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Conserved domains on  [gi|453232801|ref|NP_508896|]
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UV radiation resistance-associated gene protein-like [Caenorhabditis elegans]

Protein Classification

beclin family protein( domain architecture ID 706978)

beclin family protein plays an essential role in autophagy and other membrane-trafficking events, similar to human beclin-2 that is involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APG6 super family cl25896
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 151-244 1.36e-04

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


The actual alignment was detected with superfamily member pfam04111:

Pssm-ID: 461178  Cd Length: 176  Bit Score: 42.14  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232801  151 DVFKIDIDGGPAsmkqnrvrsdckcvlvdTIRGLHLPHIASIQLSphnERETTAAIGLLIQMLHVISRVLEYSL-RYPIV 229
Cdd:pfam04111   6 DTFHISHDGPFG-----------------TINGLRLGRLPNVPVE---WSEINAAWGQTALLLATLAKKLGLKFqGYKLV 65

                          90
                  ....*....|....*
gi 453232801  230 PAASFSKVyCPIDDK 244
Cdd:pfam04111  66 PMGSFSKI-EKLDDD 79
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 151-244 1.36e-04

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 42.14  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232801  151 DVFKIDIDGGPAsmkqnrvrsdckcvlvdTIRGLHLPHIASIQLSphnERETTAAIGLLIQMLHVISRVLEYSL-RYPIV 229
Cdd:pfam04111   6 DTFHISHDGPFG-----------------TINGLRLGRLPNVPVE---WSEINAAWGQTALLLATLAKKLGLKFqGYKLV 65

                          90
                  ....*....|....*
gi 453232801  230 PAASFSKVyCPIDDK 244
Cdd:pfam04111  66 PMGSFSKI-EKLDDD 79
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 151-244 1.36e-04

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 42.14  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232801  151 DVFKIDIDGGPAsmkqnrvrsdckcvlvdTIRGLHLPHIASIQLSphnERETTAAIGLLIQMLHVISRVLEYSL-RYPIV 229
Cdd:pfam04111   6 DTFHISHDGPFG-----------------TINGLRLGRLPNVPVE---WSEINAAWGQTALLLATLAKKLGLKFqGYKLV 65

                          90
                  ....*....|....*
gi 453232801  230 PAASFSKVyCPIDDK 244
Cdd:pfam04111  66 PMGSFSKI-EKLDDD 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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