NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17557418|ref|NP_506362|]
View 

Baculoviral IAP repeat-containing protein bir-2 [Caenorhabditis elegans]

Protein Classification

baculoviral IAP repeat-containing protein( domain architecture ID 11261028)

baculoviral inhibition of apoptosis protein (IAP) repeat (BIR)-containing protein

CATH:  1.10.1170.10
Gene Ontology:  GO:0043027|GO:0043066|GO:0004869|GO:0046872|GO:0006915|GO:0051087|GO:0031267|GO:0046983|GO:0006468|GO:0051301
PubMed:  12042762|9990849|10404221|18439892|25542341|11032169
SCOP:  4003796

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 23-99 2.46e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


:

Pssm-ID: 197595  Cd Length: 71  Bit Score: 85.45  E-value: 2.46e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17557418     23 SAAERFASFKGFVYdkriNIACTSEKLARAGFYSTASPefpASAKCPFCMLEINF-EQCDDPWEKHKSGSPHCEFVMI 99
Cdd:smart00238   1 SEEARLKTFQNWPY----NSKCTPEQLAEAGFYYTGVG---DEVKCFFCGGELDNwEPGDDPWEEHKKWSPNCPFVRN 71
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 166-242 5.19e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


:

Pssm-ID: 197595  Cd Length: 71  Bit Score: 84.68  E-value: 5.19e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17557418    166 TFDHRLATFQNFIfdkkRNVKCTSKKLAKAGWFSIANKkdkTSAKCPFCLVELDFDE-SDDPWEEHQKFSASCDFIKL 242
Cdd:smart00238   1 SEEARLKTFQNWP----YNSKCTPEQLAEAGFYYTGVG---DEVKCFFCGGELDNWEpGDDPWEEHKKWSPNCPFVRN 71
 
Name Accession Description Interval E-value
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 23-99 2.46e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 85.45  E-value: 2.46e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17557418     23 SAAERFASFKGFVYdkriNIACTSEKLARAGFYSTASPefpASAKCPFCMLEINF-EQCDDPWEKHKSGSPHCEFVMI 99
Cdd:smart00238   1 SEEARLKTFQNWPY----NSKCTPEQLAEAGFYYTGVG---DEVKCFFCGGELDNwEPGDDPWEEHKKWSPNCPFVRN 71
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 166-242 5.19e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 84.68  E-value: 5.19e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17557418    166 TFDHRLATFQNFIfdkkRNVKCTSKKLAKAGWFSIANKkdkTSAKCPFCLVELDFDE-SDDPWEEHQKFSASCDFIKL 242
Cdd:smart00238   1 SEEARLKTFQNWP----YNSKCTPEQLAEAGFYYTGVG---DEVKCFFCGGELDNWEpGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 25-99 1.72e-18

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 78.08  E-value: 1.72e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17557418  25 AERFASFKGFVYDkrinIACTSEKLARAGFYSTASPefpASAKCPFCMLEI-NFEQCDDPWEKHKSGSPHCEFVMI 99
Cdd:cd00022   1 EARLKTFKNWPIS----LKVTPEKLAEAGFYYTGRG---DEVKCFFCGLELkNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 168-242 3.53e-18

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 76.92  E-value: 3.53e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17557418 168 DHRLATFQNFifdkKRNVKCTSKKLAKAGWFSIaNKKDKtsAKCPFCLVEL-DFDESDDPWEEHQKFSASCDFIKL 242
Cdd:cd00022   1 EARLKTFKNW----PISLKVTPEKLAEAGFYYT-GRGDE--VKCFFCGLELkNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 170-241 3.05e-17

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 74.62  E-value: 3.05e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17557418   170 RLATFQNFIFDKKRnvKCTSKKLAKAGWFSIAnKKDKtsAKCPFCLVELD-FDESDDPWEEHQKFSASCDFIK 241
Cdd:pfam00653   1 RLATFENWPHSNKS--PPTPEELAEAGFYYTG-TGDR--VQCFYCGLELDgWEEGDDPWEEHKKHSPDCPFLK 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 27-98 1.07e-15

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 70.38  E-value: 1.07e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17557418    27 RFASFKGFVYDKRINiaCTSEKLARAGFYSTASPEfpaSAKCPFCMLEI-NFEQCDDPWEKHKSGSPHCEFVM 98
Cdd:pfam00653   1 RLATFENWPHSNKSP--PTPEELAEAGFYYTGTGD---RVQCFYCGLELdGWEEGDDPWEEHKKHSPDCPFLK 68
 
Name Accession Description Interval E-value
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 23-99 2.46e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 85.45  E-value: 2.46e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17557418     23 SAAERFASFKGFVYdkriNIACTSEKLARAGFYSTASPefpASAKCPFCMLEINF-EQCDDPWEKHKSGSPHCEFVMI 99
Cdd:smart00238   1 SEEARLKTFQNWPY----NSKCTPEQLAEAGFYYTGVG---DEVKCFFCGGELDNwEPGDDPWEEHKKWSPNCPFVRN 71
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 166-242 5.19e-21

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 84.68  E-value: 5.19e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17557418    166 TFDHRLATFQNFIfdkkRNVKCTSKKLAKAGWFSIANKkdkTSAKCPFCLVELDFDE-SDDPWEEHQKFSASCDFIKL 242
Cdd:smart00238   1 SEEARLKTFQNWP----YNSKCTPEQLAEAGFYYTGVG---DEVKCFFCGGELDNWEpGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 25-99 1.72e-18

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 78.08  E-value: 1.72e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17557418  25 AERFASFKGFVYDkrinIACTSEKLARAGFYSTASPefpASAKCPFCMLEI-NFEQCDDPWEKHKSGSPHCEFVMI 99
Cdd:cd00022   1 EARLKTFKNWPIS----LKVTPEKLAEAGFYYTGRG---DEVKCFFCGLELkNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 168-242 3.53e-18

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 76.92  E-value: 3.53e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17557418 168 DHRLATFQNFifdkKRNVKCTSKKLAKAGWFSIaNKKDKtsAKCPFCLVEL-DFDESDDPWEEHQKFSASCDFIKL 242
Cdd:cd00022   1 EARLKTFKNW----PISLKVTPEKLAEAGFYYT-GRGDE--VKCFFCGLELkNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 170-241 3.05e-17

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 74.62  E-value: 3.05e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17557418   170 RLATFQNFIFDKKRnvKCTSKKLAKAGWFSIAnKKDKtsAKCPFCLVELD-FDESDDPWEEHQKFSASCDFIK 241
Cdd:pfam00653   1 RLATFENWPHSNKS--PPTPEELAEAGFYYTG-TGDR--VQCFYCGLELDgWEEGDDPWEEHKKHSPDCPFLK 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 27-98 1.07e-15

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 70.38  E-value: 1.07e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17557418    27 RFASFKGFVYDKRINiaCTSEKLARAGFYSTASPEfpaSAKCPFCMLEI-NFEQCDDPWEKHKSGSPHCEFVM 98
Cdd:pfam00653   1 RLATFENWPHSNKSP--PTPEELAEAGFYYTGTGD---RVQCFYCGLELdGWEEGDDPWEEHKKHSPDCPFLK 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH