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Conserved domains on  [gi|17551416|ref|NP_510227|]
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Receptor L-domain domain-containing protein [Caenorhabditis elegans]

Protein Classification

receptor L domain-containing protein; insulin receptor family protein( domain architecture ID 10470361)

receptor L domain-containing protein may be involved in ligand binding| insulin receptor family protein is a receptor protein-tyrosine kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates, and is activated via binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit, which leads to the stimulation of downstream kinase activities that initiate signaling cascades and biological function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 43-141 5.57e-19

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 80.74  E-value: 5.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551416    43 NCTRISGSILFGGSDAINT--LYAKLAYVEEVNGCIQVTGTSYTRLDFFARLRSVTCTNTTLS-VDFMVSNNSALERLGM 119
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDseLLSFLSNVEEITGYLLIANTNLVSLSFLPNLRIIRGRNLFDDnYALYILDNPNLTELGL 80

                          90       100
                  ....*....|....*....|....*
gi 17551416   120 PVLRV---NRLGLTFNPKLCITTEE 141
Cdd:pfam01030  81 PSLKEitsGGVYIHNNPKLCYTETE 105
 
Name Accession Description Interval E-value
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 43-141 5.57e-19

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 80.74  E-value: 5.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551416    43 NCTRISGSILFGGSDAINT--LYAKLAYVEEVNGCIQVTGTSYTRLDFFARLRSVTCTNTTLS-VDFMVSNNSALERLGM 119
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDseLLSFLSNVEEITGYLLIANTNLVSLSFLPNLRIIRGRNLFDDnYALYILDNPNLTELGL 80

                          90       100
                  ....*....|....*....|....*
gi 17551416   120 PVLRV---NRLGLTFNPKLCITTEE 141
Cdd:pfam01030  81 PSLKEitsGGVYIHNNPKLCYTETE 105
 
Name Accession Description Interval E-value
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 43-141 5.57e-19

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 80.74  E-value: 5.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17551416    43 NCTRISGSILFGGSDAINT--LYAKLAYVEEVNGCIQVTGTSYTRLDFFARLRSVTCTNTTLS-VDFMVSNNSALERLGM 119
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDseLLSFLSNVEEITGYLLIANTNLVSLSFLPNLRIIRGRNLFDDnYALYILDNPNLTELGL 80

                          90       100
                  ....*....|....*....|....*
gi 17551416   120 PVLRV---NRLGLTFNPKLCITTEE 141
Cdd:pfam01030  81 PSLKEitsGGVYIHNNPKLCYTETE 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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