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Conserved domains on  [gi|17567317|ref|NP_508157|]
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G_PROTEIN_RECEP_F1_2 domain-containing protein [Caenorhabditis elegans]

Protein Classification

G-protein coupled receptor( domain architecture ID 11535993)

G-protein coupled receptor transmits physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
44-278 1.83e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


:

Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 42.66  E-value: 1.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317  44 IAVVFSAATGIFANFLVIL--LSFGHVQGDFRFFVANLALVDILCGSVFMFMGYINVNDDHHIPSQFLYYMTLAFYGSFG 121
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILviLRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 122 TM-ICAIVPISLSRVLALSNASLYSTCFGGRRSLIFCIFL------------------DFLPVCILYLICVVEHDVAKVL 182
Cdd:cd00637  83 LAsILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIwllslllalppllgwgvyDYGGYCCCCLCWPDLTLSKAYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 183 FYIFAFITTLAYFVAFTTNYMVFRVVAKHIQVV----ENLHDQARLLETRQVAIATLAQAIIPLFCQVPAFLTLSSVLLL 258
Cdd:cd00637 163 IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIrsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFG 242
                       250       260
                ....*....|....*....|
gi 17567317 259 SEPITNGHVIITTQLWLALS 278
Cdd:cd00637 243 PDPSPLPRILYFLALLLAYL 262
 
Name Accession Description Interval E-value
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
44-278 1.83e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 42.66  E-value: 1.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317  44 IAVVFSAATGIFANFLVIL--LSFGHVQGDFRFFVANLALVDILCGSVFMFMGYINVNDDHHIPSQFLYYMTLAFYGSFG 121
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILviLRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 122 TM-ICAIVPISLSRVLALSNASLYSTCFGGRRSLIFCIFL------------------DFLPVCILYLICVVEHDVAKVL 182
Cdd:cd00637  83 LAsILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIwllslllalppllgwgvyDYGGYCCCCLCWPDLTLSKAYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 183 FYIFAFITTLAYFVAFTTNYMVFRVVAKHIQVV----ENLHDQARLLETRQVAIATLAQAIIPLFCQVPAFLTLSSVLLL 258
Cdd:cd00637 163 IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIrsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFG 242
                       250       260
                ....*....|....*....|
gi 17567317 259 SEPITNGHVIITTQLWLALS 278
Cdd:cd00637 243 PDPSPLPRILYFLALLLAYL 262
 
Name Accession Description Interval E-value
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
44-278 1.83e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 42.66  E-value: 1.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317  44 IAVVFSAATGIFANFLVIL--LSFGHVQGDFRFFVANLALVDILCGSVFMFMGYINVNDDHHIPSQFLYYMTLAFYGSFG 121
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILviLRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 122 TM-ICAIVPISLSRVLALSNASLYSTCFGGRRSLIFCIFL------------------DFLPVCILYLICVVEHDVAKVL 182
Cdd:cd00637  83 LAsILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIwllslllalppllgwgvyDYGGYCCCCLCWPDLTLSKAYT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 183 FYIFAFITTLAYFVAFTTNYMVFRVVAKHIQVV----ENLHDQARLLETRQVAIATLAQAIIPLFCQVPAFLTLSSVLLL 258
Cdd:cd00637 163 IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIrsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFG 242
                       250       260
                ....*....|....*....|
gi 17567317 259 SEPITNGHVIITTQLWLALS 278
Cdd:cd00637 243 PDPSPLPRILYFLALLLAYL 262
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
41-212 1.48e-03

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 39.47  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317  41 IVGIAVVFSAATGIFANFLVIL--LSFGHVQGDFRFFVANLALVDILCGSVFMFMGYINVNDDHHIPSQFLYYMTLAFYG 118
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILavYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567317 119 SFGTM-ICAIVPISLSRVLALSNASLYSTCFGGRRSLIFCIFLDFLPVCILYLICVVEHDVAKV-------------LFY 184
Cdd:cd14967  81 LCCTAsILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPsvvdceceftpnkIYV 160
                       170       180       190
                ....*....|....*....|....*....|..
gi 17567317 185 IFAFIttLAYFVAFT----TNYMVFRVVAKHI 212
Cdd:cd14967 161 LVSSV--ISFFIPLLimivLYARIFRVARREL 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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