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Conserved domains on  [gi|32566077|ref|NP_510116|]
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A disintegrin and metalloproteinase with thrombospondin motifs adt-1 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 234-448 1.18e-72

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 240.99  E-value: 1.18e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  234 TLEIGLFLDSKLFEHFereyiqdAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALStgvhKNGQAQ 313
Cdd:cd04273    2 YVETLVVADSKMVEFH-------HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLL----ISGNAQ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  314 SLLDAFCRYQAHMNPGTDlTDMNHYDHGVLLTGYDI--YHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMG 391
Cdd:cd04273   71 KSLKSFCRWQKKLNPPND-SDPEHHDHAILLTRQDIcrSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELG 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32566077  392 HNMGMVHDGVQNQC---NKGCCLMSAVNGA--GKTTWSDCSVREFNAFLlqldESGRGNCLR 448
Cdd:cd04273  150 HVLGMPHDGDGNSCgpeGKDGHIMSPTLGAntGPFTWSKCSRRYLTSFL----DTGDGNCLL 207
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 466-534 3.74e-15

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 71.22  E-value: 3.74e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32566077    466 PGQRFTADQQCSYFWGRDYKVeIPNGKamDDICRILWC--GNSGSTISTAHPALEGSWCGANKWCHKGQCT 534
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTF-CPNGD--EDVCSKLWCsnPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 64-163 6.42e-15

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 72.73  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077     64 KFTAWNDTYHLNLRKNSRIVSPHIiSVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFL 143
Cdd:pfam01562   30 RLAAFGKKFHLHLTPNRLLLAPGF-TVTYYLDGGTGVESPPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEY 108

                           90       100
                   ....*....|....*....|
gi 32566077    144 VLQTLPKRVHHLQKERHLVY 163
Cdd:pfam01562  109 LIEPLEKYSREEGGHPHVVY 128
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1327-1378 1.99e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 1.99e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    1327 WSTWSDWTPCSASCGFGVQTRDRSCSS-PEPKGGQSCSGLAHQTSLCDLPACD 1378
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1206-1257 1.41e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.98  E-value: 1.41e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077    1206 WSLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDN 1257
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 807-851 1.70e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 1.70e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077     807 WTNWDEWSSCSQSCGGGRRYRIRKCLDDK-------CDGDDLEKESCNTQKC 851
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1385-1435 2.02e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 2.02e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    1385 WSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSP 1435
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1041-1082 5.43e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.44  E-value: 5.43e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077    1041 WSEWGPCSVTCGSGRRVRTRGC-------QEASCPEQHIQTEECNLNSC 1082
Cdd:smart00209    4 WSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1268-1318 1.50e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.90  E-value: 1.50e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    1268 WTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPA 1318
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 906-952 7.48e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.97  E-value: 7.48e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 32566077     906 WSEWGEWTTCSATCGEGLQSRERSCRR-------GSCTEDDaSQTRRCVNGPCE 952
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnggGPCTGED-VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 855-898 6.71e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 50.28  E-value: 6.71e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077     855 SWGDWLPCSVSCGIGFQIRERLC-------DGELCATANKQARTCNQQQCP 898
Cdd:smart00209    3 EWSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 710-752 1.31e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.51  E-value: 1.31e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077     710 WEEWSSWSECSVSCGlGGREVRERKCSS------GRKCQGVSEESRPCE 752
Cdd:smart00209    1 WSEWSEWSPCSVTCG-GGVQTRTRSCCSpppqngGGPCTGEDVETRACN 48
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1151-1200 1.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.05e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    1151 WSEWSSWSACS--CFSLTSTRRRFCQVVDPTVQG-FCAGAILEQIPCAPGSCS 1200
Cdd:smart00209    1 WSEWSEWSPCSvtCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQPCP 53
PTZ00441 super family cl25523
sporozoite surface protein 2 (SSP2); Provisional
 762-806 2.86e-04

sporozoite surface protein 2 (SSP2); Provisional


The actual alignment was detected with superfamily member PTZ00441:

Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.34  E-value: 2.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 32566077   762 GEWKEWGSCSEKCALGVQKRFRPCLTDQCSSkHLQEErpCDNEGC 806
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSRPILHEGCTT-HMVEE--CEEEEC 282
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1088-1130 1.69e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.69e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077    1088 WSDWSSCSKSCGqDGIQTRQKLCLFNN-----AECSSYA-ESRRCKDLP 1130
Cdd:smart00209    4 WSEWSPCSVTCG-GGVQTRTRSCCSPPpqnggGPCTGEDvETRACNEQP 51
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 234-448 1.18e-72

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 240.99  E-value: 1.18e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  234 TLEIGLFLDSKLFEHFereyiqdAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALStgvhKNGQAQ 313
Cdd:cd04273    2 YVETLVVADSKMVEFH-------HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLL----ISGNAQ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  314 SLLDAFCRYQAHMNPGTDlTDMNHYDHGVLLTGYDI--YHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMG 391
Cdd:cd04273   71 KSLKSFCRWQKKLNPPND-SDPEHHDHAILLTRQDIcrSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELG 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32566077  392 HNMGMVHDGVQNQC---NKGCCLMSAVNGA--GKTTWSDCSVREFNAFLlqldESGRGNCLR 448
Cdd:cd04273  150 HVLGMPHDGDGNSCgpeGKDGHIMSPTLGAntGPFTWSKCSRRYLTSFL----DTGDGNCLL 207
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 235-450 4.65e-20

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 89.67  E-value: 4.65e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    235 LEIGLFLDSKLFEHFEREyiqdaEQHLLEFSLALINNVHVLYQqdtlTPNLDIVIVRYEMWRTQPSalstgVHKNGQAQS 314
Cdd:pfam01421    3 IELFIVVDKQLFQKMGSD-----TTVVRQRVFQVVNLVNSIYK----ELNIRVVLVGLEIWTDEDK-----IDVSGDAND 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    315 LLDAFCRYQAHMnpgtdLTDMNHYDHGVLLTGYDIYHTTTsvaGVAPVARMCDPLFACSLVEGLH---LGRSFVLAHEMG 391
Cdd:pfam01421   69 TLRNFLKWRQEY-----LKKRKPHDVAQLLSGVEFGGTTV---GAAYVGGMCSLEYSGGVNEDHSknlESFAVTMAHELG 140

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32566077    392 HNMGMVHDGVQNQC---NKGCCLMSAVNGA-GKTTWSDCSVREFNAFLlqldESGRGNCLRDA 450
Cdd:pfam01421  141 HNLGMQHDDFNGGCkcpPGGGCIMNPSAGSsFPRKFSNCSQEDFEQFL----TKQKGACLFNK 199
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 466-534 3.74e-15

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 71.22  E-value: 3.74e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32566077    466 PGQRFTADQQCSYFWGRDYKVeIPNGKamDDICRILWC--GNSGSTISTAHPALEGSWCGANKWCHKGQCT 534
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTF-CPNGD--EDVCSKLWCsnPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 64-163 6.42e-15

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 72.73  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077     64 KFTAWNDTYHLNLRKNSRIVSPHIiSVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFL 143
Cdd:pfam01562   30 RLAAFGKKFHLHLTPNRLLLAPGF-TVTYYLDGGTGVESPPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEY 108

                           90       100
                   ....*....|....*....|
gi 32566077    144 VLQTLPKRVHHLQKERHLVY 163
Cdd:pfam01562  109 LIEPLEKYSREEGGHPHVVY 128
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1327-1378 1.99e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 1.99e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    1327 WSTWSDWTPCSASCGFGVQTRDRSCSS-PEPKGGQSCSGLAHQTSLCDLPACD 1378
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1206-1257 1.41e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.98  E-value: 1.41e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077    1206 WSLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDN 1257
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 807-851 1.70e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 1.70e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077     807 WTNWDEWSSCSQSCGGGRRYRIRKCLDDK-------CDGDDLEKESCNTQKC 851
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1385-1435 2.02e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 2.02e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    1385 WSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSP 1435
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1041-1082 5.43e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.44  E-value: 5.43e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077    1041 WSEWGPCSVTCGSGRRVRTRGC-------QEASCPEQHIQTEECNLNSC 1082
Cdd:smart00209    4 WSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1268-1318 1.50e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.90  E-value: 1.50e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    1268 WTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPA 1318
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 906-952 7.48e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.97  E-value: 7.48e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 32566077     906 WSEWGEWTTCSATCGEGLQSRERSCRR-------GSCTEDDaSQTRRCVNGPCE 952
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnggGPCTGED-VETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1328-1377 1.66e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 52.04  E-value: 1.66e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077   1328 STWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQsCSGLAHQTSLCDLPAC 1377
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEP-CTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 855-898 6.71e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 50.28  E-value: 6.71e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077     855 SWGDWLPCSVSCGIGFQIRERLC-------DGELCATANKQARTCNQQQCP 898
Cdd:smart00209    3 EWSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1041-1082 9.34e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 9.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 32566077   1041 WSEWGPCSVTCGSGRRVRTRGCQE-----ASCPEQHIQTEECNLNSC 1082
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKSpfpggEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 710-752 1.31e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.51  E-value: 1.31e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077     710 WEEWSSWSECSVSCGlGGREVRERKCSS------GRKCQGVSEESRPCE 752
Cdd:smart00209    1 WSEWSEWSPCSVTCG-GGVQTRTRSCCSpppqngGGPCTGEDVETRACN 48
TSP_1 pfam00090
Thrombospondin type 1 domain;
907-951 1.62e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 1.62e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077    907 SEWGEWTTCSATCGEGLQSRERSC-----RRGSCTEDDAsQTRRCVNGPC 951
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpGGEPCTGDDI-ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1151-1200 1.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.05e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    1151 WSEWSSWSACS--CFSLTSTRRRFCQVVDPTVQG-FCAGAILEQIPCAPGSCS 1200
Cdd:smart00209    1 WSEWSEWSPCSvtCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQPCP 53
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 710-766 1.18e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 49.17  E-value: 1.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077   710 WEEWSSWSECSVSCGLGGR-EVRERKCS--SGRKCQGVSEESRPCEGVLRDCEEFGEWKE 766
Cdd:PTZ00087  233 YTEWGEWSNCSMECDHPDNvQIRERKCAhpSGDCFKGDLKETRPCQVPLPPCNSLFEHKE 292
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 808-851 1.36e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 43.81  E-value: 1.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 32566077    808 TNWDEWSSCSQSCGGGRRYRIRKCLDDKCDG-----DDLEKESCNTQKC 851
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGgrpcpELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
1269-1314 1.42e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 32566077   1269 TDWTAWSECTDYCRNGHRSRTRFCANPKPsqGGAQCTGSDFELNPC 1314
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC 44
TSP_1 pfam00090
Thrombospondin type 1 domain;
1207-1256 1.56e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.56e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077   1207 SLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSnrGAYCSGYSFDQRPCVMD 1256
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-GIQVRQRTCKSPFPG--GEPCTGDDIETQACKMD 47
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1041-1083 1.71e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 1.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 32566077  1041 WSEWGPCSVTCGSGRRVRTRGCQEASCpEQHIQtEECNLNSCL 1083
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEGC-TTHMV-EECEEEECP 283
TSP_1 pfam00090
Thrombospondin type 1 domain;
856-897 1.85e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.18  E-value: 1.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 32566077    856 WGDWLPCSVSCGIGFQIRERLCD-----GELCATANKQARTCNQQQC 897
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKspfpgGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 906-947 8.85e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 46.48  E-value: 8.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 32566077   906 WSEWGEWTTCSATCG--EGLQSRERSC--RRGSCTEDDASQTRRCV 947
Cdd:PTZ00087  233 YTEWGEWSNCSMECDhpDNVQIRERKCahPSGDCFKGDLKETRPCQ 278
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1386-1421 1.60e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.73  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 32566077   1386 SAWNEWSGCMGNCGIGTRTRVRACVSPPvSDGGQPC 1421
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEP-QNGGRPC 38
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 762-806 2.86e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.34  E-value: 2.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 32566077   762 GEWKEWGSCSEKCALGVQKRFRPCLTDQCSSkHLQEErpCDNEGC 806
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSRPILHEGCTT-HMVEE--CEEEEC 282
TSP_1 pfam00090
Thrombospondin type 1 domain;
712-752 3.46e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.71  E-value: 3.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 32566077    712 EWSSWSECSVSCGLGGReVRERKCSS----GRKCQGVSEESRPCE 752
Cdd:pfam00090    2 PWSPWSPCSVTCGKGIQ-VRQRTCKSpfpgGEPCTGDDIETQACK 45
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 810-851 9.62e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.80  E-value: 9.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 32566077   810 WDEWSSCSQSCGGGRRYRIRKCLDDKCDgDDLEKEsCNTQKC 851
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEGCT-THMVEE-CEEEEC 282
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1088-1130 1.69e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.69e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077    1088 WSDWSSCSKSCGqDGIQTRQKLCLFNN-----AECSSYA-ESRRCKDLP 1130
Cdd:smart00209    4 WSEWSPCSVTCG-GGVQTRTRSCCSPPpqnggGPCTGEDvETRACNEQP 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 762-806 2.05e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 2.05e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 32566077    762 GEWKEWGSCSEKCALGVQKRFR-----------PCltdqcssKHLQEERPCDNEGC 806
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRtvivepqnggrPC-------PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 762-806 2.23e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.23e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077     762 GEWKEWGSCSEKCALGVQKRFRPCLTD-------QCSSKHLqEERPCDNEGC 806
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPppqngggPCTGEDV-ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1088-1130 2.78e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 2.78e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 32566077   1088 WSDWSSCSKSCGqDGIQTRQKLCL----FNNAECSSYAESRRCKDLP 1130
Cdd:pfam19028    6 WSEWSECSVTCG-GGVQTRTRTVIvepqNGGRPCPELLERRPCNLPP 51
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 1088-1135 4.49e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 41.08  E-value: 4.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 32566077  1088 WSDWSSCSKSCGQ-DGIQTRQKLCLFNNAEC--SSYAESRRCK-DLPSCSSI 1135
Cdd:PTZ00087  236 WGEWSNCSMECDHpDNVQIRERKCAHPSGDCfkGDLKETRPCQvPLPPCNSL 287
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 234-448 1.18e-72

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 240.99  E-value: 1.18e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  234 TLEIGLFLDSKLFEHFereyiqdAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALStgvhKNGQAQ 313
Cdd:cd04273    2 YVETLVVADSKMVEFH-------HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLL----ISGNAQ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  314 SLLDAFCRYQAHMNPGTDlTDMNHYDHGVLLTGYDI--YHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMG 391
Cdd:cd04273   71 KSLKSFCRWQKKLNPPND-SDPEHHDHAILLTRQDIcrSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELG 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32566077  392 HNMGMVHDGVQNQC---NKGCCLMSAVNGA--GKTTWSDCSVREFNAFLlqldESGRGNCLR 448
Cdd:cd04273  150 HVLGMPHDGDGNSCgpeGKDGHIMSPTLGAntGPFTWSKCSRRYLTSFL----DTGDGNCLL 207
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 235-449 2.03e-25

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 105.00  E-value: 2.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  235 LEIGLFLDSKLFEHFEREyiqdaEQHLLEFSLALINNVHVLYQQDtltpNLDIVIVRYEMWRTQ-PSALStgvhknGQAQ 313
Cdd:cd04269    3 VELVVVVDNSLYKKYGSN-----LSKVRQRVIEIVNIVDSIYRPL----NIRVVLVGLEIWTDKdKISVS------GDAG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  314 SLLDAFCRYQAhmnpgTDLTDMNHYDHGVLLTGYDIYHTTtsvAGVAPVARMCDPLFACSLVEGLH---LGRSFVLAHEM 390
Cdd:cd04269   68 ETLNRFLDWKR-----SNLLPRKPHDNAQLLTGRDFDGNT---VGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHEL 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 32566077  391 GHNMGMVHDGVQNQCNKGCCLMSAVNGAGKTTWSDCSVREFNAFLLQldesGRGNCLRD 449
Cdd:cd04269  140 GHNLGMEHDDGGCTCGRSTCIMAPSPSSLTDAFSNCSYEDYQKFLSR----GGGQCLLN 194
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 235-450 4.65e-20

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 89.67  E-value: 4.65e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    235 LEIGLFLDSKLFEHFEREyiqdaEQHLLEFSLALINNVHVLYQqdtlTPNLDIVIVRYEMWRTQPSalstgVHKNGQAQS 314
Cdd:pfam01421    3 IELFIVVDKQLFQKMGSD-----TTVVRQRVFQVVNLVNSIYK----ELNIRVVLVGLEIWTDEDK-----IDVSGDAND 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    315 LLDAFCRYQAHMnpgtdLTDMNHYDHGVLLTGYDIYHTTTsvaGVAPVARMCDPLFACSLVEGLH---LGRSFVLAHEMG 391
Cdd:pfam01421   69 TLRNFLKWRQEY-----LKKRKPHDVAQLLSGVEFGGTTV---GAAYVGGMCSLEYSGGVNEDHSknlESFAVTMAHELG 140

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32566077    392 HNMGMVHDGVQNQC---NKGCCLMSAVNGA-GKTTWSDCSVREFNAFLlqldESGRGNCLRDA 450
Cdd:pfam01421  141 HNLGMQHDDFNGGCkcpPGGGCIMNPSAGSsFPRKFSNCSQEDFEQFL----TKQKGACLFNK 199
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 247-435 5.69e-19

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 86.32  E-value: 5.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  247 EHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALSTGvhknGQAQSLLDAFCRYQAhm 326
Cdd:cd04267   10 DHRMVSYFNSDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPID----SDASNTLNSFSFWRA-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  327 npgtdlTDMNHYDHGVLLTGYDIYHTTTsvAGVAPVARMCDPLFACSLVE--GLHLGRSFVLAHEMGHNMGMVHDG---- 400
Cdd:cd04267   84 ------EGPIRHDNAVLLTAQDFIEGDI--LGLAYVGSMCNPYSSVGVVEdtGFTLLTALTMAHELGHNLGAEHDGgdel 155

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 32566077  401 VQNQCNKGCCLMS-AVNGAGKTTWSDCSVREFNAFL 435
Cdd:cd04267  156 AFECDGGGNYIMApVDSGLNSYRFSQCSIGSIREFL 191
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 466-534 3.74e-15

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 71.22  E-value: 3.74e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32566077    466 PGQRFTADQQCSYFWGRDYKVeIPNGKamDDICRILWC--GNSGSTISTAHPALEGSWCGANKWCHKGQCT 534
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTF-CPNGD--EDVCSKLWCsnPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 64-163 6.42e-15

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 72.73  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077     64 KFTAWNDTYHLNLRKNSRIVSPHIiSVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFL 143
Cdd:pfam01562   30 RLAAFGKKFHLHLTPNRLLLAPGF-TVTYYLDGGTGVESPPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEY 108

                           90       100
                   ....*....|....*....|
gi 32566077    144 VLQTLPKRVHHLQKERHLVY 163
Cdd:pfam01562  109 LIEPLEKYSREEGGHPHVVY 128
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1327-1378 1.99e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 1.99e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    1327 WSTWSDWTPCSASCGFGVQTRDRSCSS-PEPKGGQSCSGLAHQTSLCDLPACD 1378
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1206-1257 1.41e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.98  E-value: 1.41e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077    1206 WSLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDN 1257
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 807-851 1.70e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 1.70e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077     807 WTNWDEWSSCSQSCGGGRRYRIRKCLDDK-------CDGDDLEKESCNTQKC 851
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1385-1435 2.02e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 2.02e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    1385 WSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSP 1435
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 233-435 4.17e-10

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 61.21  E-value: 4.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  233 ITLEIGLFLDSKLFEHFEREyiqdaeQHLLEFSLALINNVHVLYQqDTLTPNLDIVIVRYEMWRTQPSALstgVHKNGQA 312
Cdd:cd04272    1 VYPELFVVVDYDHQSEFFSN------EQLIRYLAVMVNAANLRYR-DLKSPRIRLLLVGITISKDPDFEP---YIHPINY 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  313 QSLLDAFC--RYQAHMNPGTDLTDmnhYDHGVLLTGYDIYHT-----TTSVAGVAPVARMCDPLFAcSLVE-------GL 378
Cdd:cd04272   71 GYIDAAETleNFNEYVKKKRDYFN---PDVVFLVTGLDMSTYsggslQTGTGGYAYVGGACTENRV-AMGEdtpgsyyGV 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  379 HlgrsfVLAHEMGHNMGMVHDG------VQNQCNKGCC------LMS-AVNGAGKTTWSDCSVREFNAFL 435
Cdd:cd04272  147 Y-----TMTHELAHLLGAPHDGspppswVKGHPGSLDCpwddgyIMSyVVNGERQYRFSQCSQRQIRNVF 211
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1041-1082 5.43e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.44  E-value: 5.43e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077    1041 WSEWGPCSVTCGSGRRVRTRGC-------QEASCPEQHIQTEECNLNSC 1082
Cdd:smart00209    4 WSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1268-1318 1.50e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.90  E-value: 1.50e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    1268 WTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPA 1318
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 906-952 7.48e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.97  E-value: 7.48e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 32566077     906 WSEWGEWTTCSATCGEGLQSRERSCRR-------GSCTEDDaSQTRRCVNGPCE 952
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnggGPCTGED-VETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1328-1377 1.66e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 52.04  E-value: 1.66e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077   1328 STWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQsCSGLAHQTSLCDLPAC 1377
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEP-CTGDDIETQACKMDKC 49
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
266-424 5.24e-08

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 54.73  E-value: 5.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    266 LALINNVHVLYQQDTltpNLDIVIVRYEMW-RTQPSALSTGVHKNgqAQSLLDAFcryqahmnpgTDLTDMNH---YDHG 341
Cdd:pfam13688   29 INMVNTASNVYERDF---NISLGLVNLTISdSTCPYTPPACSTGD--SSDRLSEF----------QDFSAWRGtqnDDLA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    342 VLLTgydiyHTTTSVAGVAPVARMC--DPLFACSLVEGLHLGRS------FVLAHEMGHNMGMVHDGvQNQCNKGCC--- 410
Cdd:pfam13688   94 YLFL-----MTNCSGGGLAWLGQLCnsGSAGSVSTRVSGNNVVVstatewQVFAHEIGHNFGAVHDC-DSSTSSQCCpps 167

                          170       180
                   ....*....|....*....|....
gi 32566077    411 ----------LMSAVNGAGKTTWS 424
Cdd:pfam13688  168 nstcpaggryIMNPSSSPNSTDFS 191
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 855-898 6.71e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 50.28  E-value: 6.71e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 32566077     855 SWGDWLPCSVSCGIGFQIRERLC-------DGELCATANKQARTCNQQQCP 898
Cdd:smart00209    3 EWSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1041-1082 9.34e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 9.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 32566077   1041 WSEWGPCSVTCGSGRRVRTRGCQE-----ASCPEQHIQTEECNLNSC 1082
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKSpfpggEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 710-752 1.31e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.51  E-value: 1.31e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077     710 WEEWSSWSECSVSCGlGGREVRERKCSS------GRKCQGVSEESRPCE 752
Cdd:smart00209    1 WSEWSEWSPCSVTCG-GGVQTRTRSCCSpppqngGGPCTGEDVETRACN 48
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1041-1082 2.18e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.81  E-value: 2.18e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 32566077   1041 WSEWGPCSVTCGSGRRVRTR---------GcqeASCPEQHiQTEECNLNSC 1082
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRTRtvivepqngG---RPCPELL-ERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
907-951 1.62e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 1.62e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077    907 SEWGEWTTCSATCGEGLQSRERSC-----RRGSCTEDDAsQTRRCVNGPC 951
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpGGEPCTGDDI-ETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1328-1377 1.83e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.12  E-value: 1.83e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077   1328 STWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQSCSGLaHQTSLCDLPAC 1377
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 907-951 2.63e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.73  E-value: 2.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 32566077    907 SEWGEWTTCSATCGEGLQSRERSCRR------GSCTEDdaSQTRRCVNGPC 951
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVepqnggRPCPEL--LERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1151-1200 1.05e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.05e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    1151 WSEWSSWSACS--CFSLTSTRRRFCQVVDPTVQG-FCAGAILEQIPCAPGSCS 1200
Cdd:smart00209    1 WSEWSEWSPCSvtCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQPCP 53
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 710-766 1.18e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 49.17  E-value: 1.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077   710 WEEWSSWSECSVSCGLGGR-EVRERKCS--SGRKCQGVSEESRPCEGVLRDCEEFGEWKE 766
Cdd:PTZ00087  233 YTEWGEWSNCSMECDHPDNvQIRERKCAhpSGDCFKGDLKETRPCQVPLPPCNSLFEHKE 292
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 808-851 1.36e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 43.81  E-value: 1.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 32566077    808 TNWDEWSSCSQSCGGGRRYRIRKCLDDKCDG-----DDLEKESCNTQKC 851
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGgrpcpELLERRPCNLPPC 52
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 267-399 1.38e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 45.82  E-value: 1.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    267 ALINNVHVLYQQDTltpNLDIVIVRYEMWR--TQPSALSTGVHKNGQAQSLLDafcryqahmnpgtdlTDMNH--YDHGV 342
Cdd:pfam13582    5 SLVNRANTIYERDL---GIRLQLAAIIITTsaDTPYTSSDALEILDELQEVND---------------TRIGQygYDLGH 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077    343 LLTGYDIYhtttSVAGVAPVARMCDPLFACSLVEGLHLGRSF---VLAHEMGHNMGMVHD 399
Cdd:pfam13582   67 LFTGRDGG----GGGGIAYVGGVCNSGSKFGVNSGSGPVGDTgadTFAHEIGHNFGLNHT 122
TSP_1 pfam00090
Thrombospondin type 1 domain;
1269-1314 1.42e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 32566077   1269 TDWTAWSECTDYCRNGHRSRTRFCANPKPsqGGAQCTGSDFELNPC 1314
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC 44
TSP_1 pfam00090
Thrombospondin type 1 domain;
1207-1256 1.56e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.56e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077   1207 SLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSnrGAYCSGYSFDQRPCVMD 1256
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-GIQVRQRTCKSPFPG--GEPCTGDDIETQACKMD 47
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1041-1083 1.71e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 1.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 32566077  1041 WSEWGPCSVTCGSGRRVRTRGCQEASCpEQHIQtEECNLNSCL 1083
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEGC-TTHMV-EECEEEECP 283
TSP_1 pfam00090
Thrombospondin type 1 domain;
856-897 1.85e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.18  E-value: 1.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 32566077    856 WGDWLPCSVSCGIGFQIRERLCD-----GELCATANKQARTCNQQQC 897
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKspfpgGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
808-851 2.18e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.18  E-value: 2.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 32566077    808 TNWDEWSSCSQSCGGGRRYRIRKC-----LDDKCDGDDLEKESCNTQKC 851
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpGGEPCTGDDIETQACKMDKC 49
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 348-427 7.54e-05

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 44.82  E-value: 7.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  348 DIYHTTTSV------AGVAPVARMCDPLFACSLVE----GLHLGRsFVLAHEMGHNMGMVHDGVQNQCNKGC-------- 409
Cdd:cd00203   53 DIAILVTRQdfdggtGGWAYLGRVCDSLRGVGVLQdnqsGTKEGA-QTIAHELGHALGFYHDHDRKDRDDYPtiddtlna 131

                         90       100
                 ....*....|....*....|....*...
gi 32566077  410 ------CLMSAV----NGAGKTTWSDCS 427
Cdd:cd00203  132 edddyySVMSYTkgsfSDGQRKDFSQCD 159
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 906-947 8.85e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 46.48  E-value: 8.85e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 32566077   906 WSEWGEWTTCSATCG--EGLQSRERSC--RRGSCTEDDASQTRRCV 947
Cdd:PTZ00087  233 YTEWGEWSNCSMECDhpDNVQIRERKCahPSGDCFKGDLKETRPCQ 278
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1386-1421 1.60e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.73  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 32566077   1386 SAWNEWSGCMGNCGIGTRTRVRACVSPPvSDGGQPC 1421
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEP-QNGGRPC 38
TSP_1 pfam00090
Thrombospondin type 1 domain;
1386-1435 2.14e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.48  E-value: 2.14e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077   1386 SAWNEWSGCMGNCGIGTRTRVRACVSPPvsDGGQPCFGRSSEITECRQSP 1435
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPF--PGGEPCTGDDIETQACKMDK 48
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 762-806 2.86e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.34  E-value: 2.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 32566077   762 GEWKEWGSCSEKCALGVQKRFRPCLTDQCSSkHLQEErpCDNEGC 806
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSRPILHEGCTT-HMVEE--CEEEEC 282
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 851-897 3.28e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.96  E-value: 3.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 32566077    851 CISQSWGDWLPCSVSCGIGFQIRER------LCDGELCaTANKQARTCNQQQC 897
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRtvivepQNGGRPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
712-752 3.46e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.71  E-value: 3.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 32566077    712 EWSSWSECSVSCGLGGReVRERKCSS----GRKCQGVSEESRPCE 752
Cdd:pfam00090    2 PWSPWSPCSVTCGKGIQ-VRQRTCKSpfpgGEPCTGDDIETQACK 45
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 385-428 4.68e-04

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 43.00  E-value: 4.68e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 32566077    385 VLAHEMGHNMGMVHD--GVQNQC-------------NKGCCLMSAVNGAGKTTWSDCSV 428
Cdd:pfam13574  127 VVAHEVGHNFGATHDcdGSQYASsgcernaatsvcsANGSFIMNPASKSNNDLFSPCSI 185
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1207-1257 5.58e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 5.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 32566077   1207 SLWSEWSSCSKDCGdTGHQIRNRMCSEPiPSNRGAYCSGySFDQRPCVMDN 1257
Cdd:pfam19028    4 SEWSEWSECSVTCG-GGVQTRTRTVIVE-PQNGGRPCPE-LLERRPCNLPP 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 712-753 6.09e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 6.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 32566077    712 EWSSWSECSVSCGLG----GREVRERKCSSGRKCqGVSEESRPCEG 753
Cdd:pfam19028    5 EWSEWSECSVTCGGGvqtrTRTVIVEPQNGGRPC-PELLERRPCNL 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 909-951 6.55e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.18  E-value: 6.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 32566077   909 WGEWTTCSATCGEGLQSRERSCRRGSCTEDDASQtrrCVNGPC 951
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEGCTTHMVEE---CEEEEC 282
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1332-1377 7.53e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.97  E-value: 7.53e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 32566077   1332 DWTPCSASCGFGVQTRDRSC---SSPEPKGGQSCSGLA--HQTSLCDLPAC 1377
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKkpPETQSCNLKPC 55
ZnMc_ADAM_fungal cd04271
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A ...
 385-447 8.19e-04

Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.


Pssm-ID: 239799 [Multi-domain]  Cd Length: 228  Bit Score: 42.79  E-value: 8.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32566077  385 VLAHEMGHNMGMVHDGVQNQCNKG------CC-------------LMSAVNGAGKTTWSDCSVREFNAFLLQldESGRGN 445
Cdd:cd04271  148 VFAHEIGHTFGAVHDCTSGTCSDGsvgsqqCCplststcdangqyIMNPSSSSGITEFSPCTIGNICSLLGR--NPVRTS 225


                 ..
gi 32566077  446 CL 447
Cdd:cd04271  226 CL 227
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 810-851 9.62e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.80  E-value: 9.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 32566077   810 WDEWSSCSQSCGGGRRYRIRKCLDDKCDgDDLEKEsCNTQKC 851
Cdd:PTZ00441  243 WDEWTPCSVTCGKGTHSRSRPILHEGCT-THMVEE-CEEEEC 282
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1088-1130 1.69e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.69e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 32566077    1088 WSDWSSCSKSCGqDGIQTRQKLCLFNN-----AECSSYA-ESRRCKDLP 1130
Cdd:smart00209    4 WSEWSPCSVTCG-GGVQTRTRSCCSPPpqnggGPCTGEDvETRACNEQP 51
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 857-897 1.98e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.82  E-value: 1.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 32566077    857 GDWLPCSVSCGIGFQIRERLC---------DGELCATANK--QARTCNQQQC 897
Cdd:pfam19030    4 GPWGECSVTCGGGVQTRLVQCvqkgggsivPDSECSAQKKppETQSCNLKPC 55
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 762-806 2.05e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 2.05e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 32566077    762 GEWKEWGSCSEKCALGVQKRFR-----------PCltdqcssKHLQEERPCDNEGC 806
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRtvivepqnggrPC-------PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 762-806 2.23e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.23e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 32566077     762 GEWKEWGSCSEKCALGVQKRFRPCLTD-------QCSSKHLqEERPCDNEGC 806
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPppqngggPCTGEDV-ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1088-1130 2.78e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 2.78e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 32566077   1088 WSDWSSCSKSCGqDGIQTRQKLCL----FNNAECSSYAESRRCKDLP 1130
Cdd:pfam19028    6 WSEWSECSVTCG-GGVQTRTRTVIvepqNGGRPCPELLERRPCNLPP 51
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 813-851 4.35e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 4.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 32566077    813 WSSCSQSCGGGRRYRIRKC---------LDDKCDGDDL--EKESCNTQKC 851
Cdd:pfam19030    6 WGECSVTCGGGVQTRLVQCvqkgggsivPDSECSAQKKppETQSCNLKPC 55
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 1088-1135 4.49e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 41.08  E-value: 4.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 32566077  1088 WSDWSSCSKSCGQ-DGIQTRQKLCLFNNAEC--SSYAESRRCK-DLPSCSSI 1135
Cdd:PTZ00087  236 WGEWSNCSMECDHpDNVQIRERKCAHPSGDCfkGDLKETRPCQvPLPPCNSL 287
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 1089-1130 7.74e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 35.77  E-value: 7.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 32566077   1089 SDWSSCSKSCGQdGIQTRQKlclFNNAECSSYAESRRCKDLP 1130
Cdd:pfam19035    6 TEWSPCSKTCGM-GVSTRVS---NDNAECKLVTETRLCQLRP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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