NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17567233|ref|NP_508245|]
View 

Transthyretin-like family protein [Caenorhabditis elegans]

Protein Classification

transthyretin-like family protein( domain architecture ID 10470959)

transthyretin-like family protein similar to Caenorhabditis elegans transthyretin-like protein 52 (TTR-52) that functions as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1

Gene Ontology:  GO:0009986
PubMed:  22713871

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TTR-52 pfam01060
Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to ...
 36-115 3.19e-25

Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure.


:

Pssm-ID: 460046  Cd Length: 79  Bit Score: 91.49  E-value: 3.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567233    36 SGRLFCGDKPLIGIPVKLIDKDHGDDRDdLLDEKKTDEEGKFHVTGGTYEKAVIEPALKIYHDCNDGNHKCQKRLFWDIP 115
Cdd:pfam01060   1 KGRLMCGGKPASNVKVKLWEKDTLDPDD-LLDETKTDEDGNFELSGSTDEITTIDPYLKIYHDCNDGVKPCQRKIKIPIP 79
 
Name Accession Description Interval E-value
TTR-52 pfam01060
Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to ...
 36-115 3.19e-25

Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure.


Pssm-ID: 460046  Cd Length: 79  Bit Score: 91.49  E-value: 3.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567233    36 SGRLFCGDKPLIGIPVKLIDKDHGDDRDdLLDEKKTDEEGKFHVTGGTYEKAVIEPALKIYHDCNDGNHKCQKRLFWDIP 115
Cdd:pfam01060   1 KGRLMCGGKPASNVKVKLWEKDTLDPDD-LLDETKTDEDGNFELSGSTDEITTIDPYLKIYHDCNDGVKPCQRKIKIPIP 79
 
Name Accession Description Interval E-value
TTR-52 pfam01060
Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to ...
 36-115 3.19e-25

Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure.


Pssm-ID: 460046  Cd Length: 79  Bit Score: 91.49  E-value: 3.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17567233    36 SGRLFCGDKPLIGIPVKLIDKDHGDDRDdLLDEKKTDEEGKFHVTGGTYEKAVIEPALKIYHDCNDGNHKCQKRLFWDIP 115
Cdd:pfam01060   1 KGRLMCGGKPASNVKVKLWEKDTLDPDD-LLDETKTDEDGNFELSGSTDEITTIDPYLKIYHDCNDGVKPCQRKIKIPIP 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH