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Conserved domains on  [gi|71999901|ref|NP_506962|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
11-314 1.18e-92

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 278.27  E-value: 1.18e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    11 SPRGYSTIFYVISGISFPIHLFGSYCILFQTSATMKSVKWTLFNLHFWSAALDLSISFLAQPFFCTPTMAAFPLGVLSLI 90
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    91 GVPNDLLMLSIYTIFMLVPVSIISMFENRYFVLFVN--RGCWRYFRYPFLVANYIIVITYCFIIYLEIPDQEIAIKKLFK 168
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNkkRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   169 KYPRFYNFEIPVSSFIVISDEDRsWQKLRRISVISFILLEIIVFGILLRVKLKLSMKKiasSISSKTLQMQKRFIKALNL 248
Cdd:pfam10318 162 KLPCLPPEFFDNPPVFVLAIDST-YFLICIVLLILILIIQILFFVFLTIYYLFKSVKS---SLSKKTRKLQKKFFIALII 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71999901   249 QIAIPLIVIFVPIIAGMIFKALSIVNpQAFSNLLNFYFSLHGVLSTILMLYLQNPYREAVLSIFCC 314
Cdd:pfam10318 238 QVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
11-314 1.18e-92

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 278.27  E-value: 1.18e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    11 SPRGYSTIFYVISGISFPIHLFGSYCILFQTSATMKSVKWTLFNLHFWSAALDLSISFLAQPFFCTPTMAAFPLGVLSLI 90
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    91 GVPNDLLMLSIYTIFMLVPVSIISMFENRYFVLFVN--RGCWRYFRYPFLVANYIIVITYCFIIYLEIPDQEIAIKKLFK 168
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNkkRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   169 KYPRFYNFEIPVSSFIVISDEDRsWQKLRRISVISFILLEIIVFGILLRVKLKLSMKKiasSISSKTLQMQKRFIKALNL 248
Cdd:pfam10318 162 KLPCLPPEFFDNPPVFVLAIDST-YFLICIVLLILILIIQILFFVFLTIYYLFKSVKS---SLSKKTRKLQKKFFIALII 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71999901   249 QIAIPLIVIFVPIIAGMIFKALSIVNpQAFSNLLNFYFSLHGVLSTILMLYLQNPYREAVLSIFCC 314
Cdd:pfam10318 238 QVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
11-314 1.18e-92

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 278.27  E-value: 1.18e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    11 SPRGYSTIFYVISGISFPIHLFGSYCILFQTSATMKSVKWTLFNLHFWSAALDLSISFLAQPFFCTPTMAAFPLGVLSLI 90
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    91 GVPNDLLMLSIYTIFMLVPVSIISMFENRYFVLFVN--RGCWRYFRYPFLVANYIIVITYCFIIYLEIPDQEIAIKKLFK 168
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNkkRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   169 KYPRFYNFEIPVSSFIVISDEDRsWQKLRRISVISFILLEIIVFGILLRVKLKLSMKKiasSISSKTLQMQKRFIKALNL 248
Cdd:pfam10318 162 KLPCLPPEFFDNPPVFVLAIDST-YFLICIVLLILILIIQILFFVFLTIYYLFKSVKS---SLSKKTRKLQKKFFIALII 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71999901   249 QIAIPLIVIFVPIIAGMIFKALSIVNpQAFSNLLNFYFSLHGVLSTILMLYLQNPYREAVLSIFCC 314
Cdd:pfam10318 238 QVSIPLIVILIPLIYILFSIIFGYYN-QALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
12-305 7.29e-17

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 79.51  E-value: 7.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    12 PRGYSTIFYVISGISFPIHLFGSYCILFQtSATMKSVKWTLFNLHFWSAALDLSISFLAQPFFCTPTMAAFPLGVLSLI- 90
Cdd:pfam10327   8 PFWLILYYHIIGTISLILNLLGIYLIIFK-SGKIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVf 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    91 GVPNDLLMLSIYTIFMLVPVSIISMFENRYFVL--FVNRGCWRYFRYPFLVANYIIVI-TYCFIIYLEIPDQEIAIKKLF 167
Cdd:pfam10327  87 GISSHYLMTIFVFLLSFQLESLLLCFVRKHQAIakILSKHVIPKWLYIFLYILCHIFPfLTAFLFYQSGLSREEQLEYVK 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   168 KKYPRFY-------NFEIPVSSFIVIsdedrswqklRRISVISFILLEIIVFGILLRVKLKLSMKKIASSISSKTLQMQK 240
Cdd:pfam10327 167 ENYPEYLsqfsslpNFAIYDYNPWLI----------VFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHR 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71999901   241 RFIKALNLQIAIPLIVIFVPIIAGMIFkALSIVNPQAFSNLLNFYFSLHGVLSTILMLYLQNPYR 305
Cdd:pfam10327 237 AALRSLIAQFATSPVCILPPFAFVVVV-LFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYR 300
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
15-309 6.43e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 59.10  E-value: 6.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    15 YSTIFYVISGISFPIHLFGSYCILFQTSATMKSVKWTLFNlhfwSAALDLSISFLAqpFFCTP-------TMAAFPLGVL 87
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLN----TAITQIISCILA--FFTQQriipngvSMALISYGPC 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    88 SLIGVPNDLLMLSIYTIFMLVPV-SIISMFENRYFVLFVNR-GCWRYFRYPFLVanYIIVITYCFIIYLeIPDQEIAIKK 165
Cdd:pfam10317  75 KYFGPWFCYSGYSLLQHFLLHSGwSLLLTFYYRYYILKHVDpKRKKLILLIIIH--YIPSLSQLIVIFL-SPTDFLPVEA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   166 LFKKYPRFYNFEIpvSSFIVISDEdRSWQKLRRISVISFILLEIIVFGILLRVKLKLSMKKIASSISSKTLQMQKRFIKA 245
Cdd:pfam10317 152 LTKELHPNYNLTD--YTVTGFSDL-QSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKG 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71999901   246 LNLQIAIPLIvIFVPIIAGMIFKALSIVNPQAFSNLLNFYFSLHGVLSTILMLYLQNPYREAVL 309
Cdd:pfam10317 229 LTIQALLPLF-SYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
97-309 2.80e-05

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 45.14  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901    97 LMLSIYTIFMLVPVSIISM-FENRYFVLFvNRGCWRYFRYPFLVANYIIVI----TYCFIIYLEIPDQEIAIKKLFKKYP 171
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVqFIYRYLALC-RPGKLKYFDGKKLILWFLYPLifgaIWGLLVYFFLGPDEETDEYLREELL 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   172 RFYNFEIPVSSFIVI----SDEDRSWqKLRRISVISFILLE---------IIVFGIllrvKLKLSMKKIASSISSKTLQM 238
Cdd:pfam10326 163 ENYNLDIDEVAYVGPvyypTDENGSK-VIRWRSLIGLLIMTfiigisfsiIIYCGI----KMYFKMKKLKSLGSEKTRKL 237
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71999901   239 QKRFIKALNLQIAIPLIVIFVPIIAGMIFKALSIVNpQAFSNLLNFYFSLHGVLSTILMLYLQNPYREAVL 309
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEI-GFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
112-260 6.46e-04

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 41.07  E-value: 6.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   112 IISMFENRYFVLFVNRGCWRYFRYPFLVANYIIVITY----CFIIYLEI-PDQEIA--IKKLFKKYPRF--YNFEIPVSS 182
Cdd:pfam10319 106 LLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHgsvwTAICYFLLrANDEIRdyIREDFRETYGVdsMDINMLGAL 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999901   183 FIVISDE--DRSWQKLRRISVISFI-LLEIIVFGILLRVKLKlsmkKIASSISSKTLQMQKRFIKALNLQIAIPLIVIFV 259
Cdd:pfam10319 186 YWEASDEtvFRSWLGILLLTVISVYsIILYIVLGYKIMRKLN----KMSVTMSKKTKRLQKQLLKALIVQTIIPICISFS 261

                  .
gi 71999901   260 P 260
Cdd:pfam10319 262 P 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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