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Conserved domains on  [gi|72000396|ref|NP_506828|]
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Serpentine Receptor, class I [Caenorhabditis elegans]

Protein Classification

class I serpentine receptor( domain architecture ID 10563430)

class I serpentine receptor (Sri) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Gene Ontology:  GO:0016020
TCDB:  9.A.14

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
3-304 2.17e-114

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 313539  Cd Length: 303  Bit Score: 333.74  E-value: 2.17e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396     3 APCPATIPDGYLLTLDIIGGGSLSMNFLAMYMIWFQSPGMHGYKYCLTYMQFASFLVEFNLTVLVPAYYFFPLTGGIAVG 82
Cdd:pfam10327   1 MNIDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    83 EVVRKY-ISNHMGLTIWMFMFCFVLPASLSCFIYRHTAASQI-QNNASKFHLKKLVMILTHIFPFLTALGTWNCQMTFDQ 160
Cdd:pfam10327  81 FLATVFgISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKIlSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   161 KYEYVRKNYPQCLFWL-EFDRFEAYDYqvNPWIVRTACAAIGFLMISTCYGIWLGVHTMVILQRLRGHMSVQTYQMHLTA 239
Cdd:pfam10327 161 QLEYVKENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAA 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72000396   240 LISLGLQMATPTVFILPVYMFVAVIVTDAVDMQRIVSWAPCLMSTHSMLLVTVMIMSNASYRKVL 304
Cdd:pfam10327 239 LRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
3-304 2.17e-114

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 333.74  E-value: 2.17e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396     3 APCPATIPDGYLLTLDIIGGGSLSMNFLAMYMIWFQSPGMHGYKYCLTYMQFASFLVEFNLTVLVPAYYFFPLTGGIAVG 82
Cdd:pfam10327   1 MNIDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    83 EVVRKY-ISNHMGLTIWMFMFCFVLPASLSCFIYRHTAASQI-QNNASKFHLKKLVMILTHIFPFLTALGTWNCQMTFDQ 160
Cdd:pfam10327  81 FLATVFgISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKIlSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   161 KYEYVRKNYPQCLFWL-EFDRFEAYDYqvNPWIVRTACAAIGFLMISTCYGIWLGVHTMVILQRLRGHMSVQTYQMHLTA 239
Cdd:pfam10327 161 QLEYVKENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAA 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72000396   240 LISLGLQMATPTVFILPVYMFVAVIVTDAVDMQRIVSWAPCLMSTHSMLLVTVMIMSNASYRKVL 304
Cdd:pfam10327 239 LRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
3-304 2.17e-114

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 333.74  E-value: 2.17e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396     3 APCPATIPDGYLLTLDIIGGGSLSMNFLAMYMIWFQSPGMHGYKYCLTYMQFASFLVEFNLTVLVPAYYFFPLTGGIAVG 82
Cdd:pfam10327   1 MNIDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    83 EVVRKY-ISNHMGLTIWMFMFCFVLPASLSCFIYRHTAASQI-QNNASKFHLKKLVMILTHIFPFLTALGTWNCQMTFDQ 160
Cdd:pfam10327  81 FLATVFgISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKIlSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   161 KYEYVRKNYPQCLFWL-EFDRFEAYDYqvNPWIVRTACAAIGFLMISTCYGIWLGVHTMVILQRLRGHMSVQTYQMHLTA 239
Cdd:pfam10327 161 QLEYVKENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAA 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72000396   240 LISLGLQMATPTVFILPVYMFVAVIVTDAVDMQRIVSWAPCLMSTHSMLLVTVMIMSNASYRKVL 304
Cdd:pfam10327 239 LRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-309 5.11e-24

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 99.92  E-value: 5.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    10 PDGYLLTLDIIGGGSLSMNFLAMYMIWFQSPG-MHGYKYCLTYMQFASFLVEFNLTVLVPAYYFFPLTGGIAVGevVRKY 88
Cdd:pfam10318   3 PDFLSTSLHIITVISIPIHIFGFYCILFKTPKkMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLG--LLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    89 ISNHMGLTIWMFMFCF--VLPASLSCFIYRHTAASQIQNNASKFHLKKLVMILTHIFPFLTALGTWNcqMTFDQKY--EY 164
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLalVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYL--NIPDQEAakLK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   165 VRKNYPqCLFWLEFDRFEAYDYQVNPWIVRTACAAIGFLMISTCygIWLGVHT-MVILQRLRGHMSVQTYQMHLTALISL 243
Cdd:pfam10318 159 VLKKLP-CLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQI--LFFVFLTiYYLFKSVKSSLSKKTRKLQKKFFIAL 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72000396   244 GLQMATP-TVFILPVYMFVAVIVTDAVDmQRIVSWAPCLMSTHSMLLVTVMIMSNASYRKVLKDKIW 309
Cdd:pfam10318 236 IIQVSIPlIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
24-305 7.24e-05

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 43.98  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    24 SLSMNFLAMYMIWFQSPGMHG-YKYCLTYMQFASFL---VEFnltVLVPAYYFFplTGGIAVGEVVRKYISNHMGLTIWM 99
Cdd:pfam10326  12 SILLNSILIYLILFKSPKIFGtYKYLMIYFSIFGIFfsiLEF---IVKPFIHSY--NSSFIVFVDLKDLGLSKSVGQILL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   100 FMFCFVLPASLSC----FIYRHTAASQiQNNASKFHLKKLV--MILTHIFPFLTALGTWNCQMTFDQKYEYVRKNYPQ-- 171
Cdd:pfam10326  87 ALYCGFYGVSISLlavqFIYRYLALCR-PGKLKYFDGKKLIlwFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLEny 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   172 --------CLFWLEFDRFEAYDYQVNPWIVrtACAAIGFLMISTCYGIWL--GVHTMVILQRLRGHMSVQTYQMHLTALI 241
Cdd:pfam10326 166 nldidevaYVGPVYYPTDENGSKVIRWRSL--IGLLIMTFIIGISFSIIIycGIKMYFKMKKLKSLGSEKTRKLQKQLFK 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 72000396   242 SLGLQMATPTVFI-LPV-YMFVAVIVtdAVDMQRIVSWAPCLMSTHSML--LVTVMIMSNasYRKVLK 305
Cdd:pfam10326 244 ALVIQTLIPTILMyIPVgILFLLPLF--NIEIGFLSGIITATIALYPAIdpLPAMFIIKE--YRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
19-258 3.19e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 41.77  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    19 IIGGGSLSMNFLAMYMIWFQSP-GMHGYKYcltymqfasFLVEFNLTVLVPAYYFF-----PLTGGIAVGEVVR---KYI 89
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPkSLKTYRI---------LLLNTAITQIISCILAFftqqrIIPNGVSMALISYgpcKYF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396    90 SNHMGLTIWMFMFCFVLPASLS---CFIYRHTAASQIQNNASKFhlkKLVMILTHIFPFLTALGTWNCQMTFDQKYEYVR 166
Cdd:pfam10317  78 GPWFCYSGYSLLQHFLLHSGWSlllTFYYRYYILKHVDPKRKKL---ILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000396   167 KNYPQCLFwLEFDRFEAYDYQVNPWIVRTACAAIGFLMISTCYGIWLGVhTMVILQRLRGHMSVQTYQMHLTALISLGLQ 246
Cdd:pfam10317 155 ELHPNYNL-TDYTVTGFSDLQSFPALINTLIMTIPVFPIPIIILILRRK-ILKLLNSNSVNMSPTTKAQHRQLIKGLTIQ 232
                         250
                  ....*....|..
gi 72000396   247 MATPTVFILPVY 258
Cdd:pfam10317 233 ALLPLFSYIPGV 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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