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Conserved domains on  [gi|72000400|ref|NP_506830|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
2-302 1.58e-85

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 259.78  E-value: 1.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400     2 EAPHIFVHYVHAIIFVSLPVQLFSIYCILFETPKTMKSVKWSLLNARIWTVILDLSLTVLTIPFVIFPAIAGTPLGILtT 81
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLL-S 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400    82 WFGISTPFQIYFVMSTFFIVMVSHLMIMENRYYQLFA--EDTEWRHFRVPVIFFNFLITSTYMIPFMLRAPDQDEGIEIV 159
Cdd:pfam10318  80 YLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400   160 YQKVPSLSSEI-KNMKLFVLATDYNLFVVELVFMGAFLIFEMFSLTMLNRWNFKMtSTKCNLSRQTMMIQRKFLITIYTQ 238
Cdd:pfam10318 160 LKKLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFK-SVKSSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 72000400   239 FGVFSITCFVPYLYIVISCYLNYHNQSANNYTIVSFSFHGITSSMILLWTYNPYTKVVNAIFYR 302
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
2-302 1.58e-85

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 259.78  E-value: 1.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400     2 EAPHIFVHYVHAIIFVSLPVQLFSIYCILFETPKTMKSVKWSLLNARIWTVILDLSLTVLTIPFVIFPAIAGTPLGILtT 81
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLL-S 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400    82 WFGISTPFQIYFVMSTFFIVMVSHLMIMENRYYQLFA--EDTEWRHFRVPVIFFNFLITSTYMIPFMLRAPDQDEGIEIV 159
Cdd:pfam10318  80 YLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400   160 YQKVPSLSSEI-KNMKLFVLATDYNLFVVELVFMGAFLIFEMFSLTMLNRWNFKMtSTKCNLSRQTMMIQRKFLITIYTQ 238
Cdd:pfam10318 160 LKKLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFK-SVKSSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 72000400   239 FGVFSITCFVPYLYIVISCYLNYHNQSANNYTIVSFSFHGITSSMILLWTYNPYTKVVNAIFYR 302
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
2-302 1.58e-85

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 259.78  E-value: 1.58e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400     2 EAPHIFVHYVHAIIFVSLPVQLFSIYCILFETPKTMKSVKWSLLNARIWTVILDLSLTVLTIPFVIFPAIAGTPLGILtT 81
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLL-S 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400    82 WFGISTPFQIYFVMSTFFIVMVSHLMIMENRYYQLFA--EDTEWRHFRVPVIFFNFLITSTYMIPFMLRAPDQDEGIEIV 159
Cdd:pfam10318  80 YLGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400   160 YQKVPSLSSEI-KNMKLFVLATDYNLFVVELVFMGAFLIFEMFSLTMLNRWNFKMtSTKCNLSRQTMMIQRKFLITIYTQ 238
Cdd:pfam10318 160 LKKLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFK-SVKSSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 72000400   239 FGVFSITCFVPYLYIVISCYLNYHNQSANNYTIVSFSFHGITSSMILLWTYNPYTKVVNAIFYR 302
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
4-296 2.75e-19

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 86.44  E-value: 2.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400     4 PHIFVHYVHAIIFVSLPVQLFSIYCILFETPKtMKSVKWSLLNARIWTVILDLSLTVLTIPFVIFPAIAGTPLGILTTWF 83
Cdd:pfam10327   8 PFWLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400    84 GISTPFQIYFVMSTFFIVMVShLMIMENRYYQLFAEDTewRHFRVPVIFFNFLITSTYMIPFM------LRAPDQDEGIE 157
Cdd:pfam10327  87 GISSHYLMTIFVFLLSFQLES-LLLCFVRKHQAIAKIL--SKHVIPKWLYIFLYILCHIFPFLtaflfyQSGLSREEQLE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000400   158 IVYQKVPSLSSEIKNMKLFVLaTDYN---LFVVELVFMGAFLIFEMFSLTMLNrwNFKM-TSTKCNLSRQTMMIQRKFLI 233
Cdd:pfam10327 164 YVKENYPEYLSQFSSLPNFAI-YDYNpwlIVFGILAIFGGSLSFLILVYLTVD--MFRMlKRLRKKISAQTYQKHRAALR 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000400   234 TIYTQFGVFSITCFVPYLYIVISCYLNYHNQSANNYTIVSFSFHGITSSMILLWTYNPYTKVV 296
Cdd:pfam10327 241 SLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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