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Conserved domains on  [gi|17560206|ref|NP_507149|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-312 4.64e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 264.32  E-value: 4.64e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206     7 TISFTSAGLVICFITNFILIYITLFHSKRIYGTYKLMVVMFSALGFLFSVSEFIARPFTLNYNRAVILFSI-NDWILSKN 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDlKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    86 FLSIALSFWITFYLLIISLVGVQFVYRYLYIFHSTKLWYFDGVGRALWISYLLIPTIVYSVAFNQIFTPTNASDDYLREV 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206   166 IRKNFDFEISSVARFIMMPY----NENNTIQWKALSLLISAGILICFQYFIFVFFGLKIYFNMKLRLKSFSACQEKFQSQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17560206   242 LFKALVAQTIGPTIFLILPSAPFFVTTLLspytNMEINWQTGWLCSFFELYPISDNIAFMLIVSEYRNYIK 312
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLF----NIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-312 4.64e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 264.32  E-value: 4.64e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206     7 TISFTSAGLVICFITNFILIYITLFHSKRIYGTYKLMVVMFSALGFLFSVSEFIARPFTLNYNRAVILFSI-NDWILSKN 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDlKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    86 FLSIALSFWITFYLLIISLVGVQFVYRYLYIFHSTKLWYFDGVGRALWISYLLIPTIVYSVAFNQIFTPTNASDDYLREV 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206   166 IRKNFDFEISSVARFIMMPY----NENNTIQWKALSLLISAGILICFQYFIFVFFGLKIYFNMKLRLKSFSACQEKFQSQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17560206   242 LFKALVAQTIGPTIFLILPSAPFFVTTLLspytNMEINWQTGWLCSFFELYPISDNIAFMLIVSEYRNYIK 312
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLF----NIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-312 4.64e-87

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 264.32  E-value: 4.64e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206     7 TISFTSAGLVICFITNFILIYITLFHSKRIYGTYKLMVVMFSALGFLFSVSEFIARPFTLNYNRAVILFSI-NDWILSKN 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDlKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    86 FLSIALSFWITFYLLIISLVGVQFVYRYLYIFHSTKLWYFDGVGRALWISYLLIPTIVYSVAFNQIFTPTNASDDYLREV 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206   166 IRKNFDFEISSVARFIMMPY----NENNTIQWKALSLLISAGILICFQYFIFVFFGLKIYFNMKLRLKSFSACQEKFQSQ 241
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17560206   242 LFKALVAQTIGPTIFLILPSAPFFVTTLLspytNMEINWQTGWLCSFFELYPISDNIAFMLIVSEYRNYIK 312
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLF----NIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 19-311 8.59e-16

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 76.90  E-value: 8.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    19 FITNFILIYITLFHSKRIYGTYKLMVVMFSALGFLFSVSEFIARPFTLNYNRAVILFSINDWIL-SKNFLSIALSFWITF 97
Cdd:pfam10319  19 FIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFeYSELGQHALSARCSF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    98 YLLIISLVGVQFVYRYLYIFHSTKL-WYFDGVGRALWISYLLIPTIVYSVAFNQIFTPTNASDDYLREVIRKNFDFEISS 176
Cdd:pfam10319  99 ISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDSMD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206   177 VARFIMMPYNENNTIQWKALSLLISAGILICFQYFIFVFFGLKIYFNMKLRLKSFSACQEKFQSQLFKALVAQTIGPTIF 256
Cdd:pfam10319 179 INMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICI 258

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206   257 LILPsapffvtTLLSPYTNMeINWQTGWLCSFFE-----LYPISDNIAFMLIVSEYRNYI 311
Cdd:pfam10319 259 SFSP-------CVLAWYSPI-FGIDLGRWNNYLEvialsAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 16-312 1.95e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 42.54  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    16 VICFITNFILIYITLFHSKRIYGTYKLMVVMFSALGFLFSVSEFIARPFTLNYNRAVILFSINDW-ILSKNFLSIALSFW 94
Cdd:pfam10317  10 ILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCkYFGPWFCYSGYSLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206    95 ITFYLLIISLVGVQFVYRYLYIFHSTKLWyfdgvgRALWISYLLIPTIVYSVAFNQIFTPTNASDDYLREVIRK-NFDFE 173
Cdd:pfam10317  90 QHFLLHSGWSLLLTFYYRYYILKHVDPKR------KKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHpNYNLT 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560206   174 ISSVARFImmpynenNTIQWKALSLLISAGILICFQYFIFVFFGLKIYFNMKLRLKSFSACQEKFQSQLFKALVAQTIGP 253
Cdd:pfam10317 164 DYTVTGFS-------DLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17560206   254 TIFLIlpsaPFFVTTLLSPYTNMEINWQTGWLCSFFELYPISDNIAFMLIVSEYRNYIK 312
Cdd:pfam10317 237 LFSYI----PGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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