NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|212646657|ref|NP_506908|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-317 1.30e-105

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 311.31  E-value: 1.30e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   10 THNAEIIGFFLSLTLNFILLFLISEMPKKTFGSYKYLMFSFSVLGIYYSCCAFWSNPNVHITEWSFIVFNVQKYTTLTKP 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   90 IGTIAIGMYCSCYGMMLSLLTIHFYYRYLSVTCPSQLSRFSAKFVPIWAIIVVTNSSVWFFTSYHLNGPSQLKDLHVYPE 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657  170 FLKSYCLKPDDFAYASAQYFYEDHVSEgVKFHFLSLFATGVMAAIMVFTLSAIFYFGIQTYIHLYRLSSIAGLDNRELQN 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212646657  250 QLFRTLVVQTVIPFFFMYFPVSCMILLPLFGIKVKEIGNIAPIFAAIYPCFEPLVAMFIIKNFRYRII 317
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-317 1.30e-105

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 311.31  E-value: 1.30e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   10 THNAEIIGFFLSLTLNFILLFLISEMPKKTFGSYKYLMFSFSVLGIYYSCCAFWSNPNVHITEWSFIVFNVQKYTTLTKP 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   90 IGTIAIGMYCSCYGMMLSLLTIHFYYRYLSVTCPSQLSRFSAKFVPIWAIIVVTNSSVWFFTSYHLNGPSQLKDLHVYPE 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657  170 FLKSYCLKPDDFAYASAQYFYEDHVSEgVKFHFLSLFATGVMAAIMVFTLSAIFYFGIQTYIHLYRLSSIAGLDNRELQN 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212646657  250 QLFRTLVVQTVIPFFFMYFPVSCMILLPLFGIKVKEIGNIAPIFAAIYPCFEPLVAMFIIKNFRYRII 317
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-317 1.30e-105

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 311.31  E-value: 1.30e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   10 THNAEIIGFFLSLTLNFILLFLISEMPKKTFGSYKYLMFSFSVLGIYYSCCAFWSNPNVHITEWSFIVFNVQKYTTLTKP 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   90 IGTIAIGMYCSCYGMMLSLLTIHFYYRYLSVTCPSQLSRFSAKFVPIWAIIVVTNSSVWFFTSYHLNGPSQLKDLHVYPE 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657  170 FLKSYCLKPDDFAYASAQYFYEDHVSEgVKFHFLSLFATGVMAAIMVFTLSAIFYFGIQTYIHLYRLSSIAGLDNRELQN 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212646657  250 QLFRTLVVQTVIPFFFMYFPVSCMILLPLFGIKVKEIGNIAPIFAAIYPCFEPLVAMFIIKNFRYRII 317
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-316 1.61e-35

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 130.83  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   11 HNAEIIGFFLSLTLNFILLFLISEMPKKTFGSYKYLMFSFSVLGIYYSCCAFWSNPNVHITEWSFIVFNVQKYTTLTKPI 90
Cdd:pfam10319   8 YYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   91 GTIAIGMYCSCYGMMLSLLTIHFYYRYLSVTCPSQLSRFsakFVPIW----AIIVVTNSSVWFFTSYHLNGPSQLKDLHV 166
Cdd:pfam10319  88 GQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHY---FRPWGilisILFFLFHGSVWTAICYFLLRANDEIRDYI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657  167 YPEFLKSYCLKPDDFAYASAQYFYedhVSEGVKFhfLSLFATGVMAAIMVFTLSAIFYFGIQTYIHLYRLSSIAGLDNRE 246
Cdd:pfam10319 165 REDFRETYGVDSMDINMLGALYWE---ASDETVF--RSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKR 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212646657  247 LQNQLFRTLVVQTVIPFFFMYFPvsCMI--LLPLFGIKVKE-IGNIAPIFAAIYPCFEPLVAMFIIKNFRYRI 316
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSP--CVLawYSPIFGIDLGRwNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 18-317 3.65e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 54.09  E-value: 3.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   18 FFLSLTLNFILLFLISEMPKKTFGSYKYLMFSFSVLGIYYSCCAFWSNPNVHITEWSFIVFNVQKYTTLTKPIGTIAIGM 97
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657   98 YCSCYGMMLSLLTIHFYYRYLSVTCPS-QLSRFSAKFVPIWAIIVVTNSSVWFFTSYHLNGPSQLKDLHVypeflksycl 176
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHVDpKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHP---------- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657  177 kpddfayasaQYFYEDHVSEGVK--FHFLSLFATGVMAAIMVFTLSAIFYFGIQTYIHLYRLSSIAGLDNRELQNQLFRT 254
Cdd:pfam10317 159 ----------NYNLTDYTVTGFSdlQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKG 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212646657  255 LVVQTVIPFFFmYFPVSCMILLPLFGIKVKEI-GNIAPIFAAIYPCFEPLVAMFIIKNFRYRII 317
Cdd:pfam10317 229 LTIQALLPLFS-YIPGVTLYLLSQLTGTEFLIlEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 210-322 6.66e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 44.07  E-value: 6.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212646657  210 VMAAIMVFTLSAIFYFGIQTYIHLY-RLSSIAGLDNRELQNQLFRTLVVQTVIPFFFMYFPVSCMILLPLFGIKVKEIGN 288
Cdd:pfam10318 189 CIVLLILILIIQILFFVFLTIYYLFkSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNN 268

                          90       100       110
                  ....*....|....*....|....*....|....
gi 212646657  289 IAPIFAAIYPCFEPLVAMFIIKNFRYRIIGLLTC 322
Cdd:pfam10318 269 LLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH