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Conserved domains on  [gi|17550870|ref|NP_508309|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 214-360 1.61e-35

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 127.69  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550870   214 TKCFTDITKMLKSTRSIEVEDFDALQVSISDYASLLEIFPAGKLESLNIdpytfdrAELETLEHCEHLSSMDQWKMAERF 293
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIEL-------SSESDEDQFEEIVELEQWKNAKSL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17550870   294 FGRGFSLD-VPIGSFFHFKLFDVVLREFTEEDAVKLRDMIDESSDFISADITSRVMDLPSVANVFGLI 360
Cdd:pfam01827  74 KIEGSSLSsFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 12-56 9.45e-09

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


:

Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 50.98  E-value: 9.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 17550870    12 IRACILYEALDKTRLSKAYENFCRKVGKDAIPQEEFDYWYYHFSN 56
Cdd:pfam17906   4 LRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRS 48
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 73-107 3.67e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22150:

Pssm-ID: 459239  Cd Length: 46  Bit Score: 37.85  E-value: 3.67e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17550870  73 MYALPLNMIHFIVDRVDFIDTLALAKVCTGFRDVV 107
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIV 35
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 214-360 1.61e-35

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 127.69  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550870   214 TKCFTDITKMLKSTRSIEVEDFDALQVSISDYASLLEIFPAGKLESLNIdpytfdrAELETLEHCEHLSSMDQWKMAERF 293
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIEL-------SSESDEDQFEEIVELEQWKNAKSL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17550870   294 FGRGFSLD-VPIGSFFHFKLFDVVLREFTEEDAVKLRDMIDESSDFISADITSRVMDLPSVANVFGLI 360
Cdd:pfam01827  74 KIEGSSLSsFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 12-56 9.45e-09

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 50.98  E-value: 9.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 17550870    12 IRACILYEALDKTRLSKAYENFCRKVGKDAIPQEEFDYWYYHFSN 56
Cdd:pfam17906   4 LRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRS 48
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 73-107 3.67e-04

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 37.85  E-value: 3.67e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17550870  73 MYALPLNMIHFIVDRVDFIDTLALAKVCTGFRDVV 107
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIV 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 76-112 1.29e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17550870    76 LPLNMIHFIVDRVDFIDTLALAKVCTGFRDVVRIPEV 112
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
76-108 2.25e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.49  E-value: 2.25e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 17550870     76 LPLNMIHFIVDRVDFIDTLALAKVCTGFRDVVR 108
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLID 33
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 214-360 1.61e-35

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 127.69  E-value: 1.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17550870   214 TKCFTDITKMLKSTRSIEVEDFDALQVSISDYASLLEIFPAGKLESLNIdpytfdrAELETLEHCEHLSSMDQWKMAERF 293
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIEL-------SSESDEDQFEEIVELEQWKNAKSL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17550870   294 FGRGFSLD-VPIGSFFHFKLFDVVLREFTEEDAVKLRDMIDESSDFISADITSRVMDLPSVANVFGLI 360
Cdd:pfam01827  74 KIEGSSLSsFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 12-56 9.45e-09

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 50.98  E-value: 9.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 17550870    12 IRACILYEALDKTRLSKAYENFCRKVGKDAIPQEEFDYWYYHFSN 56
Cdd:pfam17906   4 LRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRS 48
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 73-107 3.67e-04

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 37.85  E-value: 3.67e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17550870  73 MYALPLNMIHFIVDRVDFIDTLALAKVCTGFRDVV 107
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIV 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 76-112 1.29e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.36  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17550870    76 LPLNMIHFIVDRVDFIDTLALAKVCTGFRDVVRIPEV 112
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
76-108 2.25e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.49  E-value: 2.25e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 17550870     76 LPLNMIHFIVDRVDFIDTLALAKVCTGFRDVVR 108
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLID 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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