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Conserved domains on  [gi|115534724|ref|NP_506593|]
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Ground-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

MOLO1 domain-containing protein( domain architecture ID 711549)

MOLO1 (modulator of levamisole receptor-1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MOLO1 super family cl25453
Modulator of levamisole receptor-1; MOLO1 is a one-pass transmembrane protein that contains a ...
 21-152 1.06e-22

Modulator of levamisole receptor-1; MOLO1 is a one-pass transmembrane protein that contains a single extracellular globular domain. It is a positive regulator of levamisole-sensitive acetylcholine receptors in Caenorhabditis elegans, UniProtKB:Q19280. These receptors are Cys-loop ligand-gated ion channels, and the MOLO1 domain is an auxiliary subunit of the gated channel. The proteins carry a Rossmann fold.


The actual alignment was detected with superfamily member pfam17175:

Pssm-ID: 435767  Cd Length: 122  Bit Score: 89.78  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534724   21 YTPYTYPDSMTQSELCGQTKPSFFCDPNNII-ERKIKMINEtvesdddnfmekELLYIRGETNCSCTQQSLCSPSPRGYT 99
Cdd:pfam17175   1 WTVETYPNPRTNPSECGRKSPSYVCDPDHILtTEQRDRLND------------NLKELRSRTSCDKPFCDDRSPRPGGYV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 115534724  100 VSIAVVEKMHLDHNETSRelILQAAKIFADVIRDRQNRGQ--CDDDILIFLSTRD 152
Cdd:pfam17175  69 IGVAIVKRIESHYNQPSP--LLEDAEQFARYLRERWKLDNesCGDSVIIVYSKDD 121
 
Name Accession Description Interval E-value
MOLO1 pfam17175
Modulator of levamisole receptor-1; MOLO1 is a one-pass transmembrane protein that contains a ...
 21-152 1.06e-22

Modulator of levamisole receptor-1; MOLO1 is a one-pass transmembrane protein that contains a single extracellular globular domain. It is a positive regulator of levamisole-sensitive acetylcholine receptors in Caenorhabditis elegans, UniProtKB:Q19280. These receptors are Cys-loop ligand-gated ion channels, and the MOLO1 domain is an auxiliary subunit of the gated channel. The proteins carry a Rossmann fold.


Pssm-ID: 435767  Cd Length: 122  Bit Score: 89.78  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534724   21 YTPYTYPDSMTQSELCGQTKPSFFCDPNNII-ERKIKMINEtvesdddnfmekELLYIRGETNCSCTQQSLCSPSPRGYT 99
Cdd:pfam17175   1 WTVETYPNPRTNPSECGRKSPSYVCDPDHILtTEQRDRLND------------NLKELRSRTSCDKPFCDDRSPRPGGYV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 115534724  100 VSIAVVEKMHLDHNETSRelILQAAKIFADVIRDRQNRGQ--CDDDILIFLSTRD 152
Cdd:pfam17175  69 IGVAIVKRIESHYNQPSP--LLEDAEQFARYLRERWKLDNesCGDSVIIVYSKDD 121
 
Name Accession Description Interval E-value
MOLO1 pfam17175
Modulator of levamisole receptor-1; MOLO1 is a one-pass transmembrane protein that contains a ...
 21-152 1.06e-22

Modulator of levamisole receptor-1; MOLO1 is a one-pass transmembrane protein that contains a single extracellular globular domain. It is a positive regulator of levamisole-sensitive acetylcholine receptors in Caenorhabditis elegans, UniProtKB:Q19280. These receptors are Cys-loop ligand-gated ion channels, and the MOLO1 domain is an auxiliary subunit of the gated channel. The proteins carry a Rossmann fold.


Pssm-ID: 435767  Cd Length: 122  Bit Score: 89.78  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534724   21 YTPYTYPDSMTQSELCGQTKPSFFCDPNNII-ERKIKMINEtvesdddnfmekELLYIRGETNCSCTQQSLCSPSPRGYT 99
Cdd:pfam17175   1 WTVETYPNPRTNPSECGRKSPSYVCDPDHILtTEQRDRLND------------NLKELRSRTSCDKPFCDDRSPRPGGYV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 115534724  100 VSIAVVEKMHLDHNETSRelILQAAKIFADVIRDRQNRGQ--CDDDILIFLSTRD 152
Cdd:pfam17175  69 IGVAIVKRIESHYNQPSP--LLEDAEQFARYLRERWKLDNesCGDSVIIVYSKDD 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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