEI- 241
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 268 HFIHLITGVAVFlGISFFIIAF--ILGYHWLTAVVFLI---GIIvanvPEGLIATVTVCLTLTAKRMAS-KN---CLVKN 338
Cdd:cd07541 242 NFLTKILFCAVL-ALSIVMVALqgFQGPWYIYLFRFLIlfsSII----PISLRVNLDMAKIVYSWQIEHdKNipgTVVRT 316
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 339 LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQ-------TSQEKRTGAsfealvriaslcnraefk 411
Cdd:cd07541 317 STIPEELGRIEYLLSDKTGTLTQNEMVFKKLHLGTVSYGGQNLNYEilqifpfTSESKRMGI------------------ 378
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 412 agqqdtpILRRDCTGdasEIAL-LKFTELTQGNVIavrEKNKKIAEipfNSTNkyqvsihdngdhyllvMKGAPERILDV 490
Cdd:cd07541 379 -------IVREEKTG---EITFyMKGADVVMSKIV---QYNDWLEE---ECGN----------------MAREGLRTLVV 426
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 491 cstiflnGKESeLTDKLREDFNTAYLE-LGGMGERVLgfcdfvlpadkfpkgfkfDVEEVNFPLKN-LRFVGLMSMIDPP 568
Cdd:cd07541 427 -------AKKK-LSEEEYQAFEKRYNAaKLSIHDRDL------------------KVAEVVESLEReLELLCLTGVEDKL 480
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 569 RAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTE--TVEDIAIRRGIPVEEVNPREA--KAAVIHGSDLr 644
Cdd:cd07541 481 QEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLVSRGQYihVFRKVTTREEAHLELNNLRRKhdCALVIDGESL- 559
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 645 EMS----EDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQI-VAVTGDGVNDSPALKKADIGVamGIAGSDvSKQAA 719
Cdd:cd07541 560 EVClkyyEHEFIELACQLPAVVCCRCSPTQKAQIVRLIQKHTGKrTCAIGDGGNDVSMIQAADVGV--GIEGKE-GKQAS 636
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
21-88 4.88e-15

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 70.67  E-value: 4.88e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17559224    21 EHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAIL 88
Cdd:pfam00690   1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
574-737 2.54e-08

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 54.76  E-value: 2.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 574 DAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGI----ISD-GTETVEdiairrgipveevnpreAKAAVIHgsdLREMSE 648
Cdd:COG0561  26 EALRRLREKGIKVVIATGRPLRSALPLLEELGLddplITSnGALIYD-----------------PDGEVLY---ERPLDP 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 649 DQLAEIIKYHSE-----IVFARTSPQ---------------QKLMIVEGFQKQgQIVAVtGDGVNDSPALKKADIGVAMG 708
Cdd:COG0561  86 EDVREILELLREhglhlQVVVRSGPGfleilpkgvskgsalKKLAERLGIPPE-EVIAF-GDSGNDLEMLEAAGLGVAMG 163
                       170       180
                ....*....|....*....|....*....
gi 17559224 709 IAGSDVsKQAADMILLDDNFASIVVGVEE 737
Cdd:COG0561 164 NAPPEV-KAAADYVTGSNDEDGVAEALEK 191
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
572-702 3.42e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.51  E-value: 3.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   572 VPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPveevnpreakaavihgsdlremsedql 651
Cdd:pfam00702 103 AAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGVGKP--------------------------- 155
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17559224   652 aeiikyhseivfartSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKAD 702
Cdd:pfam00702 156 ---------------KPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
PLN03190 PLN03190
aminophospholipid translocase; Provisional
108-718 4.74e-08

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 57.22  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   108 LYLGIVLMtVVVITGVFQYYQESKSSKIMDSfknmvpTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVS-- 185
Cdd:PLN03190  141 LPLAFVLL-VTAVKDAYEDWRRHRSDRIENN------RLAWVLVDDQFQEKKWKDIRVGEIIKIQANDTLPCDMVLLSts 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   186 -----AFgfkVDNSSLTGES---------EPQSRSPDCTNENPL-----ETRNIAFFSTNA-VEGT-------------- 231
Cdd:PLN03190  214 dptgvAY---VQTINLDGESnlktryakqETLSKIPEKEKINGLikcekPNRNIYGFQANMeVDGKrlslgpsniilrgc 290
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   232 -------AKGIVIYTGDNT-VMGRIAHLASGLDTGMTPIAREI----EHFIHLITGVAVFLGI-------SFFIIAFI-- 290
Cdd:PLN03190  291 elkntawAIGVAVYCGRETkAMLNNSGAPSKRSRLETRMNLEIiilsLFLIALCTIVSVCAAVwlrrhrdELDTIPFYrr 370
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   291 -------------LGYHWLTAVVFLIGIIVANV--PEGLIATVTVCLTLTAKRMASKNCL----------VKNLEAVETL 345
Cdd:PLN03190  371 kdfseggpknynyYGWGWEIFFTFLMSVIVFQImiPISLYISMELVRVGQAYFMIRDDQMydeasnsrfqCRALNINEDL 450
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   346 GSTSTICSDKTGTLTQNRM--TVAHMW----------------------------------YDETIHECDTTETQTSQEK 389
Cdd:PLN03190  451 GQIKYVFSDKTGTLTENKMefQCASIWgvdysdgrtptqndhagysvevdgkilrpkmkvkVDPQLLELSKSGKDTEEAK 530
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   390 RTGASFEALvriaSLCNR-AEFKAGQQDTPILR-RDCTGDASEIALLKFTELTQGNVIAVREKNKKIAEIPfNSTNKYQV 467
Cdd:PLN03190  531 HVHDFFLAL----AACNTiVPIVVDDTSDPTVKlMDYQGESPDEQALVYAAAAYGFMLIERTSGHIVIDIH-GERQRFNV 605
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   468 -SIH--DNGDHYLLVMKGAPERILDVcstiFLNGKESELTDKLREDFNTAYLE--------LGGMGERVLGFCDFVLPAD 536
Cdd:PLN03190  606 lGLHefDSDRKRMSVILGCPDKTVKV----FVKGADTSMFSVIDRSLNMNVIRateahlhtYSSLGLRTLVVGMRELNDS 681
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   537 KFPKgFKFDVEEVNFPL---------------KNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIA 601
Cdd:PLN03190  682 EFEQ-WHFSFEAASTALigraallrkvasnveNNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIG 760
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   602 KS---------------------------VGIISDGTETVEDIAIRRGIPVEEVnpREAKAAVIHGSDL-----REMsED 649
Cdd:PLN03190  761 YSsklltnkmtqiiinsnskescrksledALVMSKKLTTVSGISQNTGGSSAAA--SDPVALIIDGTSLvyvldSEL-EE 837
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   650 QLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQ-GQIVAVTGDGVNDSPALKKADIGVamGIAGSDvSKQA 718
Cdd:PLN03190  838 QLFQLASKCSVVLCCRVAPLQKAGIVALVKNRtSDMTLAIGDGANDVSMIQMADVGV--GISGQE-GRQA 904
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
574-722 1.23e-07

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 53.38  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 574 DAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGI----------ISDGTETVEDIAIRRGIpVEEVnpreAKAAVIHGSDL 643
Cdd:cd07517  24 EAIAALKEKGILVVIATGRAPFEIQPIVKALGIdsyvsyngqyVFFEGEVIYKNPLPQEL-VERL----TEFAKEQGHPV 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 644 REMS-------EDQLAEIIKYHSEIVFARTSPQ---------------QKLMIVEGFqKQGQIVAVtGDGVNDSPALKKA 701
Cdd:cd07517  99 SFYGqlllfedEEEEQKYEELRPELRFVRWHPLstdvipkggskakgiQKVIEHLGI-KKEETMAF-GDGLNDIEMLEAV 176
                       170       180
                ....*....|....*....|.
gi 17559224 702 DIGVAMGIAGSDVsKQAADMI 722
Cdd:cd07517 177 GIGIAMGNAHEEL-KEIADYV 196
HAD-SF-IB TIGR01488
Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model ...
487-701 1.04e-04

Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; This model represents a subfamily of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. Subfamily IA, B, C and D are distinguished from the rest of the superfamily by the presence of a variable domain between the first and second conserved catalytic motifs. In subfamilies IA and IB, this domain consists of an alpha-helical bundle. It was necessary to model these two subfamilies separately, breaking them at a an apparent phylogenetic bifurcation, so that the resulting model(s) are not so broadly defined that members of subfamily III (which lack the variable domain) are included. Subfamily IA includes the enzyme phosphoserine phosphatase (TIGR00338) as well as three hypothetical equivalogs. Many members of these hypothetical equivalogs have been annotated as PSPase-like or PSPase-family proteins. In particular, the hypothetical equivalog which appears to be most closely related to PSPase contains only Archaea (while TIGR00338 contains only eukaryotes and bacteria) of which some are annotated as PSPases. Although this is a reasonable conjecture, none of these sequences has sufficient evidence for this assignment. If such should be found, this model should be retired while the PSPase model should be broadened to include these sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273653 [Multi-domain]  Cd Length: 177  Bit Score: 43.88  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   487 ILDVCSTIFLNGKESELTDKL--REDFNTAYLELggMGERVLGFCDFV-LPADKFPKGFKFDVEEVnfplknlrFVGLMS 563
Cdd:TIGR01488   3 IFDFDGTLTRQDSLIDLLAKLlgTNDEVIELTRL--APSGRISFEDALgRRLALLHRSRSEEVAKE--------FLARQV 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   564 MIDPPraaVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGI---ISDGTETVEDiAIRRGIPVEEVNP-REAKAAVIH 639
Cdd:TIGR01488  73 ALRPG---ARELISWLKERGIDTVIVSGGFDFFVEPVAEKLGIddvFANRLEFDDN-GLLTGPIEGQVNPeGECKGKVLK 148
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17559224   640 gSDLREMSEDqlaeiikyhseivfartspqqklmivegfqkQGQIVAVtGDGVNDSPALKKA 701
Cdd:TIGR01488 149 -ELLEESKIT-------------------------------LKKIIAV-GDSVNDLPMLKLA 177
HAD pfam12710
haloacid dehalogenase-like hydrolase;
574-657 6.83e-04

haloacid dehalogenase-like hydrolase;


Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 41.75  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224   574 DAVAKCRSAGIKVVMVTGDHPITAKAIAKSVG---IISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHGSDLREMSEDQ 650
Cdd:pfam12710  91 ELLAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRRLRAWLAARGLGLD 170

                  ....*..
gi 17559224   651 LAEIIKY 657
Cdd:pfam12710 171 LADSVAY 177
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
685-731 1.43e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.45  E-value: 1.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 17559224   685 VAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASI 731
Cdd:pfam08282 206 VIAFGDGENDIEMLEAAGLGVAMGNA-SPEVKAAADYVTDSNNEDGV 251
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
685-722 3.81e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 40.33  E-value: 3.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17559224   685 VAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMI 722
Cdd:TIGR00099 207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV 243
HAD_like cd01427
Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily ...
571-707 8.04e-03

Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others. This superfamily includes a variety of enzymes that catalyze the cleavage of substrate C-Cl, P-C, and P-OP bonds via nucleophilic substitution pathways. All of which use a nucleophilic aspartate in their phosphoryl transfer reaction. They catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. Members of this superfamily are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319763 [Multi-domain]  Cd Length: 106  Bit Score: 36.99  E-value: 8.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17559224 571 AVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIisdgTETVEDIAIRRGIPVEEVNPREAKAAVIHgsdlremsedq 650
Cdd:cd01427  11 LAVELLKRLRAAGIKLAIVTNRSREALRALLEKLGL----GDLFDGIIGSDGGGTPKPKPKPLLLLLLK----------- 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17559224 651 laeiikyhseivfARTSPQQKLMIvegfqkqgqivavtGDGVNDSPALKKA-DIGVAM 707
Cdd:cd01427  76 -------------LGVDPEEVLFV--------------GDSENDIEAARAAgGRTVAV 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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