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Conserved domains on  [gi|17563720|ref|NP_506732|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-313 1.17e-100

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 298.99  E-value: 1.17e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    10 KTSTQIASVILSVFINSLLITLIITKSAKKMGNYRHLMIYFCCCSIMFSLMDIFIRPVIHTYESAFFMVMDLRGRDMSLD 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    90 LAGGMICAMAGCFGVIIYGIAIHFIYRYFALERNGRVKYFDTKFLPLWFMIPILGGVSWTLVSWFCFPMNPVTSGYIGPD 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   170 LYESFKLDINQSAYAAALFYPPDVNGKKLFNLKAGLGLILYLLIMAIPFFVVIYVGIKSVSKIKQLPS--SNYGKGLQMQ 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSlgSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563720   248 LHNALVAQTIIPVVFLFVPFGVLFICPIFEINCQFLATILTFVYAIYPVLDPLPIFFFVQNYRNAL 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-313 1.17e-100

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 298.99  E-value: 1.17e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    10 KTSTQIASVILSVFINSLLITLIITKSAKKMGNYRHLMIYFCCCSIMFSLMDIFIRPVIHTYESAFFMVMDLRGRDMSLD 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    90 LAGGMICAMAGCFGVIIYGIAIHFIYRYFALERNGRVKYFDTKFLPLWFMIPILGGVSWTLVSWFCFPMNPVTSGYIGPD 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   170 LYESFKLDINQSAYAAALFYPPDVNGKKLFNLKAGLGLILYLLIMAIPFFVVIYVGIKSVSKIKQLPS--SNYGKGLQMQ 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSlgSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563720   248 LHNALVAQTIIPVVFLFVPFGVLFICPIFEINCQFLATILTFVYAIYPVLDPLPIFFFVQNYRNAL 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-313 1.17e-100

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 298.99  E-value: 1.17e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    10 KTSTQIASVILSVFINSLLITLIITKSAKKMGNYRHLMIYFCCCSIMFSLMDIFIRPVIHTYESAFFMVMDLRGRDMSLD 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    90 LAGGMICAMAGCFGVIIYGIAIHFIYRYFALERNGRVKYFDTKFLPLWFMIPILGGVSWTLVSWFCFPMNPVTSGYIGPD 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   170 LYESFKLDINQSAYAAALFYPPDVNGKKLFNLKAGLGLILYLLIMAIPFFVVIYVGIKSVSKIKQLPS--SNYGKGLQMQ 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSlgSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563720   248 LHNALVAQTIIPVVFLFVPFGVLFICPIFEINCQFLATILTFVYAIYPVLDPLPIFFFVQNYRNAL 313
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 19-313 1.45e-32

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 123.12  E-value: 1.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    19 ILSVFINSLLITLIITKSAKKMGNYRHLMIYFCCCSIMFSLMDIFIRPVIHTYESAFFMVMDLRGRDMSLDLAGGMICAM 98
Cdd:pfam10319  16 VLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHALSAR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    99 AGCFGvIIYGI-AIHFIYRYFALERNGRV-KYFDTKFLPLWFMIPILGGVSWTLVSWFCFPMNPVTSGYIGPDLYESFKL 176
Cdd:pfam10319  96 CSFIS-ASYAVlLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   177 DINQSAYAAALFYppDVNGKKLFNLKAGLGLILYLLIMAIPFFVVIyvGIKSVSKIKQLPS--SNYGKGLQMQLHNALVA 254
Cdd:pfam10319 175 DSMDINMLGALYW--EASDETVFRSWLGILLLTVISVYSIILYIVL--GYKIMRKLNKMSVtmSKKTKRLQKQLLKALIV 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17563720   255 QTIIPVVFLFVPFGVLFICPIFEINC----QFLATILtfvYAIYPVLDPLPIFFFVQNYRNAL 313
Cdd:pfam10319 251 QTIIPICISFSPCVLAWYSPIFGIDLgrwnNYLEVIA---LSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 19-313 1.12e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 61.41  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    19 ILSVFINSLLITLIITKSAKKMGNYRHLMIYFCCCSIMFSLMDIFIRPVIHTYESAFFMVMDLRGRDMSLDLAGGMICAM 98
Cdd:pfam10317  10 ILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    99 AGCFGVIIYGIAIHFIYRYFALeRNGRVKYFDTKFLPLWFMIPILGgvswTLVSWFCFPMNPVTSGYIGPDLYESFKLDI 178
Cdd:pfam10317  90 QHFLLHSGWSLLLTFYYRYYIL-KHVDPKRKKLILLIIIHYIPSLS----QLIVIFLSPTDFLPVEALTKELHPNYNLTD 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   179 NQ-SAYAAALFYPPDVNgkklfnlkaglglilyLLIMAIPFFVVIYVGI----KSVSKIKQLPS--SNYGKGLQMQLHNA 251
Cdd:pfam10317 165 YTvTGFSDLQSFPALIN----------------TLIMTIPVFPIPIIILilrrKILKLLNSNSVnmSPTTKAQHRQLIKG 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17563720   252 LVAQTIIPVVFLFVPFGVLFICPIFEINCQFLATILTFVYAIYPVLDPLPIFFFVQNYRNAL 313
Cdd:pfam10317 229 LTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 7-319 1.06e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 43.30  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720     7 KTLKTSTQIASVIlSVFINSLLITLIITKSAKKMGNYRHLMIYFCCCSIMFSL-MDIFIRPVIHTYESAFFMVMDLRGRD 85
Cdd:pfam10318   4 DFLSTSLHIITVI-SIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLsLSFLTIPYIFLPALAGYPLGLLSYLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720    86 MSLDLaggMICAMAGCFGVIIYGIAIHFIYRYFALERNGRVKYFdTKFLPLWFMIPILGGVSWTLVSWFCFPmnpvtsgy 165
Cdd:pfam10318  83 VPTPI---QFYIGVTSLALVGVSIILLFENRYSILFTNKKRITW-KKTRVLYLIFNYIIALLFLIPIYLNIP-------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   166 igpdlyesfkldiNQSAYAAALF------YPPDVNGKKLF--NLKAGLGLILYLLIMAIPFFVVIYVGIKSVSKIKQLPS 237
Cdd:pfam10318 151 -------------DQEAAKLKVLkklpclPPEFFDNPPVFvlAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563720   238 SNYGKG---LQMQLHNALVAQTIIPVVFLFVPFGVLFICPIFEINCQFLATILTFVYAIYPVLDPLPIFFFVQNYRNALS 314
Cdd:pfam10318 218 SSLSKKtrkLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVL 297


                  ....*
gi 17563720   315 EWFSC 319
Cdd:pfam10318 298 SLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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