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Conserved domains on  [gi|392922179|ref|NP_506857|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 27-302 3.89e-51

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 170.71  E-value: 3.89e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179   27 KKSSSSMANYKYLMLISSFLKVFIGVLHFINQPKVHFYQASYVIY-SENPVGLPRAVSFWVLALDCAAFAMTLYLLAFHF 105
Cdd:pfam10326  25 FKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFvDLKDLGLSKSVGQILLALYCGFYGVSISLLAVQF 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  106 VYRYLADLKPDQLYFFTFPYSLIFTGIFSFMTLNWWLSAVFFAGESGSVDEYIGSNMLQKFNLTPVEFSYISSIFYKKNl 185
Cdd:pfam10326 105 IYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDIDEVAYVGPVYYPTD- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  186 QTGVEELSLHDFLLLINLMFIIDTGFLIIGYCWLKLQKVFSHTTKQylsLSKRTLEMQTQLFKCIVAQTLFPMFFLLIPS 265
Cdd:pfam10326 184 ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSL---GSEKTRKLQKQLFKALVIQTLIPTILMYIPV 260

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 392922179  266 GCILLFPLFKFEPGPVETIFLPMMGAQTVVDSMVPMY 302
Cdd:pfam10326 261 GILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMF 297
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 27-302 3.89e-51

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 170.71  E-value: 3.89e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179   27 KKSSSSMANYKYLMLISSFLKVFIGVLHFINQPKVHFYQASYVIY-SENPVGLPRAVSFWVLALDCAAFAMTLYLLAFHF 105
Cdd:pfam10326  25 FKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFvDLKDLGLSKSVGQILLALYCGFYGVSISLLAVQF 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  106 VYRYLADLKPDQLYFFTFPYSLIFTGIFSFMTLNWWLSAVFFAGESGSVDEYIGSNMLQKFNLTPVEFSYISSIFYKKNl 185
Cdd:pfam10326 105 IYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDIDEVAYVGPVYYPTD- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  186 QTGVEELSLHDFLLLINLMFIIDTGFLIIGYCWLKLQKVFSHTTKQylsLSKRTLEMQTQLFKCIVAQTLFPMFFLLIPS 265
Cdd:pfam10326 184 ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSL---GSEKTRKLQKQLFKALVIQTLIPTILMYIPV 260

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 392922179  266 GCILLFPLFKFEPGPVETIFLPMMGAQTVVDSMVPMY 302
Cdd:pfam10326 261 GILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMF 297
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 27-302 3.89e-51

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 170.71  E-value: 3.89e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179   27 KKSSSSMANYKYLMLISSFLKVFIGVLHFINQPKVHFYQASYVIY-SENPVGLPRAVSFWVLALDCAAFAMTLYLLAFHF 105
Cdd:pfam10326  25 FKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFvDLKDLGLSKSVGQILLALYCGFYGVSISLLAVQF 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  106 VYRYLADLKPDQLYFFTFPYSLIFTGIFSFMTLNWWLSAVFFAGESGSVDEYIGSNMLQKFNLTPVEFSYISSIFYKKNl 185
Cdd:pfam10326 105 IYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDIDEVAYVGPVYYPTD- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  186 QTGVEELSLHDFLLLINLMFIIDTGFLIIGYCWLKLQKVFSHTTKQylsLSKRTLEMQTQLFKCIVAQTLFPMFFLLIPS 265
Cdd:pfam10326 184 ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSL---GSEKTRKLQKQLFKALVIQTLIPTILMYIPV 260

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 392922179  266 GCILLFPLFKFEPGPVETIFLPMMGAQTVVDSMVPMY 302
Cdd:pfam10326 261 GILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMF 297
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 27-264 7.62e-13

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 67.65  E-value: 7.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179   27 KKSSSSMANYKYLMLISSFLKVFIGVLHFINQPKVHFYQASYVIY-SENPVGLPRAVSFWVLALDCAAFAMTLYLLAFHF 105
Cdd:pfam10319  31 TEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFvSDGPFFEYSELGQHALSARCSFISASYAVLLIHF 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  106 VYRYLADLKPDQLYFFTFPYSLIFTGIFSFM-TLNWWLSAVFFAGESGSVDEYIGSNMLQKFNLTPVEFSYISSIFYkkN 184
Cdd:pfam10319 111 IYRYLVLFNPQLTRHYFRPWGILISILFFLFhGSVWTAICYFLLRANDEIRDYIREDFRETYGVDSMDINMLGALYW--E 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  185 LQTGVEELSLHDFLLLINLMFIIDTGFLIIGYcwlklqKVFSHTTKQYLSLSKRTLEMQTQLFKCIVAQTLFPMFFLLIP 264
Cdd:pfam10319 189 ASDETVFRSWLGILLLTVISVYSIILYIVLGY------KIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSP 262
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 27-276 1.01e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 43.30  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179   27 KKSSSSMANYKYLMLI----SSFLKVFIGvlhFINQPKVHF-YQASYVIYSENPVGLPRAVSFWVLALDCAAFAMTLYLL 101
Cdd:pfam10318  30 FKTPKKMKSVKWSLLNlhfwSALLDLSLS---FLTIPYIFLpALAGYPLGLLSYLGVPTPIQFYIGVTSLALVGVSIILL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  102 afhFVYRYLAdLKPDQLYFFTFPYSLIFTGIFSFMTLNWWLSAVFFAGESgsvdEYIGSNMLQKFNLTPVEFSYISSIFY 181
Cdd:pfam10318 107 ---FENRYSI-LFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQ----EAAKLKVLKKLPCLPPEFFDNPPVFV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  182 KknlqtgVEELSLHDFLLLINLMFIIDTGFLIIGYCWLKLQKVFSHTtkqylsLSKRTLEMQTQLFKCIVAQTLFPMFFL 261
Cdd:pfam10318 179 L------AIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSS------LSKKTRKLQKKFFIALIIQVSIPLIVI 246

                         250
                  ....*....|....*
gi 392922179  262 LIPSGCILLFPLFKF 276
Cdd:pfam10318 247 LIPLIYILFSIIFGY 261
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 25-306 1.33e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 39.84  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179   25 IIKKSSSSMANYKYLMLISSFLKVFIGVLHFINQPKVHFYQASYVIYSENPVG-LPRAVSFWVLALDCAAFAMTLYLLAF 103
Cdd:pfam10317  23 IIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKyFGPWFCYSGYSLLQHFLLHSGWSLLL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  104 HFVYRYLA----DLKPDQLYFFTFPYSLIFtgiFSFMTLNWWLSAVFFAGESGSVDEYIgsnmlqKFNLTPVEFSYISSI 179
Cdd:pfam10317 103 TFYYRYYIlkhvDPKRKKLILLIIIHYIPS---LSQLIVIFLSPTDFLPVEALTKELHP------NYNLTDYTVTGFSDL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922179  180 FYkknlqtgveelslhdFLLLIN--LMFIIDTGFLIIGYCWLKlqKVFSHTTKQYLSLSKRTLEMQTQLFKCIVAQTLFP 257
Cdd:pfam10317 174 QS---------------FPALINtlIMTIPVFPIPIIILILRR--KILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLP 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 392922179  258 MFFLLIPSGCILLFPLFKFEPGPVETIFLPMMGAQTVVDSMVPMYQVVP 306
Cdd:pfam10317 237 LFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTP 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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