NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17569457|ref|NP_510192|]
View 

Skp1-related protein [Caenorhabditis elegans]

Protein Classification

SKP1-like protein( domain architecture ID 10649839)

SKP1-like protein is a component of E3 ubiquitin ligase SCF complex involved in ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 7-116 9.25e-32

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


:

Pssm-ID: 214704  Cd Length: 104  Bit Score: 110.08  E-value: 9.25e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457      7 APLYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDRNCeraDPILVP-FHSSIVQAVIEWLYHYQDNPLARRDSkir 85
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENN---NPIPLPnVTSKILSKVIEYCEHHVDDPPSVADK--- 74

                           90       100       110
                   ....*....|....*....|....*....|.
gi 17569457     86 yHDFSEWDKQFFNVESGVLFALLNASHALGV 116
Cdd:smart00512  75 -DDIPTWDAEFLKIDQETLFELILAANYLDI 104
Skp1 pfam01466
Skp1 family, dimerization domain;
117-155 1.60e-09

Skp1 family, dimerization domain;


:

Pssm-ID: 460222  Cd Length: 48  Bit Score: 50.96  E-value: 1.60e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17569457   117 EDLMNMGCAAAAELIRGKSTEEIRKIYGIRSDEEQMEEA 155
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEE 39
 
Name Accession Description Interval E-value
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 7-116 9.25e-32

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 110.08  E-value: 9.25e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457      7 APLYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDRNCeraDPILVP-FHSSIVQAVIEWLYHYQDNPLARRDSkir 85
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENN---NPIPLPnVTSKILSKVIEYCEHHVDDPPSVADK--- 74

                           90       100       110
                   ....*....|....*....|....*....|.
gi 17569457     86 yHDFSEWDKQFFNVESGVLFALLNASHALGV 116
Cdd:smart00512  75 -DDIPTWDAEFLKIDQETLFELILAANYLDI 104
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-131 3.17e-20

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 80.71  E-value: 3.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457   9 LYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDrnceraDPILVP-FHSSIVQAVIEWLYHYQDNPLARRD--SKIR 85
Cdd:cd18322   1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDD------DPIPLPnVTSKILKKVIEWCEHHKDDPPPEIDldSEKR 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17569457  86 YHDFSEWDKQFFNVESGVLFALLNASHALGVEDLMNMGCAAAAELI 131
Cdd:cd18322  75 TDDIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 11-154 5.19e-19

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 78.83  E-value: 5.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457  11 KLKSEDGQIFNVERGpmkfcafINQK--FIDHGVNDRNCERADPILVPFHSSIVQAVIEWLYHYQD------NPLARRDS 82
Cdd:COG5201   5 ELESIDGEIFRVDEN-------IAERsiLIKNMLCDSTACNYPIPAPNVRSSVLMKVQEWMEHHTSslsedeNDLEIRKS 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17569457  83 KiryhDFSEWDKQFFNVESGVLFALLNASHALGVEDLMNMGCAAAAELIRGKSTEEIRKIYGIRSD--EEQMEE 154
Cdd:COG5201  78 K----PSDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVAEMIRGKSPEEIRETFNIENDftPEEERR 147
Skp1 pfam01466
Skp1 family, dimerization domain;
117-155 1.60e-09

Skp1 family, dimerization domain;


Pssm-ID: 460222  Cd Length: 48  Bit Score: 50.96  E-value: 1.60e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17569457   117 EDLMNMGCAAAAELIRGKSTEEIRKIYGIRSDEEQMEEA 155
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEE 39
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
8-74 1.28e-04

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 38.44  E-value: 1.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17569457     8 PLYKLKSEDGQIFNVERgpmkfcAFINQ-KFIDHGVNDRNcerADPILVP-FHSSIVQAVIEWLYHYQD 74
Cdd:pfam03931   1 PKIVLQSSDGESFEVEE------AVARKsKTIKHMIEDDG---DDPIPLPnVTSKILEKVIEYCKHHRV 60
 
Name Accession Description Interval E-value
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 7-116 9.25e-32

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 110.08  E-value: 9.25e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457      7 APLYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDRNCeraDPILVP-FHSSIVQAVIEWLYHYQDNPLARRDSkir 85
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENN---NPIPLPnVTSKILSKVIEYCEHHVDDPPSVADK--- 74

                           90       100       110
                   ....*....|....*....|....*....|.
gi 17569457     86 yHDFSEWDKQFFNVESGVLFALLNASHALGV 116
Cdd:smart00512  75 -DDIPTWDAEFLKIDQETLFELILAANYLDI 104
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-131 3.17e-20

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 80.71  E-value: 3.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457   9 LYKLKSEDGQIFNVERGPMKFCAFINQKFIDHGVNDrnceraDPILVP-FHSSIVQAVIEWLYHYQDNPLARRD--SKIR 85
Cdd:cd18322   1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDD------DPIPLPnVTSKILKKVIEWCEHHKDDPPPEIDldSEKR 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17569457  86 YHDFSEWDKQFFNVESGVLFALLNASHALGVEDLMNMGCAAAAELI 131
Cdd:cd18322  75 TDDIPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 11-154 5.19e-19

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 78.83  E-value: 5.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17569457  11 KLKSEDGQIFNVERGpmkfcafINQK--FIDHGVNDRNCERADPILVPFHSSIVQAVIEWLYHYQD------NPLARRDS 82
Cdd:COG5201   5 ELESIDGEIFRVDEN-------IAERsiLIKNMLCDSTACNYPIPAPNVRSSVLMKVQEWMEHHTSslsedeNDLEIRKS 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17569457  83 KiryhDFSEWDKQFFNVESGVLFALLNASHALGVEDLMNMGCAAAAELIRGKSTEEIRKIYGIRSD--EEQMEE 154
Cdd:COG5201  78 K----PSDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVAEMIRGKSPEEIRETFNIENDftPEEERR 147
Skp1 pfam01466
Skp1 family, dimerization domain;
117-155 1.60e-09

Skp1 family, dimerization domain;


Pssm-ID: 460222  Cd Length: 48  Bit Score: 50.96  E-value: 1.60e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17569457   117 EDLMNMGCAAAAELIRGKSTEEIRKIYGIRSDEEQMEEA 155
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEE 39
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
8-74 1.28e-04

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 38.44  E-value: 1.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17569457     8 PLYKLKSEDGQIFNVERgpmkfcAFINQ-KFIDHGVNDRNcerADPILVP-FHSSIVQAVIEWLYHYQD 74
Cdd:pfam03931   1 PKIVLQSSDGESFEVEE------AVARKsKTIKHMIEDDG---DDPIPLPnVTSKILEKVIEYCKHHRV 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH