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Conserved domains on  [gi|17566386|ref|NP_507287|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
13-315 1.61e-94

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 282.89  E-value: 1.61e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    13 DSPQFLAISMHIVTATVTPFHLLGLYCILYKTPAQMKAVKWYLLNLHVSVMFFDNSVTLLGIPFILATRLAGYSLGLLKF 92
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    93 SSYSFLVTMAVSVLSLQSVFIAISGIFESRFRVICKFRWVEKWKKLVSPFfLPYQYIVYPSHLACCVFLIPDQESALKEL 172
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLY-LIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   173 FKTLPCLPREI-YEAPIYVIIEDMRYPMLMIVLNVAAVTIQILFFVLCLVSSSLTQLKeKKMSLKTFQMQKQFLIAVIVQ 251
Cdd:pfam10318 160 LKKLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK-SSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17566386   252 STAPIICFMVPLFYFIFAFFLAYYNQGMINCLLVIASIHGLISTIAMMVLHRPYREVLSSMIVK 315
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
13-315 1.61e-94

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 282.89  E-value: 1.61e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    13 DSPQFLAISMHIVTATVTPFHLLGLYCILYKTPAQMKAVKWYLLNLHVSVMFFDNSVTLLGIPFILATRLAGYSLGLLKF 92
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    93 SSYSFLVTMAVSVLSLQSVFIAISGIFESRFRVICKFRWVEKWKKLVSPFfLPYQYIVYPSHLACCVFLIPDQESALKEL 172
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLY-LIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   173 FKTLPCLPREI-YEAPIYVIIEDMRYPMLMIVLNVAAVTIQILFFVLCLVSSSLTQLKeKKMSLKTFQMQKQFLIAVIVQ 251
Cdd:pfam10318 160 LKKLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK-SSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17566386   252 STAPIICFMVPLFYFIFAFFLAYYNQGMINCLLVIASIHGLISTIAMMVLHRPYREVLSSMIVK 315
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
13-315 1.61e-94

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 282.89  E-value: 1.61e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    13 DSPQFLAISMHIVTATVTPFHLLGLYCILYKTPAQMKAVKWYLLNLHVSVMFFDNSVTLLGIPFILATRLAGYSLGLLKF 92
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    93 SSYSFLVTMAVSVLSLQSVFIAISGIFESRFRVICKFRWVEKWKKLVSPFfLPYQYIVYPSHLACCVFLIPDQESALKEL 172
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLY-LIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   173 FKTLPCLPREI-YEAPIYVIIEDMRYPMLMIVLNVAAVTIQILFFVLCLVSSSLTQLKeKKMSLKTFQMQKQFLIAVIVQ 251
Cdd:pfam10318 160 LKKLPCLPPEFfDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK-SSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17566386   252 STAPIICFMVPLFYFIFAFFLAYYNQGMINCLLVIASIHGLISTIAMMVLHRPYREVLSSMIVK 315
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
15-309 9.66e-15

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 73.73  E-value: 9.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    15 PQFLAISMHIVTATVTPFHLLGLYCILYKTPaQMKAVKWYLLNLHVSVMFFDNSVTLLGIPFILATRLAGYSLGLLK--F 92
Cdd:pfam10327   8 PFWLILYYHIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLAtvF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    93 SSYS-FLVTMAVSVLSLQSVFIAISgiFESRFRVICKFRWVEKWKKLVSPFFLPYqYIVYPSHLACCVFLI-PDQESALK 170
Cdd:pfam10327  87 GISShYLMTIFVFLLSFQLESLLLC--FVRKHQAIAKILSKHVIPKWLYIFLYIL-CHIFPFLTAFLFYQSgLSREEQLE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   171 ELFKTLPCLPREIYEAPIYVIIEDMRYPMLMIVLNVAAVTIQILFFVLCLVSSSLT-QLKEKKMSLKTFQMQKQFLIAVI 249
Cdd:pfam10327 164 YVKENYPEYLSQFSSLPNFAIYDYNPWLIVFGILAIFGGSLSFLILVYLTVDMFRMlKRLRKKISAQTYQKHRAALRSLI 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   250 VQSTAPIICFMVPLFYFIFAFFLAYYNQGMINCLLVIASIHGLISTIAMMVLHRPYREVL 309
Cdd:pfam10327 244 AQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
24-307 5.29e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 41.00  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386    24 IVTATVTPFHLLGLYCILYKTPAQMKAVKWYLLNLHVSVMFFDNSVTLLGIPFI-LATRLAGYSLGLLK-FSSYSFLVTM 101
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIpNGVSMALISYGPCKyFGPWFCYSGY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   102 AVSVLSLQSVFIAISGIFESRFRVICKFRwvEKWKKLVSPFFLpyqYIVYPSHLACCVFLIPDQESALKELFKTLpcLPR 181
Cdd:pfam10317  87 SLLQHFLLHSGWSLLLTFYYRYYILKHVD--PKRKKLILLIII---HYIPSLSQLIVIFLSPTDFLPVEALTKEL--HPN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17566386   182 EIYEAPIYVIIEDMRYPMLMIV-LNVAAVTIQILFFVLCLVSSSLTQLKEK--KMSLKTFQMQKQFLIAVIVQSTAPIIC 258
Cdd:pfam10317 160 YNLTDYTVTGFSDLQSFPALINtLIMTIPVFPIPIIILILRRKILKLLNSNsvNMSPTTKAQHRQLIKGLTIQALLPLFS 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 17566386   259 FMVPLFYFIFAFFLAYYNQGMINCLLVIASIHGLISTIAMMVLHRPYRE 307
Cdd:pfam10317 240 YIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRR 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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