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Conserved domains on  [gi|17564466|ref|NP_507246|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
14-310 1.30e-99

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 295.61  E-value: 1.30e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    14 TADFQQTVLHAISVISVPVYVYGFYCVLLKTPPTMQSVKWSMMNVHVFSCIFDLSLSFFTTPYVLFPVLAGYPLGVLKEI 93
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    94 GVSVEAQVYFVVLVGAYMMVAISIVFENRLFVLVMTNKM--LHKFALPIYIIHYIF-PTIVLPSLVKLPDQQTGKANFLL 170
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRitWKKTRVLYLIFNYIIaLLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466   171 KYGCVPPYV-DLERVFYLIITKRYFLITCAVFICTMFAEVWFFALVTDRLLKKQMTKTMSQKTFDLHKKFQRAFILQLLI 249
Cdd:pfam10318 162 KLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17564466   250 PFIIVFLPISYIGVTCISEYHNQFFNNLTLIIISSHGFFSTIAMIALHAPYREFTQKIFPC 310
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
14-310 1.30e-99

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 295.61  E-value: 1.30e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    14 TADFQQTVLHAISVISVPVYVYGFYCVLLKTPPTMQSVKWSMMNVHVFSCIFDLSLSFFTTPYVLFPVLAGYPLGVLKEI 93
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    94 GVSVEAQVYFVVLVGAYMMVAISIVFENRLFVLVMTNKM--LHKFALPIYIIHYIF-PTIVLPSLVKLPDQQTGKANFLL 170
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRitWKKTRVLYLIFNYIIaLLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466   171 KYGCVPPYV-DLERVFYLIITKRYFLITCAVFICTMFAEVWFFALVTDRLLKKQMTKTMSQKTFDLHKKFQRAFILQLLI 249
Cdd:pfam10318 162 KLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17564466   250 PFIIVFLPISYIGVTCISEYHNQFFNNLTLIIISSHGFFSTIAMIALHAPYREFTQKIFPC 310
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
14-310 1.30e-99

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 295.61  E-value: 1.30e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    14 TADFQQTVLHAISVISVPVYVYGFYCVLLKTPPTMQSVKWSMMNVHVFSCIFDLSLSFFTTPYVLFPVLAGYPLGVLKEI 93
Cdd:pfam10318   2 SPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    94 GVSVEAQVYFVVLVGAYMMVAISIVFENRLFVLVMTNKM--LHKFALPIYIIHYIF-PTIVLPSLVKLPDQQTGKANFLL 170
Cdd:pfam10318  82 GVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRitWKKTRVLYLIFNYIIaLLFLIPIYLNIPDQEAAKLKVLK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466   171 KYGCVPPYV-DLERVFYLIITKRYFLITCAVFICTMFAEVWFFALVTDRLLKKQMTKTMSQKTFDLHKKFQRAFILQLLI 249
Cdd:pfam10318 162 KLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17564466   250 PFIIVFLPISYIGVTCISEYHNQFFNNLTLIIISSHGFFSTIAMIALHAPYREFTQKIFPC 310
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
22-303 8.83e-14

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 70.65  E-value: 8.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466    22 LHAISVISVPVYVYGFYCVLLKTPpTMQSVKWSMMNVHVFSCIFDLSLSFFTTPYVLFPVLAGYPLGVLKEI-GVSVEAQ 100
Cdd:pfam10327  15 YHIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLATVfGISSHYL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466   101 VYFVVLVGAYMMVAISIVFENRLFVlVMTNKMLHKFALPIYIIHYIFpTIVLPSLVKLPDQQTG-KANFLLKY------G 173
Cdd:pfam10327  94 MTIFVFLLSFQLESLLLCFVRKHQA-IAKILSKHVIPKWLYIFLYIL-CHIFPFLTAFLFYQSGlSREEQLEYvkenypE 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466   174 CVPPYVDLERvFYLIITKRYFLITCAVFICTMFAEVWFFALVTDRLLK--KQMTKTMSQKTFDLHKKFQRAFILQLLIPF 251
Cdd:pfam10327 172 YLSQFSSLPN-FAIYDYNPWLIVFGILAIFGGSLSFLILVYLTVDMFRmlKRLRKKISAQTYQKHRAALRSLIAQFATSP 250
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 17564466   252 IIVFLPISYIGVTCISEYHNQFFNNLTLIIISSHGFFSTIAMIALHAPYREF 303
Cdd:pfam10327 251 VCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKF 302
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
193-283 1.19e-05

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 46.29  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564466   193 YFLITCAVFICTMFAEVWFFALVTDRLLKKQMtKTMSQKTFDLHKKFQRAFILQLLIPFIIVFLPISYIGVTCISEYHNQ 272
Cdd:pfam10326 196 IGLLIMTFIIGISFSIIIYCGIKMYFKMKKLK-SLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIG 274
                          90
                  ....*....|.
gi 17564466   273 FFNNLTLIIIS 283
Cdd:pfam10326 275 FLSGIITATIA 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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