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Conserved domains on  [gi|17561684|ref|NP_507473|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-316 2.19e-85

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 260.08  E-value: 2.19e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684     7 SIITSYINASLAFISNSILICLIITKTPRNMCNYRHLMLIFSIFGIIFAFIDGTNQPMLHFYNGAYVIF-SRNVLGLPRH 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFvDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    86 VSFWYIALNCTCYSMIMLLLVFHFLYRYLAVCKPNMSKLFSFPYVTILILIFVFVSAEWLVLGVYMASENEIIDEHIRDT 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684   166 MLTNFNLSRLDFTYASSLFYRTDpDTGKDFASFPDFLFLINHCTTIIIGFSIIIYCWLKLRNELlhsDDQTQNLSQRTLD 245
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKM---KKLKSLGSEKTRK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17561684   246 MQRQLFRSLVAQTLFPVFLMFIPAGILLCFPILRIDMGPIETIIIPLITTQPFMDALVPMYYIKIYRRAIL 316
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-316 2.19e-85

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 260.08  E-value: 2.19e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684     7 SIITSYINASLAFISNSILICLIITKTPRNMCNYRHLMLIFSIFGIIFAFIDGTNQPMLHFYNGAYVIF-SRNVLGLPRH 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFvDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    86 VSFWYIALNCTCYSMIMLLLVFHFLYRYLAVCKPNMSKLFSFPYVTILILIFVFVSAEWLVLGVYMASENEIIDEHIRDT 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684   166 MLTNFNLSRLDFTYASSLFYRTDpDTGKDFASFPDFLFLINHCTTIIIGFSIIIYCWLKLRNELlhsDDQTQNLSQRTLD 245
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKM---KKLKSLGSEKTRK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17561684   246 MQRQLFRSLVAQTLFPVFLMFIPAGILLCFPILRIDMGPIETIIIPLITTQPFMDALVPMYYIKIYRRAIL 316
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 7-316 2.19e-85

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 260.08  E-value: 2.19e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684     7 SIITSYINASLAFISNSILICLIITKTPRNMCNYRHLMLIFSIFGIIFAFIDGTNQPMLHFYNGAYVIF-SRNVLGLPRH 85
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFvDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    86 VSFWYIALNCTCYSMIMLLLVFHFLYRYLAVCKPNMSKLFSFPYVTILILIFVFVSAEWLVLGVYMASENEIIDEHIRDT 165
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684   166 MLTNFNLSRLDFTYASSLFYRTDpDTGKDFASFPDFLFLINHCTTIIIGFSIIIYCWLKLRNELlhsDDQTQNLSQRTLD 245
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKM---KKLKSLGSEKTRK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17561684   246 MQRQLFRSLVAQTLFPVFLMFIPAGILLCFPILRIDMGPIETIIIPLITTQPFMDALVPMYYIKIYRRAIL 316
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 13-315 1.48e-27

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 109.64  E-value: 1.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    13 INASLAFISNSILICLIITKTPRNMCNYRHLMLIFSIFGIIFAFIDGTNQPMLHFYNGAYVIFSRNVLGLPR-HVSFWYI 91
Cdd:pfam10319  13 IFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYsELGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    92 ALNCTCYSMIMLLLVFHFLYRYLAVCKPNMSKLFSFP-YVTILILIFVFVSAEWLVLGVYMASENEIIDEHIRDTMLTNF 170
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPwGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684   171 NLSRLDFTYASSLFYRTDPDTgkDFASFPDFLFLinhctTIIIGFSIIIYCWL------KLRNEllhsddqTQNLSQRTL 244
Cdd:pfam10319 173 GVDSMDINMLGALYWEASDET--VFRSWLGILLL-----TVISVYSIILYIVLgykimrKLNKM-------SVTMSKKTK 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17561684   245 DMQRQLFRSLVAQTLFPVFLMFIPAGILLCFPILRIDMG-PIETIIIPLITTQPFMDALVPMYYIKIYRRAI 315
Cdd:pfam10319 239 RLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGrWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 9-317 6.77e-13

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 67.96  E-value: 6.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684     9 ITSYINASLAFISNSILICLIITKTPRNMCNYRHLMLIFSIFGIIFAFID--------GTNQPMLHFYNGAYVIFSRNvl 80
Cdd:pfam10317   3 IYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAfftqqriiPNGVSMALISYGPCKYFGPW-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    81 glprhVSFWYIALNCTCYSMIMLLLVFHFLYRYLAVCKPNMSKLFSFPYVTILILIFVFVSAE-WLVLGVYMASENEIID 159
Cdd:pfam10317  81 -----FCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIViFLSPTDFLPVEALTKE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684   160 EHIrdtmltNFNLSRLDFTYASSLFYrtdpdtgkdfasfpdFLFLINHCTTIIIGFSIIIYCWLKLRNELLHSDDQTQNL 239
Cdd:pfam10317 156 LHP------NYNLTDYTVTGFSDLQS---------------FPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNM 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17561684   240 SQRTLDMQRQLFRSLVAQTLFPVFlMFIPAGILLCFPILRIDMGPI-ETIIIPLITTQPFMDALVPMYYIKIYRRAILK 317
Cdd:pfam10317 215 SPTTKAQHRQLIKGLTIQALLPLF-SYIPGVTLYLLSQLTGTEFLIlEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-273 6.12e-06

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 47.15  E-value: 6.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684     6 FSIITSYINASLAFISNSILICLIITKTPRNMCNYRHLMLIFSIFGIIFAFIDGTN-QPMLHFynGAYVIFSRNVLGLPR 84
Cdd:pfam10318   5 FLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLtIPYIFL--PALAGYPLGLLSYLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684    85 HVSFWYIALNCTCYSMIMLLLVFHFLYRYLAVCKPNMSKLFSFPYVTILILIFVFVSAewLVLGVYMASENEiidEHIRD 164
Cdd:pfam10318  83 VPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALL--FLIPIYLNIPDQ---EAAKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561684   165 TMLTNFNLSRLDFTYASSLFYRTDPDTGKDFASFPDFLFLINHCTTIIIgfsiiiYCWLKLRNEllhsddQTQNLSQRTL 244
Cdd:pfam10318 158 KVLKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVF------LTIYYLFKS------VKSSLSKKTR 225

                         250       260
                  ....*....|....*....|....*....
gi 17561684   245 DMQRQLFRSLVAQTLFPVFLMFIPAGILL 273
Cdd:pfam10318 226 KLQKKFFIALIIQVSIPLIVILIPLIYIL 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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