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Conserved domains on  [gi|72001486|ref|NP_507494|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
7-310 9.32e-90

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 270.57  E-value: 9.32e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486     7 SSPYVYSNVLFIIAGISFPIHLFGEYCILFKTPKVMKSVKWSLFDVHLWSSLMDLFLSFFVQPLAFFPVMAEFPMGVLNR 86
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    87 IGMKTDVLMCSGVLIALLVLVSIIKMFKNRYYILFSMH--TCWRYIRYSFLTMNYVLTILFVITVYVEIPeDQEFARSVL 164
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKkrITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486   165 FKNNPELLQYDIPESPILVIAWSNFRMIYRQLLFTALFLSELIVFTVLIRLNMQKAISeirSSASCKTFKIHRNFMKSLN 244
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK---SSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72001486   245 MQIAVPIVVICIPSFFGLAVPFLQGNTQGAINFIYIIVSTHGALSTLIMVYLQKSYREAVVQIVGC 310
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
7-310 9.32e-90

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 270.57  E-value: 9.32e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486     7 SSPYVYSNVLFIIAGISFPIHLFGEYCILFKTPKVMKSVKWSLFDVHLWSSLMDLFLSFFVQPLAFFPVMAEFPMGVLNR 86
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    87 IGMKTDVLMCSGVLIALLVLVSIIKMFKNRYYILFSMH--TCWRYIRYSFLTMNYVLTILFVITVYVEIPeDQEFARSVL 164
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKkrITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486   165 FKNNPELLQYDIPESPILVIAWSNFRMIYRQLLFTALFLSELIVFTVLIRLNMQKAISeirSSASCKTFKIHRNFMKSLN 244
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK---SSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72001486   245 MQIAVPIVVICIPSFFGLAVPFLQGNTQGAINFIYIIVSTHGALSTLIMVYLQKSYREAVVQIVGC 310
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
7-310 9.32e-90

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 270.57  E-value: 9.32e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486     7 SSPYVYSNVLFIIAGISFPIHLFGEYCILFKTPKVMKSVKWSLFDVHLWSSLMDLFLSFFVQPLAFFPVMAEFPMGVLNR 86
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    87 IGMKTDVLMCSGVLIALLVLVSIIKMFKNRYYILFSMH--TCWRYIRYSFLTMNYVLTILFVITVYVEIPeDQEFARSVL 164
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKkrITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486   165 FKNNPELLQYDIPESPILVIAWSNFRMIYRQLLFTALFLSELIVFTVLIRLNMQKAISeirSSASCKTFKIHRNFMKSLN 244
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK---SSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72001486   245 MQIAVPIVVICIPSFFGLAVPFLQGNTQGAINFIYIIVSTHGALSTLIMVYLQKSYREAVVQIVGC 310
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
7-301 6.68e-22

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 93.76  E-value: 6.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486     7 SSPYVYSNVLFIIAGISFPIHLFGEYCILFKTPKvMKSVKWSLFDVHLWSSLMDLFLSFFVQPLAFFPVMAEFPMGVLNR 86
Cdd:pfam10327   6 TVPFWLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLAT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    87 I-GMKTDVLMCSGVLIALLVLVSIIKMFKNRYY---ILFSMHTCWRYIRYSFLTMNYVLTILFVITVYVeIPEDQEFARS 162
Cdd:pfam10327  85 VfGISSHYLMTIFVFLLSFQLESLLLCFVRKHQaiaKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQ-SGLSREEQLE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486   163 VLFKNNPELLQyDIPESPILVIAWSNFRMIYrQLLFTALFLSELIVFTVLIRLNMQKAISEIRSSASCKTFKIHRNFMKS 242
Cdd:pfam10327 164 YVKENYPEYLS-QFSSLPNFAIYDYNPWLIV-FGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAALRS 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 72001486   243 LNMQIAVPIVVICIPSFFGLAVPFLQGNTQGAINFIYIIVSTHGALSTLIMVYLQKSYR 301
Cdd:pfam10327 242 LIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYR 300
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
13-304 1.68e-07

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 52.07  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    13 SNVLFIIAGISFPIHLFGEYCILFKTPKVMKSVKWSLFdvhlWSSLMDLFLS---FFVQPL------AFFPVMAEFPMGV 83
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMI----YFSIFGIFFSileFIVKPFihsynsSFIVFVDLKDLGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    84 LNRIGMKTDVLMCS--GVLIALLVLvsiikMFKNRYYILFSmHTCWRYI--RYSFLTMNYVLT--ILFVITVYVEIPED- 156
Cdd:pfam10326  78 SKSVGQILLALYCGfyGVSISLLAV-----QFIYRYLALCR-PGKLKYFdgKKLILWFLYPLIfgAIWGLLVYFFLGPDe 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486   157 --QEFARSVLFKN---NPE------LLQYDIPESPILVIAWSNFRMIYRQLLFTALFLSELIVFTVLIRLNMQKaiseIR 225
Cdd:pfam10326 152 etDEYLREELLENynlDIDevayvgPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKK----LK 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72001486   226 SSASCKTFKIHRNFMKSLNMQIAVPIVVICIPSFFGLAVPFLQGNTQGAINFIYIIVSTHGALSTLIMVYLQKSYREAV 304
Cdd:pfam10326 228 SLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
18-304 1.41e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 39.84  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    18 IIAGISFPIHLFGEYCILFKTPKVMKSVKWSLFDvhlwSSLMDLFLSFFVQPLAFFPVMAEFPMGVL---------NRIG 88
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLN----TAITQIISCILAFFTQQRIIPNGVSMALIsygpckyfgPWFC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486    89 MKTDVLMCSGVLIALLvlvSIIKMFKNRYYILFSMH-TCWRYIRYSFLTmnYVLTILFVITVYVeIPEDQEFARSVLFKN 167
Cdd:pfam10317  83 YSGYSLLQHFLLHSGW---SLLLTFYYRYYILKHVDpKRKKLILLIIIH--YIPSLSQLIVIFL-SPTDFLPVEALTKEL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72001486   168 NPellQYDIpeSPILVIAWSNFRMIYrqLLFTALFLSELIVFTVLI----RLNMQKAISEIRSSASCKTFKIHRNFMKSL 243
Cdd:pfam10317 157 HP---NYNL--TDYTVTGFSDLQSFP--ALINTLIMTIPVFPIPIIililRRKILKLLNSNSVNMSPTTKAQHRQLIKGL 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 72001486   244 NMQIAVPIVVICIPSFF-------GLAVPFLQgntqgaiNFIYIIVSTHGALSTLIMVYLQKSYREAV 304
Cdd:pfam10317 230 TIQALLPLFSYIPGVTLyllsqltGTEFLILE-------YFIFVLPALPPLLDPLITIYFVTPYRRAI 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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