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Conserved domains on  [gi|17557664|ref|NP_506447|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 8-252 1.15e-64

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 203.84  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664     8 QILAQKLSAPLSLGLNAILIQLILYKSPHEMGMYKYLLCYISVFEVIFAFLTVIMQPDFFSHSSVFLVIARKDRLNLPVS 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664    88 FIYIMNLMLCGMFGMSMAFFALHFIYRYLVITGHEWVKNVSFYKLTILIFAPIIYGALWMTIVVNTMKPTESSNKILMEY 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664   168 FLDCKNLTVDDINYVGPNYYETF-HGDPQLNWDALNGMLLLDIMVAFSVAIIIVFAIKCYKKVNILANsvQYSKAFRDLQ 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKS--LGSEKTRKLQ 238


                  ....*.
gi 17557664   247 SQLLRS 252
Cdd:pfam10326 239 KQLFKA 244
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-252 1.15e-64

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 203.84  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664     8 QILAQKLSAPLSLGLNAILIQLILYKSPHEMGMYKYLLCYISVFEVIFAFLTVIMQPDFFSHSSVFLVIARKDRLNLPVS 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664    88 FIYIMNLMLCGMFGMSMAFFALHFIYRYLVITGHEWVKNVSFYKLTILIFAPIIYGALWMTIVVNTMKPTESSNKILMEY 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664   168 FLDCKNLTVDDINYVGPNYYETF-HGDPQLNWDALNGMLLLDIMVAFSVAIIIVFAIKCYKKVNILANsvQYSKAFRDLQ 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKS--LGSEKTRKLQ 238


                  ....*.
gi 17557664   247 SQLLRS 252
Cdd:pfam10326 239 KQLFKA 244
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-252 1.15e-64

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 203.84  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664     8 QILAQKLSAPLSLGLNAILIQLILYKSPHEMGMYKYLLCYISVFEVIFAFLTVIMQPDFFSHSSVFLVIARKDRLNLPVS 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664    88 FIYIMNLMLCGMFGMSMAFFALHFIYRYLVITGHEWVKNVSFYKLTILIFAPIIYGALWMTIVVNTMKPTESSNKILMEY 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664   168 FLDCKNLTVDDINYVGPNYYETF-HGDPQLNWDALNGMLLLDIMVAFSVAIIIVFAIKCYKKVNILANsvQYSKAFRDLQ 246
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKS--LGSEKTRKLQ 238


                  ....*.
gi 17557664   247 SQLLRS 252
Cdd:pfam10326 239 KQLFKA 244
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 13-252 3.28e-23

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 95.77  E-value: 3.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664    13 KLSAPLSLGLNAILIQLILYKSPHEMGMYKYLLCYISVFEVIFAFLTVIMQPDFFSHSSVFLVIARKDRLNLPVSFIYIM 92
Cdd:pfam10319  12 KIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664    93 NLMLCGMFGMSMAFFALHFIYRYLVITGHEWVKNV-SFYKLTILIFAPIIYGALWMTIVVNTMKPTESSNKILMEYFLDC 171
Cdd:pfam10319  92 LSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYfRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRET 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664   172 KNLTVDDINYVGPNYYEtfhGDPQLNWDALNGMLLLDIMVAFSVAIIIVFAIKCYKKVNIlaNSVQYSKAFRDLQSQLLR 251
Cdd:pfam10319 172 YGVDSMDINMLGALYWE---ASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNK--MSVTMSKKTKRLQKQLLK 246


                  .
gi 17557664   252 S 252
Cdd:pfam10319 247 A 247
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 18-152 4.02e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 41.00  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17557664    18 LSLGLNAILIQLILYKSPHEMGMYKYLLCYISVFEVIFAFLTVIMQPDFFSHSSVFLVIArkdrlNLPVSFI------YI 91
Cdd:pfam10317  11 LGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALIS-----YGPCKYFgpwfcySG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17557664    92 MNLMLCGMFGMSMAFFaLHFIYRYLVITgHEWVKNVSFYKLTILIFAPIIYGALWMTIVVN 152
Cdd:pfam10317  86 YSLLQHFLLHSGWSLL-LTFYYRYYILK-HVDPKRKKLILLIIIHYIPSLSQLIVIFLSPT 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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