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Conserved domains on  [gi|32567242|ref|NP_506302|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
21-322 1.45e-61

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 199.69  E-value: 1.45e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242    21 PDPYKSMMHFTHVLTIPLYLTAIYALINNCPKTLKEYRKYLLWHTLGNLLFELYISLFMLPVTYLPYPVFRGAGFLKYLD 100
Cdd:pfam10318   3 PDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   101 ISGLIQFYLLVICLIHTGLSILEMFKYRFNSTISDDTLNK----KVLNYIVMFFWVIVIIIPVFCFAtlprchPKQDHYK 176
Cdd:pfam10318  83 VPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITwkktRVLYLIFNYIIALLFLIPIYLNI------PDQEAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   177 QDLYDKNPGISIHVLCNTVVTAppLIDPVFTPLMTLIMMAMLLAATIIPQTFLTIWKKLDQLSKHLSKKTIQLQKMLLTS 256
Cdd:pfam10318 157 LKVLKKLPCLPPEFFDNPPVFV--LAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIA 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32567242   257 LFIQAVIHGVMLGAPLIGFIYAVVFVLPYNYIAYMLLLLISFHGSFSTIAMIAFTKPIREGVKSLF 322
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
21-322 1.45e-61

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 199.69  E-value: 1.45e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242    21 PDPYKSMMHFTHVLTIPLYLTAIYALINNCPKTLKEYRKYLLWHTLGNLLFELYISLFMLPVTYLPYPVFRGAGFLKYLD 100
Cdd:pfam10318   3 PDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   101 ISGLIQFYLLVICLIHTGLSILEMFKYRFNSTISDDTLNK----KVLNYIVMFFWVIVIIIPVFCFAtlprchPKQDHYK 176
Cdd:pfam10318  83 VPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITwkktRVLYLIFNYIIALLFLIPIYLNI------PDQEAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   177 QDLYDKNPGISIHVLCNTVVTAppLIDPVFTPLMTLIMMAMLLAATIIPQTFLTIWKKLDQLSKHLSKKTIQLQKMLLTS 256
Cdd:pfam10318 157 LKVLKKLPCLPPEFFDNPPVFV--LAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIA 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32567242   257 LFIQAVIHGVMLGAPLIGFIYAVVFVLPYNYIAYMLLLLISFHGSFSTIAMIAFTKPIREGVKSLF 322
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
21-322 1.45e-61

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 199.69  E-value: 1.45e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242    21 PDPYKSMMHFTHVLTIPLYLTAIYALINNCPKTLKEYRKYLLWHTLGNLLFELYISLFMLPVTYLPYPVFRGAGFLKYLD 100
Cdd:pfam10318   3 PDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   101 ISGLIQFYLLVICLIHTGLSILEMFKYRFNSTISDDTLNK----KVLNYIVMFFWVIVIIIPVFCFAtlprchPKQDHYK 176
Cdd:pfam10318  83 VPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITwkktRVLYLIFNYIIALLFLIPIYLNI------PDQEAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   177 QDLYDKNPGISIHVLCNTVVTAppLIDPVFTPLMTLIMMAMLLAATIIPQTFLTIWKKLDQLSKHLSKKTIQLQKMLLTS 256
Cdd:pfam10318 157 LKVLKKLPCLPPEFFDNPPVFV--LAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIA 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32567242   257 LFIQAVIHGVMLGAPLIGFIYAVVFVLPYNYIAYMLLLLISFHGSFSTIAMIAFTKPIREGVKSLF 322
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
29-315 1.91e-15

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 76.04  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242    29 HFTHVLTIPLYLTAIYALINNCPKtLKEYRKYLLWHTLGNLLFELYISLFMLPVTYLPYPVFRGAGFL-KYLDISG--LI 105
Cdd:pfam10327  16 HIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLaTVFGISShyLM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   106 QFYLLVICLIHTGLSILEMFKYRFNSTISDDTLNKKVLNYIVMFFWVIVIIIPVFCFATLPRCHPKQDHYKQDLY----- 180
Cdd:pfam10327  95 TIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEYVKENYpeyls 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   181 --DKNPGISIHVLcntvvtappliDPVFTPLMTLIMMAMLLAATIIPQTFLTIWKKLDQLSKHLSKKTIQLQKMLLTSLF 258
Cdd:pfam10327 175 qfSSLPNFAIYDY-----------NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAALRSLI 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   259 IQAVIHGVMLGAPligFIYAVVFVLPYNY---IAYMLLLLISFHGSFSTIAMIAFTKPIR 315
Cdd:pfam10327 244 AQFATSPVCILPP---FAFVVVVLFPIEYsqeISEILLAIFSTHSSVNSIVLILTTPPYR 300
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
33-319 2.39e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 57.56  E-value: 2.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242    33 VLTIPLYLTAIYALINNCPKTLKEYRkYLLWHTLGNLLFELYISLFM--------LPVTYLPYpvfrgaGFLKYL-DISG 103
Cdd:pfam10317  10 ILGLILNLLLLYLIIFKSPKSLKTYR-ILLLNTAITQIISCILAFFTqqriipngVSMALISY------GPCKYFgPWFC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   104 LIQFYLLVICLIHTGLSILEMFKYRFNSTISddtLNKKVLNYIVMFFWVIVIIIPVFCFATLPrchpKQDHYKQDLYDKN 183
Cdd:pfam10317  83 YSGYSLLQHFLLHSGWSLLLTFYYRYYILKH---VDPKRKKLILLIIIHYIPSLSQLIVIFLS----PTDFLPVEALTKE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   184 PGISIHVLCNTVVTapplIDPVFTPLMTLIMMAMLLAATIIPQTFLT----IWKKLDQLSKHLSKKTIQLQKMLLTSLFI 259
Cdd:pfam10317 156 LHPNYNLTDYTVTG----FSDLQSFPALINTLIMTIPVFPIPIIILIlrrkILKLLNSNSVNMSPTTKAQHRQLIKGLTI 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567242   260 QAVIHGVMLGAPLIGFIYAVVFVLPYNYIAYMLLLLISFHGSFSTIAMIAFTKPIREGVK 319
Cdd:pfam10317 232 QALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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